标题
The roles of Jumonji-type oxygenases in human disease
作者
关键词
-
出版物
Epigenomics
Volume 6, Issue 1, Pages 89-120
出版商
Future Medicine Ltd
发表日期
2014-02-28
DOI
10.2217/epi.13.79
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Male-Specific Region of the Y Chromosome and Cardiovascular Risk
- (2013) Lisa D.S. Bloomer et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Overexpression of gankyrin in mouse hepatocytes induces hemangioma by suppressing factor inhibiting hypoxia-inducible factor-1 (FIH-1) and activating hypoxia-inducible factor-1
- (2013) Yu Liu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- RNAi screen identifies Jarid1b as a major regulator of mouse HSC activity
- (2013) S. Cellot et al. BLOOD
- The Histone Demethylase PHF8 Governs Retinoic Acid Response in Acute Promyelocytic Leukemia
- (2013) Maria Francisca Arteaga et al. CANCER CELL
- Inhibition of Histone Demethylase JMJD1A Improves Anti-Angiogenic Therapy and Reduces Tumor-Associated Macrophages
- (2013) T. Osawa et al. CANCER RESEARCH
- KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells
- (2013) W. L. Berry et al. CANCER RESEARCH
- Jmjd3 Inhibits Reprogramming by Upregulating Expression of INK4a/Arf and Targeting PHF20 for Ubiquitination
- (2013) Wei Zhao et al. CELL
- Ablation of Mina53 in Mice Reduces Allergic Response in the Airways
- (2013) Tetsuya Mori et al. CELL STRUCTURE AND FUNCTION
- Large-scale global identification of protein lysine methylation in vivo
- (2013) Xing-Jun Cao et al. Epigenetics
- Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia
- (2013) Cai Chen et al. GENES CHROMOSOMES & CANCER
- Structural Insights into Histone Demethylase NO66 in Interaction with Osteoblast-specific Transcription Factor Osterix and Gene Repression
- (2013) Yue Tao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6)
- (2013) Motoko Unoki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nitric Oxide Modifies Global Histone Methylation by Inhibiting Jumonji C Domain-containing Demethylases
- (2013) Jason R. Hickok et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX gene expression pattern
- (2013) J D E de Rooij et al. LEUKEMIA
- Global H3K4me3 genome mapping reveals alterations of innate immunity signaling and overexpression of JMJD3 in human myelodysplastic syndrome CD34+ cells
- (2013) Y Wei et al. LEUKEMIA
- Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15INK4B and p27Kip1
- (2013) Runtao Gao et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation
- (2013) Xudong Wu et al. MOLECULAR CELL
- Dynamic regulatory network controlling TH17 cell differentiation
- (2013) Nir Yosef et al. NATURE
- Polycomb complex recruitment in pluripotent stem cells
- (2013) Maria J. Barrero et al. NATURE CELL BIOLOGY
- Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes
- (2013) Jin He et al. NATURE CELL BIOLOGY
- TETonic shift: biological roles of TET proteins in DNA demethylation and transcription
- (2013) William A. Pastor et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- KDM4B is a Master Regulator of the Estrogen Receptor Signalling Cascade
- (2013) Luke Gaughan et al. NUCLEIC ACIDS RESEARCH
- The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover
- (2013) Kelly Coffey et al. NUCLEIC ACIDS RESEARCH
- Protein Complex Interactor Analysis and Differential Activity of KDM3 Subfamily Members Towards H3K9 Methylation
- (2013) Michael Brauchle et al. PLoS One
- The Human Melanoma Side Population Displays Molecular and Functional Characteristics of Enriched Chemoresistance and Tumorigenesis
- (2013) Jasper Wouters et al. PLoS One
- Epigenetic Activation of AP1 Promotes Squamous Cell Carcinoma Metastasis
- (2013) X. Ding et al. Science Signaling
- ALKBH4-dependent demethylation of actin regulates actomyosin dynamics
- (2013) Ming-Ming Li et al. Nature Communications
- Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
- (2013) Marc A Kerenyi et al. eLife
- OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels
- (2012) Jens Bunt et al. ACTA NEUROPATHOLOGICA
- Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma
- (2012) Adrian M. Dubuc et al. ACTA NEUROPATHOLOGICA
- Histone demethylase JMJD5 is essential for embryonic development
- (2012) Sangphil Oh et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Retinoic acid dependent histone 3 demethylation of the clustered HOX genes during neural differentiation of human embryonic stem cells
- (2012) Maryam Shahhoseini et al. Biochemistry and Cell Biology
- Expression and significance of histone H3K27 demethylases in renal cell carcinoma
- (2012) Yongqing Shen et al. BMC CANCER
- PCA-1/ALKBH3 Contributes to Pancreatic Cancer by Supporting Apoptotic Resistance and Angiogenesis
- (2012) I. Yamato et al. CANCER RESEARCH
- ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression
- (2012) Tomomi Fujii et al. CANCER SCIENCE
- Cancer Epigenetics: From Mechanism to Therapy
- (2012) Mark A. Dawson et al. CELL
- Gene networking and inflammatory pathway analysis in a JMJD3 knockdown human monocytic cell line
- (2012) Nando Dulal Das et al. CELL BIOCHEMISTRY AND FUNCTION
- Vitamin D has wide regulatory effects on histone demethylase genes
- (2012) Fábio Pereira et al. CELL CYCLE
- Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes
- (2012) L Guo et al. CELL DEATH AND DIFFERENTIATION
- Histone H3K27me3 demethylases KDM6A and KDM6B modulate definitive endoderm differentiation from human ESCs by regulating WNT signaling pathway
- (2012) Wei Jiang et al. CELL RESEARCH
- Histone Demethylases KDM4B and KDM6B Promotes Osteogenic Differentiation of Human MSCs
- (2012) Ling Ye et al. Cell Stem Cell
- Genome-Wide Association Study of Prognosis in Advanced Non-Small Cell Lung Cancer Patients Receiving Platinum-Based Chemotherapy
- (2012) L. Hu et al. CLINICAL CANCER RESEARCH
- ALKBH3 Contributes to Survival and Angiogenesis of Human Urothelial Carcinoma Cells through NADPH Oxidase and Tweak/Fn14/VEGF Signals
- (2012) K. Shimada et al. CLINICAL CANCER RESEARCH
- Anti-Tumor Effect of AlkB Homolog 3 Knockdown in Hormone- Independent Prostate Cancer Cells
- (2012) K. Koike et al. CURRENT CANCER DRUG TARGETS
- Nucleic acid modifications with epigenetic significance
- (2012) Ye Fu et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression
- (2012) A. Ishimura et al. DEVELOPMENT
- Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program
- (2012) C. Estaras et al. DEVELOPMENT
- Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver
- (2012) Wei-Dong Chen et al. HEPATOLOGY
- Histone Demethylase KDM6B Promotes Epithelial-Mesenchymal Transition
- (2012) Sivakumar Ramadoss et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- JMJD5, a Jumonji C (JmjC) Domain-containing Protein, Negatively Regulates Osteoclastogenesis by Facilitating NFATc1 Protein Degradation
- (2012) Min-Young Youn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation
- (2012) A Sprüssel et al. LEUKEMIA
- JARID1B expression in human melanoma and benign melanocytic skin lesions
- (2012) Łukasz Kuźbicki et al. MELANOMA RESEARCH
- KDM3B Is the H3K9 Demethylase Involved in Transcriptional Activation of lmo2 in Leukemia
- (2012) J.-Y. Kim et al. MOLECULAR AND CELLULAR BIOLOGY
- The emerging role of histone lysine demethylases in prostate cancer
- (2012) Francesco Crea et al. Molecular Cancer
- Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20
- (2012) Joshua D. Stender et al. MOLECULAR CELL
- Cell-Type-Specific Control of Enhancer Activity by H3K9 Trimethylation
- (2012) Yina Zhu et al. MOLECULAR CELL
- ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
- (2012) Guanqun Zheng et al. MOLECULAR CELL
- Absence of deletion and duplication of MLL2 and KDM6A genes in a large cohort of patients with Kabuki syndrome
- (2012) Manuela Priolo et al. MOLECULAR GENETICS AND METABOLISM
- A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
- (2012) Laurens Kruidenier et al. NATURE
- Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming
- (2012) Gaoyang Liang et al. NATURE CELL BIOLOGY
- Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans
- (2012) Wei Ge et al. Nature Chemical Biology
- Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
