Microfluidics-based single cell analysis reveals drug-dependent motility changes in trypanosomes

Microfluidic single-cell analysis for systems immunology

(2014) Michael Junkin et al.   LAB ON A CHIP

Optical trapping reveals propulsion forces, power generation and motility efficiency of the unicellular parasites Trypanosoma brucei brucei

(2014) Eric Stellamanns et al.   Scientific Reports

On-chip investigation of cell–drug interactions

(2013) Xin Ting Zheng et al.   ADVANCED DRUG DELIVERY REVIEWS

Luminescent multiplex viability assay for Trypanosoma brucei gambiense

(2013) Nick Van Reet et al.   Parasites & Vectors

Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy

(2013) Sam Alsford et al.   TRENDS IN PARASITOLOGY

In Vivo Imaging of Trypanosome-Brain Interactions and Development of a Rapid Screening Test for Drugs against CNS Stage Trypanosomiasis

(2013) Elmarie Myburgh et al.   PLoS Neglected Tropical Diseases

Hierarchical self-assembly of actin in micro-confinements using microfluidics

(2012) Siddharth Deshpande et al.   Biomicrofluidics

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Revisiting lab-on-a-chip technology for drug discovery

(2012) Pavel Neužil et al.   NATURE REVIEWS DRUG DISCOVERY

Three-Dimensional Structure of the Trypanosome Flagellum Suggests that the Paraflagellar Rod Functions as a Biomechanical Spring

(2012) Louise C. Hughes et al.   PLoS One

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes

(2012) Manu De Rycker et al.   PLoS Neglected Tropical Diseases

Single-cell assays

(2011) Declan Ryan et al.   Biomicrofluidics

Microfluidics for single cell analysis

(2011) Huabing Yin et al.   CURRENT OPINION IN BIOTECHNOLOGY

Structure of Trypanosoma brucei flagellum accounts for its bihelical motion

(2011) A. Y. Koyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Microscopic Motility on the Swimming Behavior of Parasites: Straighter Trypanosomes are More Directional

(2011) Sravanti Uppaluri et al.   PLoS Computational Biology

Motile and non-motile sperm diagnostic manipulation using optoelectronic tweezers

(2010) Aaron T. Ohta et al.   LAB ON A CHIP

The silicon trypanosome

(2010) BARBARA M. BAKKER et al.   PARASITOLOGY

Single cell analysis: the new frontier in ‘omics’

(2010) Daojing Wang et al.   TRENDS IN BIOTECHNOLOGY

In Vitro and In Vivo High-Throughput Assays for the Testing of Anti-Trypanosoma cruzi Compounds

(2010) Adriana M. C. Canavaci et al.   PLoS Neglected Tropical Diseases

A microfluidic cell culture platform for real-time cellular imaging

(2009) Chia-Chun Hsieh et al.   BIOMEDICAL MICRODEVICES

Human African trypanosomiasis

(2009) Reto Brun et al.   LANCET

High-resolution, long-term characterization of bacterial motility using optical tweezers

(2009) Taejin L Min et al.   NATURE METHODS

Droplet microfluidic technology for single-cell high-throughput screening

(2009) E. Brouzes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical tweezers for single cells

(2008) H. Zhang et al.   Journal of the Royal Society Interface