Article
Biochemistry & Molecular Biology
Zuberwasim Sayyad, Sreeram Kaveti, Debanjan Bhattacharjee, Dhiviya Vedagiri, Nishant Jain, Ghanshyam Swarup
Summary: M98K-OPTN is associated with normal tension glaucoma and interacts with TNF alpha polymorphism in causing glaucoma. It sensitizes retinal cells to TNF alpha and ER stress-induced cell death, and alters ER stress response signaling. These findings support the hypothesis that M98K-OPTN may contribute to retinal ganglion cell death associated with glaucoma.
Article
Cell Biology
Murali Subramani, Matthew J. Van Hook, Iqbal Ahmad
Summary: This study demonstrates a rapid generation of human retinal ganglion cells (hRGCs) from banked human pluripotent stem cell-derived retinal progenitor cells (hRPCs) by recapitulating the developmental mechanism. The resulting hRGCs are stable, functional, and transplantable, showing potential for ex vivo stem cell therapy and disease modeling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xuemeng Guo, Junlei Zhang, Xu Liu, Yichao Lu, Yingying Shi, Xiang Li, Sije Wang, Jiaxin Huang, Huihui Liu, Huanli Zhou, Qingpo Li, Lihua Luo, Jian You
Summary: Glaucoma, the third leading cause of blindness worldwide, is primarily characterized by elevated intraocular pressure. Prolonged high intraocular pressure damages retinal cells and current treatments primarily focus on reducing intraocular pressure. Researchers have developed a novel nanoemulsion that prolongs ocular retention and effectively mitigates retinal cell damage associated with glaucoma.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Cell Biology
Luming Guo, Xiaoling Xie, Jing Wang, Haiyan Xiao, Shuchun Li, Mei Xu, Ebenezer Quainoo, Rithwik Koppaka, Jiaping Zhuo, Sylvia B. Smith, Lin Gan
Summary: The generation and characterization of a knock-in mouse line, Rbpms-CreER(T2), that allows for the conditional activation of a reporter gene in retinal ganglion cells (RGCs) is reported. The knock-in mice showed efficient recombination and no detectable defects, making them a powerful tool for studying RGCs.
Article
Neurosciences
Claudia Ingensiep, Kim Schaffrath, Peter Walter, Sandra Johnen
Summary: Glaucoma is a heterogeneous eye disease characterized by atrophy of the optic nerve head. A study using a multielectrode array-based ex vivo glaucoma acute model found that high hydrostatic pressure did not affect the functionality of retinal ganglion cells (RGCs), but significantly changed their bursting behavior. The findings suggest that RGCs are tolerant to high short-term pressure stress.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Cell Biology
Sijia Huang, Kexin Liu, Ying Su, Feng Wang, Tao Feng
Summary: Ferroptosis, a novel type of programmed cell death, is associated with eye diseases such as glaucoma and optic nerve damage.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Sophie Coyle, Mohammed Naeem Khan, Melody Chemaly, Breedge Callaghan, Chelsey Doyle, Colin E. Willoughby, Sarah D. Atkinson, Meredith Gregory-Ksander, Victoria McGilligan
Summary: Glaucoma is a group of optic neuropathies characterized by the degeneration of retinal ganglion cells, with increased intraocular pressure and inflammation playing potential roles. Targeting the NLRP3 inflammasome as a therapeutic strategy may help protect vision in glaucoma patients.
Article
Food Science & Technology
Claudio Molinari, Sara Ruga, Mahitab Farghali, Rebecca Galla, Rosario Fernandez-Godino, Nausicaa Clemente, Francesca Uberti
Summary: This study aimed to develop a new oral formulation to counteract early changes in glaucomatous degeneration. The formulation based on gastrodin and vitamin D3 combined with vitamin C, blackcurrant, and lycopene showed the ability to restore glaucoma-induced damage and potentially have both preventive and therapeutic effects on glaucoma.
Article
Medicine, Research & Experimental
Sweta Pal, G. Nageswar Rao, Arttatrana Pal
Summary: Nitrosative stress exacerbates antioxidant depletion, mitochondrial dysfunction, biomolecule damage, inflammation, and apoptosis induced by high glucose exposure. Inhibition of RNS can alleviate cell cycle deregulation and apoptosis caused by high glucose.
Article
Biochemistry & Molecular Biology
Jenny Youale, Karine Bigot, Bindu Kodati, Thara Jaworski, Yan Fan, Nana Yaa Nsiah, Nathaniel Pappenhagen, Denise M. Inman, Francine Behar-Cohen, Thierry Bordet, Emilie Picard
Summary: Transferrin (TF) has been shown to protect retinal ganglion cells (RGCs) from iron-induced toxicity and oxidative stress, and can interfere with different cell death mechanisms involved in glaucoma pathogenesis. In ex vivo and in vivo models, TF significantly preserved RGCs against neurotoxicity and showed potential as a treatment for glaucoma neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yinglei Zhang, Xujiao Zhou, Yi Lu
Summary: In this study, the alterations of the gut microbiota and derived metabolites in glaucomatous rats were investigated. Significant changes in microbial composition and diversity were observed in glaucomatous rats compared to the control. The bile secretion pathway and glutathione (GSH) were found to be associated with glaucoma development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Neurosciences
Anna Pacwa, Joanna Machowicz, Saeed Akhtar, Piotr Rodak, Xiaonan Liu, Marita Pietrucha-Dutczak, Joanna Lewin-Kowalik, Marialaura Amadio, Adrian Smedowski
Summary: This study aimed to evaluate the impact of hur silencing on the age-related degeneration of retinal ganglion cells (RGC) and its neuroprotection capacity in the rat glaucoma model. The results showed that silencing the huR gene led to apoptosis and increased oxidative stress markers in RGC, accelerating their decline in number and function. This confirms the key role of HuR in maintaining cell homeostasis and its involvement in the pathogenesis of glaucoma.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ibuki Arizono, Naoki Fujita, Chihiro Tsukahara, Kana Sase, Reio Sekine, Tatsuya Jujo, Mizuki Otsubo, Naoto Tokuda, Yasushi Kitaoka
Summary: This study suggests that oral administration of nicotinamide riboside (NR) can protect against axonal damage in a rat ocular hypertension model. It increases NAD+ levels in the retina and prevents loss of optic nerve fibers and retinal ganglion cells. Furthermore, oral NR administration enhances the phosphorylated adenosine monophosphate-activated protein kinase (p-AMPK) level in rats.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yulan Lu, Zhong Chen, Jie He, Lan Li, Rong Chen, Jili Chen
Summary: This study investigates the effects of 0.03% bimatoprost, 0.5% timolol, or their combination on intraocular pressure reduction, anti-apoptotic molecule expression, and neuroretinal changes in a rat model of chronic ocular hypertension. The combination of bimatoprost and timolol shows neuroprotective effects for the treatment of chronic glaucoma in the rat model.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Sonia I. Vlaicu, Alexandru Tatomir, Matthew Fosbrink, Vinh Nguyen, Dallas Boodhoo, Cornelia Cudrici, Tudor C. Badea, Violeta Rus, Horea Rus
Summary: In this study, the involvement of RGC-32 in cell proliferation and cell cycle activation in endothelial cells and smooth muscle cells in atherosclerosis was investigated. Overexpression of RGC-32 enhanced the cell cycle activation and proliferation induced by C5b-9, while silencing of RGC-32 inhibited this activation.
CLINICAL IMMUNOLOGY
(2022)
Article
Food Science & Technology
Kwang Hyun Cha, Kyung-A Kim, Suk Woo Kang, Seemi Tasnim Alam, Jong Beom Jin, Gyhye Yoo, Sang Hoon Jung, Cheol-Ho Pan, Kyungsu Kang
JOURNAL OF FUNCTIONAL FOODS
(2019)
Article
Pharmacology & Pharmacy
Seemi Tasnim Alam, Tram Anh Ngoc Le, Jin-Soo Park, Hak Cheol Kwon, Kyungsu Kang
Article
Chemistry, Medicinal
Baskar Selvaraj, Dae Won Kim, Gyuwon Huh, Heesu Lee, Kyungsu Kang, Jae Wook Lee
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Biotechnology & Applied Microbiology
Joo Yeon Kim, So Young Lee, Seung-Hee Jung, Mi Ri Kim, Il-Dong Choi, Jung-Lyoul Lee, Jae-Hun Sim, Cheol-Ho Pan, Kyungsu Kang
BIOTECHNOLOGY LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Dhamraa W. Al-Dulaimi, Aman Shah Abdul Majid, Hussein M. Baharetha, Mohamed B. Khadeer Ahamed, Sarah Furqan Faisal, Raghdaa Hamdan Al Zarzour, Chern Ein Oon, Amin Malik Shah Abdul B. Majid, Loiy E. Ahmed Hassan
Summary: This study evaluated the cytoprotective, anti-mutagenic, and anticlastogenic activities of standardized Orthosiphon stamineus extract. The extract showed potent scavenging effects on hydrogen peroxide and other free radicals, stimulated glutathione production in liver cells, and exhibited powerful antimutagenic activities. Cytogenetic tests showed reduced mitotic and replicative indices without any chromosomal abnormalities or sister chromatid exchange. Pretreatment with the extract proved to be an efficient protocol in ameliorating the effects of mitomycin C.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Kwang Hyun Cha, Jung-Seok Yang, Kyung-A Kim, Kye-Yoon Yoon, Dae-Geun Song, Erdenedolgor Erdene-Ochir, Kyungsu Kang, Cheol-Ho Pan, GwangPyo Ko
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Integrative & Complementary Medicine
Nurhanisah Sejari, Siew Kuan Chua, Chin Fen Neoh, Kalavathy Ramasamy, Siong Meng Lim, Faizah Safina Bakrin, Kamaria Kamaruddin, Khang Wen Goh, Bey Hing Goh, Aman Shah Abdul Majid, Khairulanwar Husain, Long Chiau Ming
EUROPEAN JOURNAL OF INTEGRATIVE MEDICINE
(2020)
Review
Chemistry, Inorganic & Nuclear
Khair-Un-Nisa Sheikh, Hira Amin, Rosenani A. Haque, Aman Shah Abdul Majid, Muhammad Yaseen, Muhammad Adnan Iqbal
JOURNAL OF COORDINATION CHEMISTRY
(2020)
Article
Plant Sciences
Jae Sung Park, Keebeom Ko, Seong-Hwan Kim, Jae Kyun Lee, Jin-Soo Park, Keunwan Park, Mi Ri Kim, Kyungsu Kang, Dong-Chan Oh, Sun Yeou Kim, Silvia Yumnam, Hak Cheol Kwon, Jongheon Shin
Summary: Through a combination of spectroscopic and crystallographic methods, natural compounds with different chemical structures were isolated from Juniperus chinensis, with novel compounds being photochemically produced. One of the compounds significantly inhibited the activity of tyrosinase as predicted by a machine learning-based assay, while also displaying characteristics of inhibiting lipid accumulation and enhancing extracellular glycerol excretion.
JOURNAL OF NATURAL PRODUCTS
(2021)
Review
Biochemistry & Molecular Biology
Ece Polat, Kyungsu Kang
Summary: Antimicrobial photodynamic therapy (APDT) is constantly evolving as an effective method to combat antimicrobial resistance, utilizing reactive oxygen species produced by photosensitizers to destroy microorganisms. Research is ongoing to investigate various photosensitizers and explore new methods to enhance the properties of APDT.
Review
Food Science & Technology
Ngoc Minh Ha, Son Hung Tran, Yhong-Hee Shim, Kyungsu Kang
Summary: Apart from synthetic and semisynthetic compounds, natural products are important sources of potential therapeutic lead compounds for various diseases. In vivo assays, particularly using Caenorhabditis elegans, provide valuable insights into the efficacy, adverse effects, and modes of action of these candidates. This review highlights commonly used techniques for screening the bioactivities of natural products, and explores recent studies on their applications in anti-aging, anti-neurodegeneration, anti-obesity, anti-infection, and gut health using the C. elegans model. Technological developments in instrumental analysis and emerging methods involving C. elegans are also discussed.
APPLIED BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mijin Lee, Esther Youn, Kyungsu Kang, Yhong-Hee Shim
Summary: In this study, the effects of 3,3'-diindolylmethane (DIM) on oocyte quality and reproductive aging were investigated in a model organism. DIM was found to improve mitochondrial function, reduce oxidative stress, and decrease chromosomal aberrations in aged oocytes, leading to improved fertility. Additionally, DIM supplementation maintained proper levels of germ cell apoptosis and proliferation, further delaying the onset of reproductive aging.
Editorial Material
Biochemistry & Molecular Biology
Kyungsu Kang, Stefano Bacci
Article
Food Science & Technology
Ngoc Minh Ha, Hoseong Hwang, Seemi Tasnim Alam, Uyen Tran Tu Nguyen, Soon Kwang Lee, Jin-Soo Park, Jin-Chul Kim, Hak Cheol Kwon, Jaeyoung Kwon, Kyungsu Kang
Summary: This study evaluated the antibacterial properties of antimicrobial photodynamic therapy combined with L. fischeri extract against MRSA and various pathogens, and assessed its photopharmaceutical actions in C. elegans. The results showed that this therapy effectively inhibited the growth of pathogens and improved the quality of life and lifespan in MRSA-infected worms without causing severe side effects. These findings highlight the significance of this treatment for safe MRSA phototreatment in biomedical and cosmeceutical industries.
APPLIED BIOLOGICAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Baskar Selvaraj, Uyen Tran Tu Nguyen, Gyewon Huh, Duc Hung Nguyen, Il-Kyoon Mok, Heesu Lee, Kyungsu Kang, Ae Nim Bae, Dae Won Kim, Jae Wook Lee
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
