A genome-wide RNAi screen identifies potential drug targets in a C. elegans model of α1-antitrypsin deficiency

Autophagy protects against hypoxic injury inC. elegans

(2014) Victor Samokhvalov et al.   Autophagy

Large-scale functional RNAi screen in C. elegans identifies genes that regulate the dysfunction of mutant polyglutamine neurons

(2012) François-Xavier Lejeune et al.   BMC GENOMICS

Novel Treatment Strategies for Liver Disease Due to a1-Antitrypsin Deficiency

(2012) Nicholas Maurice et al.   CTS-Clinical and Translational Science

NSP4, an elastase-related protease in human neutrophils with arginine specificity

(2012) N. C. Perera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery

(2012) S. Karve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reliability analysis of the Ahringer Caenorhabditis elegans RNAi feeding library: a guide for genome-wide screens

(2011) Wubin Qu et al.   BMC GENOMICS

Molecular basis of α1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer

(2011) Masayuki Yamasaki et al.   EMBO REPORTS

STITCH 3: zooming in on protein-chemical interactions

(2011) M. Kuhn et al.   NUCLEIC ACIDS RESEARCH

OrthoList: A Compendium of C. elegans Genes with Human Orthologs

(2011) Daniel D. Shaye et al.   PLoS One

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

(2011) M. Catarina Silva et al.   PLoS Genetics

Global Functional Analyses of Cellular Responses to Pore-Forming Toxins

(2011) Cheng-Yuan Kao et al.   PLoS Pathogens

Alpha-1-Antitrypsin Deficiency: Importance of Proteasomal and Autophagic Degradative Pathways in Disposal of Liver Disease–Associated Protein Aggregates

(2010) David H. Perlmutter   Annual Review of Medicine

Serpins Flex Their Muscle

(2010) Gary A. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

(2010) Alexander Buchberger et al.   MOLECULAR CELL

Automated High-Content Live Animal Drug Screening Using C. elegans Expressing the Aggregation Prone Serpin α1-antitrypsin Z

(2010) Sager J. Gosai et al.   PLoS One

An Autophagy-Enhancing Drug Promotes Degradation of Mutant  1-Antitrypsin Z and Reduces Hepatic Fibrosis

(2010) T. Hidvegi et al.   SCIENCE

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Statistical methods for analysis of high-throughput RNA interference screens

(2009) Amanda Birmingham et al.   NATURE METHODS

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During Aging

(2008) Tjakko J. van Ham et al.   PLoS Genetics