Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Endocrinology & Metabolism
Robert Wagner, Sabine S. Eckstein, Hajime Yamazaki, Felicia Gerst, Juergen Machann, Benjamin Assad Jaghutriz, Annette Schuermann, Michele Solimena, Stephan Singer, Alfred Koenigsrainer, Andreas L. Birkenfeld, Hans-Ulrich Haering, Andreas Fritsche, Susanne Ullrich, Martin Heni
Summary: Pancreatic fat plays a critical role in metabolic syndrome, impaired glucose metabolism, type 2 diabetes mellitus, and insulin secretion. Various diagnostic methods are available to quantify pancreatic fat accumulation.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Lindsey J. Anderson, Jonathan Lee, Barbara Anderson, Benjamin Lee, Dorota Migula, Adam Sauer, Nicole Chong, Haiming Liu, Peter C. Wu, Atreya Dash, Yi-Ping Li, Jose M. Garcia
Summary: Cancer-related weight loss is associated with elevated levels of inflammation, lipolysis, and browning markers. BMI is associated with increased energy expenditure.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Cardiac & Cardiovascular Systems
Nadine Suffee, Elodie Baptista, Jerome Piquereau, Maharajah Ponnaiah, Nicolas Doisne, Farid Ichou, Marie Lhomme, Camille Pichard, Vincent Galand, Nathalie Mougenot, Gilles Dilanian, Laurence Lucats, Elise Balse, Mathias Mericskay, Wilfried Le Goff, Stephane N. Hatem
Summary: Prolonged high-fat diet in mice leads to vulnerability to atrial fibrillation by altering energy metabolism, causing fat accumulation, and inducing electrical remodeling of atrial myocardium. Obese mice showed a adipogenic and inflammatory phenotype in the atrial myocardium, with increased use of long-chain lipids as energy substrate and enhanced K-ATP current in isolated atrial myocytes.
CARDIOVASCULAR RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ignacio Colon-Mesa, Neira Sainz, Patricia Corrales, Maria Collantes, Philipp Kaldis, Jose Alfredo Martinez, Gema Medina-Gomez, Maria Jesus Moreno-Aliaga, Xavier Escote
Summary: The aim of this study was to investigate the effect of p27 deletion on the activity of brown adipose tissue and the susceptibility to develop obesity and glucose homeostasis disturbances in mice. The results showed that p27 knockout mice were more prone to obesity and insulin resistance. The study suggested that p27 may play a role in brown adipose tissue activation and the development of obesity and insulin resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Fenfen Li, Shirong Wang, Xin Cui, Jia Jing, Liqing Yu, Bingzhong Xue, Hang Shi
Summary: This study reveals that the histone demethylase Utx plays a significant role in the energy metabolism of both white adipose tissue (WAT) and brown adipose tissue (BAT). In a mouse model, Utx deficiency in adipocytes leads to obesity, impaired glucose tolerance, and disrupted brown fat thermogenesis. Furthermore, under high-fat diet challenge, mice lacking Utx in adipocytes exhibit dysfunction in adipose tissue, exacerbated inflammation and fibrosis, and increased lipid storage in the liver, resulting in disturbed whole body glucose homeostasis and hepatic steatosis.
Article
Cell Biology
Francesca Molinari, Alessandra Feraco, Simone Mirabilii, Serena Saladini, Luigi Sansone, Enza Vernucci, Giada Tomaselli, Vincenzo Marzolla, Dante Rotili, Matteo A. Russo, Maria Rosaria Ricciardi, Agostino Tafuri, Antonello Mai, Massimiliano Caprio, Marco Tafani, Andrea Armani
Summary: The inhibition of SIRT5 stimulates brown adipogenesis in vitro, promoting the expression of brown adipocyte and mitochondrial markers and increasing lipolysis. This approach shows potential as a strategy to target obesity and type 2 diabetes by activating brown adipose tissue.
Article
Biology
Xiao Zhang, Hero Robles, Kristann L. Magee, Madelyn R. Lorenz, Zhaohua Wang, Charles A. Harris, Clarissa S. Craft, Erica L. Scheller
Summary: Bone marrow adipocytes accumulate with age and in diverse disease states. A novel secondary adipogenesis pathway unique to the bone marrow is activated with age and in states of metabolic stress, resulting in compromised lipid mobilization and cytokine expression within regions traditionally devoted to hematopoiesis. This finding further contributes to our understanding of bone marrow adipocyte origins, adaptations, and relationships with surrounding tissues.
