The Beneficial Role of Thiamine in Parkinson Disease

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress

(2014) Ruben K. Dagda et al.   Autophagy

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

GSK3β reduces risk of sporadic Parkinson's disease in ethnic Chinese

(2012) Dong-Mei Zhao et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization

(2012) Haruyuki Hongo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantitative assessment of gait and neurochemical correlation in a classical murine model of Parkinson’s disease

(2012) Xiao Wang et al.   BMC NEUROSCIENCE

Current Status of Tyrosine Hydroxylase in Management of Parkinson’s Disease

(2012) Annaik Petithomme Feve   CNS & Neurological Disorders-Drug Targets

Overview of Tyrosine Hydroxylase in Parkinson’s Disease

(2012) Yanzhen Zhu et al.   CNS & Neurological Disorders-Drug Targets

MPTP Animal Model of Parkinsonism: Dopamine Cell Death or Only Tyrosine Hydroxylase Impairment? - A Study Using PET Imaging, Autoradiography, and Immunohistochemistry in the Cat

(2012) Nicolas Aznavour et al.   CNS Neuroscience & Therapeutics

Increased DNA-Glycation in Type 2 Diabetic Patients: The Effect of Thiamine and Pyridoxine Therapy

(2012) F. Polizzi et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Increase of Serum Vascular Endothelial Growth Factors in Wet Beriberi: Two Case Reports

(2012) Noboru Imai et al.   INTERNAL MEDICINE

A possible pathophysiological role of tyrosine hydroxylase in Parkinson’s disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer

(2012) Akira Nakashima et al.   JOURNAL OF NEURAL TRANSMISSION

Thiamine and Parkinson's disease

(2012) Khanh vinh quô′c Lương et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity

(2012) Peter Teismann et al.   NEUROBIOLOGY OF AGING

L-DOPA-induced increase in TH-immunoreactive striatal neurons in parkinsonian mice: Insights into regulation and function

(2012) Isabel Espadas et al.   NEUROBIOLOGY OF DISEASE

NADPH Oxidase 1-Mediated Oxidative Stress Leads to Dopamine Neuron Death in Parkinson's Disease

(2011) Dong-Hee Choi et al.   ANTIOXIDANTS & REDOX SIGNALING

Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: Similarity with paraquat neurotoxicity

(2011) Ashutosh Kumar et al.   BRAIN RESEARCH

The MPTP neurotoxic lesion model of Parkinson's disease activates the apolipoprotein E cascade in the mouse brain

(2011) D. Domenger et al.   EXPERIMENTAL NEUROLOGY

Rotenone activates phagocyte NADPH oxidase by binding to its membrane subunit gp91phox

(2011) Hui Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anti-inflammatory effects of benfotiamine are mediated through the regulation of the arachidonic acid pathway in macrophages

(2011) Mohammad Shoeb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations

(2011) D. A. Fraser et al.   Genes and Nutrition

Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade

(2011) W Michael Zawada et al.   Journal of Neuroinflammation

Signaling of Glial Cell Line-Derived Neurotrophic Factor and Its Receptor GFRα1 Induce Nurr1 and Pitx3 to Promote Survival of Grafted Midbrain-Derived Neural Stem Cells in a Rat Model of Parkinson Disease

(2011) Zhinian Lei et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Benfotiamine Protects against Peritoneal and Kidney Damage in Peritoneal Dialysis

(2011) L. P. Kihm et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Gastroparesis and Parkinson’s disease: A systematic review

(2011) Zaid S. Heetun et al.   PARKINSONISM & RELATED DISORDERS

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein overexpression enhances manganese-induced neurotoxicity through the NF-κB-mediated pathway

(2011) Krishnan Prabhakaran et al.   TOXICOLOGY MECHANISMS AND METHODS

Gene disruption of caspase-3 prevents MPTP-induced Parkinson’s disease in mice

(2010) Marina Yamada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Powerful beneficial effects of benfotiamine on cognitive impairment and  -amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice

(2010) X. Pan et al.   BRAIN

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress

(2010) Alexander Kurz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

(2010) N. Karachalias et al.   DIABETOLOGIA

Protective role of benfotiamine, a fat-soluble vitamin B1 analogue, in lipopolysaccharide-induced cytotoxic signals in murine macrophages

(2010) Umesh C.S. Yadav et al.   FREE RADICAL BIOLOGY AND MEDICINE

A rare novel deletion of the tyrosine hydroxylase gene in Parkinson disease

(2010) Güney Bademci et al.   HUMAN MUTATION

Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response

(2010) Rajesh Katare et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Atypical Wernicke's Encephalopathy Showing Involvement of Substantia Nigra

(2010) Bhagheerathi Kalidass et al.   JOURNAL OF NEUROIMAGING

Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulusEvidence in Parkinson's disease patients

(2010) M.A. Burguillos et al.   NEUROBIOLOGY OF DISEASE

Sulbutiamine Counteracts Trophic Factor Deprivation Induced Apoptotic Cell Death in Transformed Retinal Ganglion Cells

(2010) Kui Dong Kang et al.   NEUROCHEMICAL RESEARCH

Exposure to Pyrithiamine Increases β-Amyloid Accumulation, Tau Hyperphosphorylation, and Glycogen Synthase Kinase-3 Activity in the Brain

(2010) Jing Zhao et al.   NEUROTOXICITY RESEARCH

The Role of NADPH Oxidase 1–Derived Reactive Oxygen Species in Paraquat-Mediated Dopaminergic Cell Death

(2009) Ana Clara Cristóvão et al.   ANTIOXIDANTS & REDOX SIGNALING

G protein-coupled receptor kinase 5, overexpressed in the α-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression

(2009) Peng Liu et al.   BRAIN RESEARCH

Different apoptotic responses of human and bovine pericytes to fluctuating glucose levels and protective role of thiamine

(2009) Elena Beltramo et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Transient Protective Effect of B-Vitamins in Experimental Epilepsy in the Mouse Brain

(2009) Tamer Rabie et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Activation of p38 MAPK in the substantia nigra leads to nuclear translocation of NF-κB in MPTP-treated mice: implication in Parkinson’s disease

(2009) S. Karunakaran et al.   JOURNAL OF NEUROCHEMISTRY

Vulnerability to glutamate toxicity of dopaminergic neurons is dependent on endogenous dopamine and MAPK activation

(2009) Yasuhiko Izumi et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of  -1 Receptors and Endoplasmic Reticulum Chaperones in the Brain of Methamphetamine Self-Administering Rats

(2009) T. Hayashi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Vascular endothelial growth factor B (VEGF-B) is up-regulated and exogenous VEGF-B is neuroprotective in a culture model of Parkinson's disease

(2009) Torsten Falk et al.   Molecular Neurodegeneration

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease

(2009) Cristine Alves da Costa et al.   NATURE CELL BIOLOGY

GSK3β polymorphisms, MAPT H1 haplotype and Parkinson's disease in a Greek cohort

(2009) Kallirhoe Kalinderi et al.   NEUROBIOLOGY OF AGING

Parkinson-Linked Genes and Toxins That Affect Neuronal Cell Death Through the Bcl-2 Family

(2008) Douglas W. Ethell et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice

(2008) Eriko Aoki et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

MAPKAP kinase 2-deficiency prevents neurons from cell death by reducing neuroinflammation – relevance in a mouse model of Parkinson’s disease

(2008) Tobias Thomas et al.   JOURNAL OF NEUROCHEMISTRY

Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity

(2008) Dan Zhang et al.   Journal of Neuroinflammation

Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation

(2008) Shamim Shaikh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Brain angiotensin enhances dopaminergic cell death via microglial activation and NADPH-derived ROS

(2008) J. Rodriguez-Pallares et al.   NEUROBIOLOGY OF DISEASE

Glycogen synthase kinase-3beta is associated with Parkinson's disease

(2008) Masahiro Nagao et al.   NEUROSCIENCE LETTERS

Inhibition of glycogen synthase kinase-3 reduces l-DOPA-induced neurotoxicity

(2008) Seong-Ho Koh et al.   TOXICOLOGY