Article
Geriatrics & Gerontology
Yingqi Wang, Peijun Li, Yuanyuan Cao, Chanjing Liu, Jie Wang, Weibing Wu
Summary: Skeletal muscle dysfunction is a common extrapulmonary complication and an important prognostic factor in patients with chronic obstructive pulmonary disease. Mitochondrial dysfunction, caused by factors such as smoke exposure, hypoxia, and insufficient physical activity, plays a key role in damaging the structure and function of skeletal muscle in COPD. Exercise therapy has shown promising prospects in treating the mitochondrial dysfunction in COPD skeletal muscle by increasing mitochondrial density, regulating mitochondrial biogenesis, improving respiratory function, and reducing oxidative stress.
Article
Multidisciplinary Sciences
Maria Stella Valle, Antonino Casabona, Eugenia Di Fazio, Claudia Crimi, Cristina Russo, Lucia Malaguarnera, Nunzio Crimi, Matteo Cioni
Summary: Patients with COPD showed a statistically significant reduction in stiffness and viscosity compared to controls, negatively impacting the performance of active movements.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jing Xiong, Yanqing Le, Yafei Rao, Lu Zhou, Yuhan Hu, Suliang Guo, Yongchang Sun
Summary: The RANKL/RANK pathway plays an important role in muscle atrophy induced by COPD-related lung diseases, suggesting that it may be a potential therapeutic target for COPD-related skeletal muscle dysfunction.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2021)
Review
Physiology
Hui Zhao, Peijun Li, Jihong Wang
Summary: Skeletal muscle dysfunction in chronic obstructive pulmonary disease (COPD) is caused by changes in respiratory and peripheral muscle fiber types, resulting in reduced muscle strength and endurance, and muscle atrophy. MicroRNAs play a crucial role in modulating skeletal muscle dysfunction through regulation of muscle development, protein synthesis and degradation, inflammatory response, and metabolism. Muscle-specific miRNAs (myomiRs) may be involved in this process, although their differential expression levels and underlying mechanisms in COPD and skeletal muscle dysfunction are not yet fully understood. This paper reviews the differential expression of myomiRs in COPD and explores their possible mechanisms to provide new insights for the prevention and treatment of skeletal muscle dysfunction in COPD.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Andre Nyberg, Nadia Milad, Mickael Martin, Dany Patoine, Mathieu C. Morissette, Didier Saey, Francois Maltais
Summary: This study investigated the role of progression of training volume in intramuscular adaptations in patients with COPD undergoing resistance training. The findings suggest that continued progression of training volume can lead to improvements in fiber type distribution, muscle protein levels, and quadriceps endurance in patients with COPD. These findings highlight the importance of continued progression of training volume for counteracting quadriceps dysfunction in this population.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Yuanyuan Cao, Peijun Li, Yingqi Wang, Xiaodan Liu, Weibing Wu
Summary: Chronic obstructive pulmonary disease (COPD) affects the whole body and causes various extrapulmonary adverse effects. Diaphragm dysfunction is one of the prominent manifestations. It directly affects the respiratory efficiency of patients with COPD and is an important pathological mechanism leading to progressive exacerbation of the disease and respiratory failure. The specific mechanism of diaphragm dysfunction in COPD is still unclear, which adds difficulty to treatment and rehabilitation.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Mingming Deng, Xiaoming Zhou, Yanxia Li, Yan Yin, Chaonan Liang, Qin Zhang, Jingwen Lu, Mengchan Wang, Yu Wang, Yue Sun, Ruixia Li, Liming Yan, Qiuyue Wang, Gang Hou
Summary: This study explores the feasibility of shear wave ultrasound elastography (SWE) in measuring the stiffness of the rectus femoris muscle and finds that SWE is a promising tool for predicting sarcopenia in patients with chronic obstructive pulmonary disease (COPD).
