Article
Plant Sciences
Corinna Urmann, Lara Bieler, Eleni Priglinger, Ludwig Aigner, Sebastien Couillard-Despres, Herbert M. Riepl
Summary: Loss of neuronal tissue is a hallmark of age-related neurodegenerative diseases. Adult neurogenesis in the human brain has sparked interest in substances stimulating the endogenous neuronal regeneration mechanism. Medicinal plants are valuable sources of neuroactive small molecules. The pyrano ring is crucial for inducing neuronal differentiation of adult neural stem cells, while compounds with a prenyl group show lower activities.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Food Science & Technology
Byungjick Min, Yejin Ahn, Hyeok-Jun Cho, Woong-Kwon Kwak, Kyungae Jo, Hyung Joo Suh
Summary: This study investigated the sleep-promoting effects of different hop extracts in invertebrate and vertebrate models. Citra had a high alpha-acid content, while Saphir had high beta-acid and xanthohumol content. Simcoe and Mosaic water extracts and Saphir and Simcoe ethanol extracts increased total nighttime sleep in Drosophila melanogaster. They also improved total sleep time in mice with pentobarbital-induced sleep and upregulated the mRNA expression of GABA receptors in mouse brains.
JOURNAL OF FOOD SCIENCE
(2023)
Article
Oncology
Kartikey Kumar Gupta, Kamal Kant Sharma, Harish Chandra, Himalaya Panwar, Nitin Bhardwaj, Najla A. Altwaijry, Aisha A. Alsfouk, Zodwa Dlamini, Obaid Afzal, Abdulmalik S. A. Altamimi, Shahanavaj Khan, Abhay Prakash Mishra
Summary: Xanthohumol has demonstrated significant binding affinity to multiple targets within breast cancer-related signaling pathways in in silico analysis, offering new research possibilities for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vancha Harish, Effi Haque, Magdalena Smiech, Hiroaki Taniguchi, Sarah Jamieson, Devesh Tewari, Anupam Bishayee
Summary: Xanthohumol is an important prenylated flavonoid found in hops, known for its diverse medicinal applications and strong anticancer effects. This review focuses on the bioactivity of XH against various types of cancers, providing a comprehensive understanding of its potential in cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Bartlomiej Piasecki, Anna Biernasiuk, Agnieszka Ludwiczuk
Summary: This study analyzed the chemical composition and anti-microbial properties of essential oils and methanolic extracts from six different varieties of Humulus lupulus L. from Poland. Gas chromatography-mass spectrometry (GC/MS) and liquid chromatography-mass spectrometry (LC/MS) techniques were used to determine the chemical composition. The extracts showed a high concentration of xanthohumol, ff-acids, fi-acids, and prenylated flavonoids. The antimicrobial activity was highest in samples from the Iunga variety. Xanthohumol showed significant activity against MRSA strains with a minimum inhibitory concentration (MIC) value of 3.9 μg/mL.
Article
Microbiology
Sophie Moureu, Justine Jacquin, Jennifer Samaillie, Caroline Deweer, Celine Riviere, Jerome Muchembled
Summary: This study aimed to investigate the antifungal activity of different hop parts and metabolites against Venturia inaequalis, the causal agent of apple scab. The extracts of cones, leaves, and stems showed inhibitory effects on spore germination of the strains, while rhizomes did not. Xanthohumol, a prenylated chalcone, was found to be particularly effective in controlling both strains. Therefore, xanthohumol holds promise as a compound for the management of V. inaequalis.
Article
Chemistry, Analytical
Ali Q. Alorabi, Hussain Alessa, Nasser A. Alamrani, Ahmad A. Alluhaybi, Zehbah A. Al-Ahmed, Ali Sayqal, Hana M. Abumelha, Nashwa M. El-Metwaly
Summary: A novel smart cotton diagnostic assay was developed for onsite sensing of sweat pH variations. The assay demonstrated colorimetric changes upon exposure to sweat simulant fluid, showing potential applications in drug testing and healthcare. The addition of humulus lupulus L. extract and potassium aluminum sulfate resulted in the formation of mordant/xanthohumol nanoparticles onto cotton surface. The xanthohumol-finished cotton showed a colorimetric switch from yellow to white, indicating the successful detection of pH changes.