Article
Chemistry, Medicinal
Xueping Yang, Fan Wu, Lingli Li, Ernest C. Lynch, Linglin Xie, Yan Zhao, Ke Fang, Jingbin Li, Jinlong Luo, Lijun Xu, Xin Zou, Fuer Lu, Guang Chen
Summary: Celastrol has been shown to improve weight gain and metabolic disorders in obese mice by increasing adipose thermogenesis. Additionally, it reduces inflammatory cell infiltration and the expression of inflammatory cytokines, inhibiting the activation of TLR3/NLRP3 inflammasome molecules.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Adam Prabata, Koji Ikeda, Elda Putri Rahardini, Ken-Ichi Hirata, Noriaki Emoto
Summary: The study demonstrates that GPNMB negatively regulates macrophage inflammatory capacities and ameliorates WAT inflammation in obesity, making it a promising therapeutic target for metabolic disorders associated with obesity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Ruping Pan, Yong Chen
Summary: Obesity and metabolic disorders are prevalent and fatal human health issues, where sex and age play a role. Adipose tissues are crucial for energy balance in humans, with overlooked sex differences in their metabolism regulation. Visceral fat distribution and its impact on metabolic disorders are also discussed in this review.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Karen M. Wagner, Jun Yang, Christophe Morisseau, Bruce D. Hammock
Summary: The soluble epoxide hydrolase (sEH) enzyme regulates bioactive lipids, with its activity affected more by high-fat diets in male mice than in female mice. High-fat diets increase sEH activity, prostaglandins, and triglycerides in male mice, but these effects are limited by sEH knockout. Similar changes occur in female mice but to a different degree and are also improved by sEH enzyme knockout.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Imke L. Lemmer, Alexander Bartelt
Summary: An elegant quantitative analysis of brown fat and skeletal muscle metabolite flux reveals that brown fat predominantly uses glucose and lactate and acts as a nitrogen scavenger during thermogenesis.
Article
Biochemistry & Molecular Biology
Yuki Kitamura, Shinji Oikawa, Jie Chang, Yurie Mori, Gaku Ichihara, Sahoko Ichihara
Summary: This study used 2D-Oxyblot and 2D-DIGE techniques to analyze carbonylated proteins induced by oxidative stress in a metabolic syndrome animal model, as well as changes in protein expression levels in adipose tissue at different stages of the syndrome. The results showed that up-regulated proteins at the pre-symptomatic stage were mainly involved in ATP production and redox reactions, while down-regulated proteins at the symptomatic stage were associated with antioxidant activity and the TCA cycle. Increased levels of carbonylated proteins, including gelsolin, may contribute to the oxidative stress state and progression of metabolic syndrome.
Article
Geriatrics & Gerontology
Ming Xu, Elizabeth W. Bradley, Megan M. Weivoda, Soyun M. Hwang, Tamar Pirtskhalava, Teresa Decklever, Geoffry L. Curran, Mikolaj Ogrodnik, Diana Jurk, Kurt O. Johnson, Val Lowe, Tamar Tchkonia, Jennifer J. Westendorf, James L. Kirkland
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2017)
Article
Geriatrics & Gerontology
Michael B. Stout, Frederik J. Steyn, Michael J. Jurczak, Joao-Paulo G. Camporez, Yi Zhu, John R. Hawse, Diana Jurk, Allyson K. Palmer, Ming Xu, Tamar Pirtskhalava, Glenda L. Evans, Roberta de Souza Santos, Aaron P. Frank, Thomas A. White, David G. Monroe, Ravinder J. Singh, Grace Casaclang-Verzosa, Jordan D. Miller, Deborah J. Clegg, Nathan K. LeBrasseur, Thomas von Zglinicki, Gerald I. Shulman, Tamara Tchkonia, James L. Kirkland
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2017)
Article
Gastroenterology & Hepatology
Anja Moncsek, Mohammed S. Al-Suraih, Christy E. Trussoni, Steven P. O'Hara, Patrick L. Splinter, Camille Zuber, Eleonora Patsenker, Piero V. Valli, Christian D. Fingas, Achim Weber, Yi Zhu, Tamar Tchkonia, James L. Kirkland, Gregory J. Gores, Beat Mullhaupt, Nicholas F. LaRusso, Joachim C. Mertens
Article
Geriatrics & Gerontology
James L. Kirkland, Tamara Tchkonia, Yi Zhu, Laura J. Niedernhofer, Paul D. Robbins
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2017)
Article
Geriatrics & Gerontology
Jamie N. Justice, Heather Gregory, Tamar Tchkonia, Nathan K. LeBrasseur, James L. Kirkland, Stephen B. Kritchevsky, Barbara J. Nicklas
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2018)
Review
Oncology
Kirsten K. Ness, James L. Kirkland, Maria Monica Gramatges, Zhaoming Wang, Mondira Kundu, Kelly McCastlain, Xiujie Li-Harms, Jinghui Zhang, Tamar Tchkonia, Saskia Martine Francesca Pluijm, Gregory T. Armstrong
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer, Megan M. Weivoda, Christina L. Inman, Mikolaj B. Ogrodnik, Christine M. Hachfeld, Daniel G. Fraser, Jennifer L. Onken, Kurt O. Johnson, Grace C. Verzosa, Larissa G. P. Langhi, Moritz Weigl, Nino Giorgadze, Nathan K. LeBrasseur, Jordan D. Miller, Diana Jurk, Ravinder J. Singh, David B. Allison, Keisuke Ejima, Gene B. Hubbard, Yuji Ikeno, Hajrunisa Cubro, Vesna D. Garovic, Xiaonan Hou, S. John Weroha, Paul D. Robbins, Laura J. Niedernhofer, Sundeep Khosla, Tamara Tchkonia, James L. Kirkland
Review
Medicine, General & Internal
J. L. Kirkland, T. Tchkonia
JOURNAL OF INTERNAL MEDICINE
(2020)
Review
Biochemistry & Molecular Biology
Selim Chaib, Tamar Tchkonia, James L. Kirkland
Summary: Cellular senescence has emerged as a promising therapeutic target for disorders across the lifespan; targeting persistent senescent cells causing tissue damage may delay, prevent, or alleviate multiple diseases.
Article
Endocrinology & Metabolism
Jessica Murphy, Bjorn T. Tam, James L. Kirkland, Tamara Tchkonia, Nino Giorgadze, Tamar Pirtskhalava, Michael A. Tsoukas, Jose A. Morais, Sylvia Santosa
Summary: This study aimed to examine the effects of obesity onset on markers of senescence in subcutaneous adipose tissue (SAT) before and after weight loss. The results showed that individuals with childhood-onset obesity had higher levels of DNA damage and senescence markers in SAT compared to those with adult-onset obesity. Weight loss reduced DNA damage in SAT, but did not affect senescence markers. Overall, weight loss improved the aging state associated with obesity.
Article
Endocrinology & Metabolism
Ritesh K. Baboota, Aidin Rawshani, Laurianne Bonnet, Xiangyu Li, Hong Yang, Adil Mardinoglu, Tamar Tchkonia, James L. Kirkland, Anne Hoffmann, Arne Dietrich, Jeremie Boucher, Matthias Bluher, Ulf Smith
Summary: Hepatic cell senescence is a key factor in human NAFLD/NASH. BMP4 and Gremlin 1 are identified as novel therapeutic targets.
Article
Endocrinology & Metabolism
Tamar Tchkonia, Allyson K. Palmer, James L. Kirkland
Summary: The elderly population is growing faster worldwide, and age is a major predictor of chronic diseases. Enhancing healthspan and targeting fundamental aging mechanisms may lead to greater benefits than treating age-related diseases individually. More research is needed on interventions for aging processes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Physiology
H. Salah, W. Fury, J. Gromada, Y. Bai, T. Tchkonia, J. L. Kirkland, L. Larsson
Article
Cell Biology
Renuka Kandhaya-Pillai, Francesc Miro-Mur, Jaume Alijotas-Reig, Tamara Tchkonia, James L. Kirkland, Simo Schwartz
Article
Cell Biology
Yi Zhu, Ewald J. Doornebal, Tamar Pirtskhalava, Nino Giorgadze, Mark Wentworth, Heike Fuhrmann-Stroissnigg, Laura J. Niedernhofer, Paul D. Robbins, Tamara Tchkonia, James L. Kirkland