期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 14, 期 11, 页码 1253-1261出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2008.08.011
关键词
Hodgkin lymphoma; Hematopoietic stem cell mobilization; AMD3100; Plerixafor
资金
- American Society of Hematology
- Genzyme Corporation
Collection of an adequate number of hematopoietic stem cells can be difficult in patients with relapsed or refractory Hodgkin lymphoma (HL) who are candidates for autologous stem cell transplantation (ASCT). Plerixafor (AMD3100), an inhibitor of the interaction between stromal cell-derived factor I (SDF-1) and its receptor CXCR4, is an effective hematopoietic stem cell mobilization agent in patients with multiple myeloma and non-Hodgkin lymphoma (NHL). This study was undertaken to investigate the efficacy and safety of hematopoietic stem cell mobilization with plerixafor in patients with HL. Twenty-two patients with HL who were candidates for ASCT underwent hematopoietic stem cell mobilization with a combination of granulocyle-colony stimulating factor (G-CSF), 10 mu g/kg daily, and plerixafor, 240 mu g/kg subcutaneous, 10-11 hours prior to apheresis. The primary endpoint was the proportion of patients who collected >= 5 x 10(6) CD34(+) cells/kg. Outcomes were compared to a historical control population of HL patients mobilized with G-CSF alone. Pharmacokinetic (PK) analysis of plerixafor was performed in a subset of patients. Fifteen patients (68%) collected >= 5 x 10(6) CD34(+) cells/kg, and 21 patients (95%) achieved the minimum collection of; >= 2 x 10(6) CD34(+) cells/kg, in a median 2 apheresis procedures. Both the proportion of patients collecting >= 5 x 10(6) CD34(+) cells/kg and the median CD34(+) cells collected in days 1-2 of apheresis were significantly improved over historical controls. The PK of plerixafor in this patient population was similar to that previously seen in healthy volunteers. The regimen was generally safe and well tolerated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据