Article
Cell Biology
Yanan Li, Anshuman Bhanja, Arpita Upadhyaya, Xiaodong Zhao, Wenxia Song
Summary: This study examines the role of WASp-mediated branched actin polymerization in the GCB immunological synapse. Results reveal essential roles for WASp in the generation and maintenance of unique structures for GCB immunological synapses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Anna Grochmal, Ben Woods, Lilia Milanesi, Manuel Perez-Soto, Salvador Tomas
Summary: Research on mimicking biological systems reveals that minimal environmental changes can trigger high avidity membrane receptor assembly, which can be modulated by weakly binding divalent ligands. Mathematical models and equations can predict the modulation intensity of the ligand-messenger on the ligand-receptor ON signal, providing valuable tools for studying membrane receptors in biological and biomimetic systems.
Review
Immunology
Barbara Molon, Cristina Liboni, Antonella Viola
Summary: This article discusses the important role of T cells in immune response and the regulatory mechanisms of signaling compartmentalization during T cell activation and functions, focusing on the role of CD28, chemokine receptors, and the actin cytoskeleton. It also considers the detrimental effect of mutations in signaling proteins on T cell functionality.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Audun Kvalvaag, Salvatore Valvo, Pablo F. Cespedes, David G. Saliba, Elke Kurz, Kseniya Korobchevskaya, Michael L. Dustin
Summary: Ligation of TCR to pMHC induces TCR ubiquitination and either internalization by T cell or release in extracellular vesicles. Clathrin-mediated ectocytosis facilitates the release of TCR, while clathrin-mediated trans-endocytosis enables the uptake of pMHC-TCR conjugates from the APC.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Chih-Chun Lee, Chia-Hsuan Tsai, Chih-Hao Chen, Yuan-Chieh Yeh, Wen-Hung Chung, Chun-Bing Chen
Summary: Keloid is a unique type of disfiguring pathological scarring in human skin that is characterized by excessive collagen deposition. Immune cell infiltration is a common feature of normal and pathological tissue repair, but the immunopathological mechanisms of keloid remain unclear. Recent studies have highlighted the crucial role of innate and adaptive immunity in regulating the abnormal behavior of keloid fibroblasts. Novel therapeutics targeting immune pathways have shown varying efficacy in restoring regulation of the immune microenvironment in keloid.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Jose Luis Rodriguez-Fernandez, Olga Criado-Garcia
Summary: Dendritic cells are powerful antigen-presenting cells that control T cell activation through the immunological synapse. While most studies focus on the T cell side, dendritic cell side also plays a significant role in T cell activation, especially through actin polarization at the IS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Fisheries
Quanquan Cao, Hongying Shan, Ju Zhao, Jinhe Deng, Man Xu, Hao Kang, Tong Li, Ye Zhao, Haifeng Liu, Jun Jiang
Summary: Liver fibrosis is a pathological process characterized by the activation of hepatic stellate cells, imbalance of extracellular matrix generation, and deposition in the liver. This review focuses on the understanding of liver fibrosis in aquaculture fish, discussing its pathophysiology, diagnosis methods, and treatment options. The article highlights the importance of further research in order to develop effective prevention and treatment strategies for liver fibrosis in fish, ensuring the sustainability of aquaculture and the health of farmed fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Neurosciences
Sophie H. Lee, Aline Mak, Mark H. G. Verheijen
Summary: Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) have become a popular method in neuroscience for studying the functional aspects of astrocyte activity, particularly G-protein coupled receptor (GPCR)-mediated intracellular calcium dynamics and cyclic adenosine monophosphate dynamics. This method allows for a direct link between astrocytic function and cognitive processes such as memory.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Immunology
Bonah Kim, Hee Young Kim, Won-Woo Lee
Summary: Zinc, an essential microelement, plays immunoregulatory roles by influencing signaling pathways to enhance immune function. Zinc deficiency impairs immunity and increases susceptibility to infection. The interaction between Zip6-mediated zinc influx and TCR activation regulates T-cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sara Danielli, Zhongming Ma, Eirini Pantazi, Amrendra Kumar, Benjamin Demarco, Fabian A. Fischer, Usha Paudel, Jillian Weissenrieder, Robert J. Lee, Sebastian Joyce, J. Kevin Foskett, Jelena S. Bezbradica
Summary: CALHM6, a membrane ion channel, promotes cell-cell crosstalk at neuronal synapses via ATP release and is highly expressed in immune cells. It has been linked to NK cell anti-tumor activity, but its mechanism of action and broader functions in the immune system remain unclear.
