High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

A Decade of Toxicogenomic Research and Its Contribution to Toxicological Science

(2012) Minjun Chen et al.   TOXICOLOGICAL SCIENCES

Is Toxicogenomics a More Reliable and Sensitive Biomarker than Conventional Indicators from Rats To Predict Drug-Induced Liver Injury in Humans?

(2011) Min Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Developing Structure−Activity Relationships for the Prediction of Hepatotoxicity

(2010) Nigel Greene et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Lipophilicity in drug discovery

(2010) Michael J Waring   Expert Opinion on Drug Discovery

Back to basics for idiosyncratic drug-induced liver injury: Dose and metabolism make the poison

(2010) F. Ballet   GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE

Risk Factors for Idiosyncratic Drug-Induced Liver Injury

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability

(2009) Michael J. Waring   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds

(2009) Jens-Uwe Peters et al.   ChemMedChem

Physicochemical drug properties associated within vivotoxicological outcomes: a review

(2009) David A Price et al.   Expert Opinion on Drug Metabolism & Toxicology

Oral medications with significant hepatic metabolism at higher risk for hepatic adverse events

(2009) Craig Lammert et al.   HEPATOLOGY

3.3 Trovafloxacin: a case study of idiosyncratic or iatrogenic liver toxicity – molecular mechanisms and lessons for pharmacotoxicity

(2009) J Borlak   HUMAN & EXPERIMENTAL TOXICOLOGY

The Liver Toxicity Biomarker Study: Phase I Design and Preliminary Results

(2009) Robert N. Mcburney et al.   TOXICOLOGIC PATHOLOGY

Physiochemical drug properties associated with in vivo toxicological outcomes

(2008) Jason D. Hughes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of earlyin vivotoxicity testing in drug discovery toxicology

(2008) Mark R Fielden et al.   Expert Opinion On Drug Safety

Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: Search for signals

(2008) Craig Lammert et al.   HEPATOLOGY

Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies

(2008) Laura K. Schnackenberg et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY