Sequence and Structure Signatures of Cancer Mutation Hotspots in Protein Kinases

Computational Modeling of Structurally Conserved Cancer Mutations in the RET and MET Kinases: The Impact on Protein Structure, Dynamics, and Stability

(2009) Anshuman Dixit et al.   BIOPHYSICAL JOURNAL

Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

(2009) Wei Zheng et al.   NATURE GENETICS

Mapping the conformational transition in Src activation by cumulating the information from multiple molecular dynamics trajectories

(2009) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hierarchical Modeling of Activation Mechanisms in the ABL and EGFR Kinase Domains: Thermodynamic and Mechanistic Catalysts of Kinase Activation by Cancer Mutations

(2009) Anshuman Dixit et al.   PLoS Computational Biology

High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia

(2008) M. M. Loriaux et al.   BLOOD

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia

(2008) M. H. Tomasson et al.   BLOOD

Cancer driver mutations in protein kinase genes

(2008) Ali Torkamani et al.   CANCER LETTERS

Prediction of Cancer Driver Mutations in Protein Kinases

(2008) A. Torkamani et al.   CANCER RESEARCH

Design and analysis issues in genome-wide somatic mutation studies of cancer

(2008) Giovanni Parmigiani et al.   GENOMICS

Structure and Clinical Relevance of the Epidermal Growth Factor Receptor in Human Cancer

(2008) Amit Kumar et al.   JOURNAL OF CLINICAL ONCOLOGY

Protein Conformational Transitions: The Closure Mechanism of a Kinase Explored by Atomistic Simulations

(2008) Anna Berteotti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-throughput mutational screen of the tyrosine kinome in chronic myelomonocytic leukemia

(2008) J W Tyner et al.   LEUKEMIA

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

(2008) Lambertus A Kiemeney et al.   NATURE GENETICS

MoKCa database—mutations of kinases in cancer

(2008) Christopher J. Richardson et al.   NUCLEIC ACIDS RESEARCH

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Congenital disease SNPs target lineage specific structural elements in protein kinases

(2008) Ali Torkamani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A conserved protonation-dependent switch controls drug binding in the Abl kinase

(2008) Y. Shan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

(2008) C.-H. Yun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric cooperativity in protein kinase A

(2008) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An electrostatic network and long-range regulation of Src kinases

(2008) Elif Ozkirimli et al.   PROTEIN SCIENCE

Detailed conformational dynamics of juxtamembrane region and activation loop in c-Kit kinase activation process

(2008) Jun Zou et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Conformational dynamics of the EGFR kinase domain reveals structural features involved in activation

(2008) Athanasios Papakyriakou et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases

(2008) Nilesh K. Banavali et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Src Kinase Conformational Activation: Thermodynamics, Pathways, and Mechanisms

(2008) Sichun Yang et al.   PLoS Computational Biology