Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases

Mechanism and Function of Oxidative Reversal of DNA and RNA Methylation

(2014) Li Shen et al.   Annual Review of Biochemistry

Studies on Deacetoxycephalosporin C Synthase Support a Consensus Mechanism for 2-Oxoglutarate Dependent Oxygenases

(2014) Hanna Tarhonskaya et al.   BIOCHEMISTRY

More than just a Halogenase: Modification of Fatty Acyl Moieties by a Trifunctional Metal Enzyme

(2014) Sarah M. Pratter et al.   CHEMBIOCHEM

Excited state potential energy surfaces and their interactions in FeIVO active sites

(2014) Martin Srnec et al.   DALTON TRANSACTIONS

The Function and Catalysis of 2-Oxoglutarate-Dependent Oxygenases Involved in Plant Flavonoid Biosynthesis

(2014) Ai-Xia Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alternative Pathway for the Reaction Catalyzed by DNA Dealkylase AlkB from Ab Initio QM/MM Calculations

(2014) Dong Fang et al.   Journal of Chemical Theory and Computation

Oxygen sensing strategies in mammals and bacteria

(2014) Cornelius Y. Taabazuing et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The Role of Chloride in the Mechanism of O2 Activation at the Mononuclear Nonheme Fe(II) Center of the Halogenase HctB

(2014) Sarah M. Pratter et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A new family of iron-dependent halogenases acts on freestanding substrates

(2014) Matthew L Hillwig et al.   Nature Chemical Biology

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

(2014) Megan L Matthews et al.   Nature Chemical Biology

Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

(2014) W.-c. Chang et al.   SCIENCE

The roles of Jumonji-type oxygenases in human disease

(2014) Catrine Johansson et al.   Epigenomics

4-Hydroxyphenylpyruvate dioxygenase and hydroxymandelate synthase: Exemplars of the α-keto acid dependent oxygenases

(2013) Graham R. Moran   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Substrate Placement Influences Reactivity in Non-heme Fe(II) Halogenases and Hydroxylases

(2013) Heather J. Kulik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of the Fe(iv)=O intermediate in the catalytic cycle of the halogenase SyrB2

(2013) Shaun D. Wong et al.   NATURE

Mechanistic studies of an unprecedented enzyme-catalysed 1,2-phosphono-migration reaction

(2013) Wei-chen Chang et al.   NATURE

Functional characterization of recombinant hyoscyamine 6β-hydroxylase from Atropa belladonna

(2012) Jing Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

(2012) WeiShen Aik et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

1-Aminocyclopropane-1-carboxylic acid oxidase: insight into cofactor binding from experimental and theoretical studies

(2012) Lydie Brisson et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

The enzymes of β-lactam biosynthesis

(2012) Refaat B. Hamed et al.   NATURAL PRODUCT REPORTS

Phytanic acid metabolism in health and disease

(2011) Ronald J.A. Wanders et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibition of 2-oxoglutarate dependent oxygenases

(2011) Nathan R. Rose et al.   CHEMICAL SOCIETY REVIEWS

Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases

(2010) Nima Mosammaparast et al.   Annual Review of Biochemistry

Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin

(2010) Satish K. Nair et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Prolyl 4-hydroxylase

(2010) Kelly L. Gorres et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Insight into the mechanism of an iron dioxygenase by resolution of steps following the FeIVboxHO species

(2010) P. K. Grzyska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate-Triggered Formation and Remarkable Stability of the C−H Bond-Cleaving Chloroferryl Intermediate in the Aliphatic Halogenase, SyrB2

(2009) Megan L. Matthews et al.   BIOCHEMISTRY

Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3

(2009) Cintyu Wong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic considerations of halogenating enzymes

(2009) Alison Butler et al.   NATURE

FtmOx1, a non-heme Fe(ii) and α-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus

(2009) Nicola Steffan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2

(2009) M. L. Matthews et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Perspective on Enzymatic Halogenation

(2008) Leah C. Blasiak et al.   ACCOUNTS OF CHEMICAL RESEARCH

Expanding chemical biology of 2-oxoglutarate oxygenases

(2008) Christoph Loenarz et al.   Nature Chemical Biology