Herbal Therapies for Type 2 Diabetes Mellitus: Chemistry, Biology, and Potential Application of Selected Plants and Compounds

Anti-apoptotic Function and Mechanism of Ginseng Saponins in Rattus Pancreatic β-Cells

(2015) Fang Chen et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes

(2012) Zhuo Fu et al.   Applied Physiology Nutrition and Metabolism

Maintenance of  -Cell Maturity and Plasticity in the Adult Pancreas: Developmental Biology Concepts in Adult Physiology

(2012) M. Szabat et al.   DIABETES

Curcumin Extract for Prevention of Type 2 Diabetes

(2012) S. Chuengsamarn et al.   DIABETES CARE

Berberine in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis

(2012) Hui Dong et al.   Evidence-based Complementary and Alternative Medicine

Preventive and Protective Properties ofZingiber officinale(Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review

(2012) Yiming Li et al.   Evidence-based Complementary and Alternative Medicine

Fagopyrum tataricum(Buckwheat) Improved High-Glucose-Induced Insulin Resistance in Mouse Hepatocytes and Diabetes in Fructose-Rich Diet-Induced Mice

(2012) Chia-Chen Lee et al.   Experimental Diabetes Research

Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1

(2012) David G Parkes et al.   Expert Opinion on Drug Discovery

Turmeric (Curcuma longaL.) volatile oil inhibits key enzymes linked to type 2 diabetes

(2012) P. C. Lekshmi et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Korean red ginseng (Panax ginseng) ameliorates type 1 diabetes and restores immune cell compartments

(2012) Young Joo Hong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Regulation of signaling molecules associated with insulin action, insulin secretion and pancreatic β-cell mass in the hypoglycemic effects of Korean red ginseng in Goto-Kakizaki rats

(2012) Hye Young Kim et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Hypoglycemic Effects of American Red Ginseng (Panax quinquefolius L.) on a Diabetic Mouse Model

(2012) Kyung Mi Yoo et al.   JOURNAL OF FOOD SCIENCE

Extract from Dioscorea batatas Ameliorates Insulin Resistance in Mice Fed a High-Fat Diet

(2012) Soyoung Kim et al.   JOURNAL OF MEDICINAL FOOD

Polypharmacy (herbal and synthetic drug combination): a novel approach in the treatment of type-2 diabetes and its complications in rats

(2012) Rupinder Kaur et al.   Journal of Natural Medicines

Genistein accelerates refractory wound healing by suppressing superoxide and FoxO1/iNOS pathway in type 1 diabetes

(2012) Lu Tie et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol ameliorates diabetes-related metabolic changes via activation of AMP-activated protein kinase and its downstream targets indb/dbmice

(2012) Gyeong-Min Do et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cinnamon polyphenols regulate multiple metabolic pathways involved in insulin signaling and intestinal lipoprotein metabolism of small intestinal enterocytes

(2012) Bolin Qin et al.   NUTRITION

Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus

(2012) Jayesh Kumar Bhatt et al.   NUTRITION RESEARCH

Acute assessment of an aspalathin-enriched green rooibos (Aspalathus linearis) extract with hypoglycemic potential

(2012) C.J.F. Muller et al.   PHYTOMEDICINE

Amorfrutins are potent antidiabetic dietary natural products

(2012) C. Weidner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

[6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice

(2012) Debrup Chakraborty et al.   TOXICOLOGY LETTERS

Phytochemicals and their impact on adipose tissue inflammation and diabetes

(2012) Andreas Leiherer et al.   VASCULAR PHARMACOLOGY

Insulin is secreted upon glucose stimulation by both gastrointestinal enteroendocrine K-cells and L-cells engineered with the preproinsulin gene

(2011) Gonzalo Encina et al.   BIOLOGICAL RESEARCH

Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism

(2011) Jeong Sook Noh et al.   BRITISH JOURNAL OF NUTRITION

Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

(2011) Sina Kim et al.   Chinese Journal of Integrative Medicine

Controversies surrounding the clinical potential of cinnamon for the management of diabetes