Article
Plant Sciences
Josef Patzak, Alena Henychova, Karel Krofta, Petr Svoboda, Ivana Malirova
Summary: Viroids are small infectious pathogens composed of short single-stranded circular RNA. The study evaluated the impact of HLVd infection on secondary metabolite content and composition in mature hop cones, as well as gene expression analyses in different hop cultivars. Viroid infection significantly reduced the contents of alpha bitter acids and xanthohumol, and affected gene expression related to secondary metabolite biosynthesis.
Article
Biochemistry & Molecular Biology
Sneha Singh, Rishi K. Somvanshi, Ujendra Kumar
Summary: This study compared the expression of key markers in differentiated and non-differentiated SH-SY5Y cells, and explored the role of somatostatin (SST) in regulating neurotransmitter distribution and expression. The results suggest the potential therapeutic implication of SST in neurodegeneration.
Article
Agronomy
J. A. Henning, M. S. Townsend, D. H. Gent, M. S. Wiseman, D. B. Walsh, D. P. Groenendale, A. M. Randazzo
Summary: The "USDA Triumph" hop cultivar, developed by the USDA-ARS hop breeding program, is a new high-yielding, widely adapted hop variety with excellent characteristics for brewing various beer styles, which has received positive reviews and wide application by brewers.
JOURNAL OF PLANT REGISTRATIONS
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Klimek, Katarzyna Tyskiewicz, Malgorzata Miazga-Karska, Agnieszka Debczak, Edward Roj, Grazyna Ginalska
Summary: This study developed an efficient extraction method to isolate bioactive compounds from Polish Marynka hops, with the crude extract showing better antibacterial activity and selective anti-proliferative effects compared to xanthohumol. Cell culture experiments also demonstrated that the crude extract had less impact on normal skin fibroblast viability and divisions than xanthohumol.
Article
Chemistry, Medicinal
Sun Xiao-Lei, Xia Tian-Shuang, Jiang Yi-Ping, Wang Na-Ni, Xu Ling-Chuan, Han Ting, Xin Hai-Liang
Summary: The study demonstrates that hops extract and its active constituent xanthohumol have protective effects against iron-induced nerve injury and memory impairment. The mechanisms involve activation of antioxidant pathways and improvement of oxidative stress levels.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Biochemistry & Molecular Biology
Jorge A. Sierra-Fonseca, Manuel Miranda, Siddhartha Das, Sukla Roychowdhury
Summary: The b gamma subunit of heterotrimeric G proteins interacts with both microtubules and actin filaments, playing a key role in modulating the neuronal cytoskeleton and participating in various aspects of neuronal differentiation. The interaction of Gb gamma with actin is independent of microtubules, and contributes to axon and growth cone formation during neuronal differentiation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Kevin S. Brown, Paige Jamieson, Wenbin Wu, Ashish Vaswani, Armando Alcazar Magana, Jaewoo Choi, Luce M. Mattio, Dylan Nelson, Patrick N. Reardon, Cristobal L. Miranda, Claudia S. Maier, Jan F. Stevens
Summary: In this study, the utility of machine learning techniques, Elastic Net and Random Forests, was explored for rapidly identifying individual anti-inflammatory components in complex mixtures. By fractionating and analyzing a plant extract, bioactivity predictors were identified and the predicted result was validated. This research demonstrates that individual bioactive natural products can be identified without extensive and repetitive bioassay-guided fractionation.
Article
Materials Science, Biomaterials
Oroitz Sanchez-Aguinagalde, Emilio Meaurio, Ainhoa Lejardi, Jose-Ramon Sarasua
Summary: This paper demonstrates the successful dispersion of xanthohumol (XH) in PCL in amorphous form, with positive interactions observed between the two components. The use of PCL as a matrix allows for the development of completely amorphous bioactive materials suitable for non-stiff biomedical devices, with high toughness retention up to 50 wt% XH content. The miscibility and specific interactions between XH and PCL were confirmed through DSC, XRD, FTIR, and AFM analyses.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Neurosciences
Adriana Covarrubias-Pinto, Alejandra Parra, Gonzalo Mayorga-Weber, Eduardo Papic, Isidora Vicencio, Pamela Ehrenfeld, Francisco J. Rivera, Maite A. Castro
Summary: Huntington's disease is a neurodegenerative disorder caused by a glutamine expansion in the huntingtin gene, associated with energy metabolism failure and oxidative damage. Ascorbic acid, a powerful antioxidant highly concentrated in the brain, modulates neuronal metabolism through the SVCT2 transporter. Alterations in SVCT2 trafficking to the plasma membrane in resting and active conditions in HD result in redox imbalance during early stages of the disease.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Review
Neurosciences
Felipe A. Bustamante-Barrientos, Maxs Mendez-Ruette, Alexander Ortloff, Patricia Luz-Crawford, Francisco J. Rivera, Carlos D. Figueroa, Luis Molina, Luis Federico Batiz
Summary: Estrogens and estrogen-like molecules have a significant impact on the biology of various cell types, with estrogen receptors playing a crucial role in modulating cell proliferation, differentiation, and survival, particularly in the central nervous system. Estrogens can exert neuroprotective roles, regulate the balance between proliferation and differentiation of neural stem/progenitor cells, and influence neurogenesis through multiple mechanisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Ophthalmology
Daniela Mayr, Julia Preishuber-Pfluegl, Andreas Koller, Susanne M. Brunner, Christian Runge, Anja-Maria Ladek, Francisco J. Rivera, Herbert A. Reitsamer, Andrea Trost
Summary: Pericytes (PCs) play a crucial role in vascular development and stability. In this study, two inducible reporter mouse models were used to investigate the expression efficiency of the tdTomato reporter gene in PCs. The results showed that both models successfully labeled PCs, but with different induction efficiencies. These models represent promising tools for fate-mapping studies of PCs, although one model showed additional labeling of Muller cells, which may hinder the analysis of reporter-positive PCs.
CURRENT EYE RESEARCH
(2022)
Review
Neurosciences
Gonzalo Mayorga-Weber, Francisco J. Rivera, Maite A. Castro
Summary: Life expectancy is increasing, resulting in a growing aging population. One of the factors related to inefficient brain function during aging is hypometabolism. This review focuses on the metabolic interactions between glial cells and neurons, particularly during aging. Aging alters the main metabolic exchange machinery, leading to inefficient levels of nutrients, detrimental mitochondrial activity, high reactive oxygen species levels, reduced ATP production, and a highly inflammatory environment. Ageing is a crucial risk factor for developing neurodegenerative/neuroinflammatory diseases.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Pasquale Romanelli, Lara Bieler, Patrick Heimel, Sinisa Skokic, Dominika Jakubecova, Christina Kreutzer, Pia Zaunmair, Tomislav Smolcic, Bruno Benedetti, Eva Rohde, Mario Gimona, David Hercher, Marina Dobrivojevic Radmilovic, Sebastien Couillard-Despres
Summary: Intralesional application of EVs after spinal cord injury leads to better motor recovery and reduces inflammation and scarring more effectively than intravenous administration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Siw Johannesen, Anita Friedrich, Susanne Mailaender, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn
Summary: Through the study of the pharmacology, safety, and tolerability of LNA Gapmer Antisense Oligonucleotide NVP-13 in nonhuman primates, we found that it effectively reduces the expression of TGFBR2, decreases TGF beta signal transduction, and enhances neurogenic niche activity. The use of NVP-13 in cynomolgus monkeys did not result in any adverse events.
Article
Biochemistry & Molecular Biology
Karin Strohmeier, Martina Hofmann, Jaroslaw Jacak, Marie-Sophie Narzt, Marlene Wahlmueller, Mario Mairhofer, Barbara Schaedl, Wolfgang Holnthoner, Martin Barsch, Matthias Sandhofer, Susanne Wolbank, Eleni Priglinger
Summary: The study found altered gene expression on the cellular and tissue levels in patients with lipedema, and revealed morphological differences in the cellular junctions of endothelial cell cultures derived from healthy individuals and those with lipedema through machine learning analysis. Additionally, the secretome of SVF cells from lipedema patients was shown to induce endothelial barrier dysfunction in early-stage lipedema, as evidenced by increased leakiness of healthy human primary endothelial cells.
Article
Biochemistry & Molecular Biology
Jennifer Baas, Sebastian Bieringer, Corazon Frias, Jerico Frias, Carolina Soehnchen, Corinna Urmann, Steffi Ritter, Herbert Riepl, Aram Prokop
Summary: Isatis tinctoria and its indigo dyes have provided active anti-leukaemic compounds, particularly indirubin. This study explores more indigoids in the plant extract and synthesizes new substituted quingdainones. The research shows that improving water solubility does not enhance anti-leukaemic activity, and identifies dihydroxyquingdainone as the most effective compound with multidrug resistance overcoming ability.
Article
Biochemistry & Molecular Biology
Carina Hromada, Jaana Hartmann, Johannes Oesterreicher, Anton Stoiber, Anna Daerr, Barbara Schaedl, Eleni Priglinger, Andreas H. Teuschl-Woller, Wolfgang Holnthoner, Johannes Heinzel, David Hercher
Summary: This study reveals increased lymphangiogenesis after peripheral nerve injury and repair. The findings suggest that Schwann cells may have an inhibitory effect on lymphatic vessel formation.
Article
Pharmacology & Pharmacy
Judith Kozole, Rosmarie Heydn, Eva Wirkert, Sabrina Kuespert, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn, Sebastian Peters, Siw Johannesen
Summary: This pilot study analyzed the molecular effects of a single high-dose G-CSF application on different regions of the rodent brain. The results showed minor suppressive or stimulatory effects on neurogenic and non-neurogenic differentiation markers, with an upregulation observed in the cerebellum and hypothalamus.
Article
Biochemistry & Molecular Biology
Maria Elena Silva, Matias Hernandez-Andrade, Nerea Abasolo, Cristobal Espinoza-Cruells, Josselyne B. Mansilla, Carolina R. Reyes, Selena Aranda, Yaiza Esteban, Ricardo Rodriguez-Calvo, Lourdes Martorell, Gerard Muntane, Francisco J. Rivera, Elisabet Vilella
Summary: The study investigated the activation and function of DDR1 in OLs by collagen IV. The results showed that collagen IV could induce DDR1 phosphorylation in OLs derived from both neural stem cells and human oligodendroglial cells. The protein expression of DDR1 decreased during OL differentiation. The addition of collagen IV did not change the number of DDR1+/MBP+ cells but accelerated OL branching.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Bruno Benedetti, Lara Bieler, Christina Erhardt-Kreutzer, Dominika Jakubecova, Ariane Benedetti, Maximilian Reisinger, Dominik Dannehl, Christian Thome, Maren Engelhardt, Sebastien Couillard-Despres
Summary: Spinal cord injury leads to axonal damage in the neocortex, resulting in dysfunctional cortical activity. This study focuses on the hyperexcitability of axotomized neurons in the primary motor cortex layer V (M1LV) and investigates the role of hyperpolarization cyclic nucleotide gated (HCN) channels. It is found that the dysfunction of HCN channels contributes to the pathophysiology of axotomized M1LV neurons, but its impact varies among neurons and interacts with other mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Ekaterina-Michaela Tomou, Lara Bieler, Tobias Spoettl, Sebastien Couillard-Despres, Helen Skaltsa, Corinna Urmann
Summary: In recent years, research has shown that Sideritis extracts can improve memory. However, their potential to promote the generation of new neurons through neural stem cell differentiation has not been explored. This study evaluates the neurogenic effects of different Sideritis infusions on neural stem and precursor cells, as well as their impact on cell viability. Metabolic fingerprints were also recorded using various analytical techniques. The results suggest that Sideritis infusions have potent neurogenic potential and may be useful in the treatment of neurodegenerative diseases.
Article
Physiology
Julia Preishuber-Pfluegl, Daniela Mayr, Veronika Altinger, Susanne M. Brunner, Andreas Koller, Christian Runge, Anja-Maria Ladek, Markus Lenzhofer, Francisco J. Rivera, Herbert Tempfer, Ludwig Aigner, Herbert A. Reitsamer, Andrea Trost
Summary: In this study, the participation and transdifferentiation of endogenous pericyte-derived cells in optic nerve injury were investigated using a lineage tracing reporter mouse model. The results showed the presence of pericyte-derived cells in the lesion, which increased in number over time. The non-vascular associated pericyte-derived cells in the lesion core suggest their participation in the injury response.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)