Review
Biochemistry & Molecular Biology
Margaux Sambon, Pierre Wins, Lucien Bettendorff
Summary: Thiamine thioesters, such as benfotiamine (BFT) and dibenzoylthiamine (DBT), have shown potential benefits in treating neurodegenerative diseases with antioxidant and anti-inflammatory properties. Recent studies suggest that DBT may be even more efficient than BFT in terms of anti-inflammatory potency. These thiamine thioesters have pleiotropic properties and may lead to promising advancements in neurodegenerative, neurodevelopmental, and psychiatric conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Dan Wu, Xue Bai, Jiasi Yu, Linli Guo, Yanan Zhao, Ping Liu
Summary: Alzheimer's disease (AD) has caused a significant economic burden due to its prevalence and impact on society and families. A new glycogen synthase kinase-3 (GSK-3) inhibitor, PIMPC, with antioxidant and metal chelating properties, was designed and synthesized as a potential anti-AD compound. A quantitative HPLC method was established to determine the pharmacokinetics (PK) of PIMPC in rats, revealing fast absorption, rapid distribution, and elimination following intragastric administration. Additionally, PIMPC did not have adverse effects on liver and kidney function at therapeutic doses, supporting its potential as an anti-AD drug.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Review
Biochemistry & Molecular Biology
Divya M. Teli, Anuradha K. Gajjar
Summary: Elevated glucose level due to β-cell dysfunction is a key marker of Type-II diabetes. GSK-3, an enzyme involved in glycogen metabolism control, has been explored for its potential as a target for diabetes treatment. This review article examines the structural analysis and molecular modeling of GSK-3, as well as advancements in the development of GSK-3 inhibitors as potential therapeutics for Type II diabetes.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Davoud Ghazanfari, Mahboubeh S. Noori, Stephen C. Bergmeier, Jennifer Hines, Kelly D. McCall, Douglas J. Goetz
Summary: COB-187 inhibits GSK3 beta via a specific, reversible, time and Cys-199-dependent mechanism, demonstrating high selectivity and potent activity against the target enzyme.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Songyang Dai, Fanlin Zhou, Jieyun Sun, Yu Li
Summary: This study demonstrates that NPD1 can reduce levels of Aβ(42) and hyperphosphorylated tau, suppress cell death, promote autophagy activity, and inhibit GSK-3β activation in AD cell models. The neuroprotective effects of NPD1 may be mediated by decreasing GSK-3β activity.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, General & Internal
Qiuzhi Zhou, Shihong Li, Mengzhu Li, Dan Ke, Qun Wang, Ying Yang, Gong-Ping Liu, Xiao-Chuan Wang, Enjie Liu, Jian-Zhi Wang
Summary: This study revealed a vicious cycle between tau hyperphosphorylation and GSK-3R activation through tau-mediated acetylation of GSK-3R. Inhibiting GSK-3R acetylation competitively improved cognitive impairment and AD-like pathologies.
Review
Cell Biology
Chandler Marrs, Derrick Lonsdale
Summary: Thiamine, also known as vitamin B1, is essential for mitochondrial energetics and energy production, but deficiency is common in modern life and poses significant health risks.
