Article
Neurosciences
Stephanie M. Muscat, Nicholas P. Deems, Michael J. Butler, Emmanuel A. Scaria, Menaz N. Bettes, Sean P. Cleary, Ross H. Bockbrader, Steven F. Maier, Ruth M. Barrientos
Summary: This study highlights the importance of addressing perioperative neurocognitive disorders (PNDs) and provides evidence that blocking toll-like receptor 4 (TLR4) activation can mitigate the cognitive impairment caused by morphine treatment. These findings offer a promising therapeutic target for preventing or treating PNDs.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Steven A. Bloomer
Summary: Liver macrophages play important roles in iron homeostasis and can be affected by aging and iron accumulation. This study found that iron administration in young rats mimicked age-related iron deposition but did not alter macrophage number or phenotype. Aging, on the other hand, increased both M1 and M2 macrophage numbers in the liver. These findings suggest that factors other than iron excess contribute to the accumulation of hepatic macrophages with aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Stephanie M. Muscat, Nicholas P. Deems, Heather D'Angelo, Meagan M. Kitt, Peter M. Grace, Nathan D. Andersen, Shaelyn N. Silverman, Kenner C. Rice, Linda R. Watkins, Steven F. Maier, Ruth M. Barrientos
Summary: Postoperative cognitive dysfunction (POCD) is a collection of cognitive impairments experienced by individuals following surgery, with persistent POCD most commonly affecting older individuals. In a study on aged rats, it was found that postsurgical treatment with morphine led to long-term memory impairments through a neuroinflammatory mechanism rather than pain modulation. Central blockade of IL-1b signaling completely prevented the memory impairment in rats, suggesting a potential target for future treatment discoveries.
NEUROBIOLOGY OF AGING
(2021)
Review
Cell Biology
Wei-Feng Wu, Jia-Tao Lin, Yong-Kang Qiu, Shuai Li, Hui Zheng, Yu-Qing Wu
Summary: With the ageing of the population, the health problems of elderly individuals have become particularly important. Through a large number of clinical studies and trials, it has been confirmed that elderly patients can experience postoperative cognitive dysfunction after general anesthesia/surgery. However, the mechanism of postoperative cognitive dysfunction is still unknown. In recent years, the role of epigenetics in postoperative cognitive dysfunction has been widely studied and reported. This article summarizes the epigenetic mechanism of cognitive impairment after general anesthesia/surgery and analyses the broad prospects of epigenetics as a therapeutic target for postoperative cognitive dysfunction.
AGEING RESEARCH REVIEWS
(2023)
Article
Geriatrics & Gerontology
Meng-Xue Zhang, Jing-Run Lin, Shu-Ting Yang, Jun Zou, Yao Xue, Chen-Zhuo Feng, Lin Cao
Summary: This study found that elderly mice were more likely to develop POCD through analyzing hippocampal RNA sequencing in young and aging mice. The constructed circRNA-associated-ceRNA networks revealed that the pathogenesis of POCD is involved in modulating the Wnt and VEGF signaling pathways as well as neural processes.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Immunology
Yile Zhou, Huihui Ju, Yan Hu, Tingting Li, Zhouyi Chen, Yuan Si, Xia Sun, Yi Shi, Hao Fang
Summary: This study aimed to investigate the involvement of regulatory T cells (Tregs) in the development of postoperative cognitive dysfunction (POCD). The findings from animal experiments demonstrated that POCD in aged mice was accompanied by elevated levels of inflammatory factors and increased circulating Tregs. Transfusion of Tregs from young mice partially restored the blood-brain barrier structure and alleviated POCD in aged mice, indicating a crucial role of aged Tregs in the occurrence of POCD.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Keitaro Tachi, Taeko Fukuda, Makoto Tanaka
Summary: Olanzapine attenuated spatial cognitive dysfunction and microglial activity of the hippocampus induced by surgery and LPS injection in adult rats. These effects were unrelated to inflammatory cytokine concentrations.