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Knut Sindre Molmen, Daniel Hammarstrom, Gunnar Slettalokken Falch, Morten Grundtvig, Lise Koll, Marita Hanestadhaugen, Yusuf Khan, Rafi Ahmad, Bente Malerbakken, Tore Jorgen Rodolen, Roger Lien, Bent R. Ronnestad, Truls Raastad, Stian Ellefsen
Summary: Despite the well-known pathophysiologies associated with COPD, resistance training led to improvements in lower-limb muscle strength, muscle mass, muscle quality, and endurance performance in COPD subjects, resembling or exceeding responses seen in healthy controls. These findings highlight the largely unrecognized responsiveness of COPD patients to resistance training and suggest it as a potent measure to relieve disease-related impairments.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Respiratory System
Rohini Bhadra, Shinjini Bhattacharya, George A. D'Souza, Annemie M. W. J. Schols, Sucharita Sambashivaiah
Summary: COPD is a significant public health concern in India, and the implementation of PR in the country is poor. PR is recommended as an integral part of COPD management, targeting both pulmonary and extrapulmonary manifestations to improve functional capacity. Latest evidence supports the effectiveness of PR and highlights the challenges and potential solutions for its implementation in India.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2021)
Review
Physiology
Bingzhi Zhang, Peijun Li, Jian Li, Xiaodan Liu, Weibing Wu
Summary: Oxidative stress is a main factor causing diaphragm dysfunction in COPD, while exercise plays a positive role in preventing and improving this dysfunction. The effects of exercise on oxidative stress and diaphragm function depend on the intensity, duration, and style of exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Matthias Catteau, Emilie Passerieux, Leo Blervaque, Fares Gouzi, Bronia Ayoub, Maurice Hayot, Pascal Pomies
Summary: This study found that COPD muscle cells have impaired response to contraction, which may contribute to muscle weakness observed in patients with COPD.
Article
Sport Sciences
M. O. S. T. A. F. A. M. ALI, R. Y. A. N. P. MCMILLAN, D. A. N. E. W. FAUSNACHT, J. O. H. N. W. KAVANAUGH, M. O. R. D. E. C. A. I. M. HARVEY, J. O. S. E. P. H. R. STEVENS, Y. A. R. U. WU, R. A. N. D. A. L. L. L. MYNATT, M. A. T. T. H. E. W. W. HULVER
Summary: This study established a novel muscle-specific TLR4 knockout mouse model and identified mTLR4 as an immunomodulatory effector of exercise-induced metabolic adaptations in skeletal muscle.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Physiology
Jinelle Gelinas, Megan Harper, John Sasso, Stephen Wright, Bernie Melzer, Gloria Agar, Jordan Guenette, Gregory duManoir, Michael Roman, J. Douglass Rolf, Neil Eves
Summary: This study investigated the integrative exercise responses associated with different exercise limitation phenotypes in COPD patients. The results showed that the cardiovascular phenotype had less static hyperinflation, lower end-expiratory lung volume, and larger tidal volume during exercise compared to other phenotypes. The cardiovascular phenotype also showed higher peak ventilation, cardiopulmonary fitness, and maximum workload compared to the ventilatory phenotype. Categorizing COPD patients phenotypically may aid in optimizing exercise prescription for rehabilitation purposes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Lijiao Zhang, Chunxiao Li, Jing Xiong, Chun Chang, Yongchang Sun
Summary: Skeletal muscle dysfunction is a significant extrapulmonary comorbidity of chronic obstructive pulmonary disease (COPD). This study revealed a novel regulatory mechanism of myokines in the pathogenesis of skeletal muscle comorbidities of COPD, in which CSE exposure upregulated p-Erk1/2 to promote Mstn expression, leading to the inhibition of Fndc5 expression via the p-Smad3/PGC-1 alpha pathway.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Michele Vitacca, Mara Paneroni, Antonio Spanevello, Piero Ceriana, Bruno Balbi, Beatrice Salvi, Nicolino Ambrosino
Summary: This real-life study found that in-patient pulmonary rehabilitation provides significant benefits for individuals with COPD, regardless of whether they are using inhaled triple therapy (TT). However, individuals using TT reported greater improvements in exercise tolerance compared to those not using TT.
