The ROS-sensitive microRNA-9/9* controls the expression of mitochondrial tRNA-modifying enzymes and is involved in the molecular mechanism of MELAS syndrome

Mitochondria as signaling organelles

(2014) Navdeep S Chandel   BMC BIOLOGY

Mixing and matching mitochondrial aminoacyl synthetases and their tRNAs: a new way to treat respiratory chain disorders?

(2014) H. Tyynismaa et al.   EMBO Molecular Medicine

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs

(2014) T. Suzuki et al.   NUCLEIC ACIDS RESEARCH

MTO1 Mutations are Associated with Hypertrophic Cardiomyopathy and Lactic Acidosis and Cause Respiratory Chain Deficiency in Humans and Yeast

(2013) Enrico Baruffini et al.   HUMAN MUTATION

Oxidative Stress and MicroRNAs in Vascular Diseases

(2013) Alessandra Magenta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Why translation counts for mitochondria - retrograde signalling links mitochondrial protein synthesis to mitochondrial biogenesis and cell proliferation

(2013) B. J. Battersby et al.   JOURNAL OF CELL SCIENCE

The UK MRC Mitochondrial Disease Patient Cohort Study: clinical phenotypes associated with the m.3243A>G mutation--implications for diagnosis and management

(2013) V. Nesbitt et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Essential nontranslational functions of tRNA synthetases

(2013) Min Guo et al.   Nature Chemical Biology

Phenotypic heterogeneity of the 8344A>G mtDNA "MERRF" mutation

(2013) M. Mancuso et al.   NEUROLOGY

Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing

(2013) M. Pratt-Hyatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modification of tRNALysUUU by Elongator Is Essential for Efficient Translation of Stress mRNAs

(2013) Jorge Fernández-Vázquez et al.   PLoS Genetics

Loss of a Conserved tRNA Anticodon Modification Perturbs Cellular Signaling

(2013) Boris Zinshteyn et al.   PLoS Genetics

Mutations of the Mitochondrial-tRNA Modifier MTO1 Cause Hypertrophic Cardiomyopathy and Lactic Acidosis

(2012) Daniele Ghezzi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway

(2012) Jose Félix Moruno-Manchón et al.   BIOCHEMICAL JOURNAL

Enzymology of tRNA modification in the bacterial MnmEG pathway

(2012) M.-Eugenia Armengod et al.   BIOCHIMIE

MicroRNA-21 Modulates the Levels of Reactive Oxygen Species by Targeting SOD3 and TNF 

(2012) X. Zhang et al.   CANCER RESEARCH

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response

(2012) Ashish Patil et al.   CELL CYCLE

MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery

(2012) Armaz Aschrafi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage

(2012) Alexandros Sfikas et al.   CELLULAR SIGNALLING

Evaluation of Systemic Redox States in Patients Carrying the MELAS A3243G Mutation in Mitochondrial DNA

(2012) Masamichi Ikawa et al.   EUROPEAN NEUROLOGY

Epigenetics, epidemiology and mitochondrial DNA diseases

(2012) Patrick F Chinnery et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

MicroRNA-9 Inhibition of Cell Proliferation and Identification of Novel miR-9 Targets by Transcriptome Profiling in Breast Cancer Cells

(2012) S. Duygu Selcuklu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA

(2012) Veronika Reiter et al.   NUCLEIC ACIDS RESEARCH

A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase—extensive moonlighting in mitochondrial tRNA biogenesis

(2012) Elisa Vilardo et al.   NUCLEIC ACIDS RESEARCH

A New Module in Neural Differentiation Control: Two MicroRNAs Upregulated by Retinoic Acid, miR-9 and -103, Target the Differentiation Inhibitor ID2

(2012) Daniela Annibali et al.   PLoS One

The Natural Anticancer Agent Plumbagin Induces Potent Cytotoxicity in MCF-7 Human Breast Cancer Cells by Inhibiting a PI-5 Kinase for ROS Generation

(2012) Ju-Hee Lee et al.   PLoS One

MicroRNA-30b-Mediated Regulation of Catalase Expression in Human ARPE-19 Cells

(2012) Rashidul Haque et al.   PLoS One

Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins

(2012) Clement T.Y. Chan et al.   Nature Communications

Cellular Dynamics of RNA Modification

(2011) Chengqi Yi et al.   ACCOUNTS OF CHEMICAL RESEARCH

A simple synthesis of APM ([p-(N-acrylamino)-phenyl]mercuric chloride), a useful tool for the analysis of thiolated biomolecules

