期刊
NEUROSCIENCE LETTERS
卷 449, 期 2, 页码 103-107出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2008.10.104
关键词
Lewy bodies; Synphilin-1; Alpha-synuclein; Ubiquitylation; Apoptosis
资金
- Tokyo Metropolitan Government
We immunohistochemically examined the expression of glycogen synthase kinase-3beta (GSK-3beta) in the brains of Parkinson's disease (PD) patients. GSK-3beta was localized in punctate structures in the cytosol of subsets of neurons in the midbrain and upper pons. GSK-3beta was also localized in Lewy bodies (LBs) as was phosphorylated GSK-3beta (Ser9) (pGSK-3beta (Ser9)). Both GSK-3beta and pGSK-3beta (Ser9) were localized specifically in the halo of LBs. The core of LBs was negative for GSK-3beta, while pGSK-3beta (Ser9) was present in only a small number of LB cores. Cortical LBs were positive for pGSK-3beta (Ser9) but not for GSK-3beta. Neither GSK-3beta nor pGSK-3beta (Ser9) was present in glial cytoplasmic inclusions (GCIs) in the brains of multiple system atrophy (MSA) patients. Our results suggest that GSK-3beta plays a role in the pathogenesis of PD but not in that of MSA. Crown Copyright (C) 2008 Published by Elsevier Ireland Ltd. All rights reserved.
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