Article
Nutrition & Dietetics
Yang Li, Miao Sun, Fuyang Cao, Yu Chen, Linlin Zhang, Hao Li, Jiangbei Cao, Jie Song, Yulong Ma, Weidong Mi, Xiaoying Zhang
Summary: The study found that the ferroptosis inhibitor liproxstatin-1 can ameliorate inflammation-related cognitive impairment by reducing the release of inflammatory mediators and oxidative stress, and by regulating iron metabolism and iron ferroptosis-related proteins.
Article
Biochemistry & Molecular Biology
Rengasamy Balakrishnan, Ju-Young Park, Duk-Yeon Cho, Jae-Yong Ahn, Dong-Sun Yoo, Sang-Ho Seol, Sung-Hwa Yoon, Dong-Kug Choi
Summary: AD-1 small molecule protects against cognitive decline and memory impairment induced by oxidative brain damage, by inhibiting AChE activity, reducing oxidant factors, alleviating neuroinflammation and neuronal apoptosis. It also increases the expression of neuroprotective markers and improves spatial learning behavior and memory formation.
Article
Geriatrics & Gerontology
Ying-Ying Nie, Long-Jian Zhou, Yan-Mei Li, Wen-Cong Yang, Ya-Yue Liu, Zhi-You Yang, Xiao-Xiang Ma, Yong-Ping Zhang, Peng-Zhi Hong, Yi Zhang
Summary: The study suggests that Hizikia fusiforme functional oil (HFFO) has potential as a neuroprotective agent, capable of preventing memory impairment caused by cholinergic deficiency and neuroinflammation. The main components of HFFO, arachidonic acid and phytol, show good affinity with anti-inflammatory targets and have acceptable drug-like properties and ADMET profiles.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Hongxiang Hong, Xu Lu, Qun Lu, Chao Huang, Zhiming Cui
Summary: Sinomenine, a natural compound from Sinomenium acutum, has shown beneficial effects in various CNS disorders, including cerebral ischemia, traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy. Its mechanisms of action involve inhibition of oxidative stress, neuroinflammation, and neuronal apoptosis. Sinomenine also exhibits anti-glioma effects and improves morphine dependence and sleep disturbance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Hend Mohamed Hussien, Mokhtar Ibrahim Yousef
Summary: This study aimed to investigate the neuroprotective effect of ginseng extract against neurological and behavior abnormalities induced by cisplatin. The results showed that ginseng extract could alleviate the memory dysfunction and locomotor disability induced by cisplatin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Neurosciences
Ji-Ren An, Jun-Tong Liu, Xiao-Meng Gao, Qing-Feng Wang, Gui-Yan Sun, Jia-Nan Su, Chi Zhang, Jia-Xiang Yu, Yu-Feng Yang, Yan Shi
Summary: Neuroinflammation is a critical factor in the development of cognitive impairment in type 2 diabetes. Astrocyte polarization is involved in neuroinflammation, and liraglutide has shown potential protective effects on neurons and astrocytes. This study explored the impact of liraglutide on astrocyte activation and neuroinflammation in the hippocampus, revealing its potential for treating diabetic cognitive impairment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Entesar Yaseen Abdo Qaid, Zuraidah Abdullah, Rahimah Zakaria, Idris Long
Summary: Minocycline treatment can protect against LPS-induced cognitive impairment by reducing oxidative stress and upregulating the CREB-BDNF signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Neurosciences
Fereshteh Farajdokht, Seyed Mehdi Vatandoust, Leila Hosseini, Kiarash Fekri, Sepideh Rahigh Aghsan, Alireza Majdi, Saeed Sadigh-Eteghad, Javad Mahmoudi
Summary: Serotonin can improve memory impairment caused by sleep deprivation through its antioxidant and anti-inflammatory effects, as well as regulating the expression of synaptic proteins in the hippocampus.
BRAIN RESEARCH BULLETIN
(2021)
Article
Chemistry, Multidisciplinary
Yoko Hirata, Tomohiro Hashimoto, Kaori Ando, Yuji O. Kamatari, Hiroshi Takemori, Kyoji Furuta
Summary: This study identifies the structural features of N,N-dimethylaniline derivatives as potent ferroptosis inhibitors and demonstrates the localization of a specific compound, GIF-2197-r, in lysosomes through its aliphatic tertiary amine moiety.
Article
Environmental Sciences
Khalaf F. Alsharif, Ashraf Albrakati, Naif E. Al Omairi, Abdulraheem S. Almalki, Walaa F. Alsanie, Zakaria Y. Abd Elmageed, Ola A. Habotta, Maha S. Lokman, Hussam A. Althagafi, Abdullah A. A. Alghamdi, Ahmed E. Abdel Moneim, Hussain Alyami, Saied K. M. Belal, Ghaliah Alnefaie, Abdulhakeem S. Alamri, Nisreen Khalid Aref Albezrah, Rami B. Kassab, Alaa Jameel A. Albarakati, Khalid Ebraheem Hassan, Ahmad Agil
Summary: The combined administration of prodigiosin (PDG) and selenium (Na2SeO3) has shown promising therapeutic effects in a rat model of schizophrenia induced by amphetamine. The treatment improved social interaction, decreased acetylcholinesterase (AChE) and dopamine levels, and modulated the expression of NMDAR1 and neurotrophic factors. It also enhanced antioxidant defense, reduced neuroinflammation and apoptosis, resulting in significant improvements in schizophrenia-related symptoms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Kurach, Sylwia Kulczycka-Mamona, Joanna Kowalczyk, Krystyna Skalicka-Wozniak, Anna Boguszewska-Czubara, Nesrine El Sayed, Mitat Osmani, Karol Iwaniak, Barbara Budzynska
Summary: Coumarins, including xanthotoxin and umbelliferone, have been shown to improve cognitive function and reduce neuroinflammation in mice with lipopolysaccharide-induced cognitive dysfunction. Xanthotoxin significantly enhanced learning and memory function and reduced acetylcholinesterase levels, suggesting its potential as a treatment for neuroinflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
Weijie Zhai, Meng Zhao, Guimei Zhang, Zicheng Wang, Chunxiao Wei, Li Sun
Summary: Vascular cognitive impairment and dementia (VCID) is a neurodegenerative disease and there are currently no effective therapies. Recent studies have shown that microRNAs play an important role in the pathology of VCID and may serve as potential diagnostic biomarkers and therapeutic targets.
FRONTIERS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Vasudevan Mani, Salem Rashed Almutairi
Summary: This study aimed to investigate the protective effects of levetiracetam against lipopolysaccharide-induced cognitive impairment and explore the underlying mechanisms. The results showed that levetiracetam could increase acetylcholine levels, reduce neuroinflammation, cellular apoptosis, and oxidative stress, suggesting its potential in treating neuroinflammatory-related memory loss.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Review
Chemistry, Applied
Zhiyuan Zhang, Shuai Wang, Haining Tan, Pei Yang, Yuanyuan Li, Lingchuan Xu, Baoguo Duan, Yuhong Liu
Summary: This paper reviews recent research on the regulation of natural polysaccharides in Alzheimer's disease (AD) and systematically lists possible intervention pathways of polysaccharides targeting different mechanisms.
CARBOHYDRATE POLYMERS
(2022)
Article
Medicine, Research & Experimental
Xingyong Chen, Yanguang Mao, Yueting Guo, Dongyun Xiao, Zejing Lin, Yiyi Huang, Ying Chun Liu, Xu Zhang, Yinzhou Wang
Summary: This study aims to explore the contribution of the immunoproteasome subunit LMP2 in neurobehavioral functions. The results showed that LMP2 gene deletion caused metabolic abnormalities, cognitive impairment, increased anxiety-like behavior, multiple myelin loss, increased blood-brain barrier leakage, and enhanced amyloid-beta protein deposition in rats. These factors led to chronic oxidative stress and neuroinflammation in the brain, contributing to cognitive impairment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Faqiang Zhang, Mu Niu, Long Wang, Yanhong Liu, Likai Shi, Jiangbei Cao, Weidong Mi, Yulong Ma, Jing Liu
Summary: The study investigated the clinical prognostic values of the preoperative systemic-immune-inflammation index (SII) in older patients undergoing non-cardiac surgery. The results indicated that an elevated SII, based on an optimal cut-off value of 583, was an independent risk factor for perioperative ischemic stroke within 30 days after surgery. This suggests that preoperative SII may serve as a potential prognostic biomarker in predicting ischemic stroke after non-cardiac surgery in elderly patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Xiaoying Zhang, Aisheng Hou, Jiangbei Cao, Yanhong Liu, Jingsheng Lou, Hao Li, Yulong Ma, Yuxiang Song, Weidong Mi, Jing Liu
Summary: Diabetes mellitus is a risk factor for various complications, hospitalization, and death after non-cardiac surgery. These findings underscore the importance of preoperative risk factor assessment for diabetes mellitus in surgical patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Yan Wang, Wen-Gang Liu, Ai-Sheng Hou, Yu-Xiang Song, Yu-Long Ma, Xiao-Dong Wu, Jiang-Bei Cao, Wei-Dong Mi
Summary: This study found that the dysfunction of EAAT3 is associated with POCD, and riluzole can improve POCD symptoms. This study provides a new therapeutic target for the treatment of POCD.
Article
Neurosciences
Yu-Xiang Song, Xiao-Dong Yang, Yun-Gen Luo, Chun-Lei Ouyang, Yao Yu, Yu-Long Ma, Hao Li, Jing-Sheng Lou, Yan-Hong Liu, Yi-Qiang Chen, Jiang-Bei Cao, Wei-Dong Mi
Summary: This study compared the performance of logistic regression and machine learning methods in predicting postoperative delirium in elderly patients. The results showed that the logistic regression model had better sensitivity, fewer variables, and easier interpretability compared to the machine learning models.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Urology & Nephrology
Cheng Peng, Hao Shen, Senming Cao, Shengpan Wu, Qingbo Huang, Shichao Li, Hongzhao Li, Xu Zhang, Baojun Wang, Jiangbei Cao, Xin Ma
Summary: This study evaluated the effects of CO2 pneumoperitoneum on venous hemodynamics and cardiopulmonary function during laparoscopic surgery. The results showed that transperitoneal CO2 insufflation led to a rapid increase in central venous pressure, peak airway pressure, and inferior vena cava blood flow velocity, while retroperitoneal CO2 insufflation resulted in a gradual increase. Additionally, transperitoneal CO2 insufflation caused a reduction in inferior vena cava diameter. There was a decrease in cardiac output after pneumoperitoneum, and the increase in arterial carbon dioxide and end-tidal carbon dioxide tension was higher in retroperitoneal surgery.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Multidisciplinary Sciences
Yanfeng Wang, Yanping Song, Li Tong, Lu Wang, Jiangbei Cao, Gang Qin, Xingyang Liu, Weidong Mi, E. Wang, Yongxin Guo
Summary: The GABA system in the central nervous system plays a crucial role in regulating anesthetic consciousness. The medial hypothalamus, including the ventromedial hypothalamus and dorsomedial hypothalamus, is involved in sleep and circadian rhythm. However, the specific role of GABAergic neurons in the medial hypothalamus in anesthesia is still unknown.
Article
Surgery
Chun-lei OuYang, Xin-yu Hao, Yao Yu, Jing-sheng Lou, Jiang-bei Cao, Ying-qun Yu, Wei-dong Mi
Summary: A review of 1,143 medical records of older patients (≥ 65 years old) who underwent total knee or hip arthroplasty and received intraoperative allogeneic or autologous blood transfusion at the Chinese PLA General Hospital revealed that intraoperative allogeneic blood transfusion was associated with an increased risk of postoperative delirium.
FRONTIERS IN SURGERY
(2023)
Article
Pharmacology & Pharmacy
Meng Wu, Ao Li, Yongxin Guo, Fuyang Cao, Shaohua You, Jiangbei Cao, Weidong Mi, Li Tong
Summary: General anaesthetics, including sevoflurane, have the potential to relieve symptoms of depression and exhibit rapid and long-lasting antidepressant effects by modulating neuronal activities in the nucleus accumbens core.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Correction
Geriatrics & Gerontology
Faqiang Zhang, Yulong Ma, Yao Yu, Miao Sun, Hao Li, Jingsheng Lou, Jiangbei Cao, Yanhong Liu, Mu Niu, Long Wang, Weidong Mi
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Dinghao Xue, Xu Guo, Yanxiang Li, Zhuoqi Sheng, Long Wang, Luyu Liu, Jiangbei Cao, Yanhong Liu, Jingsheng Lou, Hao Li, Xinyu Hao, Zhikang Zhou, Qiang Fu
Summary: Depression is a common mental disorder among the elderly, particularly after video-assisted thoracoscopic surgery (VATS). Risk factors for postoperative depressive symptoms include high fibrinogen levels, postoperative anxiety, poor sleep quality, and pain. The developed predictive model can help identify elderly patients at risk of developing depressive disorders associated with VATS for clinical purposes.
Article
Cardiac & Cardiovascular Systems
Kai Zhang, Chang Liu, Xiaoling Sha, Siyi Yao, Zhao Li, Yao Yu, Jingsheng Lou, Qiang Fu, Yanhong Liu, Jiangbei Cao, Jiaqiang Zhang, Yitian Yang, Weidong Mi, Hao Li
Summary: A new prediction model was developed using traditional statistical methods and machine learning algorithms to predict major adverse cardiovascular events (MACEs) in elderly patients undergoing noncardiac surgery. Both the traditional model and machine learning models showed good performance in predicting MACEs risk.
Article
Anesthesiology
Yao Yu, Haotian Wu, Chang Liu, Changsheng Zhang, Yuxiang Song, Yulong Ma, Hao Li, Jingsheng Lou, Yanhong Liu, Jiangbei Cao, Huan Zhang, Zhipeng Xu, Roger G. Evans, Chongyang Duan, Weidong Mi
Summary: The objective of this study was to determine the association between intraoperative renal tissue desaturation, as measured using near-infrared spectroscopy, and the increased likelihood of developing postoperative acute kidney injury (AKI) in older patients undergoing hepatectomy. A multicenter prospective cohort study was conducted, and the results showed that patients with renal desaturation were at a higher risk of AKI. Intraoperative near-infrared spectroscopy monitoring enhances the detection of AKI.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Geriatrics & Gerontology
Zile He, Chuangxin Zhang, Mingzi Ran, Xin Deng, Zilin Wang, Yanhong Liu, Hao Li, Jingsheng Lou, Weidong Mi, Jiangbei Cao
Summary: This study aimed to develop a novel modified lymphocyte C-reactive protein (CRP) score (mLCS) to predict 3-year mortality in elderly patients undergoing intertrochanteric fracture surgery. The mLCS was found to be a promising predictor for predicting the 3-year mortality in these patients.
Article
Multidisciplinary Sciences
Yongxin Guo, Yanping Song, Fuyang Cao, Ao Li, Xinyu Hao, Wenzhu Shi, Zhikang Zhou, Jiangbei Cao, Yanhong Liu, Weidong Mi, Li Tong
Summary: The mechanism of general anesthesia is still not well understood. However, recent studies have shown that the activity of GABA neurons in the ventrolateral periaque-ductal gray (vlPAG) decreases during sevoflurane anesthesia and is reactivated after anesthesia. Activating GABAergic neurons in vlPAG promotes arousal during anesthesia, while inhibiting them delays this process. Furthermore, cortico-midbrain circuits involving vlPAG GABAergic neurons and their projections to the medial prefrontal cortex (mPFC) and ventral tegmental area (VTA) play an important role in the anesthesia-awake transition.
Article
Clinical Neurology
Xin-Yu Hao, Yong-Xin Guo, Jing-Sheng Lou, Jiang-Bei Cao, Miao Liu, Tian-Yue Mi, Ao Li, Shao-Hua You, Fu-Yang Cao, Yan-Hong Liu, Hao Li, Zhi-Kang Zhou, Jun-Mei Xu, Qing-Ping Wu, Xiao-Ping Gu, Di-Fen Wang, Yu-Ming Peng, Li-Bin Ma, Li-Yun Wang, Li Tong, Wei-Dong Mi
Summary: This study examined the changes in mental health trends among non-cardiac surgical patients aged 65 and above in China during the COVID-19 pandemic. The findings revealed a significant decrease in the prevalence of depression and anxiety in elderly surgery patients during the post-pandemic period.
JOURNAL OF AFFECTIVE DISORDERS
(2023)