(2011) H. Rafehi et al.   DIABETES OBESITY & METABOLISM

GLP-1 receptor agonists today

(2011) Michel Marre et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

High oolong tea consumption predicts future risk of diabetes among Japanese male workers: a prospective cohort study

(2011) Y. Hayashino et al.   DIABETIC MEDICINE

Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic β-cell and the cleavage of poly (ADP-ribose) polymerase

(2011) Cheol Ryong Ku et al.   ENDOCRINE JOURNAL

Conophylline Suppresses Pancreatic Stellate Cells and Improves Islet Fibrosis in Goto-Kakizaki Rats

(2011) Rie Saito et al.   ENDOCRINOLOGY

Antidiabetic, antihyperlipidemic and antioxidant effects of the flavonoid rich fraction of Pilea microphylla (L.) in high fat diet/streptozotocin-induced diabetes in mice

(2011) Punit Bansal et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Inhibitory Effect of Blueberry Polyphenolic Compounds on Oleic Acid-Induced Hepatic Steatosis in Vitro

(2011) Yixiang Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Inhibitory Effects of Dioscorea Polysaccharide on TNF-α-Induced Insulin Resistance in Mouse FL83B Cells

(2011) Bao-Hong Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Blueberry Intake Alters Skeletal Muscle and Adipose Tissue Peroxisome Proliferator-Activated Receptor Activity and Reduces Insulin Resistance in Obese Rats

(2011) E. Mitchell Seymour et al.   JOURNAL OF MEDICINAL FOOD

Management of type 2 diabetes: new and future developments in treatment

(2011) Abd A Tahrani et al.   LANCET

Cinnamon increases liver glycogen in an animal model of insulin resistance

(2011) Karine Couturier et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Antihyperglycaemic effects of ethanol extracts ofCarica papayaandPandanus amaryfolliusleaf in streptozotocin-induced diabetic mice

(2011) Sreenivasan Sasidharan et al.   NATURAL PRODUCT RESEARCH

Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor

(2011) Dan Jones   NATURE REVIEWS DRUG DISCOVERY

Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus

(2011) Ji-Hye Kim et al.   Nutrition Research and Practice

Resveratrol and Red Wine Function as Antioxidants in the Nervous System without Cellular Proliferative Effects during Experimental Diabetes

(2011) Carina Duarte Venturini et al.   Oxidative Medicine and Cellular Longevity

Intragastric infusion of pea-protein hydrolysate reduces test-meal size in rats more than pea protein

(2011) Doreen Häberer et al.   PHYSIOLOGY & BEHAVIOR

Protective and ameliorative effects of maté (Ilex paraguariensis) on metabolic syndrome in TSOD mice

(2011) Ghazi M.E. Hussein et al.   PHYTOMEDICINE

Potent α-Glucosidase Inhibitors from Safflower (Carthamus tinctorius L.) Seed

(2011) Toshiyuki Takahashi et al.   PHYTOTHERAPY RESEARCH

Resveratrol Attenuates Renal Hypertrophy in Early-Stage Diabetes by Activating AMPK

(2010) Da-Fa Ding et al.   AMERICAN JOURNAL OF NEPHROLOGY

Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging

(2010) Hanrui Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

Berberine inhibits PTP1B activity and mimics insulin action

(2010) Chunhua Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

Promotion of β-cell differentiation by the alkaloid conophylline in porcine pancreatic endocrine cells

(2010) M. Kawakami et al.   BIOMEDICINE & PHARMACOTHERAPY

Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice

(2010) Jeong Sook Noh et al.   BRITISH JOURNAL OF NUTRITION

Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin–nicotinamide diabetic rats

(2010) Hafez R. Madkor et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol Shows Vasoprotective Effect Reducing Oxidative Stress Without Affecting Metabolic Disturbances in Insulin-dependent Diabetes of Rabbits

(2010) Fatma Akar et al.   CARDIOVASCULAR DRUGS AND THERAPY

Resveratrol Confers Endothelial Protection in Insulin-Dependent Diabetes Mellitus

(2010) Zoltan Ungvari et al.   CARDIOVASCULAR DRUGS AND THERAPY

Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice

(2010) Zhuo Fu et al.   ENDOCRINOLOGY

Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidates

(2010) Sunmin Park et al.   EUROPEAN JOURNAL OF NUTRITION

Resveratrol, obesity and diabetes

(2010) Katarzyna Szkudelska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine: a potential phytochemical with multispectrum therapeutic activities

(2010) Parameswara Rao Vuddanda et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Insulin and resveratrol act synergistically, preventing cardiac dysfunction in diabetes, but the advantage of resveratrol in diabetics with acute heart attack is antagonized by insulin

(2010) Jiung-Pang Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress

(2010) M. Priya Rani et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Glyceollins, One of the Phytoalexins Derived from Soybeans under Fungal Stress, Enhance Insulin Sensitivity and Exert Insulinotropic Actions

(2010) Sunmin Park et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism

(2010) Laurène Vetterli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus

(2010) Jack L. Leahy et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Recent advances on Ilex paraguariensis research: Minireview

(2010) N. Bracesco et al.   JOURNAL OF ETHNOPHARMACOLOGY

Soy Product and Isoflavone Intakes Are Associated with a Lower Risk of Type 2 Diabetes in Overweight Japanese Women

(2010) Akiko Nanri et al.   JOURNAL OF NUTRITION

Bioactives in Blueberries Improve Insulin Sensitivity in Obese, Insulin-Resistant Men and Women

(2010) April J. Stull et al.   JOURNAL OF NUTRITION

The combination of bortezomib and resveratrol may prevent muscle wasting in diabetes

(2010) Halil Resmi   MEDICAL HYPOTHESES

Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues

(2010) Taku Uemura et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects

(2010) Jennie Wickenberg et al.   Nutrition Journal

Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus

(2010) C. Soto et al.   PHYTOMEDICINE

A novel Gymnema sylvestre extract stimulates insulin secretion from human islets in vivo and in vitro

(2010) A. Al-Romaiyan et al.   PHYTOTHERAPY RESEARCH

Beta cell regeneration in human pancreas

(2010) Roberto Gianani   Seminars in Immunopathology

Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects

(2009) Joanna Hlebowicz et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity

(2009) Woo Sik Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Berberine suppresses proinflammatory responses through AMPK activation in macrophages

(2009) Hyun Woo Jeong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Antidiabetic effect of orally administered conophylline-containing plant extract on streptozotocin-treated and Goto-Kakizaki rats

(2009) Mikio Fujii et al.   BIOMEDICINE & PHARMACOTHERAPY

Partial regeneration of β-cells in the islets of Langerhans by Nymphayol a sterol isolated from Nymphaea stellata (Willd.) flowers

(2009) P. Subash-Babu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Gymnema montanum H. Protects Against Alloxan-induced Oxidative Stress and Apoptosis in Pancreatic β-cells

(2009) Kunga M. Ramkumar et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Inhibiting Islet Amyloid Polypeptide Fibril Formation by the Red Wine Compound Resveratrol

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation

(2009) Jean-François Tanti et al.   CURRENT OPINION IN PHARMACOLOGY

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Comparison between a basal-bolus and a premixed insulin regimen in individuals with type 2 diabetes-results of the GINGER study

(2009) A. Fritsche et al.   DIABETES OBESITY & METABOLISM

Global estimates of the prevalence of diabetes for 2010 and 2030

(2009) J.E. Shaw et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Administration of Conophylline and Betacellulin-δ4 Increases the β-cell Mass in Neonatal Streptozotocin-treated Rats

