Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs
出版年份 2012 全文链接
标题
Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs
作者
关键词
-
出版物
TOXICOLOGICAL SCIENCES
Volume 127, Issue 1, Pages 187-198
出版商
Oxford University Press (OUP)
发表日期
2012-02-14
DOI
10.1093/toxsci/kfs083
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye
- (2011) K. Pernelle et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The discovery and development of proteomic safety biomarkers for the detection of drug-induced liver toxicity
- (2010) David E. Amacher TOXICOLOGY AND APPLIED PHARMACOLOGY
- Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project
- (2010) María José Gómez-Lechón et al. TOXICOLOGY IN VITRO
- Cytometric analysis for drug-induced steatosis in HepG2 cells
- (2009) M. Teresa Donato et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity
- (2009) Stefan Russmann et al. CURRENT MEDICINAL CHEMISTRY
- Simultaneous Expression of Plural Forms of Human Cytochrome P450 at Desired Ratios in HepG2 Cells: Adenovirus-mediated Tool for Cytochrome P450 Reconstitution
- (2009) Kazunobu Aoyama et al. Drug Metabolism and Pharmacokinetics
- Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage
- (2009) Rosilla F. Bachmann et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Development of a High-Throughput Human HepG2 Dual Luciferase Assay for Detection of Metabolically Activated Hepatotoxicants and Genotoxicants
- (2009) Xuemei Liu et al. INTERNATIONAL JOURNAL OF TOXICOLOGY
- Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity
- (2009) Benjamin D. Cosgrove et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- An integrated approach to improved toxicity prediction for the safety assessment during preclinical drug development using Hep G2 cells
- (2009) Fozia Noor et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Biochemical mechanisms in drug-induced liver injury: Certainties and doubts
- (2009) Ignazio Grattagliano et al. WORLD JOURNAL OF GASTROENTEROLOGY
- High-Content Screening as a Universal Tool for Fingerprinting of Cytotoxicity of Nanoparticles
- (2008) Edward Jan et al. ACS Nano
- Cell Lines: A Tool for In Vitro Drug Metabolism Studies
- (2008) M. Gomez-Lechon et al. CURRENT DRUG METABOLISM
- Identification of Apoptotic Drugs: Multiparametric Evaluation in Cultured Hepatocytes
- (2008) Maria Gomez-Lechon et al. CURRENT MEDICINAL CHEMISTRY
- Markers of Electrophilic Stress Caused by Chemically Reactive Metabolites in Human Hepatocytes
- (2008) H. Takakusa et al. DRUG METABOLISM AND DISPOSITION
- Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies
- (2008) Gilles Labbe et al. FUNDAMENTAL & CLINICAL PHARMACOLOGY
- Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: A new role in the treatment of leukaemia for these agents
- (2008) Silvia De la Iglesia Iñigo et al. LEUKEMIA RESEARCH
- In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone
- (2008) James A. Dykens et al. TOXICOLOGICAL SCIENCES
- Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury
- (2008) Jinghai J. Xu et al. TOXICOLOGICAL SCIENCES
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started