Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metabolic syndrome: an update on diagnostic criteria, pathogenesis, and genetic links
Authors
Keywords
Metabolic syndrome, Insulin resistance, Central obesity, Cytokines, Single-nucleotide polymorphisms
Journal
Hormones-International Journal of Endocrinology and Metabolism
Volume 17, Issue 3, Pages 299-313
Publisher
Springer Nature America, Inc
Online
2018-09-01
DOI
10.1007/s42000-018-0051-3
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Sex- and gender-related prevalence, cardiovascular risk and therapeutic approach in metabolic syndrome: A review of the literature
- (2017) Giacomo Pucci et al. PHARMACOLOGICAL RESEARCH
- Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management
- (2017) Arun Chaudhury et al. Frontiers in Endocrinology
- Association between Metabolic Syndrome and Cancer
- (2016) Mehmet Uzunlulu et al. ANNALS OF NUTRITION AND METABOLISM
- Obesity alters molecular and functional cardiac responses to ischemia/reperfusion and glucagon-like peptide-1 receptor agonism
- (2016) Daniel J. Sassoon et al. BASIC RESEARCH IN CARDIOLOGY
- Electrophysiological basis of metabolic-syndrome-induced cardiac dysfunction
- (2016) Esma N. Okatan et al. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
- Treatment of Obesity
- (2016) Bruce M. Wolfe et al. CIRCULATION RESEARCH
- Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination
- (2016) Jason S. L. Yu et al. DEVELOPMENT
- Uric acid in metabolic syndrome: From an innocent bystander to a central player
- (2016) Mehmet Kanbay et al. European Journal of Internal Medicine
- Lipotoxicity: Many Roads to Cell Dysfunction and Cell Death: Introduction to a Thematic Review Series
- (2016) Jean E. Schaffer JOURNAL OF LIPID RESEARCH
- Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α
- (2016) Henrique Nascimento et al. Childhood Obesity
- Hepcidin: regulation of the master iron regulator
- (2015) Gautam Rishi et al. BIOSCIENCE REPORTS
- Are There Genetic Paths Common to Obesity, Cardiovascular Disease Outcomes, and Cardiovascular Risk Factors?
- (2015) T. Rankinen et al. CIRCULATION RESEARCH
- Association of liver X receptor α (LXRα) gene polymorphism and ischemic stroke
- (2015) H.X. Wang et al. GENETICS AND MOLECULAR RESEARCH
- Prevalence of the Metabolic Syndrome in the United States, 2003-2012
- (2015) Maria Aguilar et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Calcium release channel RyR2 regulates insulin release and glucose homeostasis
- (2015) Gaetano Santulli et al. JOURNAL OF CLINICAL INVESTIGATION
- Dyad content is reduced in cardiac myocytes of mice with impaired calmodulin regulation of RyR2
- (2015) Manuela Lavorato et al. JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
- Comparisons of Different Metabolic Syndrome Definitions and Associations with Coronary Heart Disease, Stroke, and Peripheral Arterial Disease in a Rural Chinese Population
- (2015) Jiangping Wen et al. PLoS One
- Uric Acid Levels Can Predict Metabolic Syndrome and Hypertension in Adolescents: A 10-Year Longitudinal Study
- (2015) Hai-Lun Sun et al. PLoS One
- Adiponectin: a manifold therapeutic target for metabolic syndrome, diabetes, and coronary disease?
- (2014) Enrique Z Fisman et al. Cardiovascular Diabetology
- Comprehensive analysis of circulating adipokines and hsCRP association with cardiovascular disease risk factors and metabolic syndrome in Arabs
- (2014) Mohamed Abu-Farha et al. Cardiovascular Diabetology
- TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants – past, present and future
- (2014) Lisa M. Sedger et al. CYTOKINE & GROWTH FACTOR REVIEWS
- Obesity-related gene ADRB2, ADRB3 and GHRL polymorphisms and the response to a weight loss diet intervention in adult women
- (2014) Louise F. Saliba et al. GENETICS AND MOLECULAR BIOLOGY
- Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent
- (2014) Adeela Shahid et al. Hormones-International Journal of Endocrinology and Metabolism
- Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis
- (2014) Jie-fu Lu et al. HUMAN IMMUNOLOGY
- Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies
- (2014) S. O'Neill et al. Obesity Reviews
- Genetics of metabolic syndrome
- (2014) Alena Stančáková et al. REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
- Insulin Receptor Signaling in Normal and Insulin-Resistant States
- (2014) J. Boucher et al. Cold Spring Harbor Perspectives in Biology
- Link between insulin resistance and hypertension: What is the evidence from evolutionary biology?
- (2014) Ming-Sheng Zhou et al. Diabetology & Metabolic Syndrome
- Hypoxia in Diabetic Kidneys
- (2014) Yumi Takiyama et al. Biomed Research International
- What is metabolic syndrome, and why are children getting it?
- (2013) Ram Weiss et al. Annals of the New York Academy of Sciences
- Hypoxia-Inducible Factor 1 and Cardiovascular Disease
- (2013) Gregg L. Semenza Annual Review of Physiology
- Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator
- (2013) Keisuke Watanabe et al. BIOCHEMICAL PHARMACOLOGY
- Cyanidin, a natural flavonoid, is an agonistic ligand for liver X receptor alpha and beta and reduces cellular lipid accumulation in macrophages and hepatocytes
- (2013) Yaoyao Jia et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Potential Role of Uric Acid in Metabolic Syndrome, Hypertension, Kidney Injury, and Cardiovascular Diseases: Is It Time for Reappraisal?
- (2013) Zohreh Soltani et al. CURRENT HYPERTENSION REPORTS
- Associations of −308G/APolymorphism ofTumor Necrosis Factor(TNF)–αGene and Serum TNF-αLevels with Measures of Obesity, Intra-Abdominal and Subcutaneous Abdominal Fat, Subclinical Inflammation and Insulin Resistance in Asian Indians in North India
- (2013) Naval K. Vikram et al. DISEASE MARKERS
- Metabolic Syndrome and Risk of Incident Peripheral Artery Disease
- (2013) Parveen K. Garg et al. HYPERTENSION
- Prevalence and Trends of Metabolic Syndrome in the Adult U.S. Population, 1999–2010
- (2013) Hiram Beltrán-Sánchez et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
- (2013) Shannon M Reilly et al. NATURE MEDICINE
- Triglyceride to HDL-C Ratio and Increased Arterial Stiffness in Children, Adolescents, and Young Adults
- (2013) E. M. Urbina et al. PEDIATRICS
- Correction: Increased Serum Hepcidin Levels in Subjects with the Metabolic Syndrome: A Population Study
- (2013) Nicola Martinelli et al. PLoS One
- Adiponectin-11377CG Gene Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis of 6425 Subjects
- (2013) Yan-yan Li et al. PLoS One
- Association of Interleukin-6 Gene Promoter Polymorphism with Coronary Artery Disease in Pakistani Families
- (2013) Humayoon Shafiq Satti et al. TheScientificWorldJOURNAL
- Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells
- (2013) Yue Chen et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Prospective Study of Serum Adiponectin and Incident Metabolic Syndrome: The ARIRANG study
- (2012) J.-Y. Kim et al. DIABETES CARE
- Impact of the Hypoxia-Inducible Factor-1 (HIF1A) Pro582Ser Polymorphism on Diabetes Nephropathy
- (2012) H. F. Gu et al. DIABETES CARE
- Cytokine Gene Polymorphisms in the Susceptibility to Acute Coronary Syndrome
- (2012) Baddela M.V. Srikanth Babu et al. Genetic Testing and Molecular Biomarkers
- Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist–Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India
- (2012) Vipin Gupta et al. Genetic Testing and Molecular Biomarkers
- Surrogate Lipid Markers for Small Dense Low-Density Lipoprotein Particles in Overweight Youth
- (2012) Stephen F. Burns et al. JOURNAL OF PEDIATRICS
- Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial function
- (2012) Amanda R Martins et al. Lipids in Health and Disease
- Regulation of Insulin Signaling by the Phosphatidylinositol 3,4,5-Triphosphate Phosphatase SKIP through the Scaffolding Function of Pak1
- (2012) T. Ijuin et al. MOLECULAR AND CELLULAR BIOLOGY
- Physical Activity and Risk of Cardiovascular Disease—A Meta-Analysis of Prospective Cohort Studies
- (2012) Jian Li et al. International Journal of Environmental Research and Public Health
- Novel variations in the adiponectin gene (ADIPOQ) may affect distribution of oligomeric complexes
- (2012) Leah C Kottyan et al. SpringerPlus
- Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?