(2009) Tsutomu KODERA et al.   ENDOCRINE JOURNAL

Central Administration of Resveratrol Improves Diet-Induced Diabetes

(2009) Giorgio Ramadori et al.   ENDOCRINOLOGY

Diphlorethohydroxycarmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice

(2009) Soo-Jin Heo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Influence of water activity and temperature on growth and mycotoxin production by isolates of Pyrenophora tritici-repentis from wheat

(2009) Noureddine Bouras et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKAy mice

(2009) T Vuong et al.   INTERNATIONAL JOURNAL OF OBESITY

Comparative Evaluation of Quercetin, Isoquercetin and Rutin as Inhibitors of α-Glucosidase

(2009) Yan Qin Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Astragalus polysaccharide improves insulin sensitivity in KKAy mice: Regulation of PKB/GLUT4 signaling in skeletal muscle

(2009) Min Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Dietary Blueberry Attenuates Whole-Body Insulin Resistance in High Fat-Fed Mice by Reducing Adipocyte Death and Its Inflammatory Sequelae

(2009) Jason DeFuria et al.   JOURNAL OF NUTRITION

Korean red ginseng (Panax ginseng) improves insulin sensitivity and attenuates the development of diabetes in Otsuka Long-Evans Tokushima fatty rats

(2009) Hyun Joo Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Influence of diabetes on liver injury induced by antitubercular drugs and on silymarin hepatoprotection in rats

(2009) R.K. Srivasta et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Anti-diabetic properties of three common Bidens pilosa variants in Taiwan

(2009) Shih-Chang Chien et al.   PHYTOCHEMISTRY

Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton

(2009) Mary H. Grace et al.   PHYTOMEDICINE

Hypoglycemic effect of aspalathin, a rooibos tea component from Aspalathus linearis, in type 2 diabetic model db/db mice

(2009) Atsutoshi Kawano et al.   PHYTOMEDICINE

Hypoglycemic effect of polysaccharide enriched extract of Astragalus membranaceus in diet induced insulin resistant C57BL/6J mice and its potential mechanism

(2009) Xian-qing Mao et al.   PHYTOMEDICINE

Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders

(2009) S. K. Kulkarni et al.   PHYTOTHERAPY RESEARCH

Coffee, glucose homeostasis, and insulin resistance: physiological mechanisms and mediators

(2008) Jasmine M. Tunnicliffe et al.   Applied Physiology Nutrition and Metabolism

A Phase II Study of Plerixafor (AMD3100) plus G-CSF for Autologous Hematopoietic Progenitor Cell Mobilization in Patients with Hodgkin Lymphoma

(2008) Amanda Cashen et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Dietary Curcumin Significantly Improves Obesity-Associated Inflammation and Diabetes in Mouse Models of Diabesity

(2008) Stuart P. Weisberg et al.   ENDOCRINOLOGY

Ginseng on Hyperglycemia: Effects and Mechanisms

(2008) John Zeqi Luo et al.   Evidence-based Complementary and Alternative Medicine

α-Glucosidase inhibitor from Chinese aloes

(2008) Nilubon Jong-Anurakkun et al.   FITOTERAPIA

Comparative Effects of Dietary Ginger (Zingiber officinale) and Garlic (Allium sativum) Investigated in a Type 2 Diabetes Model of Rats

(2008) Md. Shahidul Islam et al.   JOURNAL OF MEDICINAL FOOD

Dietary red chilli (Capsicum frutescens L.) is insulinotropic rather than hypoglycemic in type 2 diabetes model of rats

(2008) Md. Shahidul Islam et al.   PHYTOTHERAPY RESEARCH

Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine

(2008) Mohsen Imanshahidi et al.   PHYTOTHERAPY RESEARCH

Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: Results of a randomized, double-blind, placebo-controlled study of efficacy and safety

(2006) Vladimir Vuksan et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES