Article
Hematology
Hisashi Sawada, Satoko Ohno-Urabe, Dien Ye, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Adam E. Mullick, Alan Daugherty, Hong S. Lu
Summary: This study found that inhibition of angiotensin II action or production of the renin-angiotensin system does not attenuate BAPN-induced thoracic aortopathies in mice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Peripheral Vascular Disease
Dominique M. Bovee, Liwei Ren, Estrellita Uijl, Marian C. Clahsen-van Groningen, Richard van Veghel, Ingrid M. Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Jae B. Kim, Stephen Huang, Lauren Melton, Xifeng Lu, Ewout J. Hoorn, Don Foster, A. H. Jan Danser
Summary: AGT siRNA demonstrates blood pressure-lowering and renal protective effects in hypertensive chronic kidney disease, independently of blood pressure, mainly through suppression of renal Ang II formation from liver-derived AGT.
Review
Peripheral Vascular Disease
Edwyn O. Cruz-Lopez, Dien Ye, Congqing Wu, Hong S. Lu, Estrellita Uijl, Katrina M. Mirabito Colafella, A. H. Jan Danser
Summary: Multiple types of RAS blockers exist to treat hypertension, but patient noncompliance and RAS escape remain challenges. New approaches using antisense oligonucleotides and siRNA to target angiotensinogen show promise in circumventing RAS escape. However, limited clinical data is available to support these methods.
Article
Cardiac & Cardiovascular Systems
Patrick J. Trainor, Michela Brambatti, Samantha M. Carlisle, Adam E. Mullick, Sanjiv J. Shah, Tanvir Kahlon, Diana Otero Mostacero, Hossein Mousavi, Erin S. Morgan, Yvonne Tami, Erin D. Michos, Pamela Ouyang, Sotirios Tsimikas, Andrew P. DeFilippis
Summary: This study explores the relationship between circulating angiotensinogen levels and ethnicity, sex, blood pressure (BP), and hypertension. The results suggest significant differences in angiotensinogen levels between sexes and ethnicities, with a positive association between levels and prevalent hypertension and BP, which differs between sexes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cell Biology
Sarfaraz Ahmad, Henry A. Punzi, Kendra N. Wright, Leanne Groban, Carlos M. Ferrario
Summary: A reliable RIA method was developed to measure Ang-(1-12) in human plasma and urine, showing significantly higher levels in patients with high blood pressure. The study suggests potential therapeutic value of the anti-Ang(1-12) antibody in preventing hypertension and organ damage.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Peripheral Vascular Disease
Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Joongyub Lee, Suah Sung, Ji Yong Jung, Young Youl Hyun, Kook-Hwan Oh, Shin-Wook Kang, Seung Hyeok Han
Summary: This study found that higher systolic blood pressure (SBP) was associated with the progression of chronic kidney disease (CKD) when urinary angiotensinogen levels were low, but this association was not observed when urinary angiotensinogen levels were high. This finding suggests that intrarenal renin-angiotensin system activity may modify the relationship between SBP and adverse kidney outcome.
