Review
Immunology
Shen-ping Tang, Xin-li Mao, Ya-hong Chen, Ling-ling Yan, Li-ping Ye, Shao-wei Li
Summary: Liver transplantation is the ultimate method for treating end-stage liver disease. The increasing prevalence of obesity and non-alcoholic fatty liver has led to a rise in the number of patients who may require liver transplantation. Ischemia-reperfusion injury and oxidative stress play key roles in the pathogenesis of non-alcoholic fatty liver and its sensitivity to transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Qi Chen, Yating Song, Ningli Yang, Xiaoming Ai, Liyong Pu, Lianbao Kong
Summary: This study found that aging worsened ischemia/reperfusion injury and suppressed TRIB1 protein expression and anti-inflammatory function in macrophages. Restoring TRIB1 can alleviate liver damage by activating M2 polarization and anti-inflammatory response.
Review
Biochemistry & Molecular Biology
Raquel G. Bardallo, Arnau Panisello-Rosello, Sergio Sanchez-Nuno, Norma Alva, Joan Rosello-Catafau, Teresa Carbonell
Summary: In response to stress signal, Nrf2 regulates the expression of genes involved in antioxidant defense and detoxification, maintaining cellular homeostasis. During ischemia-reperfusion injury, Nrf2 activation can enhance cellular defense and promote hepatic recovery by mitigating oxidative stress and inflammation.
Article
Medicine, Research & Experimental
Zhangliu Jin, Meng Dou, Weihui Peng, Boen Xiao, Jinjin Liu, Wen Meng, Wei Liu
Summary: This study aimed to analyze alterations in gene expression, immune infiltration components, and potential biomarkers in liver ischemia-reperfusion injury (IRI) following liver transplantation (LT). The study identified differentially expressed genes associated with inflammation, apoptosis, cell proliferation, immune disorders, and cellular response, as well as various immune cell types infiltrating the IRI. The study also identified potential biological biomarkers, which may contribute to the diagnosis and prognosis of IRI post-transplant.
Article
Cell Biology
Ling Zhou, Xinlu Yang, Shuhua Shu, Sheng Wang, Fenglin Guo, Ying Yin, Weide Zhou, Han Han, Xiaoqing Chai
Summary: The study demonstrated that sufentanil exerts a significant protective effect against liver I/R injury by inhibiting inflammatory factors and reducing hepatocyte apoptosis. TP53BP2 is a key target for sufentanil in protecting the liver, with ATF4 potentially influencing sufentanil's protective effects by regulating TP53BP2 expression.
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Tamara Merz, Oscar McCook, Cosima Brucker, Christiane Waller, Enrico Calzia, Peter Radermacher, Thomas Datzmann
Summary: The discovery of endogenous H2S with cytoprotective properties has led to efforts in developing H2S as a therapeutic agent. H2S's ability to regulate various processes makes it potentially useful in managing critical illnesses. However, current methods of delivering H2S are not feasible for clinical use. Na2S2O3, a clinically approved compound, shows promise in pre-clinical studies for managing critical illnesses. Clinical trials are investigating its potential in myocardial infarction, and it may also be relevant for pre-eclampsia and COVID-19 pneumonia.
Review
Cell Biology
Christof Kaltenmeier, Ronghua Wang, Brandon Popp, David Geller, Samer Tohme, Hamza O. Yazdani
Summary: Ischemia reperfusion injury (IRI) is a common complication in liver surgery and transplantation, involving the activation of various cytokines and chemokines, as well as the release of damage-associated molecular patterns. The injury leads to cell death and a cytokine/chemokine storm, which attracts immune cells to the site and worsens the damage.
Article
Cell Biology
Lin Zhuang, Wenbin Ding, Qi Zhang, Wei Ding, Xuezhong Xu, Xiaolong Yu, Dong Xi
Summary: The study revealed that TGR5 plays a crucial role in modulating hepatic ischemia/reperfusion injury by activating the Keap1-Nrf2 signaling pathway to alleviate inflammation response. The results showed that knockdown of TGR5 worsened hepatic tissue injury significantly, while treatment with a TGR5 agonist reversed this effect.
Article
Medicine, Research & Experimental
Zhe Tang, Ye Feng, Wen Nie, Chenglong Li
Summary: This study evaluated the impact of xanthohumol (XN) on renal ischemia/reperfusion injury (IRI) in rats and found that XN effectively decreased renal injury by inhibiting ferroptosis and oxidative stress. The protective mechanism may be associated with the Nrf2/HO-1 signaling pathway.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jiao Lu, Menghao Wang, Yucheng Chen, Hua Song, Diguang Wen, Jianfei Tu, Yuan Guo, Zuojin Liu
Summary: The study aimed to investigate the role of NAMPT in liver ischemia-reperfusion injury (IRI). The results showed that NAMPT was upregulated in IRI, and treatment with the NAMPT inhibitor FK866 improved IRI and suppressed inflammation. Further mechanistic studies revealed that FK866 inhibited NAMPT activity, leading to decreased NAD+ levels and activity of NAD+-dependent enzymes, including PARP1, which in turn inhibited macrophage M1 polarization by reducing the expression of CD86, iNOS, TNF-alpha, and IL-1β. In conclusion, NAMPT can regulate macrophage polarization through NAD+/PARP1 to ameliorate liver injury, and FK866-mediated NAMPT blockade may serve as a therapeutic approach in liver IRI.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Engineering, Biomedical
Xu Liao, Xudong Song, Jiejing Li, Lisha Li, Xianglin Fan, Qin Qin, Chongbin Zhong, Pingzhen Yang, Jie Zhan, Yanbin Cai
Summary: The overproduction of reactive oxygen species (ROS) and burst of inflammation following cardiac ischemia-reperfusion (I/R) are the leading causes of cardiomyocyte injury. Monotherapeutic strategies designed to enhance anti-inflammatory or anti-ROS activity explicitly for treating I/R injury have demonstrated limited success because of the complex mechanisms involved. In this study, an injectable hydrogel system was designed and prepared to block the ROS-inflammation cycle, leading to improved treatment outcomes.
ACTA BIOMATERIALIA
(2022)
Article
Physiology
Xinghua Qin, Binghua Liu, Feng Gao, Yuanyuan Hu, Ziwei Chen, Jie Xu, Xing Zhang
Summary: In this study, gluconolactone (GDL) was found to provide cardioprotection against ischemia/reperfusion (I/R) injury by reducing infarct size, release of cardiac injury markers, and apoptosis. GDL also decreased reperfusion-induced arrhythmias and oxidative stress. Mechanistically, GDL activated pro-survival extracellular signal-regulated kinase (ERK) signaling through the activation of protein kinase C (PKC) epsilon, thereby protecting the heart against I/R injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hui Liu, Kwan Man
Summary: Liver transplantation is effective for end-stage liver disease patients, but may lead to hepatic ischemia reperfusion injury (IRI) causing acute inflammation, graft dysfunction, acute rejection, chronic rejection, cancer recurrence, and fibrogenesis. Understanding the mechanisms of inflammation and immune activation during IRI, as well as developing therapeutic strategies, is crucial for improving transplant outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Viktorija Zitkute, Mindaugas Kvietkauskas, Vygante Maskoliunaite, Bettina Leber, Diana Ramasauskaite, Kestutis Strupas, Philipp Stiegler, Peter Schemmer
Summary: The study showed that melatonin, glycine, and their combination can significantly reduce ischemia/reperfusion injury in a rat model, potentially by protecting tissue from oxidative stress and inflammation. Further clinical studies are needed to evaluate the protective effects of these substances in uterine IRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)