Article
Neurosciences
Li-Na Zhang, Meng-Jie Li, Ying-Hui Shang, Yun-Ru Liu, Huang Han-Chang, Feng-Xue Lao
Summary: The study found that Zeaxanthin (Zea) can protect against endoplasmic reticulum stress (ERS), glycogen synthase kinase 3 beta (GSK-3 beta) activity, and tau phosphorylation.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Maria-Angeles Cortes-Gomez, Esther Llorens-Alvarez, Jordi Alom, Teodoro del Ser, Jesus Avila, Javier Saez-Valero, Maria-Salud Garcia-Ayllon
Summary: This study demonstrates that P-tau can modulate AChE expression, and suggests that AChE may increase in the initial phases of AD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Rim Hamze, Etienne Delangre, Stefania Tolu, Manon Moreau, Nathalie Janel, Danielle Bailbe, Jamileh Movassat
Summary: The global prevalence of diabetes mellitus and Alzheimer's disease is increasing alarmingly with the aging of the population. There is a strong association between type 2 diabetes and an increased risk of dementia. The amyloid cascade, altered glucose metabolism, and insulin signaling may play key roles in the pathophysiology of Alzheimer's disease. Impaired insulin and IGF-1 signaling, as well as GSK3 beta and DYRK1A, could be potential therapeutic targets for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Review
Chemistry, Medicinal
Neha Chauhan, Swati Paliwal, Smita Jain, Kanika Verma, Sarvesh Paliwal, Swapnil Sharma
Summary: Alzheimer's disease is a major health and socioeconomic burden worldwide, characterized by neuronal loss, memory loss, and cognitive impairment. GSK-3 beta plays a significant role in the molecular mechanisms of AD progression, making it a potential therapeutic target for the disease.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Ning Zhang, Yu-Nan Tian, Li-Na Zhou, Meng-Zhu Li, Hua-Dong Chen, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Ao Zhang, Ze-Hong Miao, Jin-Xue He
Summary: The combination of GSK3 inhibitors and PARP inhibitors shows a strong synergistic effect in colorectal cancer cells, enhancing cell sensitivity to treatment and improving therapeutic outcomes.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Prachi Umbarkar, Sulivette Y. Ruiz Ramirez, Angelica Toro Cora, Sultan Tousif, Hind Lal
Summary: This article focuses on the isoform-specific roles of GSK-3 in the pathophysiology of cardiometabolic disorders. GSK-3α plays a critical role in promoting adverse fibrotic remodeling and deterioration of cardiac function, while GSK-3β has the opposite effect in cardiac fibrosis. Inhibition of both GSK-3 isoforms shows benefits against obesity-associated cardiometabolic pathologies, and the molecular interactions with other signaling pathways are discussed. The article also reviews the limitations and potential applications of small molecule inhibitors targeting GSK-3 for the treatment of metabolic disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Chia-Ling Chen, Po-Chun Tseng, Rahmat Dani Satria, Thi Thuy Nguyen, Cheng-Chieh Tsai, Chiou-Feng Lin
Summary: GSK-3 is a vital regulator of glycogen synthesis that plays a crucial role in cellular bioregulation. Abnormal GSK-3 activation and inactivation can lead to liver damage. Targeting GSK-3 with drugs is a potential therapeutic approach for liver protection. Additionally, blocking GSK-3 has a protective effect in IFN-gamma-mediated immune hepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Melissa C. Wren, Jing Zhao, Chia-Chen Liu, Melissa E. Murray, Yuka Atagi, Mary D. Davis, Yuan Fu, Hirotaka J. Okano, Kotaro Ogaki, Audrey J. Strongosky, Pawel Tacik, Rosa Rademakers, Owen A. Ross, Dennis W. Dickson, Zbigniew K. Wszolek, Takahisa Kanekiyo, Guojun Bu
MOLECULAR NEURODEGENERATION
(2015)
Article
Neurosciences
Jing Zhao, Yi Wang, Huan Xu, Yuan Fu, Ting Qian, Deng Bo, Yan-Xin Lu, Yi Xiong, Jun Wan, Xiang Zhang, Qiang Dong, Xiang-Jun Chen
CNS NEUROSCIENCE & THERAPEUTICS
(2016)
Article
Neurosciences
Yuan Fu, Jing Zhao, Yuka Atagi, Henrietta M. Nielsen, Chia-Chen Liu, Honghua Zheng, Mitsuru Shinohara, Takahisa Kanekiyo, Guojun Bu
MOLECULAR NEURODEGENERATION
(2016)
Article
Clinical Neurology
Xiaoli Pan, Neng Gong, Jing Zhao, Zhe Yu, Fenghua Gu, Jia Chen, Xiaojing Sun, Lei Zhao, Meijing Yu, Zhiru Xu, Wenxin Dong, Yan Qin, Guoqiang Fei, Chunjiu Zhong, Tian-Le Xu
Article
Biochemistry & Molecular Biology
Jing Zhao, Yuan Fu, Chia-Chen Liu, Mitsuru Shinohara, Henrietta M. Nielsen, Qiang Dong, Takahisa Kanekiyo, Guojun Bu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Yanling Zhao, Xiaoli Pan, Jing Zhao, Yang Wang, Yun Peng, Chunjiu Zhong
JOURNAL OF NEUROCHEMISTRY
(2009)
Review
Neurosciences
Jing Zhao, Chun-Jiu Zhong
NEUROSCIENCE BULLETIN
(2009)