Peptidyl-prolyl cis–trans isomerase Pin1 in ageing, cancer and Alzheimer disease

Death-Associated Protein Kinase 1 Phosphorylates Pin1 and Inhibits Its Prolyl Isomerase Activity and Cellular Function

(2011) Tae Ho Lee et al.   MOLECULAR CELL

Pin1 expression contributes to lung cancer prognosis and carcinogenesis

(2010) Xiaogang Tan et al.   CANCER BIOLOGY & THERAPY

Membrane Permeable Cyclic Peptidyl Inhibitors against Human Peptidylprolyl Isomerase Pin1

(2010) Tao Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Elevated PIN1 expression by C/EBPα-p30 blocks C/EBPα-induced granulocytic differentiation through c-Jun in AML

(2010) J A Pulikkan et al.   LEUKEMIA

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

Oxidative Stress and Vascular Smooth Muscle Cell Growth: A Mechanistic Linkage by Cyclophilin A

(2009) Kimio Satoh et al.   ANTIOXIDANTS & REDOX SIGNALING

Structure-based design of novel human Pin1 inhibitors (I)

(2009) Chuangxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure-guided design of α-amino acid-derived Pin1 inhibitors

(2009) Andrew J. Potter et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The functional promoter polymorphism (−842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger

(2009) Chan H. Han et al.   BREAST CANCER RESEARCH AND TREATMENT

Inhibition of the Peptidyl-Prolyl-Isomerase Pin1 Enhances the Responses of Acute Myeloid Leukemia Cells to Retinoic Acid via Stabilization of RAR  and PML-RAR 

(2009) M. Gianni' et al.   CANCER RESEARCH

Peptidyl-Prolyl Isomerase Pin1 Markedly Enhances the Oncogenic Activity of the Rel Proteins in the Nuclear Factor- B Family

(2009) G. Fan et al.   CANCER RESEARCH

The prolyl isomerase Pin1 interacts with a ribosomal protein S6 kinase to enhance insulin-induced AP-1 activity and cellular transformation

(2009) N. Y. Lee et al.   CARCINOGENESIS

A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity

(2009) J. Lu et al.   CARCINOGENESIS

A Common Biological Mechanism in Cancer and Alzheimers Disease?

(2009) M. Behrens et al.   Current Alzheimer Research

Pin1 as an anticancer drug target

(2009) G.G. Xu et al.   DRUG NEWS & PERSPECTIVES

Pin1 Down-regulates Transforming Growth Factor-β (TGF-β) Signaling by Inducing Degradation of Smad Proteins

(2009) Ayako Nakano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF- B

(2009) J.-M. Peloponese et al.   JOURNAL OF VIROLOGY

Pin1 affects Tau phosphorylation in response to Aβ oligomers

(2009) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST

(2009) Yanhua Zheng et al.   MOLECULAR CELL

The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer

(2009) Alessandra Rustighi et al.   NATURE CELL BIOLOGY

The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation

(2009) Zhong-Jian Shen et al.   NATURE IMMUNOLOGY

Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation

(2009) Y Liao et al.   ONCOGENE

The rotamase Pin1 is up-regulated, hypophosphorylated and required for cell cycle progression in head and neck squamous cell carcinomas

(2009) Susanne Wiegand et al.   ORAL ONCOLOGY

G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression

(2009) P. Penela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pinning down HER2–ER crosstalk in SMRT regulation

(2009) Akihide Ryo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity

(2008) E. Pani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

(2008) Q. Ding et al.   CANCER RESEARCH

The Peptidyl-Isomerase Pin1 Regulates p27kip1 Expression through Inhibition of Forkhead Box O Tumor Suppressors

(2008) A. B. Brenkman et al.   CANCER RESEARCH

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer’s disease

(2008) Siddhartha Mondragón-Rodríguez et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Regulation of Amyloid β-Protein Precursor by Phosphorylation and Protein Interactions

(2008) Toshiharu Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

(2008) Sadasivam Jeganathan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT

(2008) Kristopher J. Stanya et al.   JOURNAL OF CELL BIOLOGY

Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart

(2008) Byung-Kwan Lim et al.   JOURNAL OF CLINICAL INVESTIGATION

Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability

(2008) Prudence B Lam et al.   Molecular Cancer

Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance

(2008) Tae Ho Lee et al.   NATURE CELL BIOLOGY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development