- (2012) Tino Schenk et al. NATURE MEDICINE
- Complexities of occupancy and sequence
- (2012) Mary Muers NATURE REVIEWS GENETICS
- Histone methylation: a dynamic mark in health, disease and inheritance
- (2012) Eric L. Greer et al. NATURE REVIEWS GENETICS
- Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation
- (2012) Gerard L Brien et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells
- (2012) Tor-Christian Aase Johannessen et al. NEURO-ONCOLOGY
- Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice
- (2012) Amit K. Srivastava et al. NEUROBIOLOGY OF DISEASE
- Regulation of Tumor Suppressor p53 and HCT116 Cell Physiology by Histone Demethylase JMJD2D/KDM4D
- (2012) Tae-Dong Kim et al. PLoS One
- Itga2b Regulation at the Onset of Definitive Hematopoiesis and Commitment to Differentiation
- (2012) Stephanie Dumon et al. PLoS One
- Human ALKBH4 Interacts with Proteins Associated with Transcription
- (2012) Linn G. Bjørnstad et al. PLoS One
- Novel Genetic Loci Identified for the Pathophysiology of Childhood Obesity in the Hispanic Population
- (2012) Anthony G. Comuzzie et al. PLoS One
- Lysine-specific demethylase 2A (KDM2A) normalizes human embryonic stem cell derived keratinocytes
- (2012) S. Iuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development
- (2012) S. Canovas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence
- (2012) A. Chicas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Demethylation of Epiregulin Gene by Histone Demethylase FBXL11 and BCL6 Corepressor Inhibits Osteo/dentinogenic Differentiation
- (2012) Juan Du et al. STEM CELLS
- Reversible RNA adenosine methylation in biological regulation
- (2012) Guifang Jia et al. TRENDS IN GENETICS
- The H3K27 Demethylase JMJD3 Is Required for Maintenance of the Embryonic Respiratory Neuronal Network, Neonatal Breathing, and Survival
- (2012) Thomas Burgold et al. Cell Reports
- KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands
- (2012) Anca M Farcas et al. eLife
- Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE
- (2012) C Nava et al. Translational Psychiatry
- Major Chromosomal Breakpoint Intervals in Breast Cancer Co-Localize with Differentially Methylated Regions
- (2012) Man-Hung Tang et al. Frontiers in Oncology
- Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome
- (2011) Damien Lederer et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Role of the Hypoxia-Related Gene, JMJD1A, in Hepatocellular Carcinoma: Clinical Impact on Recurrence after Hepatic Resection
- (2011) Daisaku Yamada et al. ANNALS OF SURGICAL ONCOLOGY
- Mechanism of JmjC-containing protein Hairless in the regulation of vitamin D receptor function
- (2011) Yang Mi et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia
- (2011) J. He et al. BLOOD
- The role of the fat mass and obesity associated gene (FTO) in breast cancer risk
- (2011) Virginia Kaklamani et al. BMC Medical Genetics
- ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer
- (2011) M Tasaki et al. BRITISH JOURNAL OF CANCER
- Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis
- (2011) M N Khan et al. BRITISH JOURNAL OF CANCER
- Binding of the JmjC Demethylase JARID1B to LSD1/NuRD Suppresses Angiogenesis and Metastasis in Breast Cancer Cells by Repressing Chemokine CCL14
- (2011) Q. Li et al. CANCER RESEARCH
- Novel Histone Demethylase LSD1 Inhibitors Selectively Target Cancer Cells with Pluripotent Stem Cell Properties
- (2011) J. Wang et al. CANCER RESEARCH
- Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3
- (2011) Yongju Lu et al. CELL CYCLE
- The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner
- (2011) Tao Wang et al. Cell Stem Cell
- The 2-Oxoglutarate-Dependent Oxygenase JMJD6 Catalyses Oxidation of Lysine Residues to give 5S-Hydroxylysine Residues
- (2011) Monica Mantri et al. CHEMBIOCHEM
- Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs
- (2011) Si Wan Kim et al. DEVELOPMENTAL BIOLOGY
- Direct repair of 3,N4-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase
- (2011) Dragony Fu et al. DNA REPAIR
- H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic geneBCL2determines ERα ligand dependency
- (2011) Amy Svotelis et al. EMBO JOURNAL
- Jarid1b targets genes regulating development and is involved in neural differentiation
- (2011) Sandra U Schmitz et al. EMBO JOURNAL
- The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
- (2011) Rasheduzzaman Chowdhury et al. EMBO REPORTS
- Plant homeodomain fingers form a helping hand for transcription
- (2011) Klaus Fortschegger et al. Epigenetics
- The obesity gene and colorectal cancer risk: A population study in Northern Italy
- (2011) E. Tarabra et al. European Journal of Internal Medicine
- Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains
- (2011) Ming Yang et al. FEBS Journal
- CpG islands and the regulation of transcription
- (2011) A. M. Deaton et al. GENES & DEVELOPMENT
- The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis
- (2011) J J Pointon et al. GENES AND IMMUNITY
- KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells
- (2011) Fábio Pereira et al. HUMAN MOLECULAR GENETICS
- Inhibited expression of hematopoietic progenitor kinase 1 associated with loss of jumonji domain containing 3 promoter binding contributes to autoimmunity in systemic lupus erythematosus
- (2011) Qing Zhang et al. JOURNAL OF AUTOIMMUNITY
- Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human KDM4 Histone Demethylase Family
- (2011) Lars Hillringhaus et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epigenetic regulation of osteoclast differentiation: Possible involvement of Jmjd3 in the histone demethylation of Nfatc1
- (2011) Tetsuro Yasui et al. JOURNAL OF BONE AND MINERAL RESEARCH
- The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice
- (2011) Qing-Jun Zhang et al. JOURNAL OF CLINICAL INVESTIGATION
- Effects of RNA interference-mediated gene silencing of JMJD2A on human breast cancer cell line MDA-MB-231 in vitro
- (2011) Bei-Xu Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- FGF-2 Regulates Cell Proliferation, Migration, and Angiogenesis through an NDY1/KDM2B-miR-101-EZH2 Pathway
- (2011) Filippos Kottakis et al. MOLECULAR CELL
- DNA Unwinding by ASCC3 Helicase Is Coupled to ALKBH3-Dependent DNA Alkylation Repair and Cancer Cell Proliferation
- (2011) Sebastian Dango et al. MOLECULAR CELL
- Too many roads not taken
- (2011) Aled M. Edwards et al. NATURE
- N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
- (2011) Guifang Jia et al. Nature Chemical Biology
- The Expression of Histone Demethylase JMJD1A in Renal Cell Carcinoma
- (2011) X. GUO et al. NEOPLASMA
- The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population
- (2011) J. A. Hubacek et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Huge Splicing Frequency in Human Y Chromosomal UTY Gene
- (2011) Ingeborg Laaser et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- The H3K27me3 demethylase, KDM6B, is induced by Epstein–Barr virus and over-expressed in Hodgkin's Lymphoma
- (2011) J A Anderton et al. ONCOGENE
- The von Hippel–Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C
- (2011) X Niu et al. ONCOGENE
- Histone Demethylase JMJD2B Functions as a Co-Factor of Estrogen Receptor in Breast Cancer Proliferation and Mammary Gland Development
- (2011) Masahito Kawazu et al. PLoS One
- p53 Interaction with JMJD3 Results in Its Nuclear Distribution during Mouse Neural Stem Cell Differentiation
- (2011) Susana Solá et al. PLoS One
- Overexpression of the HIF Hydroxylases PHD1, PHD2, PHD3 and FIH Are Individually and Collectively Unfavorable Prognosticators for NSCLC Survival
- (2011) Sigve Andersen et al. PLoS One
- Human papillomavirus E7 oncoprotein induces KDM6A and KDM6B histone demethylase expression and causes epigenetic reprogramming
- (2011) Margaret E. McLaughlin-Drubin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis
- (2011) L. Shi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Histone Lysine Demethylase JARID1a Activates CLOCK-BMAL1 and Influences the Circadian Clock
- (2011) L. DiTacchio et al. SCIENCE
- Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine
- (2011) S. Ito et al. SCIENCE
- A cryptic deletion in 5q31.2 provides further evidence for a minimally deleted region in myelodysplastic syndromes
- (2011) Ruth N. MacKinnon et al. Cancer Genetics
- Subcellular FIH-1 expression patterns in invasive breast cancer in relation to HIF-1α expression
- (2011) Agon Hyseni et al. CELLULAR ONCOLOGY
- Reversal of Histone Methylation: Biochemical and Molecular Mechanisms of Histone Demethylases
- (2010) Nima Mosammaparast et al. Annual Review of Biochemistry
- Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors
- (2010) Jianfei Qi et al. CANCER CELL
- miR-31 Ablates Expression of the HIF Regulatory Factor FIH to Activate the HIF Pathway in Head and Neck Carcinoma
- (2010) C.-J. Liu et al. CANCER RESEARCH
- The Histone Demethylase JMJD2B Is Regulated by Estrogen Receptor and Hypoxia, and Is a Key Mediator of Estrogen Induced Growth
- (2010) J. Yang et al. CANCER RESEARCH
- A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
- (2010) Sreenath V. Sharma et al. CELL
- A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth
- (2010) Alexander Roesch et al. CELL
- Nucleosome-Interacting Proteins Regulated by DNA and Histone Methylation
- (2010) Till Bartke et al. CELL
- The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism
- (2010) Na Zhang et al. Cell Metabolism
- Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
- (2010) Chengyang Huang et al. CELL RESEARCH
- PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis
- (2010) Ziqi Zhu et al. CELL RESEARCH
- Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase
- (2010) Ivanhoe K.H. Leung et al. CHEMISTRY & BIOLOGY
- Jumonji Domain Containing 1A Is a Novel Prognostic Marker for Colorectal Cancer: In vivo Identification from Hypoxic Tumor Cells
- (2010) M. Uemura et al. CLINICAL CANCER RESEARCH
- Structural studies on human 2-oxoglutarate dependent oxygenases
- (2010) Michael A McDonough et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Histone Demethylase JmjD2A Regulates Neural Crest Specification
- (2010) Pablo Hernan Strobl-Mazzulla et al. DEVELOPMENTAL CELL
- JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation
- (2010) Yuji Tanaka et al. EMBO JOURNAL
- Epigenetics: The epicenter of the hypoxic response
- (2010) Jenny A. Watson et al. Epigenetics
- Expression of nuclear FIH independently predicts overall survival of clear cell renal cell carcinoma patients
- (2010) Stephanie G.C. Kroeze et al. EUROPEAN JOURNAL OF CANCER
- Crystal structure of the PHF8 Jumonji domain, anNε-methyl lysine demethylase
- (2010) Wyatt W. Yue et al. FEBS LETTERS
- KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development
- (2010) Y.-i. Tsukada et al. GENES & DEVELOPMENT
- Molecular mechanisms by which T-bet regulates T-helper cell commitment
- (2010) Sara A. Miller et al. IMMUNOLOGICAL REVIEWS
- Recognition of Histone H3K4 Trimethylation by the Plant Homeodomain of PHF2 Modulates Histone Demethylation
- (2010) Hong Wen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expanding Role of the Jumonji C Domain as an RNA Hydroxylase
- (2010) Akiko Noma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
- (2010) Ming Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Jmjd3 activates Mash1 gene in RA-induced neuronal differentiation of P19 cells
- (2010) Jin-po Dai et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis
- (2010) Dominic J. Ciavatta et al. JOURNAL OF CLINICAL INVESTIGATION
- Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6
- (2010) Monica Mantri et al. JOURNAL OF MOLECULAR BIOLOGY
- PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription
- (2010) K. Fortschegger et al. MOLECULAR AND CELLULAR BIOLOGY
- Human AlkB Homolog ABH8 Is a tRNA Methyltransferase Required for Wobble Uridine Modification and DNA Damage Survival
- (2010) D. Fu et al. MOLECULAR AND CELLULAR BIOLOGY
- Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression
- (2010) Sara A. Miller et al. MOLECULAR CELL
- A Functional Link between the Histone Demethylase PHF8 and the Transcription Factor ZNF711 in X-Linked Mental Retardation
- (2010) Daniela Kleine-Kohlbrecher et al. MOLECULAR CELL
- CpG Islands Recruit a Histone H3 Lysine 36 Demethylase
- (2010) Neil P. Blackledge et al. MOLECULAR CELL
- PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
- (2010) Wen Liu et al. NATURE
- Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
- (2010) Hank H. Qi et al. NATURE
- JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells
- (2010) Diego Pasini et al. NATURE
- Crystal structure of the FTO protein reveals basis for its substrate specificity
- (2010) Zhifu Han et al. NATURE
- Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators
- (2010) David Landeira et al. NATURE CELL BIOLOGY
- The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
- (2010) Takashi Satoh et al. NATURE IMMUNOLOGY
- PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation
- (2010) Weijun Feng et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Regulation of mouse steroidogenesis by WHISTLE and JMJD1C through histone methylation balance
- (2010) Sung-Mi Kim et al. NUCLEIC ACIDS RESEARCH
- Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism – The Finnish Diabetes Prevention Study
- (2010) T. Lappalainen et al. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
- Analysis of Jmjd6 Cellular Localization and Testing for Its Involvement in Histone Demethylation
- (2010) Phillip Hahn et al. PLoS One
- The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice
- (2010) Xue Gao et al. PLoS One
- Jumonji domain protein JMJD5 functions in both the plant and human circadian systems
- (2010) M. A. Jones et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interaction of JMJD6 with single-stranded RNA
- (2010) X. Hong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation
- (2010) D. A. Hsia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
- (2010) M.-C. Tsai et al. SCIENCE
- Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
- (2010) Christoph Loenarz et al. TRENDS IN BIOCHEMICAL SCIENCES
- Histone demethylases in development and disease
- (2010) Marianne Terndrup Pedersen et al. TRENDS IN CELL BIOLOGY
- Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations
- (2009) Sarah Boissel et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Identification of non-histone substrates for JMJD2A–C histone demethylases
- (2009) V.K. Chaithanya Ponnaluri et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
- (2009) O. Abdel-Wahab et al. BLOOD
- Epigenetic regulation of the alternatively activated macrophage phenotype
- (2009) M. Ishii et al. BLOOD
- A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression
- (2009) K. Shimada et al. CANCER RESEARCH
- Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells
- (2009) Jamy C. Peng et al. CELL
- LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer
- (2009) Yan Wang et al. CELL
- Jumonji Modulates Polycomb Activity and Self-Renewal versus Differentiation of Stem Cells
- (2009) Xiaohua Shen et al. CELL
- Oxygen Sensors at the Crossroad of Metabolism
- (2009) Julián Aragonés et al. Cell Metabolism
- Autism-associated familial microdeletion of Xp11.22
- (2009) Y Qiao et al. CLINICAL GENETICS
- Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites
- (2009) Tina A. Müller et al. DNA REPAIR
- Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase
- (2009) Krishna M Sinha et al. EMBO JOURNAL
- Jmjd3 contributes to the control of gene expression in LPS-activated macrophages
- (2009) Francesca De Santa et al. EMBO JOURNAL
- Epigenetic reprogramming during wound healing: loss of polycomb-mediated silencing may enable upregulation of repair genes
- (2009) Tanya Shaw et al. EMBO REPORTS
- Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS
- (2009) M. Barradas et al. GENES & DEVELOPMENT
- The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
- (2009) K. Agger et al. GENES & DEVELOPMENT
- Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice
- (2009) Takeshi Inagaki et al. GENES TO CELLS
- Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination
- (2009) T. Fei et al. GENOME RESEARCH
- Jmjd1a Demethylase-regulated Histone Modification Is Essential for cAMP-response Element Modulator-regulated Gene Expression and Spermatogenesis
- (2009) Zhaoliang Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nickel Ions Inhibit Histone Demethylase JMJD1A and DNA Repair Enzyme ABH2 by Replacing the Ferrous Iron in the Catalytic Centers
- (2009) Haobin Chen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Novel Mammalian Flavin-dependent Histone Demethylase
- (2009) Aristotele Karytinos et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
- (2009) Patrick Trojer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of Mina53, a novel c-Myc target gene, is a favorable prognostic marker in early stage lung cancer
- (2009) Kazutoshi Komiya et al. LUNG CANCER
- KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints
- (2009) David N. Ciccone et al. NATURE
- Role of Jhdm2a in regulating metabolic gene expression and obesity resistance
- (2009) Keisuke Tateishi et al. NATURE
- Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
- (2009) Gijs van Haaften et al. NATURE GENETICS
- Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases
- (2009) John R Horton et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
- (2009) G Liu et al. ONCOGENE
- Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence
- (2009) Hanane Agherbi et al. PLoS One
- Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing theInk4a/Arflocus
- (2009) Alexandros Tzatsos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of NF- B by NSD1/FBXL11-dependent reversible lysine methylation of p65
- (2009) T. Lu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Jmjd6 Catalyses Lysyl-Hydroxylation of U2AF65, a Protein Associated with RNA Splicing
- (2009) Celia J. Webby et al. SCIENCE
- Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
- (2009) M. Tahiliani et al. SCIENCE
- Gene expression analysis on anterior temporal neocortex of patients with intractable epilepsy
- (2009) Zhi-Qin Xi et al. SYNAPSE
- A novel mutation inJARID1C/SMCX in a patient with autism spectrum disorder (ASD)
- (2008) Abidemi Adegbola et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Hypoxia upregulates the histone demethylase JMJD1A via HIF-1
- (2008) Sven Wellmann et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
- (2008) Patrick J. Pollard et al. BIOCHEMICAL JOURNAL
- Dynamic protein methylation in chromatin biology
- (2008) S. S. Ng et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Genetic Variants of FTO Influence Adiposity, Insulin Sensitivity, Leptin Levels, and Resting Metabolic Rate in the Quebec Family Study
- (2008) R. Do et al. DIABETES
- Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO
- (2008) Guifang Jia et al. FEBS LETTERS
- Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
- (2008) G. L. Sen et al. GENES & DEVELOPMENT
- dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing
- (2008) A. Lagarou et al. GENES & DEVELOPMENT
- Spermatogenesis-specific association of SMCY and MSH5
- (2008) Chihiro Akimoto et al. GENES TO CELLS
- Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents
- (2008) J A Jacobsson et al. INTERNATIONAL JOURNAL OF OBESITY
- Human AlkB Homolog 1 Is a Mitochondrial Protein That Demethylates 3-Methylcytosine in DNA and RNA
- (2008) Marianne Pedersen Westbye et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Comprehensive Analysis of DNA Repair Gene Variants and Risk of Meningioma
- (2008) Lara Bethke et al. JNCI-Journal of the National Cancer Institute
- The Histone Demethylase KDM5b/JARID1b Plays a Role in Cell Fate Decisions by Blocking Terminal Differentiation
- (2008) B. K. Dey et al. MOLECULAR AND CELLULAR BIOLOGY
- Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: Pathological significance in early- and late-onset breast carcinoma
- (2008) Satyabrata Sinha et al. Molecular Cancer
- The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
- (2008) Jing Wang et al. NATURE GENETICS
- The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
- (2008) Jin He et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Apoptotic signaling by c-MYC
- (2008) B Hoffman et al. ONCOGENE
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