A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover

piRNAs Initiate an Epigenetic Memory of Nonself RNA in the C. elegans Germline

(2012) Masaki Shirayama et al.   CELL

Daf-2 Signaling Modifies Mutant SOD1 Toxicity in C. elegans

(2012) Marco Boccitto et al.   PLoS One

A Pro-Cathepsin L Mutant Is a Luminal Substrate for Endoplasmic-Reticulum-Associated Degradation in C. elegans

(2012) Mark T. Miedel et al.   PLoS One

CREST - a large and diverse superfamily of putative transmembrane hydrolases

(2011) Jimin Pei et al.   Biology Direct

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

(2011) Masayuki Yamasaki et al.   EMBO REPORTS

TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling

(2011) Tao Zhang et al.   HUMAN MOLECULAR GENETICS

Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates

(2010) David H. Perlmutter   Annual Review of Medicine

SID1 transmembrane family, member 2 (Sidt2): A novel lysosomal membrane protein

(2010) Gao Jialin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

(2010) Sager J. Gosai et al.   PLoS One

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

(2009) Richard Killick et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

(2009) Ehud Cohen et al.   CELL

Silencing by small RNAs is linked to endosomal trafficking

(2009) Young Sik Lee et al.   NATURE CELL BIOLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Selection and validation of a set of reliable reference genes for quantitative sod gene expression analysis in C. elegans

(2008) David Hoogewijs et al.   BMC MOLECULAR BIOLOGY

The insulin paradox: aging, proteotoxicity and neurodegeneration

(2008) Ehud Cohen et al.   NATURE REVIEWS NEUROSCIENCE