Review
Medicine, Research & Experimental
Chuanxin Su, Jinhua Xue, Chao Ye, Aidong Chen
Summary: Hypertension, present in over one billion adults, is closely related to the disruption of the renin-angiotensin system (RAS). The AT1R receptor is the most important angiotensin II receptor, playing a critical role in vasoconstriction and being associated with multiple signaling pathways, including AT1R/JAK/STAT and Ras/Raf/MAPK pathways.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chantelle Thimm, Lars Erichsen, Wasco Wruck, James Adjaye
Summary: Podocytes, specialized cells in the kidney, play a crucial role in blood filtration and dysfunction of these cells can lead to renal diseases. Studying and utilizing podocytes is important in the field of regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Jeff Z. Chen, Hisashi Sawada, Dien Ye, Yuriko Katsumata, Masayoshi Kukida, Satoko Ohno-Urabe, Jessica J. Moorleghen, Michael K. Franklin, Deborah A. Howatt, Mary B. Sheppard, Adam E. Mullick, Hong S. Lu, Alan Daugherty
Summary: Deletion of AT1aR and inhibition of Ang II production had similar effects in attenuating pathologies in the proximal thoracic aorta of male Fbn1(C1041G/+) mice. Inhibition of the renin-angiotensin system attenuated dysregulation of genes within the aorta related to pathology of Fbn1(C1041G/+) mice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Lars Erichsen, Chantelle Thimm, Martina Bohndorf, Md Shaifur Rahman, Wasco Wruck, James Adjaye
Summary: High blood pressure is a major public health problem that causes severe disorders in tissues, including the kidneys. The renin-angiotensin system, specifically angiotensin II, plays a crucial role in regulating blood pressure and its dysregulation can lead to cardiovascular and renal tissue dysfunction. This study describes a differentiation protocol for urine-derived renal progenitor cells to differentiate into podocytes, which are specialized cells in the kidneys. The researchers also found that angiotensin II receptor type 1 signaling mediates cytoskeletal disruption in podocytes, which can be rescued by using a selective angiotensin II receptor type 1 antagonist. This research confirms the usefulness of these differentiated podocytes for studying nephrogenesis and associated diseases, and suggests their potential applications in nephrotoxicity studies and drug screening.
Review
Pharmacology & Pharmacy
M. Ekholm, T. Kahan
Summary: Atherosclerosis is a disease caused by chronic inflammation and endothelial dysfunction, with up-regulated mediators of inflammation in affected individuals. Oxidative stress, imbalance between antioxidants and oxidants, leads to tissue damage. The renin-angiotensin-aldosterone system plays a vital role in vascular disease pathobiology, with angiotensin II causing hypertension and reactive oxygen species production. Blocking this system could potentially reduce inflammatory and thrombotic complications.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Dettlaff-Pokora, Julian Swierczynski
Summary: SARS-CoV-2 impairs the renin-angiotensin-aldosterone system by binding the ACE2 enzyme, leading to an increase in angiotensin 2 and a decrease in angiotensin (1-7), potentially worsening damage to the lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Maria Jose Soler, Aida Ribera, Josep R. Marsal, Ana Belen Mendez, Mireia Andres, Maria Antonia Azancot, Gerard Oristrell, Leonardo Mendez-Boo, Jordana Cohen, Jose A. Barrabes, Ignacio Ferreira-Gonzalez
Summary: In a cohort study of HTN patients, it was found that the use of ACEi/ARBs reduced the risk of COVID-19 infection without increasing disease severity.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Infectious Diseases
Shamil Haroon, Anuradhaa Subramanian, Jennifer Cooper, Astha Anand, Krishna Gokhale, Nathan Byne, Samir Dhalla, Dionisio Acosta-Mena, Thomas Taverner, Kelvin Okoth, Jingya Wang, Joht Singh Chandan, Christopher Sainsbury, Dawit Tefra Zemedikun, G. Neil Thomas, Dhruv Parekh, Tom Marshall, Elizabeth Sapey, Nicola J. Adderley, Krishnarajah Nirantharakumar
Summary: This study investigated the association between prescription of ACE inhibitors or ARBs and the incidence of COVID-19 and all-cause mortality. The results showed that there was no significant difference in COVID-19 incidence between users of ACE inhibitors and CCBs, while users of ARBs had a slightly higher incidence rate. However, there were no significant associations between prescription of either ACE inhibitors or ARBs and all-cause mortality.
BMC INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Raul Loera-Valencia, Francesca Eroli, Sara Garcia-Ptacek, Silvia Maioli
Summary: The article explores the role of the brain renin-angiotensin system in cognition and Alzheimer's disease pathogenesis, as well as its relationship with risk factors such as hypercholesterolemia. Current RAS inhibition therapy's efficacy in improving cognition in AD patients is uncertain, with only one therapy under consideration in clinical trials. Additionally, research on novel drugs may offer potential for highly specific treatments targeting the brain RAS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Tomoko Mizushige, Hiroyuki Kobori, Yoko Nishijima, Yuichiro Yano, Koji Sakata, Manabu Hayakawa, Akira Nishiyama
JOURNAL OF DIABETES RESEARCH
(2015)
Review
Biochemistry & Molecular Biology
Asadur Rahman, Arif Ul Hasan, Akira Nishiyama, Hiroyuki Kobori
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Medicine, General & Internal
Kayoko Miyata, Ryousuke Satou, Daisuke Inui, Akemi Katsurada, Dale Seth, Allison Davis, Maki Urushihara, Hiroyuki Kobori, Kenneth D. Mitchell, L. Gabriel Navar
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2014)
Article
Pharmacology & Pharmacy
Shamshad J. Sherajee, Kazi Rafiq, Daisuke Nakano, Hirohito Mori, Hideki Kobara, Hirofumi Hitomi, Yoshihide Fujisawa, Hiroyuki Kobori, Tsutomu Masaki, Akira Nishiyama
EUROPEAN JOURNAL OF PHARMACOLOGY
(2013)
Article
Peripheral Vascular Disease
Satoshi Morimoto, Takashi Ando, Michita Niiyama, Yasufumi Seki, Naohiro Yoshida, Daisuke Watanabe, Fumiko Kawakami-Mori, Hiroyuki Kobori, Akira Nishiyama, Atsuhiro Ichihara
HYPERTENSION RESEARCH
(2014)
Article
Pharmacology & Pharmacy
Keisuke Ohnishi, Miki Murase, Daisuke Nakano, Nicolas Pelisch, Hirofumi Hitomi, Hiroyuki Kobori, Satoshi Morimoto, Hirohito Mori, Tsutomu Masaki, Koji Ohmori, Masakazu Kohno, Atsuhiro Ichihara, Akira Nishiyama
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2013)
Article
Pharmacology & Pharmacy
Ya Liu, Hirofumi Hitomi, Suwami Diah, Kazushi Deguchi, Hirohito Mori, Tsutomu Masaki, Daisuke Nakano, Hiroyuki Kobori, Akira Nishiyama
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2013)
Review
Physiology
Hiroyuki Kobori, Maki Urushihara
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2013)
Article
Multidisciplinary Sciences
Kazi Rafiq, Shamshad J. Sherajee, Hirofumi Hitomi, Daisuke Nakano, Hiroyuki Kobori, Koji Ohmori, Hirohito Mori, Hideki Kobara, Tsutomu Masaki, Masakazu Kohno, Akira Nishiyama
Article
Multidisciplinary Sciences
Keisuke Ishizawa, Yuki Izawa-Ishizawa, Noriko Yamano, Maki Urushihara, Takumi Sakurada, Masaki Imanishi, Shoko Fujii, Asami Nuno, Licht Miyamoto, Yoshitaka Kihira, Yasumasa Ikeda, Shoji Kagami, Hiroyuki Kobori, Koichiro Tsuchiya, Toshiaki Tamaki
Review
Biochemistry & Molecular Biology
Arif Ul Hasan, Asadur Rahman, Hiroyuki Kobori
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Physiology
Kayoko Miyata, Ryousuke Satou, Weijian Shao, Minolfa C. Prieto, Maki Urushihara, Hiroyuki Kobori, L. Gabriel Navar
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2014)
Article
Pharmacology & Pharmacy
Hiroyuki Kobori, Hirohito Mori, Tsutomu Masaki, Akira Nishiyama
CURRENT PHARMACEUTICAL DESIGN
(2013)
Article
Physiology
Weijian Shao, Dale M. Seth, Minolfa C. Prieto, Hiroyuki Kobori, L. Gabriel Navar
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2013)
Article
Medicine, General & Internal
Hiroyuki Kobori, Masumi Kamiyama, Lisa M. Harrison-Bernard, L. Gabriel Navar
JOURNAL OF INVESTIGATIVE MEDICINE
(2013)