HIV-1 Nef: a multifaceted modulator of T cell receptor signaling

Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections

(2012) Rémi Lasserre et al.   EMBO JOURNAL

End-binding protein 1 controls signal propagation from the T cell receptor

(2012) Noa B Martín-Cófreces et al.   EMBO JOURNAL

HIV-1 Nef Limits Communication between Linker of Activated T Cells and SLP-76 To Reduce Formation of SLP-76-Signaling Microclusters following TCR Stimulation

(2012) L. Abraham et al.   JOURNAL OF IMMUNOLOGY

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes

(2012) Wei Zou et al.   Retrovirology

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

(2011) X. Pan et al.   BLOOD

Mechanisms of HIV-1 Nef Function and Intracellular Signaling

(2011) John L. Foster et al.   Journal of Neuroimmune Pharmacology

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events

(2011) David J Williamson et al.   NATURE IMMUNOLOGY

Mutation of a diacidic motif in SIV-PBj Nef impairs T-cell activation and enteropathic disease

(2011) Ulrich Tschulena et al.   Retrovirology

How HIV Takes Advantage of the Cytoskeleton in Entry and Replication

(2011) Bettina Stolp et al.   Viruses-Basel

The Immunological Synapse: a Dynamic Platform for Local Signaling

(2010) Matthew F. Krummel et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Lentiviral Nef Proteins Utilize PAK2-Mediated Deregulation of Cofilin as a General Strategy To Interfere with Actin Remodeling

(2010) B. Stolp et al.   JOURNAL OF VIROLOGY

Human immunodeficiency virus (HIV) type-1, HIV-2 and simian immunodeficiency virus Nef proteins

(2010) Nadine Laguette et al.   MOLECULAR ASPECTS OF MEDICINE

Dynamics of Subsynaptic Vesicles and Surface Microclusters at the Immunological Synapse

(2010) M. A. Purbhoo et al.   Science Signaling

The HIV-1 Nef protein has a dual role in T cell receptor signaling in infected CD4+ T lymphocytes

(2010) Francesca Neri et al.   VIROLOGY

Understanding the Structure and Function of the Immunological Synapse

(2010) M. L. Dustin et al.   Cold Spring Harbor Perspectives in Biology

The LAT Story: A Tale of Cooperativity, Coordination, and Choreography

(2010) L. Balagopalan et al.   Cold Spring Harbor Perspectives in Biology

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Massive Secretion by T Cells Is Caused by HIV Nef in Infected Cells and by Nef Transfer to Bystander Cells

(2009) Claudia Muratori et al.   Cell Host & Microbe

HIV-1 Nef Interferes with Host Cell Motility by Deregulation of Cofilin

(2009) Bettina Stolp et al.   Cell Host & Microbe

Dynamic regulation of T-cell costimulation through TCR-CD28 microclusters

(2009) Tadashi Yokosuka et al.   IMMUNOLOGICAL REVIEWS

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

(2009) Robert J. Salmond et al.   IMMUNOLOGICAL REVIEWS

Uncoordinated 119 Protein Controls Trafficking of Lck via the Rab11 Endosome and Is Critical for Immunological Synapse Formation

(2009) M. M. Gorska et al.   JOURNAL OF IMMUNOLOGY

Inhibition of T-Cell Receptor-Induced Actin Remodeling and Relocalization of Lck Are Evolutionarily Conserved Activities of Lentiviral Nef Proteins

(2009) J. M. Rudolph et al.   JOURNAL OF VIROLOGY

Ras/MAPK signaling from endomembranes

(2009) Nicole Fehrenbacher et al.   Molecular Oncology

Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo

(2009) Stefanie Homann et al.   Retrovirology

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Endothelial nitric oxide synthase regulates N-Ras activation on the Golgi complex of antigen-stimulated T cells

(2008) S. Ibiza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting

(2007) Dietlinde Wolf et al.   VIROLOGY