Regulation of pyruvate metabolism and human disease

The isoenzyme pattern of LDH does not play a physiological role; except perhaps during fast transitions in energy metabolism

(2016) Bjørn Quistorff et al.   Aging-US

p53 regulates glucose metabolism by miR-34a

(2013) Hwa-Ryeon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Molecular Pathways: Reactive Oxygen Species Homeostasis in Cancer Cells and Implications for Cancer Therapy

(2013) V. Nogueira et al.   CLINICAL CANCER RESEARCH

Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle

(2013) Paulo A. Gameiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Expression of Glut-1, CAIX, and MCT4 in Mucinous Carcinoma

(2013) Sewha Kim et al.   Journal of Breast Cancer

Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?

(2013) Stephen Yiu Chuen Choi et al.   JOURNAL OF PATHOLOGY

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Gene Expression Profile Analysis of Type 2 Diabetic Mouse Liver

(2013) Fang Zhang et al.   PLoS One

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

(2013) A. S. Divakaruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells

(2013) Yefei Rong et al.   TUMOR BIOLOGY

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Mitochondrion-Derived Reactive Oxygen Species Lead to Enhanced Amyloid Beta Formation

(2012) Kristina Leuner et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting mitochondrial oxidative metabolism as an approach to treat heart failure

(2012) Natasha Fillmore et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cancer metabolism: Key players in metabolic reprogramming

(2012) Tomoyoshi Soga   CANCER SCIENCE

Targeting Hypoxia, HIF-1, and Tumor Glucose Metabolism to Improve Radiotherapy Efficacy

(2012) T. W. H. Meijer et al.   CLINICAL CANCER RESEARCH

Alanine Aminotransferase: A Clinical and Regulatory Tool for Detecting Liver Injury–Past, Present, and Future

(2012) J R Senior   CLINICAL PHARMACOLOGY & THERAPEUTICS

Heme metabolism and erythropoiesis

(2012) Jacky Chung et al.   CURRENT OPINION IN HEMATOLOGY

The Role of FOXO and PPAR Transcription Factors in Diet-Mediated Inhibition of PDC Activation and Carbohydrate Oxidation During Exercise in Humans and the Role of Pharmacological Activation of PDC in Overriding These Changes

(2012) Dumitru Constantin-Teodosiu et al.   DIABETES

Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes

(2012) M. G. Rosca et al.   DIABETES

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

Pyruvate dehydrogenase deficiency caused by a new mutation of PDHX gene in two Moroccan patients

(2012) Mariam Tajir et al.   European Journal of Medical Genetics

Hypoxia-inducible factor-1 as a therapeutic target in cancer

(2012) Ceen-Ming Tang et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

(2012) Richard A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer's disease

(2012) Misha Zilberter et al.   JOURNAL OF NEUROCHEMISTRY

Region-Specific Hierarchy between Atrophy, Hypometabolism, and  -Amyloid (A ) Load in Alzheimer's Disease Dementia

(2012) R. La Joie et al.   JOURNAL OF NEUROSCIENCE

Review: Quantifying Mitochondrial Dysfunction in Complex Diseases of Aging

(2012) Martin P. Horan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Attenuation of Aβ-induced neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative stress

(2012) Andleeb Khan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Calorie Restriction and SIRT3 Trigger Global Reprogramming of the Mitochondrial Protein Acetylome

(2012) Alexander S. Hebert et al.   MOLECULAR CELL

Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project

(2012) Silvia Morbelli et al.   NEUROBIOLOGY OF AGING

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism

(2012) David N. Hauser et al.   NEUROBIOLOGY OF DISEASE

The Warburg effect: Insights from the past decade

(2012) Mohita Upadhyay et al.   PHARMACOLOGY & THERAPEUTICS

Cystinosin, MPDU1, SWEETs and KDELR Belong to a Well-Defined Protein Family with Putative Function of Cargo Receptors Involved in Vesicle Trafficking

(2012) Vladimir Saudek   PLoS One

Combination of Sulindac and Dichloroacetate Kills Cancer Cells via Oxidative Damage

(2012) Kasirajan Ayyanathan et al.   PLoS One

CNS SIRT3 Expression Is Altered by Reactive Oxygen Species and in Alzheimer’s Disease

(2012) Heather J. M. Weir et al.   PLoS One

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

(2012) S. Herzig et al.   SCIENCE

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

(2012) D. K. Bricker et al.   SCIENCE

High-Resolution Genome-wide Mapping of AHR and ARNT Binding Sites by ChIP-Seq

(2012) Raymond Lo et al.   TOXICOLOGICAL SCIENCES

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

(2012) Hui-Ming Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Erythrocyte pyruvate kinase deficiency in an old-order Amish cohort: Longitudinal risk and disease management

(2011) Nicholas L. Rider et al.   AMERICAN JOURNAL OF HEMATOLOGY

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

(2011) Rommy von Bernhardi et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of the structure and activity of pyruvate carboxylase by acetyl CoA

(2011) Abdussalam Adina-Zada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Variation in the organization and subunit composition of the mammalian pyruvate dehydrogenase complex E2/E3BP core assembly

(2011) Swetha Vijayakrishnan et al.   BIOCHEMICAL JOURNAL

Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics

(2011) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Targeting fatty acid and carbohydrate oxidation — A novel therapeutic intervention in the ischemic and failing heart

(2011) Jagdip S. Jaswal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

(2011) J. Schodel et al.   BLOOD

Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake

(2011) Charles A. Stuart et al.   BRAIN RESEARCH

Regulation of Monocarboxylate Transporter MCT1 Expression by p53 Mediates Inward and Outward Lactate Fluxes in Tumors

(2011) R. Boidot et al.   CANCER RESEARCH

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Nuclear localization of pyruvate dehydrogenase complex-E2 (PDC-E2), a mitochondrial enzyme, and its role in signal transducer and activator of transcription 5 (STAT5)-dependent gene transcription

(2011) Fu-Yu Chueh et al.   CELLULAR SIGNALLING

Optimization of Cardiac Metabolism in Heart Failure

(2011) Tomohisa Nagoshi et al.   CURRENT PHARMACEUTICAL DESIGN

Structural and Thermodynamic Basis for Weak Interactions between Dihydrolipoamide Dehydrogenase and Subunit-binding Domain of the Branched-chain α-Ketoacid Dehydrogenase Complex

(2011) Chad A. Brautigam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response

(2011) Kari T. Chambers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ethyl Pyruvate Rescues Nigrostriatal Dopaminergic Neurons by Regulating Glial Activation in a Mouse Model of Parkinson's Disease

(2011) S. H. Huh et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial Dysfunction as a Therapeutic Target in Progressive Supranuclear Palsy

(2011) Vincent Ries et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mitochondrial regulators of fatty acid metabolism reflect metabolic dysfunction in type 2 diabetes mellitus

(2011) Sameer S. Kulkarni et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism

(2011) Taro Hitosugi et al.   MOLECULAR CELL

Molecular characterization of 82 patients with pyruvate dehydrogenase complex deficiency. Structural implications of novel amino acid substitutions in E1 protein

(2011) A. Imbard et al.   MOLECULAR GENETICS AND METABOLISM

The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients

(2011) Kavi P. Patel et al.   MOLECULAR GENETICS AND METABOLISM

The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease

(2011) D.J. Surmeier et al.   NEUROSCIENCE

Alanine Aminotransferase Regulation by Androgens in Non-hepatic Tissues

(2011) Christopher C. Coss et al.   PHARMACEUTICAL RESEARCH

Gene Expression Profile Change and Associated Physiological and Pathological Effects in Mouse Liver Induced by Fasting and Refeeding

(2011) Fang Zhang et al.   PLoS One

Pyruvate carboxylase is required for glutamine-independent growth of tumor cells

(2011) T. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallization and preliminary crystallographic studies of the catalytic subunits of human pyruvate dehydrogenase phosphatase isoforms 1 and 2

(2010) Junko Kato et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

(2010) Laurent Mouchiroud et al.   AGING CELL

Metabolic Modulation: A New Therapeutic Target in Treatment of Heart Failure

(2010) Chandrasekar Palaniswamy et al.   AMERICAN JOURNAL OF THERAPEUTICS

Exercise and Weight Loss Improve Exercise Capacity Independent of Cardiac Function in Metabolic Syndrome

(2010) Anand Chockalingam et al.   ANGIOLOGY

The effect of dichloroacetate on health- and lifespan in C. elegans

(2010) S. Schaffer et al.   BIOGERONTOLOGY

Rational therapeutic approaches to progressive supranuclear palsy

(2010) M. Stamelou et al.   BRAIN

Energetics and metabolism in the failing heart: important but poorly understood

(2010) Aslan T Turer et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Vascular remodeling in pulmonary arterial hypertension: Multiple cancer-like pathways and possible treatment modalities

(2010) Seiichiro Sakao et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

My favorite pyruvate carboxylase

(2010) John C. Wallace   IUBMB LIFE

LDHC: The Ultimate Testis-Specific Gene

(2010) E. Goldberg et al.   JOURNAL OF ANDROLOGY

Solution Structure and Characterisation of the Human Pyruvate Dehydrogenase Complex Core Assembly

(2010) S. Vijayakrishnan et al.   JOURNAL OF MOLECULAR BIOLOGY

Pyruvate carboxylase deficiency: Mechanisms, mimics and anaplerosis

(2010) Isaac Marin-Valencia et al.   MOLECULAR GENETICS AND METABOLISM

Myocardial Fatty Acid Metabolism in Health and Disease

(2010) Gary D. Lopaschuk et al.   PHYSIOLOGICAL REVIEWS

High brain lactate is a hallmark of aging and caused by a shift in the lactate dehydrogenase A/B ratio

(2010) J. M. Ross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition

(2010) Andrei G. Vlassenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of human metabolism by hypoxia-inducible factor

(2010) Federico Formenti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional aerobic glycolysis in the human brain

(2010) S. Neil Vaishnavi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human pyruvate kinase M2: A multifunctional protein

(2010) Vibhor Gupta et al.   PROTEIN SCIENCE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

