Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits

Disrupted in Schizophrenia 1 forms pathological aggresomes that disrupt its function in intracellular transport

(2012) Talia A. Atkin et al.   HUMAN MOLECULAR GENETICS

Convergence of Two Independent Mental Disease Genes on the Protein Level: Recruitment of Dysbindin to Cell-Invasive Disrupted-In-Schizophrenia 1 Aggresomes

(2011) Philipp Ottis et al.   BIOLOGICAL PSYCHIATRY

Polyreactive antibodies in adaptive immune responses to viruses

(2011) Hugo Mouquet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Collapsin Response Mediator Proteins (CRMPs) Are a New Class of Microtubule-associated Protein (MAP) That Selectively Interacts with Assembled Microtubules via a Taxol-sensitive Binding Interaction

(2011) Pao-Chun Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ability of LCRMP-1 to promote cancer invasion by enhancing filopodia formation is antagonized by CRMP-1

(2011) Szu-Hua Pan et al.   JOURNAL OF CLINICAL INVESTIGATION

Collapsin Response Mediator Protein-2: An Emerging Pathologic Feature and Therapeutic Target for Neurodisease Indications

(2011) Kenneth Hensley et al.   MOLECULAR NEUROBIOLOGY

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

(2011) Nicholas J. Brandon et al.   NATURE REVIEWS NEUROSCIENCE

The neurobiology of anhedonia and other reward-related deficits

(2011) Andre Der-Avakian et al.   TRENDS IN NEUROSCIENCES

Biochemical and Functional Interaction of Disrupted-in-Schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration during Mammalian Cortical Development

(2010) T. L. Young-Pearse et al.   JOURNAL OF NEUROSCIENCE

Reelin Signals through Apolipoprotein E Receptor 2 and Cdc42 to Increase Growth Cone Motility and Filopodia Formation

(2010) J. Leemhuis et al.   JOURNAL OF NEUROSCIENCE

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function

(2010) Q Wang et al.   MOLECULAR PSYCHIATRY

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Disrupted-in-Schizophrenia-1 expression is regulated by  -site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

(2010) S. Seshadri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolving concepts of specificity in immune reactions

(2010) H. N. Eisen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reelin-mediated signaling in neuropsychiatric and neurodegenerative diseases

(2010) Irene Knuesel   PROGRESS IN NEUROBIOLOGY

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

Association of Variants in DISC1 With Psychosis-Related Traits in a Large Population Cohort

(2009) Liisa Tomppo et al.   ARCHIVES OF GENERAL PSYCHIATRY

Prepulse inhibition and genetic mouse models of schizophrenia

(2009) Susan B. Powell et al.   BEHAVIOURAL BRAIN RESEARCH

Oligomer Assembly of the C-Terminal DISC1 Domain (640−854) Is Controlled by Self-Association Motifs and Disease-Associated Polymorphism S704C

(2009) S. Rutger Leliveld et al.   BIOCHEMISTRY

Association Between Genes of Disrupted in Schizophrenia 1 (DISC1) Interactors and Schizophrenia Supports the Role of the DISC1 Pathway in the Etiology of Major Mental Illnesses

(2009) Liisa Tomppo et al.   BIOLOGICAL PSYCHIATRY

Understanding the Role of DISC1 in Psychiatric Disease and during Normal Development

(2009) N. J. Brandon et al.   JOURNAL OF NEUROSCIENCE

The DISC1 Pathway Modulates Expression of Neurodevelopmental, Synaptogenic and Sensory Perception Genes

(2009) William Hennah et al.   PLoS One

Neurodevelopmental mechanisms of schizophrenia: understanding disturbed postnatal brain maturation through neuregulin-1–ErbB4 and DISC1

(2009) Hanna Jaaro-Peled et al.   TRENDS IN NEUROSCIENCES

Nudel Binds Cdc42GAP to Modulate Cdc42 Activity at the Leading Edge of Migrating Cells

(2008) Yidong Shen et al.   DEVELOPMENTAL CELL

Schizophrenia as a progressive brain disease

(2008) N.E.M. van Haren et al.   EUROPEAN PSYCHIATRY

Insolubility of Disrupted-in-Schizophrenia 1 Disrupts Oligomer-Dependent Interactions with Nuclear Distribution Element 1 and Is Associated with Sporadic Mental Disease

(2008) S. R. Leliveld et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1

(2008) S. Shen et al.   JOURNAL OF NEUROSCIENCE

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder

(2008) W Hennah et al.   MOLECULAR PSYCHIATRY

The validity of Psychosis Proneness Scales as vulnerability indicators in recent-onset schizophrenia patients

(2008) William P. Horan et al.   SCHIZOPHRENIA RESEARCH