The enzymes of β-lactam biosynthesis

A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tü1718 and Streptomyces clavuligerus

(2012) Sarah Goomeshi Nobary et al.   CANADIAN JOURNAL OF MICROBIOLOGY

In Vivo Characterization of Nonribosomal Peptide Synthetases NocA and NocB in the Biosynthesis of Nocardicin A

(2012) Jeanne M. Davidsen et al.   CHEMISTRY & BIOLOGY

Autocatalysed oxidative modifications to 2-oxoglutarate dependent oxygenases

(2012) Monica Mantri et al.   FEBS Journal

Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement

(2012) A. R. Buller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering the synthetic potential of β-lactam synthetase and the importance of catalytic loop dynamics

(2012) Jason W. Labonte et al.   MedChemComm

Mutational Analysis of the Thienamycin Biosynthetic Gene Cluster fromStreptomyces cattleya

(2011) Miriam Rodríguez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Improvement of l-Arginine Production by Overexpression of a Bifunctional Ornithine Acetyltransferase in Corynebacterium crenatum

(2011) Wenfang Dou et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Comparative analysis of a cryptic thienamycin-like gene cluster identified in Streptomyces flavogriseus by genome mining

(2011) Gloria Blanco   ARCHIVES OF MICROBIOLOGY

Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation

(2011) Xiaobin Wu et al.   BIOCHIMIE

The ATP-grasp enzymes

(2011) Maria V. Fawaz et al.   BIOORGANIC CHEMISTRY

Characterization of 2-Octenoyl-CoA Carboxylase/Reductase UtilizingpteBfromStreptomyce avermitilis

(2011) Hye-Gyeong YOO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Biosynthetic concepts for the production of β-lactam antibiotics in Penicillium chrysogenum

(2011) Stefan S. Weber et al.   Biotechnology Journal

Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes

(2011) Hum Nath Jnawali et al.   BIOTECHNOLOGY LETTERS

Definition of the Common and Divergent Steps in Carbapenem β-Lactam Antibiotic Biosynthesis

(2011) Micah J. Bodner et al.   CHEMBIOCHEM

Critical shortage of new antibiotics in development against multidrug-resistant bacteria—Time to react is now

(2011) Laura Freire-Moran et al.   DRUG RESISTANCE UPDATES

Optically active 1,3,4,4-tetrasubstituted β-lactams: Synthesis and evaluation as tumor cell growth inhibitors

(2011) Paula Pérez-Faginas et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cloning and characterization of a novel CoA-ligase gene from Penicillium chrysogenum

(2011) Zhou-Liang Yu et al.   FOLIA MICROBIOLOGICA

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Complete Genome Sequence of Streptomyces cattleya NRRL 8057, a Producer of Antibiotics and Fluorometabolites

(2011) V. Barbe et al.   JOURNAL OF BACTERIOLOGY

Theoretical Investigation on Reaction of Sulbactam with Wild-Type SHV-1 β-Lactamase: Acylation, Tautomerization, and Deacylation

(2011) Rui Li et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Crotonase Catalysis Enables Flexible Production of Functionalized Prolines and Carbapenams

(2011) Refaat B. Hamed et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distinctive Attributes of β-Lactam Target Proteins inAcinetobacter baumanniiRelevant to Development of New Antibiotics

(2011) Seungil Han et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Radical S-adenosylmethionine enzymes: Mechanism, control and function

(2011) Martin R. Challand et al.   NATURAL PRODUCT REPORTS

Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoAcarboxylase/reductase homologs in expanding polyketide diversity

(2011) Micheal C. Wilson et al.   NATURAL PRODUCT REPORTS

Unusual carbon fixation gives rise to diverse polyketide extender units

(2011) Nick Quade et al.   Nature Chemical Biology

Stereoselective C–C bond formation catalysed by engineered carboxymethylproline synthases

(2011) Refaat B. Hamed et al.   Nature Chemistry

Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

(2011) Aman Iqbal et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

(2010) Olivier A. Pierrat et al.   ACS Chemical Biology

Mechanistic Studies of the Inactivation of TEM-1 and P99 by NXL104, a Novel Non- -Lactam  -Lactamase Inhibitor

(2010) T. Stachyra et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Evaluation of Ceftazidime and NXL104 in Two Murine Models of Infection Due to KPC-ProducingKlebsiella pneumoniae

(2010) Andrea Endimiani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clavulanic acid biosynthesis and genetic manipulation for its overproduction

(2010) Ju Yeon Song et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biotechnological potential of the ethylmalonyl-CoA pathway

(2010) Birgit E. Alber   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Saturation mutagenesis of Acremonium chrysogenum deacetoxy/deacetylcephalosporin C synthase R308 site confirms its role in controlling substrate specificity

