期刊
ENDOCRINE JOURNAL
卷 59, 期 2, 页码 103-109出版社
JAPAN ENDOCRINE SOC
DOI: 10.1507/endocrj.EJ11-0194
关键词
Resveratrol; Pancreatic beta-cell; Poly(ADP-ribose) polymerase; Streptozotocin
资金
- Ministry of Health & Welfare, Republic of Korea [A085136]
Resveratrol (3,5,4'-trihydroxystilbene; RSV) is one kind of polyphenolic phytoalexin that has many effects on metabolic diseases. This study aimed to evaluate the protective effect of RSV pretreatment on beta-cell. Male Sprague Dawley rats weighing 200-230 g were divided into 4 groups: (I) RSV; (2) streptozotocin (STZ, 70 mg/kg, intraperitoneally); (3) STZ after 7 days pretreatment with RSV; and (4) STZ pretreated with nicotinamide. Fasting glucose concentration was measured and an intraperitoneal glucose tolerance test was performed 72 h after STZ injection to determine the diabetic condition. The pancreas was removed 3, 6, 36, and 48 h after STZ injection. STZ induced diabetes in all rats not given RSV pretreatment, whereas none of the RSV-pretreated rats developed diabetes. Pretreatment with RSV inhibited apoptosis and reduced the activation of caspase-3 and poly(ADP-ribose) polymerase (PARP). However, expression of the total length PARP was not affected by pretreatment. Our findings suggest that RSV protects beta-cells from STZ simultaneously with inhibiting the activation of PARP.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据