Article
Oncology
Qinglian He, Ziqi Li, Jinbao Yin, Yuling Li, Yuting Yin, Xue Lei, Wei Zhu
Summary: A prognostic risk assessment model based on 11 autophagy-associated genes was successfully constructed in colorectal cancer (CRC), providing valuable insights into predicting survival outcomes for CRC patients. The model showed significant enrichment in tumor-relevant pathways and biological processes, offering new directions for evaluating prognosis and guiding treatment strategies for CRC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zilong Xiao, Xinxin Wang, Xiaoxiao Chen, Jiawei Zhou, Haitao Zhu, Jiangnan Zhang, Wensheng Deng
Summary: This study retrospectively analyzed clinical and survival data of 448 patients with colorectal cancer who underwent surgical resection, and found that the preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were negatively correlated with overall survival, while lymphocyte-to-monocyte ratio (LMR) was positively correlated with overall survival. Multivariate analysis showed that an increase in NLR was associated with increased risk of death, while a decrease in LMR was associated with reduced risk of death. Therefore, preoperative inflammatory markers NLR, PLR, and LMR are associated with the overall survival of postoperative colorectal cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Kohei Yasui, Dai Shida, Yuya Nakamura, Yuka Ahiko, Shunsuke Tsukamoto, Yukihide Kanemitsu
Summary: This study suggests that postoperative changes in inflammation-based prognostic markers are more accurate in predicting overall survival and recurrence-free survival in patients with stage III CRC. The study found that patients with a normalised inflammatory state had better prognosis compared to those with persistently elevated inflammatory state.
BRITISH JOURNAL OF CANCER
(2021)
Review
Oncology
Magdalena C. Liebl, Thomas G. Hofmann
Summary: The transcription factor p53 is a crucial tumor suppressor that is often mutated or dysregulated in colorectal cancer (CRC), promoting tumorigenesis. Mutations in p53 reduce its tumor suppressor activity and can even provide neo-morphic functions that contribute to cancer development.
Article
Biochemistry & Molecular Biology
Sanghyun An, Soo-Ki Kim, Hye Youn Kwon, Cheol Su Kim, Hui-Jae Bang, Hyejin Do, BoRa Kim, Kwangmin Kim, Youngwan Kim
Summary: The study identified immune-related and inflammatory markers expressed in freshly frozen colorectal cancer tissues and found that APRIL/TNFSF13, BAFF, and MMP-3 were significantly overexpressed and associated with unfavorable clinicopathological features and poor prognosis in colorectal cancer patients. These markers could serve as diagnostic and prognostic biomarkers for colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Alessandro Ottaiano, Mariachiara Santorsola, Maurizio Capuozzo, Francesco Perri, Luisa Circelli, Marco Cascella, Monica Ianniello, Francesco Sabbatino, Vincenza Granata, Francesco Izzo, Domenico Iervolino, Marika Casillo, Nadia Petrillo, Oreste Gualillo, Guglielmo Nasti, Giovanni Savarese
Summary: A meta-analysis was conducted to estimate the prognostic value of p53 mutations in metastatic colorectal cancer (CRC) patients. The analysis found a strong association between p53 alteration and left-sided CRC. However, the available evidence does not support a prognostic role for p53 in metastatic CRC patients. Prospective studies with larger sample sizes and consistent methodology are needed to further explore the prognostic role of p53 in this patient population.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Liangliang Liao, Yongjian Gao, Jie Su, Ye Feng
Summary: This study identified differentially expressed genes and driver genes in colon adenocarcinoma (COAD) using RNA-seq and mutation data. The analysis revealed suppressed energy supply and inflammatory response in advanced tumors. Three potential prognostic markers were identified through Cox regression analysis. Immune infiltration analysis showed a significant correlation between resting CD4(+) T cells and overall survival of COAD patients.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Yanliang Liu, Fengqin Guo, Wenyi Guo, Yatao Wang, Wei Song, Tao Fu
Summary: The study identified 13 most significantly related FRGs to the OS of CRC patients and established a prognostic risk signature with 10 genes. The predictive value of the risk scores for OS in CRC patients was confirmed through testing in the validation cohort. Establishing a genomic-clinicopathologic nomogram further improved prediction accuracy and clinical value.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Genetics & Heredity
Ilya G. Serebriiskii, Valerii A. Pavlov, Grigorii V. Andrianov, Samuel Litwin, Stanley Basickes, Justin Y. Newberg, Garrett M. Frampton, Joshua E. Meyer, Erica A. Golemis
Summary: Somatic PTEN mutations are less frequent in colorectal cancers and their relationship with tumor aggressiveness is controversial. PTEN alterations co-occur with certain other mutations in microsatellite stable tumors but not in microsatellite instability tumors. Interestingly, PTEN deletions are associated with poor survival in microsatellite stable colorectal cancers, while PTEN mutations are associated with improved survival in microsatellite instability colorectal cancers.
