Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

DNA Repair Proteins as Molecular Targets for Cancer Therapeutics

(2012) Mark Kelley et al.   Anti-Cancer Agents in Medicinal Chemistry

Oxidation and Reduction of Cysteines in the Intermembrane Space of Mitochondria: Multiple Facets of Redox Control

(2010) Johannes M. Herrmann et al.   ANTIOXIDANTS & REDOX SIGNALING

The Intermembrane Space of Mitochondria

(2010) Johannes M. Herrmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1

(2010) Mark R. Kelley et al.   ANTIOXIDANTS & REDOX SIGNALING

Interactions of Apurinic/Apyrimidinic Endonuclease with a Redox Inhibitor: Evidence for an Alternate Conformation of the Enzyme

(2010) Dian Su et al.   BIOCHEMISTRY

Oxidation-driven protein import into mitochondria: Insights and blind spots

(2010) Jan Riemer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dual Regulation by Apurinic/Apyrimidinic Endonuclease-1 Inhibits Gastric Epithelial Cell Apoptosis duringHelicobacter pyloriInfection

(2010) Ranajoy Chattopadhyay et al.   CANCER RESEARCH

Targeting DNA repair proteins for cancer treatment

(2010) Gianluca Tell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment

(2010) Gianluca Tell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of the redox function of APE1/Ref-1 in myeloid leukemia cell lines results in a hypersensitive response to retinoic acid-induced differentiation and apoptosis

(2010) Melissa L. Fishel et al.   EXPERIMENTAL HEMATOLOGY

Proximity ligation assays: a recent addition to the proteomics toolbox

(2010) Irene Weibrecht et al.   Expert Review of Proteomics

Identification and Characterization of Mitochondrial Targeting Sequence of Human Apurinic/Apyrimidinic Endonuclease 1

(2010) Mengxia Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Small-Molecule Inhibitor of Apurinic/Apyrimidinic Endonuclease 1 Blocks Proliferation and Reduces Viability of Glioblastoma Cells

(2010) A. Bapat et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury

(2010) Bartosz Szczesny et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions

(2010) Damiano Fantini et al.   NUCLEIC ACIDS RESEARCH

Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

(2009) Meihua Luo et al.   ANTIOXIDANTS & REDOX SIGNALING

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation

(2009) April M Reed et al.   Future Oncology

Intrusion of a DNA Repair Protein in the RNome World: Is This the Beginning of a New Era?

(2009) G. Tell et al.   MOLECULAR AND CELLULAR BIOLOGY

APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process

(2009) C. Vascotto et al.   MOLECULAR AND CELLULAR BIOLOGY

SIRT1 deacetylates APE1 and regulates cellular base excision repair

(2009) Tohru Yamamori et al.   NUCLEIC ACIDS RESEARCH

Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA

(2009) T. Barnes et al.   NUCLEIC ACIDS RESEARCH

Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53–MDM2 signaling pathway

(2009) C S Busso et al.   ONCOGENE

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells

(2009) Carlo Vascotto et al.   PROTEOMICS

Role of the Multifunctional DNA Repair and Redox Signaling Protein Ape1/Ref-1 in Cancer and Endothelial Cells: Small-Molecule Inhibition of the Redox Function of Ape1

(2008) Meihua Luo et al.   ANTIOXIDANTS & REDOX SIGNALING

Going Ape as an Approach to Cancer Therapeutics

(2008) Aditi Bapat et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting truncated APE1 in mitochondria enhances cell survival after oxidative stress

(2008) Meng-Xia Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Functional and stoichiometric analysis of subunit e in bovine heart mitochondrial F0F1ATP synthase

(2008) Elena Bisetto et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes

(2008) Bartosz Szczesny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unusual Role of a Cysteine Residue in Substrate Binding and Activity of Human AP-Endonuclease 1

(2008) Anil K. Mantha et al.   JOURNAL OF MOLECULAR BIOLOGY

Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration

(2008) G.-M. Zou et al.   MOLECULAR CANCER THERAPEUTICS

Evolution of the redox function in mammalian apurinic/apyrimidinic endonuclease

(2008) M.M. Georgiadis et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS