The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APPswe Cell Model of AD

Beta-secretase inhibitors in phase I and phase II clinical trials for Alzheimer’s disease

(2017) Charbel E-H. Moussa   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease

(2017) Kazunori Kikuchi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer’s disease mice

(2017) Cheng Zhang et al.   PLoS One

Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK/GSK3β-Nrf2 signal axis

(2017) Hongming Lv et al.   Redox Biology

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios: better diagnostic markers of Alzheimer disease

(2016) Shorena Janelidze et al.   Annals of Clinical and Translational Neurology

Activated AMPK boosts the Nrf2/HO-1 signaling axis—A role for the unfolded protein response

(2015) Kristin Zimmermann et al.   FREE RADICAL BIOLOGY AND MEDICINE

Xanthohumol, a Polyphenol Chalcone Present in Hops, Activating Nrf2 Enzymes To Confer Protection against Oxidative Damage in PC12 Cells

(2015) Juan Yao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases

(2015) Irina Milisav et al.   MOLECULES

Xanthohumol improved cognitive flexibility in young mice

(2014) Daniel R. Zamzow et al.   BEHAVIOURAL BRAIN RESEARCH

Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides

(2014) Georg Meisl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing

(2014) Shusaku Uchida et al.   Nature Communications

Effect of xanthohumol and 8-prenylnaringenin on MCF-7 breast cancer cells oxidative stress and mitochondrial complexes expression

(2013) M. Mar Blanquer-Rosselló et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Chroman-like cyclic prenylflavonoids promote neuronal differentiation and neurite outgrowth and are neuroprotective

(2013) Eleni Oberbauer et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease

(2013) Lauren D Stutzbach et al.   Acta Neuropathologica Communications

Xanthohumol suppresses inflammatory response to warm ischemia–reperfusion induced liver injury

(2012) Christoph Dorn et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Neuroprotective Effects of Xanthohumol, a Prenylated Flavonoid from Hops (Humulus lupulus), in Ischemic Stroke of Rats

(2012) Ting-Lin Yen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Protective effect of edaravone against Alzheimer's disease-relevant insults in neuroblastoma N2a cells

(2012) Yufang Yan et al.   NEUROSCIENCE LETTERS

Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease

(2011) Tae Ho Lee et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Xanthohumol Induces Apoptosis in Human Malignant Glioblastoma Cells by Increasing Reactive Oxygen Species and Activating MAPK Pathways

(2011) Michela Festa et al.   JOURNAL OF NATURAL PRODUCTS

Biological reactive intermediates (BRIs) formed from botanical dietary supplements

(2010) Birgit M. Dietz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via a mitochondria-mediated mechanism

(2010) Julia Strathmann et al.   FASEB JOURNAL

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and Frogs

(2010) Mariana Bollo et al.   PLoS One

Neuronal expression of vimentin in the Alzheimer's disease brain may be part of a generalized dendritic damage-response mechanism

(2009) Eli C. Levin et al.   BRAIN RESEARCH

8-hydroxy-2′ -deoxyguanosine (8-OHdG): A Critical Biomarker of Oxidative Stress and Carcinogenesis

(2009) ATHANASIOS VALAVANIDIS et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris

(2009) Naoto Yamaguchi et al.   PHYTOMEDICINE

Modification of the cysteine residues in I B  kinase and NF- B (p65) by xanthohumol leads to suppression of NF- B-regulated gene products and potentiation of apoptosis in leukemia cells

(2008) K. B. Harikumar et al.   BLOOD