Article
Neurosciences
Natacha Dreumont, Khalid Mimoun, Carine Pourie, Edward V. Quadros, Jean-Marc Alberto, Remy Umoret, Deborah Helle, Aurelie Robert, Jean-Luc Daval, Jean-Louis Gueant, Gregory Pourie
Summary: This study investigated the molecular mechanisms of cognitive dysfunction in mice with Cbl deficiency, finding that impaired learning memory in Cd320KO mice could be alleviated by moderate stress and increased levels of plasma corticosterone. These findings suggest potential therapeutic targets for cognitive manifestations in patients with poor response to conventional Cbl treatment.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Dermatology
Yangyiyi Yu, Haijing Wu, Qing Zhang, Rei Ogawa, Siqi Fu
Summary: Research indicates that the pathogenesis of keloids is related to the immune mechanism, with limited treatment options available. The article categorizes the immune processes, explores the reasons for keloid recurrence, cell communication phenomena, and inflammation-related signaling pathways.
JOURNAL OF DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Allison Ogren, Sneha Parmar, Soumya Mukherjee, Samuel J. Gonzalez, Melissa Plooster, Mark McClellan, Anirudh G. Mannava, Elliott Davidson, Trisha N. Davis, Melissa K. Gardner
Summary: Kinesin-14 motors play a role in controlling microtubule lengths by interacting with microtubule plus-ends and walking towards the minus-end. The binding of Kinesin-14 motors to microtubule plus-ends results in a decrease in microtubule lifetime and elongation, while inhibition of Kinesin-14 minus-end-directed motility leads to extended interactions and stabilization of microtubule plus-ends. This study demonstrates the importance of Kinesin-14 motors in regulating microtubule dynamics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Materials Science, Biomaterials
Shimo Yu, Shining Wu, Jing Zhang, Xinfu Zhao, Xiaochan Liu, Xibin Yi, Xuechen Li
Summary: The interactions between lysosomes and the plasma membrane play a crucial role in maintaining normal cell activity, and a newly constructed dual-targeting probe, Mem-Lyso, allows for simultaneous visualization of these organelles for the first time. Through its ability to track and analyze dynamic changes in different bioprocesses, Mem-Lyso revealed noticeable fusion between the plasma membrane and lysosomes during apoptosis, while also distinguishing cholesterol content in the plasma membrane, providing a potential tool for biological research and disease diagnosis.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Cell Biology
Nikola Deretic, Madison Bolger-Munro, Kate Choi, Libin Abraham, Michael R. R. Gold
Summary: Signaling through the B cell antigen receptor (BCR) triggers actin remodeling, with the Arp2/3 complex nucleating branched actin networks that exert outward force on the plasma membrane. Glia maturation factor gamma (GMF gamma) functions as an actin disassembly protein, releasing actin filaments to either oppose or support Arp2/3 complex-nucleated actin polymerization. Depletion of GMF gamma in human B cell lines impairs cell spreading, reduces actin retrograde flow velocity, diminishes BCR microclusters coalescence, and decreases BCR signaling, similar to Arp2/3 complex inhibition.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Jerome Bouchet, Iratxe del Rio-Iniguez, Elena Vazquez-Chavez, Remi Lasserre, Sonia Aguera-Gonzalez, Celine Cuche, Mary W. McCaffrey, Vincenzo Di Bartolo, Andres Alcover
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Victor H. Navas, Celine Cuche, Andres Alcover, Vincenzo Di Bartolo
Article
Multidisciplinary Sciences