RESPIRATORY MEDICINE
(2022)
Article
Endocrinology & Metabolism
Cecile Betry, Aline Nixon, Paul L. Greenhaff, Elizabeth J. Simpson
Summary: The study found that the position of the antecubital vein cannula significantly impacts the calculation of postprandial forearm glucose uptake. These findings have important implications for longitudinal intervention studies requiring continuous determination of forearm glucose uptake.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Respiratory System
Lorna E. Latimer, Dumitru Constantin-Teodosiu, Bhavesh Popat, Despina Constantin, Linzy Houchen-Wolloff, Charlotte E. Bolton, Michael C. Steiner, Paul L. Greenhaff
Summary: The study found that aging and COPD do not impair intrinsic mitochondrial function in untrained state, but AET has robust effects on whole-body and muscle mitochondrial responses in HY, significant effects in HO, and deficiencies in COPD. All groups showed strong muscle mRNA responses.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Medicine, General & Internal
Gavin D. Perkins, Chen Ji, Bronwen A. Connolly, Keith Couper, Ranjit Lall, J. Kenneth Baillie, Judy M. Bradley, Paul Dark, Chirag Dave, Anthony De Soyza, Anna Dennis, Anne Devrell, Sara Fairbairn, Hakim Ghani, Ellen A. Gorman, Christopher A. Green, Nicholas Hart, Siew Wan Hee, Zoe Kimbley, Shyam Madathil, Nicola McGowan, Benjamin Messer, Jay Naisbitt, Chloe Norman, Dhruv Parekh, Emma M. Parkin, Jaimin Patel, Scott E. Regan, Clare Ross, Anthony J. Rostron, Mohammad Saim, Anita K. Simonds, Emma Skilton, Nigel Stallard, Michael Steiner, Rama Vancheeswaran, Joyce Yeung, Daniel F. McAuley
Summary: Among patients with acute hypoxemic respiratory failure due to COVID-19, an initial strategy of CPAP significantly reduced the risk of tracheal intubation or mortality compared with conventional oxygen therapy, but there was no significant difference between an initial strategy of HFNO compared with conventional oxygen therapy. The study may have been underpowered for the comparison of HFNO vs conventional oxygen therapy, and early study termination and crossover among the groups should be considered when interpreting the findings.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Medicine, General & Internal
Azamat Akylbekov, Mark W. Orme, Amy Jones, Maamed Mademilov, Aibermet Muratbekova, Shoira Aidaralieva, Gulzada Mirzalieva, Alena Oleinik, Kamila Magdieva, Aijan Taalaibekova, Aidai Rysbek Kyzy, Zainab K. Yusuf, Jones Rupert, Andy Barton, Ruhme B. Miah, Adrian Manise, Jesse A. Matheson, Dominic Malcolm, Robert C. Free, Michael C. Steiner, Talant Sooronbaev, Sally J. Singh
Summary: Pulmonary rehabilitation (PR) is recommended for managing COPD and other chronic respiratory diseases, but is often not available for people with TB or PTBLD in low and middle-income countries. This study aims to adapt a culturally appropriate PR programme in Kyrgyzstan for people with PTBLD and to test its effectiveness in improving exercise capacity through a fully powered RCT.
Article
Respiratory System
A. Chamilya H. Perera, Akila R. Jayamaha, Amy Jones, Zainab K. Yusuf, K. D. C. Upendra Wijayasiri, Thamara Amarasekara, Anthony Seneviratne, Ruhme Miah, Andy Barton, Michael C. Steiner, Savithri W. Wimalasekara, Mark W. Orme, Sally J. Singh
Summary: Adults living with COPD in Sri Lanka are interested in participating in a culturally appropriate Pulmonary Rehabilitation (PR) programme, preferably in a supervised, group-based setting in hospitals. However, there is a lack of awareness about PR among both patients and healthcare providers (HCPs), and HCPs feel unprepared to refer patients to PR programmes. It is crucial to provide training for HCPs and develop effective referral strategies to support the uptake and delivery of PR for adults living with COPD in Sri Lanka.
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2022)
Editorial Material
Respiratory System
Edward Caruana, Michael C. Steiner
Article
Primary Health Care
Gillian E. Doe, Marie T. Williams, Stacey Chantrell, Michael C. Steiner, Natalie Armstrong, Ann Hutchinson, Rachael A. Evans
Summary: This study explored the experiences of patients with chronic breathlessness who were awaiting a diagnosis and primary care clinicians. The findings identified potential reasons for delays in diagnosis and suggested interventions to improve symptom recognition, diagnostic approaches, and clinician communication to achieve earlier diagnosis and management for better patient outcomes.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Cardiac & Cardiovascular Systems
Alvar Agusti, Nicolino Ambrosino, Felicity Blackstock, Jean Bourbeau, Richard Casaburi, Bartolome Celli, Rebecca Crouch, Roberto Dal Negro, Michael Dreher, Christine Garvey, Daniel Gerardi, Roger Goldstein, Nicola Hanania, Anne E. Holland, Antarpreet Kaur, Suzanne Lareau, Peter K. Lindenauer, David Mannino, Barry Make, Francois Maltais, Jeffrey D. Marciniuk, Paula Meek, Mike Morgan, Jean-Louis Pepin, Jane Z. Reardon, Carolyn Rochester, Sally Singh, Martijn A. Spruit, Michael C. Steiner, Thierry Troosters, Michele Vitacca, Enico Clini, Jose Jardim, Linda Nici, Jonathan Raskin, Richard ZuWallack
Summary: Chronic Obstructive Pulmonary Disease (COPD) is a common and preventable disease with significant morbidity and mortality. Understanding the complexity of COPD is a major challenge, as it is now recognized as a multi-component disease with various clinical phenotypes and associated co-morbidities. Optimizing treatment strategies and delivery of care in COPD has shown impressive benefits in patient outcomes and healthcare utilization.
RESPIRATORY MEDICINE
(2023)
Article
Primary Health Care
Gillian Doe, Simon Wathall, Jill Clanchy, Sarah Edwards, Helen Evans, Michael C. Steiner, Rachael A. Evans
Summary: This study compared two recruitment strategies and found that using an electronic template triggered during a consultation significantly increased recruitment of patients with breathlessness for prospective research.
NPJ PRIMARY CARE RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
Ruth E. Trethewey, Nicole L. Spartano, Ramachandran S. Vasan, Martin G. Larson, George T. O'Connor, Dale W. Esliger, Emily S. Petherick, Michael C. Steiner
Summary: The study finds that low body mass index (BMI) is associated with COPD, and also identifies associations between the development of emphysema and airflow obstruction with BMI and lung density.
CHRONIC RESPIRATORY DISEASE
(2022)
Article
Respiratory System
Amy V. Jones, Rachael A. Evans, Alexander S. Harrison, Lauren B. Sherar, Michael C. Steiner, Patrick Doherty, Sally J. Singh
Summary: This study investigated the participation and completion of rehabilitation programs by patients with coexisting COPD and CHF, and compared the outcomes. The results showed that patients with COPD and CHF had lower participation in cardiac rehabilitation, but higher participation in pulmonary rehabilitation. Patients with COPD had better performance in the incremental shuttle walk test following rehabilitation compared to patients with COPD+CHF. The improvements in the 6-min walk test, quality of life, and mood state were similar between the two groups, regardless of diagnosis.
Article
Respiratory System
Urvee Karsanji, Rachael A. Evans, Jennifer K. Quint, Kamlesh Khunti, Claire A. Lawson, Emily Petherick, Neil J. Greening, Sally J. Singh, Matthew Richardson, Michael C. Steiner
Summary: The prevalence of MetS in COPD patients is 10.1%, and it is associated with higher 5-year mortality risk. However, the impact is minimal when adjusted for COPD disease severity and other comorbidities. Individual components of MetS have differential impacts on mortality.
Article
Health Care Sciences & Services
Grace Hawthorne, Neil Greening, Dale Esliger, Samuel Briggs-Price, Matthew Richardson, Emma Chaplin, Lisa Clinch, Michael C. Steiner, Sally J. Singh, Mark W. Orme
Summary: This study investigated the usability and acceptability of continuous vital signs monitoring using wearable multiparameter technology in people with chronic obstructive pulmonary disease (COPD). The results showed that the technology was well accepted by participants and was able to accurately measure vital signs, although the data quality was influenced by body composition.
JMIR HUMAN FACTORS
(2022)
Article
Respiratory System
Grace Hawthorne, Matthew Richardson, Neil J. Greening, Dale Esliger, Samuel Briggs-Price, Emma J. Chaplin, Lisa Clinch, Michael C. Steiner, Sally J. Singh, Mark W. Orme
Summary: This study found that increased heart rate and reduced physical activity may be associated with exacerbations of chronic obstructive pulmonary disease. Respiratory rate and heart rate are potential indicators for predicting worsening symptoms in the future.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Michael C. Steiner
CHRONIC RESPIRATORY DISEASE
(2022)
