Granzyme A activates another way to die

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

(2009) J. Thiery et al.   BLOOD

The cytotoxic T lymphocyte protease granzyme A cleaves and inactivates poly(adenosine 5'-diphosphate-ribose) polymerase-1

(2009) P. Zhu et al.   BLOOD

Response: Granzyme A: cell death-inducing protease, proinflammatory agent, or both?

(2009) D. Martinvalet et al.   BLOOD

Ignition of p53 Bomb Sensitizes Tumor Cells to Granzyme K-Mediated Cytolysis

(2009) G. Hua et al.   JOURNAL OF IMMUNOLOGY

Death by a Thousand Cuts: Granzyme Pathways of Programmed Cell Death

(2008) Dipanjan Chowdhury et al.   Annual Review of Immunology

Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

(2008) Denis Martinvalet et al.   CELL

Human and Mouse Granzyme A Induce a Proinflammatory Cytokine Response

(2008) Sunil S. Metkar et al.   IMMUNITY

Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A

(2008) Niels Bovenschen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis

(2008) Vincent Idone et al.   JOURNAL OF CELL BIOLOGY

Neuroprotective Actions of PIKE-L by Inhibition of SET Proteolytic Degradation by Asparagine Endopeptidase

(2008) Zhixue Liu et al.   MOLECULAR CELL

Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity

(2008) Yuming Guo et al.   MOLECULAR IMMUNOLOGY

Granzyme K Expressing Cytotoxic T Lymphocytes Protects Against Influenza Virus in Granzyme AB−/− Mice

(2008) Misty R. Jenkins et al.   VIRAL IMMUNOLOGY