Heart Failure Management: The Present and the Future

(2009) Mohammad N. Jameel et al.   ANTIOXIDANTS & REDOX SIGNALING

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

(2009) Ramon C. Sun et al.   BREAST CANCER RESEARCH AND TREATMENT

Dichloroacetate Modulates the Oxidative Stress and Inflammatory Response to Exercise in COPD

(2009) Evi M. Mercken et al.   CHEST

Cardiac Resynchronization Therapy Corrects Dyssynchrony-Induced Regional Gene Expression Changes on a Genomic Level

(2009) Andreas S. Barth et al.   Circulation-Cardiovascular Genetics

Modulation of Mitochondrial Proteome and Improved Mitochondrial Function by Biventricular Pacing of Dyssynchronous Failing Hearts

(2009) Giulio Agnetti et al.   Circulation-Cardiovascular Genetics

Low Muscle Glycogen and Elevated Plasma Free Fatty Acid Modify but Do Not Prevent Exercise-Induced PDH Activation in Human Skeletal Muscle

(2009) K. Kiilerich et al.   DIABETES

Pyruvate dehydrogenase E2 deficiency: A potentially treatable cause of episodic dystonia

(2009) Catherine A. McWilliam et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

Pyruvate dehydrogenase phosphatase 1 (PDP1) null mutation produces a lethal infantile phenotype

(2009) J. M. Cameron et al.   HUMAN GENETICS

Detection of the mitochondrial and catalytically active alanine aminotransferase in human tissues and plasma

(2009) Glinghammar   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Subunit and Catalytic Component Stoichiometries of anin VitroReconstituted Human Pyruvate Dehydrogenase Complex

(2009) Chad A. Brautigam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic modulation and cellular therapy of cardiac dysfunction and failure

(2009) Diana Revenco et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice

(2009) J Han et al.   JOURNAL OF ENDOCRINOLOGY

Adenosine Triphosphate Depletion of Erythrocytes Simulates the Phenotype Associated with Pyruvate Kinase Deficiency and Confers Protection againstPlasmodium falciparumIn Vitro

(2009) Kodjo Ayi et al.   JOURNAL OF INFECTIOUS DISEASES

Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex

(2009) Mulchand S. Patel et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle

(2009) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Proteome, Phosphoproteome, and Hydroxyproteome of Liver Mitochondria in Diabetic Rats at Early Pathogenic Stages

(2009) Wen-Jun Deng et al.   MOLECULAR & CELLULAR PROTEOMICS

Ethyl Pyruvate Inhibits Peroxynitrite-induced DNA Damage and Hydroxyl Radical Generation: Implications for Neuroprotection

(2009) Wei Chen et al.   NEUROCHEMICAL RESEARCH

Genotype-confirmed alanine aminotransferase deficiency in a Chinese patient with acute liver failure: a potential diagnostic pitfall

(2009) Chloe Miu Mak et al.   PATHOLOGY

Substrate Utilization by the Failing Human Heart by Direct Quantification Using Arterio-Venous Blood Sampling

(2009) Junichi Funada et al.   PLoS One

Glycolysis: a bioenergetic or a survival pathway?

(2009) Juan P. Bolaños et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart

(2009) Jun Wang et al.   Science in China. Series C, Life sciences / Chinese Academy of Sciences

The Cancer Paradigm of Severe Pulmonary Arterial Hypertension

(2008) Pradeep R. Rai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dichloroacetate Enhances Performance and Reduces Blood Lactate during Maximal Cycle Exercise in Chronic Obstructive Pulmonary Disease

(2008) Lori D. Calvert et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Brain's Default Network

(2008) Randy L. Buckner et al.   Annals of the New York Academy of Sciences

Structure, mechanism and regulation of pyruvate carboxylase

(2008) Sarawut Jitrapakdee et al.   BIOCHEMICAL JOURNAL

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Structural and Functional Insights into the Molecular Mechanisms Responsible for the Regulation of Pyruvate Dehydrogenase Kinase 2

(2008) Todd Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate Dehydrogenase Kinase-4 Structures Reveal a Metastable Open Conformation Fostering Robust Core-free Basal Activity

(2008) R. Max Wynn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)

(2008) Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2in cortical neurons

(2008) Phullara B. Shelat et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson's disease: clinical features and diagnosis

(2008) J Jankovic   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

The molecular basis of pyruvate carboxylase deficiency: Mosaicism correlates with prolonged survival

(2008) Dong Wang et al.   MOLECULAR GENETICS AND METABOLISM

Mutations of the E1β subunit gene (PDHB) in four families with pyruvate dehydrogenase deficiency

(2008) K. Okajima et al.   MOLECULAR GENETICS AND METABOLISM

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction

(2008) Song Xiang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Pyruvate Kinase Deficiency and Malaria

(2008) Kodjo Ayi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Is the failing heart out of fuel or a worn engine running rich? A study of mitochondria in old spontaneously hypertensive rats

(2008) Mia Jüllig et al.   PROTEOMICS

Structural Basis for Inactivation of the Human Pyruvate Dehydrogenase Complex by Phosphorylation: Role of Disordered Phosphorylation Loops

(2008) Masato Kato et al.   STRUCTURE