Iron chelator deferiprone rescues memory deficits, hippocampal BDNF levels and antioxidant defenses in an experimental model of memory impairment

Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically

(2018) Sonal Agrawal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Brain Iron Accumulation in Cognitive Dysfunction: Evidence from Animal Models and Human Studies

(2018) Nadja Schröder et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of BDNF in Alzheimer's disease

(2017) Heikki Tanila   NEUROBIOLOGY OF DISEASE

Deferiprone Rescues Behavioral Deficits Induced by Mild Iron Exposure in a Mouse Model of Alpha-Synuclein Aggregation

(2017) Eleonora Carboni et al.   NEUROMOLECULAR MEDICINE

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Role of iron in neurodegenerative diseases

(2016) Kai Li et al.   JOURNAL OF NEURAL TRANSMISSION

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

(2016) Abdel A. Belaidi et al.   JOURNAL OF NEUROCHEMISTRY

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction

(2016) Yuping Li et al.   Journal of Neuroinflammation

Iron chelation in the treatment of neurodegenerative diseases

(2016) Petr Dusek et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Parkinson's disease-related increase of T2*-weighted hypointensity in substantia nigra pars compacta

(2016) Jason Langley et al.   MOVEMENT DISORDERS

Deferoxamine pre-treatment protects against postoperative cognitive dysfunction of aged rats by depressing microglial activation via ameliorating iron accumulation in hippocampus

(2016) Ke Pan et al.   NEUROPHARMACOLOGY

Neural circuitry for rat recognition memory

(2015) E.C. Warburton et al.   BEHAVIOURAL BRAIN RESEARCH

Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone

(2015) Liangliang Zhao et al.   JOURNAL OF NEUROCHEMISTRY

Deferoxamine attenuates lipopolysaccharide-induced neuroinflammation and memory impairment in mice

(2015) Xiao-Ying Zhang et al.   Journal of Neuroinflammation

Effect Comparison of Both Iron Chelators on Outcomes, Iron Deposit, and Iron Transporters After Intracerebral Hemorrhage in Rats

(2015) Gaiqing Wang et al.   MOLECULAR NEUROBIOLOGY

Iron Loading Selectively Increases Hippocampal Levels of Ubiquitinated Proteins and Impairs Hippocampus-Dependent Memory

(2015) Luciana Silva Figueiredo et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective and neurorestorative activities of a novel iron chelator-brain selective monoamine oxidase-A/monoamine oxidase-B inhibitor in animal models of Parkinson's disease and aging

(2015) Orit Bar-Am et al.   NEUROBIOLOGY OF AGING

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

(2015) Peng Lei et al.   NEUROBIOLOGY OF DISEASE

Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice

(2015) Chuang Guo et al.   Frontiers in Aging Neuroscience

Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor inhibit ferrous iron influx via divalent metal transporter 1 and iron regulatory protein 1 regulation in ventral mesencephalic neurons

(2014) Hao-Yun Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reduced levels of brain-derived neurotrophic factor contribute to synaptic imbalance during the critical period of respiratory development in rats

(2014) Xiu-ping Gao et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells

(2014) Elizabeth Huerta-García et al.   FREE RADICAL BIOLOGY AND MEDICINE

Long-lasting recognition memory impairment and alterations in brain levels of cytokines and BDNF induced by maternal deprivation: effects of valproic acid and topiramate

(2014) Rose Mary Carvalho Pinheiro et al.   JOURNAL OF NEURAL TRANSMISSION

Brain catalase in the streptozotocin-rat model of sporadic Alzheimer’s disease treated with the iron chelator–monoamine oxidase inhibitor, M30

(2014) E. Sofic et al.   JOURNAL OF NEURAL TRANSMISSION

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Astaxanthin Activates Nuclear Factor Erythroid-Related Factor 2 and the Antioxidant Responsive Element (Nrf2-ARE) Pathway in the Brain after Subarachnoid Hemorrhage in Rats and Attenuates Early Brain Injury

(2014) Qi Wu et al.   Marine Drugs

MRI for Iron Mapping in Alzheimer's Disease

(2014) Christian Langkammer et al.   Neurodegenerative Diseases

Combined Therapy of Iron Chelator and Antioxidant Completely Restores Brain Dysfunction Induced by Iron Toxicity

(2014) Jirapas Sripetchwandee et al.   PLoS One

Targeting Chelatable Iron as a Therapeutic Modality in Parkinson's Disease

(2013) David Devos et al.   ANTIOXIDANTS & REDOX SIGNALING

Cannabidiol Normalizes Caspase 3, Synaptophysin, and Mitochondrial Fission Protein DNM1L Expression Levels in Rats with Brain Iron Overload: Implications for Neuroprotection

(2013) Vanessa Kappel da Silva et al.   MOLECULAR NEUROBIOLOGY

The need for transparency and good practices in the qPCR literature

(2013) Stephen A Bustin et al.   NATURE METHODS

BDNF and memory processing

(2013) Pedro Bekinschtein et al.   NEUROPHARMACOLOGY

Interleukin-1β enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75NTR and sortillin

(2013) S. Choi et al.   NEUROSCIENCE

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

GSK3β, CREB, and BDNF in peripheral blood of patients with Alzheimer's disease and depression

(2013) Jan Pláteník et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The Role of Hippocampal Iron Concentration and Hippocampal Volume in Age-Related Differences in Memory

(2012) K. M. Rodrigue et al.   CEREBRAL CORTEX

Chelating Agents for the Treatment of Systemic Iron Overload

(2012) Y. Ma et al.   CURRENT MEDICINAL CHEMISTRY

Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease

(2012) Chuang Guo et al.   NEUROBIOLOGY OF AGING

Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury

(2012) Lijun Zhang et al.   NEUROLOGICAL SCIENCES

Brain Derived Neurotrophic Factor: A novel neurotrophin involved in psychiatric and neurological disorders

(2012) Sivasankaran Balaratnasingam et al.   PHARMACOLOGY & THERAPEUTICS

Intranasal deferoxamine improves performance in radial arm water maze, stabilizes HIF-1α, and phosphorylates GSK3β in P301L tau transgenic mice

(2012) J. M. Fine et al.   EXPERIMENTAL BRAIN RESEARCH

Potential therapeutic uses of BDNF in neurological and psychiatric disorders

(2011) Alan H. Nagahara et al.   NATURE REVIEWS DRUG DISCOVERY

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

(2011) Susanna Kemppainen et al.   NEUROBIOLOGY OF AGING

Novel molecular targets of the neuroprotective/neurorescue multimodal iron chelating drug M30 in the mouse brain

(2011) L. Kupershmidt et al.   NEUROSCIENCE

Memory impairment induced by brain iron overload is accompanied by reduced H3K9 acetylation and ameliorated by sodium butyrate

(2011) P.F. da Silva et al.   NEUROSCIENCE

Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

(2011) Elen V. Fagherazzi et al.   PSYCHOPHARMACOLOGY

Iron redistribution as a therapeutic strategy for treating diseases of localized iron accumulationThis review is one of a selection of papers published in a Special Issue on Oxidative Stress in Health and Disease.

(2010) Or Kakhlon et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Brain iron deposits are associated with general cognitive ability and cognitive aging

(2010) Lars Penke et al.   NEUROBIOLOGY OF AGING

Neonatal Iron Treatment Increases Apoptotic Markers in Hippocampal and Cortical Areas of Adult Rats

(2010) Clivia Pazin Miwa et al.   NEUROTOXICITY RESEARCH

Early Post-Natal Iron Administration Induces Astroglial Response in the Brain of Adult and Aged Rats

(2010) Liana Lisboa Fernandez et al.   NEUROTOXICITY RESEARCH

Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease

(2009) Mark P. Mattson   Annals of the New York Academy of Sciences

Correlation of iron in the hippocampus with MMSE in patients with Alzheimer's disease

(2009) Bei Ding et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Reference genes for normalization: A study of rat brain tissue

(2008) Birgit Egeskov Bonefeld et al.   SYNAPSE

Reversion of age-related recognition memory impairment by iron chelation in rats

(2007) Maria Noêmia Martins de Lima et al.   NEUROBIOLOGY OF AGING