(2010) Xiao-Bin Wu et al.   BIOTECHNOLOGY LETTERS

Adenosyl Radical: Reagent and Catalyst in Enzyme Reactions

(2010) E. Neil G. Marsh et al.   CHEMBIOCHEM

Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles

(2010) Refaat B. Hamed et al.   CHEMICAL COMMUNICATIONS

Structural and Mechanistic Studies on γ-Butyrobetaine Hydroxylase

(2010) Ivanhoe K.H. Leung et al.   CHEMISTRY & BIOLOGY

Three Decades of  -Lactamase Inhibitors

(2010) S. M. Drawz et al.   CLINICAL MICROBIOLOGY REVIEWS

Structural studies on human 2-oxoglutarate dependent oxygenases

(2010) Michael A McDonough et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nonribosomal peptide synthetases: structures and dynamics

(2010) Matthias Strieker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Fungal secondary metabolites – Strategies to activate silent gene clusters

(2010) Axel A. Brakhage et al.   FUNGAL GENETICS AND BIOLOGY

The Sequence of a 1.8-Mb Bacterial Linear Plasmid Reveals a Rich Evolutionary Reservoir of Secondary Metabolic Pathways

(2010) Marnix H. Medema et al.   Genome Biology and Evolution

Draft Genome Sequence of Streptomyces clavuligerus NRRL 3585, a Producer of Diverse Secondary Metabolites

(2010) J. Y. Song et al.   JOURNAL OF BACTERIOLOGY

Do we need new antibiotics? The search for new targets and new compounds

(2010) Jaroslav Spížek et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Structural Basis for the Interaction of Lactivicins with Serine β-Lactamases

(2010) Tom Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Molecular Structure of Ornithine Acetyltransferase from Mycobacterium tuberculosis Bound to Ornithine, a Competitive Inhibitor

(2010) Ramasamy Sankaranarayanan et al.   JOURNAL OF MOLECULAR BIOLOGY

Role of σ-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585

(2010) Hum Nath Jnawali et al.   MICROBIOLOGICAL RESEARCH

Enzymes that catalyse SN2 reaction mechanisms

(2010) David O'Hagan et al.   NATURAL PRODUCT REPORTS

Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase

(2010) L. M. Iyer et al.   NUCLEIC ACIDS RESEARCH

Monamphilectine A, a Potent Antimalarial β-Lactam from Marine SpongeHymeniacidonsp: Isolation, Structure, Semisynthesis, and Bioactivity

(2010) Edward Avilés et al.   ORGANIC LETTERS

Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme

(2010) Marcel Bokhove et al.   STRUCTURE

Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases

(2010) Christoph Loenarz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

(2010) Marnix H. Medema et al.   Microbial Biotechnology

Structural and mechanistic studies on N2-(2-carboxyethyl)arginine synthase

(2009) Matthew E.C. Caines et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Conserved Tyrosyl−Glutamyl Catalytic Dyad in Evolutionarily Linked Enzymes: Carbapenam Synthetase and β-Lactam Synthetase

(2009) Mary L. Raber et al.   BIOCHEMISTRY

Inhibition of the Class C β-Lactamase fromAcinetobacterspp.: Insights into Effective Inhibitor Design

(2009) Sarah M. Drawz et al.   BIOCHEMISTRY

Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue

(2009) Wei Ge et al.   CHEMBIOCHEM

A Conserved Lysine in β-Lactam Synthetase Assists Ring Cyclization: Implications for Clavam and Carbapenem Biosynthesis

(2009) Mary L. Raber et al.   CHEMBIOCHEM

Asymmetric synthesis of anticancer β-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

(2009) Bimal K. Banik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for the erythro-stereospecificity of the l-arginine oxygenase VioC in viomycin biosynthesis

(2009) Verena Helmetag et al.   FEBS Journal

The Penicillium chrysogenum aclA gene encodes a broad-substrate-specificity acyl-coenzyme A ligase involved in activation of adipic acid, a side-chain precursor for cephem antibiotics

(2009) Martijn J. Koetsier et al.   FUNGAL GENETICS AND BIOLOGY

A Two-component Regulatory System Involved in Clavulanic Acid Production

(2009) Hum Nath Jnawali et al.   JOURNAL OF ANTIBIOTICS

In vitro activity of the  -lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases

(2009) T. Stachyra et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production

(2009) Kian-Sim Goo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Crystal Structures of an Oligopeptide-Binding Protein from the Biosynthetic Pathway of the β-Lactamase Inhibitor Clavulanic Acid

(2009) Alasdair K. Mackenzie et al.   JOURNAL OF MOLECULAR BIOLOGY

Non-Heme Iron Oxygenases Generate Natural Structural Diversity in Carbapenem Antibiotics