(2011) V. Lemau de Talancé et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isoleucyl-tRNA synthetase levels modulate the penetrance of a homoplasmic m.4277T>C mitochondrial tRNAIle mutation causing hypertrophic cardiomyopathy

(2011) Elena Perli et al.   HUMAN MOLECULAR GENETICS

The 2-thiouridylase function of the human MTU1 (TRMU) enzyme is dispensable for mitochondrial translation

(2011) F. Sasarman et al.   HUMAN MOLECULAR GENETICS

miRWalk – Database: Prediction of possible miRNA binding sites by “walking” the genes of three genomes

(2011) Harsh Dweep et al.   JOURNAL OF BIOMEDICAL INFORMATICS

MicroRNA-9 is an activation-induced regulator of PDGFR-beta expression in cardiomyocytes

(2011) Jianhu Zhang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

miR-335 and miR-34a Promote Renal Senescence by Suppressing Mitochondrial Antioxidative Enzymes

(2011) X.-Y. Bai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reactive Oxygen Species (ROS)––Induced genetic and epigenetic alterations in human carcinogenesis

(2011) Dominique Ziech et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

MicroRNAs can generate thresholds in target gene expression

(2011) Shankar Mukherji et al.   NATURE GENETICS

NF-kappaB P50/P65 hetero-dimer mediates differential regulation of CD166/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative auto-regulatory loop

(2011) Jiayi Wang et al.   NUCLEIC ACIDS RESEARCH

TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms

(2011) H Rauert et al.   Cell Death & Disease

Evolution Meets Disease: Penetrance and Functional Epistasis of Mitochondrial tRNA Mutations

(2011) Raquel Moreno-Loshuertos et al.   PLoS Genetics

Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs

(2011) Suzuki Tsutomu et al.   Wiley Interdisciplinary Reviews-RNA

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Acute liver failure with subsequent cirrhosis as the primary manifestation of TRMU mutations

(2010) Ulrike Schara et al.   JOURNAL OF INHERITED METABOLIC DISEASE

MicroRNA Functions in Stress Responses

(2010) Anthony K.L. Leung et al.   MOLECULAR CELL

Mitochondrial DNA Mutation-Elicited Oxidative Stress, Oxidative Damage, and Altered Gene Expression in Cultured Cells of Patients with MERRF Syndrome

(2010) Shi-Bei Wu et al.   MOLECULAR NEUROBIOLOGY

A minicircuitry involving REST and CREB controls miR-9-2 expression during human neuronal differentiation

(2010) Pietro Laneve et al.   NUCLEIC ACIDS RESEARCH

A Quantitative Systems Approach Reveals Dynamic Control of tRNA Modifications during Cellular Stress

(2010) Clement T. Y. Chan et al.   PLoS Genetics

Acute Infantile Liver Failure Due to Mutations in the TRMU Gene

(2009) Avraham Zeharia et al.   AMERICAN JOURNAL OF HUMAN GENETICS

OXPHOS gene expression and control in mitochondrial disorders

(2009) Fimmie Reinecke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line

(2009) Javier G. Pizarro et al.   FREE RADICAL RESEARCH

Combination of the Loss of cmnm5U34 with the Lack of s2U34 Modifications of tRNALys, tRNAGlu, and tRNAGln Altered Mitochondrial Biogenesis and Respiration

(2009) Xinjian Wang et al.   JOURNAL OF MOLECULAR BIOLOGY

The Bifunctional microRNA miR-9/miR-9* Regulates REST and CoREST and Is Downregulated in Huntington's Disease

(2009) A. N. Packer et al.   JOURNAL OF NEUROSCIENCE

Accumulation of oxidative stress around the stroke-like lesions of MELAS patients

(2009) Yuri Katayama et al.   MITOCHONDRION

Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions

(2009) Ismaïl Moukadiri et al.   NUCLEIC ACIDS RESEARCH

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

(2009) F. Bazzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular medicine of microRNAs: structure, function and implications for diabetes

(2008) Erica Hennessy et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Expression of islet-specific microRNAs during human pancreatic development

(2008) Mugdha V. Joglekar et al.   GENE EXPRESSION PATTERNS

The Mechanism of Mitochondrial Superoxide Production by the Cytochromebc1Complex

(2008) Stefan Dröse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System

(2008) M. J. O. Johansson et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of Human GTPBP3, a GTP-Binding Protein Involved in Mitochondrial tRNA Modification

(2008) M. Villarroya et al.   MOLECULAR AND CELLULAR BIOLOGY

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE