期刊
JOURNAL OF ANDROLOGY
卷 31, 期 1, 页码 86-94出版社
AMER SOC ANDROLOGY, INC
DOI: 10.2164/jandrol.109.008367
关键词
Lactate dehydrogenase C; glycolysis; male fertility; sperm
类别
资金
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [ZIAES070076] Funding Source: NIH RePORTER
- Intramural NIH HHS [Z01 ES070076-22] Funding Source: Medline
- NICHD NIH HHS [HD05863, R01 HD005863] Funding Source: Medline
Lactate dehydrogenase C (LDHC) was, to the best of our knowledge, the first testis-specific isozyme discovered in male germ cells. In fact, this was accomplished shortly before isozymes or isoenzymes became a field of study. LDHC was detected initially in human spermatozoa and spermatogenic cells of the testes by gel electrophoresis. Immunohistochemistry was used to localize LDHC first in early-pachytene primary spermatocytes, with an apparent increase in quantity after meiosis, to its final localization in and on the principal piece of the sperm tail. After several decades of biologic, biochemical, and genetic investigations, we now know that the lactate dehydrogenase isozymes are ubiquitous in vertebrates, developmentally regulated, tissue and cell specific, and multifunctional. Here, we will review the history of LDHC and the work that demonstrates clearly that it is required for sperm to accomplish their ultimate goal, fertilization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据