(2009) Micah J. Bodner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering of Penicillium chrysogenum for fermentative production of a novel carbamoylated cephem antibiotic precursor

(2009) Diana M. Harris et al.   METABOLIC ENGINEERING

Structural insights into nonribosomal peptide enzymatic assembly lines

(2009) Alexander Koglin et al.   NATURAL PRODUCT REPORTS

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

(2009) Robert H. Cichewicz   NATURAL PRODUCT REPORTS

Synthesis of regio- and stereoselectively deuterium-labelled derivatives of l-glutamate semialdehyde for studies on carbapenem biosynthesis

(2009) Christian Ducho et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

(2009) T. J. Erb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity

(2009) Michael Y. Galperin et al.   PROTEIN SCIENCE

Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis

(2009) J.-E. Hugonnet et al.   SCIENCE

Complete genome sequence of Actinosynnema mirum type strain (101T)

(2009) Miriam Land et al.   Standards in Genomic Sciences

Thioester Hydrolysis and CC Bond Formation by Carboxymethylproline Synthase from the Crotonase Superfamily

(2008) Edward T. Batchelar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of the Covalent Adduct Formed between Mycobacterium tuberculosis β-Lactamase and Clavulanate†‡

(2008) Lee W. Tremblay et al.   BIOCHEMISTRY

Outer membrane permeability and antibiotic resistance

(2008) Anne H. Delcour   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mechanisms and structures of crotonase superfamily enzymes – How nature controls enolate and oxyanion reactivity

(2008) R. B. Hamed et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evidence that Thienamycin Biosynthesis Proceeds via C-5 Epimerization: ThnE Catalyzes the Formation of (2S,5S)-trans-Carboxymethylproline

(2008) Refaat B. Hamed et al.   CHEMBIOCHEM

The human oxygen sensing machinery and its manipulation

(2008) Rasheduzzaman Chowdhury et al.   CHEMICAL SOCIETY REVIEWS

The Radical SAM Superfamily

(2008) Perry A. Frey et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

α-Methylacyl-CoA racemase - an ‘obscure’ metabolic enzyme takes centre stage

(2008) Matthew D. Lloyd et al.   FEBS Journal

Identification and Characterization of NocR as a Positive Transcriptional Regulator of the β-Lactam Nocardicin A inNocardia uniformis

(2008) Jeanne M. Davidsen et al.   JOURNAL OF BACTERIOLOGY

Alanylclavam Biosynthetic Genes Are Clustered Together with One Group of Clavulanic Acid Biosynthetic Genes in Streptomyces clavuligerus

(2008) N. J. Zelyas et al.   JOURNAL OF BACTERIOLOGY

Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus

(2008) Paloma Liras et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production

(2008) Ju Yeon Song et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

The Last Step in Cephalosporin C Formation Revealed: Crystal Structures of Deacetylcephalosporin C Acetyltransferase from Acremonium chrysogenum in Complexes with Reaction Intermediates

(2008) Sara Lejon et al.   JOURNAL OF MOLECULAR BIOLOGY

Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?

(2008) Wei Ge et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anatomy of a Simple Acyl Intermediate in Enzyme Catalysis: Combined Biophysical and Modeling Studies on Ornithine Acetyl Transferase

(2008) Aman Iqbal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Treatment of health-care-associated infections caused by Gram-negative bacteria: a consensus statement

(2008) Ian Chopra et al.   LANCET INFECTIOUS DISEASES

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster fromStreptomyces cattleya

(2008) Miriam Rodríguez et al.   MOLECULAR MICROBIOLOGY

Gastric and Duodenal Antiulcer Activity of Alkaloids: A Review

(2008) Heloina De Sousa Falcão et al.   MOLECULES

Terpenoid alkaloids of the Buxaceae family with potential biological importance

(2008) Krishna P. Devkota et al.   NATURAL PRODUCT REPORTS

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

(2008) Dominique P. Frueh et al.   NATURE

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

(2008) Marco A van den Berg et al.   NATURE BIOTECHNOLOGY

Epigenetic remodeling of the fungal secondary metabolome

(2008) Russell B. Williams et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis

(2008) M. F. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unconventional serine proteases: Variations on the catalytic Ser/His/Asp triad configuration

(2008) Özlem Doğan Ekici et al.   PROTEIN SCIENCE

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE

The Mechanism for Isopenicillin N Synthase from Density-Functional Modeling Highlights the Similarities with Other Enzymes in the 2-His-1-carboxylate Family†

(2007) Marcus Lundberg et al.   BIOCHEMISTRY

The realm of penicillin G acylase in β-lactam antibiotics

(2007) Anuj K. Chandel et al.   ENZYME AND MICROBIAL TECHNOLOGY