Article
Multidisciplinary Sciences
Adam M. Brickman, Lok-Kin Yeung, Daniel M. Alschuler, Javier I. Ottaviani, Gunter G. C. Kuhnle, Richard P. Sloan, Heike Luttmann-Gibson, Trisha Copeland, Hagen Schroeter, Howard D. Sesso, JoAnn E. Manson, Melanie Wall, Scott A. Small
Summary: Dietary flavanols, found in certain fruits and vegetables, have been associated with cognitive aging. In a large-scale study, habitual flavanol consumption and diet quality were positively correlated with hippocampal-dependent memory. Although the intervention did not improve memory in all participants after 1 year, it restored memory in those with lower diet quality or lower habitual flavanol consumption.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Jiangnan Wu, Yanjing Guo, Wei Li, Zihao Zhang, Xinlei Li, Qidi Zhang, Qihang Du, Xinhuan Niu, Xijiang Liu, Gongming Wang
Summary: This study found that exploratory laparotomy induced cognitive function decline in aged mice but not in young mice, accompanied by inflammatory activation of microglia in the hippocampus. Depletion of microglia using a CSF1R inhibitor protected aged mice from POCD. The downregulation of the immune checkpoint Mef2C in aged microglia contributed to microglial priming and neuroinflammation, leading to increased vulnerability to POCD in aged individuals.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Chenglong Li, Qi Li, Shuai Liu, Jiaying Li, Wei Yu, Yan Li, Ruirui Zhang, Sihua Qi
Summary: Postoperative cognitive dysfunction (POCD) is a severe complication following surgery, but its underlying mechanisms are not fully understood. This study found that the upregulation of VCAM1 and its soluble form, sVCAM1, in the hippocampus is associated with microglial activation and cognitive dysfunction after surgery. Further experiments demonstrated that anti-VCAM1 treatment can inhibit microglial activation, inflammation, and improve cognitive function.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ayasa Takamino, Masakazu Kotoda, Yosuke Nakadate, Sohei Hishiyama, Tetsuya Iijima, Takashi Matsukawa
Summary: With the aging population and increasing number of elderly patients undergoing surgery, postoperative cognitive decline has become a significant healthcare concern. This study found that sleep duration less than 5 hours before surgery was associated with worse attentional function and a higher incidence of cognitive decline after surgery.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Mengdi Zhang, Yao Cheng, Yujie Zhai, Yaru Cui, Wenshen Zhang, Hongwei Sun, Wenyu Xin, Ling Zhou, Xue Gao, Shucui Li, Hongliu Sun
Summary: Hypoxia causes neuronal damage in neonates. This study investigated changes in succinate levels and identified the mechanisms underlying hypoxia-induced damage. The results showed that increased succinate levels in the early stage of hypoxia led to oxidative stress, iron stress, neuronal damage, and cognitive deficits. Inhibitors of succinate dehydrogenase, the purine nucleotide cycle, and the malate/aspartate shuttle significantly reduced succinate levels and alleviated the associated damage.
CELL DEATH DISCOVERY
(2022)
Article
Neurosciences
Yating Zhang, Xue Bai, Yi Zhang, Shanshan Yao, Yiduo Cui, Lin-Hao You, Peng Yu, Yan-Zhong Chang, Guofen Gao
Summary: This study demonstrates that hippocampal iron overload leads to reduced furin expression, which impairs the maturation of brain-derived neurotrophic factor and downregulates synaptogenesis-related proteins, resulting in cognitive decline. Iron chelation or furin overexpression can restore these abnormalities and improve cognitive function. Therefore, hippocampal iron accumulation and the inhibition of furin may play an important role in iron-mediated synaptic damage and memory loss in Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Clinical Neurology
Li Zhao, Hongyu Zhu, Wei Mao, Xuelei Zhou, Ying Xie, Linji Li
Summary: A meta-analysis of nine clinical trials showed that perioperative cognitive training may be effective in reducing the incidence of postoperative cognitive dysfunction (POCD), but not postoperative delirium (POD).
FRONTIERS IN NEUROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chen Hong, Zhi Wang, Si-li Zheng, Wen-jun Hu, Shu-na Wang, Yan Zhao, Chao-yu Miao
Summary: Aging is a main risk factor for cognitive dysfunction, and Metrnl, a neurotrophic factor, has been found to regulate cognitive functions and hippocampal BDNF levels during the aging process. Metrnl may become a new candidate for the treatment or alleviation of aging-related cognitive dysfunction.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Neurosciences
Zhongxing Wang, Weiran Shan, Jiangbei Cao, Max Wintermark, Wenqi Huang, Zhiyi Zuo
JOURNAL OF NEUROSCIENCE RESEARCH
(2018)
Article
Neurosciences
Jun Li, Weiran Shan, Zhiyi Zuo
MOLECULAR NEUROBIOLOGY
(2018)
Article
Genetics & Heredity
Wei Xing, Pinjie Huang, Yang Lu, Weian Zeng, Zhiyi Zuo
JOURNAL OF MOLECULAR MEDICINE-JMM
(2018)
Letter
Immunology
Zhiyi Zuo, Zhi Wang, Shiyu Meng, Shuling Peng
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Immunology
Peng Liang, Weiran Shan, Zhiyi Zuo
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Neurosciences
Foquan Luo, Jia Min, Jumei Wu, Zhiyi Zuo
MOLECULAR NEUROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Fei Lin, Weiran Shan, Yuxin Zheng, Linghui Pan, Zhiyi Zuo
Summary: Post-operative cognitive dysfunction (POCD) is associated with poor clinical outcomes. The study found that TLR2 contributes to surgery-induced neuroinflammation and cognitive impairment, with HMGB1 up-regulating TLR2 expression to facilitate this effect. Therefore, TLR2 and HMGB1 may be potential targets for reducing POCD.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Neurosciences
Jia Min, Zhongmeng Lai, Hui Wang, Zhiyi Zuo
Summary: Surgery reduces neuroligin 1 expression in the brain, while environmental enrichment (EE) for 2 weeks can reduce postoperative cognitive dysfunction (POCD). The protective effect of EE on POCD may be mediated through preserving neuroligin 1 expression by attenuating surgery-induced epigenetic dysregulation.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Zhongmeng Lai, Weiran Shan, Jun Li, Jia Min, Xianzhang Zeng, Zhiyi Zuo
Summary: Surgery-induced cognitive dysfunction in adult mice can be improved by low intensity exercise, which reduces neuroinflammation and promotes gut microbiota diversity. The exercise effects on learning and memory were also present in non-exercise mice receiving feces from exercise mice. Valeric acid, a gut microbiota product, worsens neuroinflammation, learning, and memory in mice with surgery, but exercise reduced its levels in the blood. This study suggests that gut microbiota alteration plays a role in POCD development and exercise may have potential therapeutic benefits for brain health in the presence of insults like surgery.
MOLECULAR PSYCHIATRY
(2021)
Article
Chemistry, Multidisciplinary
Juan Xin, Weiran Shan, Jun Li, Hai Yu, Zhiyi Zuo
Summary: A study found that surgery activates the LHb-VTA neural circuit, which is associated with POCD and neuropathological changes in the brain.
Article
Genetics & Heredity
Hui Wang, Gang Ma, Jia Min, Jun Li, Weiran Shan, Zhiyi Zuo
Summary: Exposure to surgery with anesthesia early in life may lead to abnormal behavior, learning, and memory in humans. This study investigates the role of glial cell-derived neurotrophic factor (GDNF) and the inhibition of the ERK-CREB pathway in these effects. The results show that surgery and anesthesia decrease GDNF concentration, impair learning and memory, and increase proinflammatory cytokines. Intracerebroventricular injection of GDNF attenuates inflammation and inhibits ERK. Surgery also increases brain-derived natriuretic peptide (BNP) which impairs learning and memory through ERK inhibition and GDNF reduction.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Multidisciplinary Sciences
Ziyad O. Knio, Lena Zhang, David A. Watts, Zhiyi Zuo
Summary: This study investigated the effect of surgical start time on blood transfusion after gastric bypass surgery. The findings show that patients who underwent surgery between 15:00 and 18:43 had an increased risk of blood transfusion. This suggests that surgical start time may be associated with the occurrence of blood transfusion.
Article
Neurosciences
Qun Jiang, Mingyan Guo, Zhiyi Zuo
Summary: The aim of this study was to investigate whether living with familiar observers attenuates learning and memory dysfunction in mice with surgery. The results showed that living with familiar observers reduced anxiety and dysfunction of learning and memory in young adult male mice with surgery. It also attenuated learning and memory dysfunction and neuroinflammation in old male mice.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Letter
Neurosciences
Jun Li, Weiran Shan, Zhiyi Zuo
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Ting Zhou, Jun Li, Aobing Cheng, Zhiyi Zuo
Summary: Hypoxic-ischemic (HI) brain injury is a major cause of mortality and morbidity in neonates and children. A study investigated the protective effects of desflurane, a volatile anesthetic, against HI-induced brain damage and the role of TRPA1 in this protection. The results showed that desflurane attenuated brain tissue loss and improved neurological functions. It also inhibited the expression of TRPA1, which played a role in HI-induced brain injury.
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