- (2012) U. Deniz Dincer Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Hepcidin and iron regulation, 10 years later
- (2011) T. Ganz BLOOD
- Metabolic syndrome: definitions and controversies
- (2011) Eva Kassi et al. BMC Medicine
- An association between TRP64ARG polymorphism of the B3 adrenoreceptor gene and some metabolic disturbances
- (2011) Aibek E Mirrakhimov et al. Cardiovascular Diabetology
- Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease
- (2011) Kris V. Kowdley et al. HEPATOLOGY
- Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts
- (2011) Hartmut Jaeschke JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Association of Serum Retinol Binding Protein 4 with Adiposity and Pubertal Development in Korean Children and Adolescents
- (2011) Young Jun Rhie et al. JOURNAL OF KOREAN MEDICAL SCIENCE
- Plasma visfatin and adiponectin concentrations in physically active adolescent girls: relationships with insulin sensitivity and body composition variables
- (2011) Jaak Jürimäe et al. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
- Association of the apolipoprotein A5 gene -1131 T>C polymorphism with fasting blood lipids: a meta-analysis in 37859 subjects
- (2010) Tongfeng Zhao et al. BMC Medical Genetics
- Age and Sex Differences in the Clustering of Metabolic Syndrome Factors: Association with mortality risk
- (2010) J. L. Kuk et al. DIABETES CARE
- The Metabolic Syndrome and Cardiovascular Risk
- (2010) Salvatore Mottillo et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Management of type 2 diabetes: evolving strategies for the treatment of patients with type 2 diabetes
- (2010) Ebenezer A. Nyenwe et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Role of adipokines in complications related to obesity. A review
- (2009) M Gnacińska et al. Advances in Medical Sciences
- Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample
- (2009) Geza Nagy et al. BMC Medical Genetics
- Harmonizing the Metabolic Syndrome
- (2009) K.G.M.M. Alberti et al. CIRCULATION
- Vascular insulin resistance: A potential link between cardiovascular and metabolic diseases
- (2009) Ivonne Hernandez Schulman et al. CURRENT HYPERTENSION REPORTS
- Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes
- (2009) R. A. DeFronzo et al. DIABETES CARE
- Mitogenic action of insulin: friend, foe or ‘frenemy’?
- (2009) B. Draznin DIABETOLOGIA
- The β3-adrenoceptor as a therapeutic target: Current perspectives
- (2009) Maria Grazia Ursino et al. PHARMACOLOGICAL RESEARCH
- Metabolic Syndrome Pandemic
- (2008) Scott M. Grundy ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans
- (2008) Sara Fröjdö et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Selective versus Total Insulin Resistance: A Pathogenic Paradox
- (2008) Michael S. Brown et al. Cell Metabolism
- Adipose Tissue Macrophages, Low Grade Inflammation and Insulin Resistance in Human Obesity
- (2008) Leonie Heilbronn et al. CURRENT PHARMACEUTICAL DESIGN
- Adipokines: The missing link between insulin resistance and obesity
- (2008) B. Antuna-Puente et al. DIABETES & METABOLISM
- The Metabolic Syndrome
- (2008) Marc-Andre Cornier et al. ENDOCRINE REVIEWS
- Intramuscular lipid metabolism, insulin action, and obesity
- (2008) Leslie A. Consitt et al. IUBMB LIFE
- Adipose Inflammation, Insulin Resistance, and Cardiovascular Disease
- (2008) Arti Shah et al. JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
- The Role of Inflammatory Cytokines in Diabetic Nephropathy
- (2008) J. F. Navarro-Gonzalez et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Prevalence of Metabolic Syndrome in Pakistan
- (2008) Abdul Basit et al. Metabolic Syndrome and Related Disorders
- Physiological, Pharmacological, and Nutritional Regulation of Circulating Adiponectin Concentrations in Humans
- (2008) Michael M. Swarbrick et al. Metabolic Syndrome and Related Disorders
- Prevalence of Metabolic Syndrome in Urban Pakistan (Karachi): Comparison of Newly Proposed International Diabetes Federation and Modified Adult Treatment Panel III Criteria
- (2008) M. Zafar Iqbal Hydrie et al. Metabolic Syndrome and Related Disorders
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started