Flow-induced stress on adherent cells in microfluidic devices

A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells

(2015) R. Sinha et al.   LAB ON A CHIP

Well plate-based perfusion culture device for tissue and tumor microenvironment replication

(2015) W. Zhang et al.   LAB ON A CHIP

Centrifugo-pneumatic multi-liquid aliquoting – parallel aliquoting and combination of multiple liquids in centrifugal microfluidics

(2015) F. Schwemmer et al.   LAB ON A CHIP

Characterization of syringe-pump-driven induced pressure fluctuations in elastic microchannels

(2015) Wen Zeng et al.   LAB ON A CHIP

A quantitative microfluidic angiogenesis screen for studying anti-angiogenic therapeutic drugs

(2015) Choong Kim et al.   LAB ON A CHIP

Mining the microbial dark matter

(2015) Corie Lok   NATURE

Emerging trends in the pathophysiology of lymphatic contractile function

(2015) Sanjukta Chakraborty et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Controlled electromechanical cell stimulation on-a-chip

(2015) Andrea Pavesi et al.   Scientific Reports

An ultra-high-throughput spiral microfluidic biochip for the enrichment of circulating tumor cells

(2014) Majid Ebrahimi Warkiani et al.   ANALYST

Releasing Pressure in Tumors: What Do We Know So Far and Where Do We Go from Here? A Review

(2014) A. B. Ariffin et al.   CANCER RESEARCH

Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction

(2014) Yue Shao et al.   Integrative Biology

Shear-induced endothelial NOS activation and remodeling via heparan sulfate, glypican-1, and syndecan-1

(2014) Eno E. Ebong et al.   Integrative Biology

Microfluidic perfusion culture chip providing different strengths of shear stress for analysis of vascular endothelial function

(2014) Koji Hattori et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Contractile forces regulate cell division in three-dimensional environments

(2014) Ayelet Lesman et al.   JOURNAL OF CELL BIOLOGY

Continuous flow micro-bioreactors for the production of biopharmaceuticals: the effect of geometry, surface texture, and flow rate

(2014) Lucía D. Garza-García et al.   LAB ON A CHIP

Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform

(2014) Manjunath Hegde et al.   LAB ON A CHIP

Engineering interconnected 3D vascular networks in hydrogels using molded sodium alginate lattice as the sacrificial template

(2014) Xue-Ying Wang et al.   LAB ON A CHIP

A centrifugal fluidic immunoassay for ocular diagnostics with an enzymatically hydrolyzed fluorogenic substrate

(2014) David I. Walsh III et al.   LAB ON A CHIP

DVD technology-based molecular diagnosis platform: quantitative pregnancy test on a disc

(2014) Xiaochun Li et al.   LAB ON A CHIP

Testing Aβ toxicity on primary CNS cultures using drug-screening microfluidic chips

(2014) A. Ruiz et al.   LAB ON A CHIP

Induced charge electroosmosis micropumps using arrays of Janus micropillars

(2014) Joel S. Paustian et al.   LAB ON A CHIP

A multiple-channel, multiple-assay platform for characterization of full-range shear stress effects on vascular endothelial cells

(2014) R. Booth et al.   LAB ON A CHIP

A biomimetic multicellular model of the airways using primary human cells

(2014) Katelyn L. Sellgren et al.   LAB ON A CHIP

A Microfluidic-Based Multi-Shear Device for Investigating the Effects of Low Fluid-Induced Stresses on Osteoblasts

(2014) Weiliang Yu et al.   PLoS One

Mechanotransduction of fluid stresses governs 3D cell migration

(2014) W. J. Polacheck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Low voltage non-gassing electro-osmotic pump with zeta potential tuned aluminosilicate frits and organic dye electrodes

(2014) Harish Lakhotiya et al.   RSC Advances

Pumpless steady-flow microfluidic chip for cell culture

(2013) Mohana Marimuthu et al.   ANALYTICAL BIOCHEMISTRY

Mechanical modulation of nascent stem cell lineage commitment in tissue engineering scaffolds

(2013) Min Jae Song et al.   BIOMATERIALS

A new experimental system for simultaneous application of cyclic tensile strain and fluid shear stress to tenocytes in vitro

(2013) Eijiro Maeda et al.   BIOMEDICAL MICRODEVICES

The Relationship between Tumor Blood Flow, Angiogenesis, Tumor Hypoxia, and Aerobic Glycolysis

(2013) L. Ostergaard et al.   CANCER RESEARCH

Peroxynitrite Disrupts Endothelial Caveolae Leading to eNOS Uncoupling and Diminished Flow-Mediated Dilation in Coronary Arterioles of Diabetic Patients

(2013) J. Cassuto et al.   DIABETES

Pumps for microfluidic cell culture

(2013) Chang Kyu Byun et al.   ELECTROPHORESIS

Oscillatory shear stress induced calcium flickers in osteoblast cells

(2013) Bibhas Roy et al.   Integrative Biology

A lab-in-a-droplet bioassay strategy for centrifugal microfluidics with density difference pumping, power to disc and bidirectional flow control