NPJ GENOMIC MEDICINE
(2023)
Article
Oncology
Yuan Yin, Zhiyuan Jiang, Jiamei Fu, Yang Li, Chao Fang, Xiaonan Yin, Ye Chen, Na Chen, Junshu Li, Yanhong Ji, Xiaolan Su, Meng Qiu, Wei Huang, Bo Zhang, Hongxin Deng, Lei Dai
Summary: The study reveals the expression and function of SLC5 family members in colorectal cancer, showing that downregulation of SLC5A7 correlates with CRC staging and prognosis response. Overexpression of SLC5A7 inhibits CRC growth by promoting p53 protein expression, suggesting a potential therapeutic target for CRC.
Article
Oncology
Kun Wang, Ming Liu, Hong-Wei Wang, Ke-Min Jin, Xiao-Luan Yan, Quan Bao, Da Xu, Li-Jun Wang, Wei Liu, Yan-Yan Wang, Juan Li, Li-Juan Liu, Xiao-Yu Zhang, Chun-He Yang, Ge Jin, Bao-Cai Xing
Summary: Mutations in DDR pathways are significantly correlated with worse overall survival in CRLM patients, with co-mutated pathways showing even stronger correlations. Additionally, mutated DDR pathways can predict pre-operative chemotherapy response and post-operative survival in CRLM patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Andela Horvat, Ana Tadijan, Ignacija Vlasic, Neda Slade
Summary: The p53 family members, including p53, p63, and p73, play crucial roles in carcinogenesis, particularly in colorectal carcinoma. They have the ability to form tetramers that activate the transcription of specific genes, making them potential targets for cancer treatment. Understanding the interactions and activities of the p53 family members can contribute to the development of new targeted therapies for cancer.
Article
Biochemistry & Molecular Biology
Kaisa Cui, Liang Gong, Han Zhang, Ying Chen, Bingxin Liu, Zhicheng Gong, Jiuming Li, Yuanben Wang, Shengbai Sun, Yajun Li, Qiang Zhang, Yulin Cao, Qilin Li, Bojian Fei, Zhaohui Huang
Summary: This study reveals that the RNA exosome gene (EXOSC8) promotes colorectal cancer (CRC) tumorigenesis by regulating cancer-related ribosome biogenesis in CRC. Silencing of EXOSC8 decreases levels of nucleolar proteins and proliferation markers, as well as rRNA/DNA and global protein syntheses. EXOSC8 knockdown triggers ribosomal stress, releasing nucleolar protein RPL5/11 into the nucleoplasm and hijacking Mdm2 to block its E3 ubiquitin ligase function, thereby releasing and activating p53. EXOSC8 may serve as a potential therapeutic target in CRC.
Article
Oncology
Kosuke Ozaki, Kazuhito Sasaki, Hiroyuki Abe, Hiroaki Nozawa, Koji Murono, Shigenobu Emoto, Tetsuo Ushiku, Soichiro Ishihara
Summary: This study aimed to investigate the relationship between apoptosis, apoptosis-related protein expression, and prognosis in the central and invasive front regions of colorectal cancer (CRC). The study found that a lower apoptosis percentage at the invasive front is associated with a poorer prognosis.
ANTICANCER RESEARCH
(2023)
Article
Immunology
Kang Lin, Xiaojian Zhu, Chen Luo, Fanqin Bu, Jinfeng Zhu, Zhengming Zhu
Summary: The study confirms CEP55 as a potential diagnostic and prognostic biomarker for CRC, with its role in promoting CRC cell proliferation and metastasis by activating the p53/p21 axis. Additionally, other genes like CDK1, CCNB1, NEK2, KIF14, CDCA5, and RFC3 are upregulated in tumors and their mutations may affect the prognosis of CRC patients.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Review
Immunology
Mariana Aris, Maria Marcela Barrio
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Immunology
Mariana Aris, Alicia Ines Bravo, Maria Marcela Barrio, Jose Mordoh
FRONTIERS IN IMMUNOLOGY
(2015)
Review
Immunology
Maria Vela, Mariana Aris, Mercedes Llorente, Jose. Garcia-Sanz, Leonor Kremer
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Oncology
Juan Martin Arriaga, Alicia Ines Bravo, Jose Mordoh, Michele Bianchini
Article
Immunology
Jose Mordoh, Maria Betina Pampena, Mariana Aris, Paula Alejandra Blanco, Monica Lombardo, Erika Maria von Euw, Soledad Mac Keon, Michelle Yepez Crow, Alicia Ines Bravo, Juan Manuel O'Connor, Ana Gabriela Orlando, Franco Ramello, Estrella Mariel Levy, Maria Marcela Barrio
FRONTIERS IN IMMUNOLOGY
(2017)
Review
Immunology
Mariana Aris, Jose Mordoh, Maria Marcela Barrio
FRONTIERS IN IMMUNOLOGY
(2017)
Meeting Abstract
Oncology
Juan Martin Arriaga, Cory Abate-Shen
Article
Medicine, Research & Experimental
Juan M. Arriaga, Cory Abate-Shen
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE
(2019)
Article
Immunology
Mariana Aris, Alicia Ines Bravo, Maria Betina Pampena, Paula Alejandra Blanco, Ibel Carri, Daniel Koile, Patricio Yankilevich, Estrella Mariel Levy, Maria Marcela Barrio, Jose Mordoh
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Alvaro Aytes, Arianna Giacobbe, Antonina Mitrofanova, Katia Ruggero, Joanna Cyrta, Juan Arriaga, Luis Palomero, Sonia Farran-Matas, Mark A. Rubin, Michael M. Shen, Andrea Califano, Cory Abate-Shen
NATURE COMMUNICATIONS
(2018)
Article
Immunology
Mariana Aris, Alicia Ines Bravo, Heli Magali Garcia Alvarez, Ibel Carri, Enrique Podaza, Paula Alejandra Blanco, Cecilia Rotondaro, Sofia Bentivegna, Morten Nielsen, Maria Marcela Barrio, Jose Mordoh
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Enrique Podaza, Ibel Carri, Mariana Aris, Erika von Euw, Alicia Ines Bravo, Paula Blanco, Juan Manuel Ortiz Wilczynski, Daniel Koile, Patricio Yankilevich, Morten Nielsen, Jose Mordoh, Maria Marcela Barrio
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Ana Mordoh, Mariana Aris, Ibel Carri, Alicia Ines Bravo, Enrique Podaza, Juan Carlos Trivino Pardo, Gerardo Ruben Cueto, Maria Marcela Barrio, Jose Mordoh
Summary: The CSF-470 vaccine, in combination with BCG and GM-CSF, has shown potential as an adjuvant treatment for cutaneous melanoma patients, and can be used in combination with immune checkpoint inhibitors. This study provides an effective treatment option for patients with stage IIB, IIC, and III cutaneous melanoma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Ana Mordoh, Juan Carlos Trivino Pardo, Ibel Carri, Maria Marcela Barrio, Jose Mordoh, Mariana Aris
Summary: This study found that genetic events in precursor lesions may contribute to the rapid clinical progression of cutaneous melanoma. The research also revealed a sequential and cumulative pattern of genetic alterations throughout tumorigenesis, suggesting the importance of early genetic changes in tumor development.
BMC MEDICAL GENOMICS
(2023)
Article
Oncology
Juan M. Arriaga, Sukanya Panja, Mohammed Alshalalfa, Junfei Zhao, Min Zou, Arianna Giacobbe, Chioma J. Madubata, Jaime Yeji Kim, Antonio Rodriguez, Ilsa Coleman, Renu K. Virk, Hanina Hibshoosh, Onur Ertunc, Busra Ozbek, Julia Fountain, R. Jeffrey Karnes, Jun Luo, Emmanuel S. Antonarakis, Peter S. Nelson, Felix Y. Feng, Mark A. Rubin, Angelo M. De Marzo, Raul Rabadan, Peter A. Sims, Antonina Mitrofanova, Cory Abate-Shen