Barbara Piasecka, Darragh Duffy, Alejandra Urrutia, Helene Quach, Etienne Patin, Celine Posseme, Jacob Bergstedt, Bruno Charbit, Vincent Rouilly, Cameron R. MacPherson, Milena Hasan, Benoit Albaud, David Gentien, Jacques Fellay, Matthew L. Albert, Lluis Quintana-Murci
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Cell Biology
Sonia Aguera-Gonzalez, Oliver T. Burton, Elena Vazquez-Chavez, Celine Cuche, Floriane Herit, Jerome Bouchet, Remi Lasserre, Iratxe del Rio-Iniguez, Vincenzo Di Bartolo, Andres Alcover
Review
Immunology
Andres Alcover, Balbino Alarcon, Vincenzo Di Bartolo
ANNUAL REVIEW OF IMMUNOLOGY, VOL 36
(2018)
Article
Immunology
Etienne Patin, Milena Hasan, Jacob Bergstedt, Vincent Rouilly, Valentina Libri, Alejandra Urrutia, Cecile Alanio, Petar Scepanovic, Christian Hammer, Friederike Jonsson, Benoit Beitz, Helene Quach, Yoong Wearn Lim, Julie Hunkapiller, Magge Zepeda, Cherie Green, Barbara Piasecka, Claire Leloup, Lars Rogge, Francois Huetz, Isabelle Peguillet, Olivier Lantz, Magnus Fontes, James P. Santo, Stephanie Thomas, Jacques Fellay, Darragh Duffy, Lluis Quintana-Murci, Matthew L. Albert
Article
Multidisciplinary Sciences
Stephanie Kilens, Dimitri Meistermann, Diego Moreno, Caroline Chariau, Anne Gaignerie, Arnaud Reignier, Yohann Lelievre, Miguel Casanova, Celine Vallot, Steven Nedellec, Lea Flippe, Julie Firmin, Juan Song, Eric Charpentier, Jenna Lammers, Audrey Donnart, Nadege Marec, Wallid Deb, Audrey Bihouee, Cedric Le Caignec, Claire Pecqueur, Richard Redon, Paul Barriere, Jeremie Bourdon, Vincent Pasque, Magali Soumillon, Tarjei S. Mikkelsen, Claire Rougeulle, Thomas Freour, Laurent David
NATURE COMMUNICATIONS
(2018)
Article
Genetics & Heredity
Petar Scepanovic, Cecile Alanio, Christian Hammer, Flavia Hodel, Jacob Bergstedt, Etienne Patin, Christian W. Thorball, Nimisha Chaturvedi, Bruno Charbit, Laurent Abel, Lluis Quintana-Murci, Darragh Duffy, Matthew L. Albert, Jacques Fellay
Article
Immunology
Iratxe del Rio-Iniguez, Elena Vazquez-Chavez, Celine Cuche, Vincenzo Di Bartolo, Jerome Bouchet, Andres Alcover
JOURNAL OF IMMUNOLOGY
(2018)
Article
Microbiology
Petar Scepanovic, Flavia Hodel, Stanislas Mondot, Valentin Partula, Allyson Byrd, Christian Hammer, Cecile Alanio, Jacob Bergstedt, Etienne Patin, Mathilde Touvier, Olivier Lantz, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci, Jacques Fellay
Article
Cell Biology
Shirsendu Ghosh, Vincenzo Di Bartolo, Liron Tubul, Eyal Shimoni, Elena Kartvelishvily, Tali Dadosh, Sara W. Feigelson, Ronen Alon, Andres Alcover, Gilad Haran
Review
Cell Biology
Marta Mastrogiovanni, Marie Juzans, Andres Alcover, Vincenzo Di Bartolo
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Marta Mastrogiovanni, Vincenzo Di Bartolo, Andres Alcover
Summary: Cell polarity regulators, multifunctional proteins that are evolutionarily conserved, play crucial roles in cell processes such as growth, differentiation, tissue formation, migration, and wound healing by regulating cell polarity, which influences the asymmetric localization of proteins and RNA, influencing cell shape and function.
BIOMEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Marta Mastrogiovanni, Pablo Vargas, Thierry Rose, Celine Cuche, Elric Esposito, Marie Juzans, Helene Laude, Amandine Schneider, Mathilde Bernard, Sophie Goyard, Charlotte Renaudat, Marie-Noelle Ungeheuer, Jerome Delon, Andres Alcover, Vincenzo Di Bartolo
Summary: APC mutations in familial adenomatous polyposis (FAP) not only drive intestinal neoplasms but also impair T cell migration, potentially contributing to inefficient antitumor immunity.
Article
Immunology
Natalia Gonzalez-Mancha, Cristina Rodriguez-Rodriguez, Andres Alcover, Isabel Merida
Summary: SNX27 plays a crucial role in intracellular trafficking and organization at immune synapse formation in T lymphocytes.
FRONTIERS IN IMMUNOLOGY
(2022)