(2013) Guanghui Wang et al.   LAB ON A CHIP

Active liquid degassing in microfluidic systems

(2013) J. Mikael Karlsson et al.   LAB ON A CHIP

Cardiac-like flow generator for long-term imaging of endothelial cell responses to circulatory pulsatile flow at microscale

(2013) Huaying Chen et al.   LAB ON A CHIP

Optimal periodic perfusion strategy for robust long-term microfluidic cell culture

(2013) Stefano Giulitti et al.   LAB ON A CHIP

Collaborative effects of electric field and fluid shear stress on fibroblast migration

(2013) Sukhyun Song et al.   LAB ON A CHIP

Study of endothelial cell apoptosis using fluorescence resonance energy transfer (FRET) biosensor cell line with hemodynamic microfluidic chip system

(2013) J. Q. Yu et al.   LAB ON A CHIP

Microfluidic platforms for mechanobiology

(2013) William J. Polacheck et al.   LAB ON A CHIP

Side view thrombosis microfluidic device with controllable wall shear rate and transthrombus pressure gradient

(2013) Ryan W. Muthard et al.   LAB ON A CHIP

Integrating biological vasculature into a multi-organ-chip microsystem

(2013) Katharina Schimek et al.   LAB ON A CHIP

Hydrodynamic effects on bacterial biofilm development in a microfluidic environment

(2013) Junghyun Kim et al.   LAB ON A CHIP

Engineering of functional, perfusable 3D microvascular networks on a chip

(2013) Sudong Kim et al.   LAB ON A CHIP

A novel tool for dynamic cell adhesion studies – the De-Adhesion Number Investigator DANI

(2013) Andreas Hartmann et al.   LAB ON A CHIP

Microfabricated perfusable cardiac biowire: a platform that mimics native cardiac bundle

(2013) Yun Xiao et al.   LAB ON A CHIP

Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules

(2013) I. Rizvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

(2013) Erik Westein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering approaches for inducing blood vessel formation

(2013) YJ Blinder et al.   Current Opinion in Chemical Engineering

The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo

(2012) Hiroshi Maeda et al.   ADVANCED DRUG DELIVERY REVIEWS

Solid-supported lipid bilayers to drive stem cell fate and tissue architecture using periosteum derived progenitor cells

(2012) Sarah F. Evans et al.   BIOMATERIALS

Cell culture using centrifugal microfluidic platform with demonstration on Pichia pastoris

(2012) Yong Ren et al.   BIOMEDICAL MICRODEVICES

Selectin-mediated adhesion in shear flow using micropatterned substrates: multiple-bond interactions govern the critical length for cell binding

(2012) ZiQiu Tong et al.   Integrative Biology

Mechanism of a flow-gated angiogenesis switch: early signaling events at cell–matrix and cell–cell junctions

(2012) Vernella Vickerman et al.   Integrative Biology

RhoA mediates flow-induced endothelial sprouting in a 3-D tissue analogue of angiogenesis

(2012) Jonathan W. Song et al.   LAB ON A CHIP

A multichannel dampened flow system for studies on shear stress-mediated mechanotransduction

(2012) Peter L. Voyvodic et al.   LAB ON A CHIP

Microfluidic system for simultaneous optical measurement of platelet aggregation at multiple shear rates in whole blood

(2012) Melissa Li et al.   LAB ON A CHIP

A microfluidic platform for rapid, stress-induced antibiotic susceptibility testing of Staphylococcus aureus

(2012) Maxim Kalashnikov et al.   LAB ON A CHIP

Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis

(2012) Raymond H. W. Lam et al.   LAB ON A CHIP

Microfluidic very large scale integration (mVLSI) with integrated micromechanical valves

(2012) Ismail Emre Araci et al.   LAB ON A CHIP

A multi-shear perfusion bioreactor for investigating shear stress effects in endothelial cell constructs

(2012) Menahem Y. Rotenberg et al.   LAB ON A CHIP

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

A microfluidic flow-stretch chip for investigating blood vessel biomechanics

(2012) Wenfu Zheng et al.   LAB ON A CHIP

A three-dimensional microfluidic tumor cell migration assay to screen the effect of anti-migratory drugs and interstitial flow

(2012) Johann Kalchman et al.   Microfluidics and Nanofluidics

Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue

(2012) G. S. Karagiannis et al.   MOLECULAR CANCER RESEARCH

Mapping the Mechanome of Live Stem Cells Using a Novel Method to Measure Local Strain Fields In Situ at the Fluid-Cell Interface

(2012) Min Jae Song et al.   PLoS One

Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells

(2012) S. S. Hur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function

(2012) I. K. Zervantonakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biophysical regulation of stem cell behavior within the niche

(2012) Anthony Conway et al.   Stem Cell Research & Therapy

Fabrication of multi-layer polymeric micro-sieve having narrow slot pores with conventional ultraviolet-lithography and micro-fabrication techniques

(2011) Majid Ebrahimi Warkiani et al.   Biomicrofluidics

Tumor Cell Invasion Is Promoted by Interstitial Flow-Induced Matrix Priming by Stromal Fibroblasts

(2011) A. C. Shieh et al.   CANCER RESEARCH

The use of controlled surface topography and flow-induced shear stress to influence renal epithelial cell function

(2011) Else M. Frohlich et al.   Integrative Biology

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

MEMS sensors and microsystems for cell mechanobiology

(2011) Jagannathan Rajagopalan et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Patterning cells and shear flow conditions: Convenient observation of endothelial cell remoulding, enhanced production of angiogenesis factors and drug response

(2011) Li Wang et al.   LAB ON A CHIP

Bubbles no more: in-plane trapping and removal of bubbles in microfluidic devices

(2011) Conrad Lochovsky et al.   LAB ON A CHIP

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

(2011) Masha Prager-Khoutorsky et al.   NATURE CELL BIOLOGY

High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays

(2011) Véronique Lecault et al.   NATURE METHODS

Fluid forces control endothelial sprouting

(2011) J. W. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect

(2010) Jun Fang et al.   ADVANCED DRUG DELIVERY REVIEWS

Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction

(2010) Yi-Chin Toh et al.   FASEB JOURNAL

A microfluidic device for continuous cancer cell culture and passage with hydrodynamic forces

(2010) Liyu Liu et al.   LAB ON A CHIP

Centrifugal microfluidics for biomedical applications

(2010) Robert Gorkin et al.   LAB ON A CHIP

Use of a porous membrane for gas bubble removal in microfluidic channels: physical mechanisms and design criteria

(2010) Jie Xu et al.   Microfluidics and Nanofluidics

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Microengineered Platforms for Cell Mechanobiology

(2009) Deok-Ho Kim et al.   Annual Review of Biomedical Engineering

Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades

(2009) Wissam A. AbouAlaiwi et al.   CIRCULATION RESEARCH

Detachment of captured cancer cells under flow acceleration in a bio-functionalized microchannel

(2009) Luthur Siu Lun Cheung et al.   LAB ON A CHIP

Tapered microfluidic chip for the study of biochemical and mechanical response at subcellular level of endothelial cells to shear flow

(2009) Massimiliano Rossi et al.   LAB ON A CHIP

Micro-Particle Image Velocimetry (µPIV): Recent developments, applications, and guidelines

(2009) Ralph Lindken et al.   LAB ON A CHIP

A novel multishear microdevice for studying cell mechanics

(2009) Lien Chau et al.   LAB ON A CHIP

Centrifugo-pneumatic valve for metering of highly wetting liquids on centrifugal microfluidic platforms

(2009) Daniel Mark et al.   LAB ON A CHIP

Macro- and microscale fluid flow systems for endothelial cell biology

(2009) Edmond W. K. Young et al.   LAB ON A CHIP

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

(2009) Warwick S Nesbitt et al.   NATURE MEDICINE

Probing Cellular Dynamics with a Chemical Signal Generator

(2009) Brandon Kuczenski et al.   PLoS One

Single-cell response to stiffness exhibits muscle-like behavior

(2009) D. Mitrossilis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosis

(2008) Jeng-Jiann Chiu et al.   ANNALS OF MEDICINE

Molecular Regulation of Lymphatic Contractility

(2008) Mariappan Muthuchamy et al.   Annals of the New York Academy of Sciences

Primary cilia sensitize endothelial cells for fluid shear stress

(2008) Beerend P. Hierck et al.   DEVELOPMENTAL DYNAMICS

Mechanical modulation of osteochondroprogenitor cell fate

(2008) Melissa L. Knothe Tate et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Electronic control of elastomeric microfluidic circuits with shape memory actuators

(2008) Saurabh Vyawahare et al.   LAB ON A CHIP

The deformation of flexible PDMS microchannels under a pressure driven flow

(2008) Brian S. Hardy et al.   LAB ON A CHIP

Spatial Regulation of Inflammation by Human Aortic Endothelial Cells in a Linear Gradient of Shear Stress

(2008) Jean K. Tsou et al.   MICROCIRCULATION

Mechanism of shape determination in motile cells

(2008) Kinneret Keren et al.   NATURE

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Endothelial Glycocalyx: A Mechano-Sensor and -Transducer

(2008) J. M. Tarbell et al.   Science Signaling

Modulation of Stem Cell Shape and Fate B: Mechanical Modulation of Cell Shape and Gene Expression

(2008) Sara H. McBride et al.   TISSUE ENGINEERING PART A

A microfluidic processor for gene expression profiling of single human embryonic stem cells

(2007) Jiang F. Zhong et al.   LAB ON A CHIP