Article
Biochemistry & Molecular Biology
Yurika Hata, Takahiro Shimizu, Suo Zou, Masaki Yamamoto, Yohei Shimizu, Hideaki Ono, Takaaki Aratake, Shogo Shimizu, Youichirou Higashi, Nobutaka Shimizu, Takashi Karashima, Motoaki Saito
Summary: This study investigated the effects of central CRF on micturition and the involvement of CRF receptor subtypes and glutamatergic receptors. The results suggest that stimulation of brain CRFR1 may facilitate rat micturition via brain NMDA/AMPA receptors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Clinical Neurology
Mirmohammadali Mirramezani Alizamini, Xing Chen, Lina Nie, Zhonghua Dai, Ying Liu, Abbas Haghparast, Ning Wu, Jianjun Zhang, Fang Shen, Nan Sui, Jing Liang
Summary: Chronic stress can lead to a bias towards habitual behavioral strategies, and it is still unclear which neuronal system modulates stress-induced behavioral abnormalities during decision making. This study found that the corticotropin-releasing factor (CRF) system in the medial prefrontal cortex (mPFC) plays a critical role in governing strategy choice and stress response. Antagonists of CRF receptor 1 (CRFR1) can alleviate stress-induced behavioral abnormalities, suggesting that CRFR1 may be a potential target for treating chronic stress-altered behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Behavioral Sciences
Krystyna A. Rybka, Jennifer J. Lafrican, Zachary J. Rosinger, Deborah O. Ariyibi, Mecca R. Brooks, Jason S. Jacobskind, Damian G. Zuloaga
Summary: In this study, researchers found that corticotropin releasing factor (CRF) expressing neurons co-express androgen receptor (AR) and estrogen receptor alpha (ER alpha), which may be a mechanism for gonadal hormone regulation of hypothalamic-pituitary-adrenal (HPA) axis responsivity and stress-related behaviors. Sex differences were observed in the co-expression of CRF/AR and CRF/ER alpha, and the activation of CRF neurons in restraint-stressed mice also showed sex-specific differences.
HORMONES AND BEHAVIOR
(2023)
Article
Clinical Neurology
Hannah M. Edwards, Clare E. Wallace, Woodrow D. Gardiner, Brookelyn M. Doherty, Ryan T. Harrigan, Kayla M. Yuede, Carla M. Yuede, John R. Cirrito
Summary: The risk of developing Alzheimer's disease is influenced by genetics and environmental factors, such as stress, sleep abnormalities, and traumatic brain injury. Women have a higher risk of Alzheimer's disease compared to men, even after accounting for lifespan differences. Women are more likely to experience high levels of stress. Sex differences in stress response may contribute to the increased risk of Alzheimer's disease in women. In this study, we used microdialysis to measure A beta levels in male and female mice in response to acute stress. We found that A beta levels were altered differently in females compared to males, with females showing significantly increased levels of A beta. This response is mediated through differences in the Corticotrophin Releasing Factor receptor signaling pathway involving beta-arrestin in male and female mice, as male mice lacking beta-arrestin also showed an increase in A beta levels in response to stress, similar to females.
Review
Biochemistry & Molecular Biology
Kazunori Kageyama, Yasumasa Iwasaki, Makoto Daimon
Summary: This review focuses on the molecular mechanisms of CRF regulation in the hypothalamus during stress and stress resilience, highlighting the central role of CRF in regulating the stress response. The involvement of ACTH, glucocorticoids, various regulatory factors, and different CRF receptors in stress resilience are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Emi Kasama, Miho Moriya, Ryuma Kamimura, Tohru Matsuki, Kenjiro Seki
Summary: The study revealed that knockdown of hypothalamic corticotropin-releasing factor enhances the induction of false fear memories, while overexpression enhances the onset of false fear memory formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Michael H. Riad, Kwanghoon Park, Ines Ibanez-Tallon, Nathaniel Heintz
Summary: The study reveals the role of neuromodulatory substances in the medial prefrontal cortex (mPFC). It shows that a specific class of mPFC interneurons releases corticotropin-releasing hormone (CRH) to enhance excitability of pyramidal cells, leading to increased novelty exploration in male mice. The effect of CRH is influenced by sex and does not affect anxiety-related behaviors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Yukiomi Nakade, Rena Kitano, Taeko Yamauchi, Satoshi Kimoto, Kazumasa Sakamoto, Tadahisa Inoue, Yuji Kobayashi, Tomohiko Ohashi, Yoshio Sumida, Kiyoaki Ito, Masashi Yoneda
Summary: The study showed that central corticotropin-releasing factor (CRF) affects hepatic de novo lipogenesis and inflammation-related gene expression in rats through the sympathetic-noradrenergic nervous system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Bin Wang, Haixia Shi, Bo Yang, Zhigang Miao, Miao Sun, Hao Yang, Xingshun Xu
Summary: This study found that in the brains of depressed mice and Ahi1 knockout mice, ATP levels decreased while mtDNA copy numbers increased. Two proteins, Ahi1 and glucocorticoid receptor (GR), which are related to stress and depressive behaviors, were significantly decreased. Regular exercise is shown to increase Ahi1/GR complex levels and improve depressive behaviors.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Environmental Sciences
Ya Wang, Yajie Zhang, Zhaochun Shi, Tingting Di, Wenfeng Yu, Ling Chen
Summary: Exposure to PFOA in male mice enhances CRF expression in BLA neurons by increasing hepatic FGF21 synthesis, which then enhances CRF-R1 mediated presynaptic glutamate release to facilitate NMDAR-dependent BLA-LTP induction, leading to anxiety-like behaviors.
Article
Pharmacology & Pharmacy
Vadim Yakhnitsa, Guangchen Ji, Matthew Hein, Peyton Presto, Zack Griffin, Olga Ponomareva, Edita Navratilova, Frank Porreca, Volker Neugebauer
Summary: Functional pain syndromes occur without tissue injury or noxious events. Stress is a common trigger for pain attacks in these syndromes. Recent research suggests that kappa opioid receptors in the central nucleus of amygdala contribute to functional pain syndromes, but the underlying mechanisms are still unclear. Blocking these receptors may represent a new therapeutic strategy for stress-induced functional pain syndromes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Tsubaki Kijima, Yoshikage Muroi, Toshiaki Ishii
Summary: The study indicates that CRF receptor signaling in the DRN plays a positive role in regulating maternal care in lactating female mice by enhancing behaviors related to maternal care while not affecting anxiety-related behaviors.
BEHAVIORAL NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Ahmed Khattab, R. Will Charlton
Summary: Treatment with Tildacerfont in males can effectively reduce A4 levels, correct A4/T ratio and increase LH levels, indicating the potential of the drug to enhance testicular testosterone production. However, more data is needed to confirm its favorable impact on male reproductive health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang
Summary: In the neuroendocrine system, corticotropin-releasing hormone (CRH) activates CRHRs and plays a vital role in the HPA/HPI axis. Two CRHR1 subtypes, LcCRHR1-1 and LcCRHR1-2, were identified in Larimichthys crocea genome and were found to be highly homologous to known teleost CRHRs. These receptors were found to be localized in the cell membrane and respond to LcCRH by increasing cAMP, Ca2+ and mitogen-activated protein kinase phosphorylation. LcCRHR1s were expressed in various tissues, with high expression in the brain and ovaries, and shown to be specifically localized in ovarian follicle cells. This study suggests that the CRH/CRHR1 system may be involved in the neuroendocrine regulation of reproduction in L. crocea.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Anesthesiology
Zheng Xu, Yu Zhou, Qingchen Guo, Di Wang, Yi-Hong Gao, Wei -Nan Zhao, Hui-Mei Tang, Jun-Xia Yang, Xiaolu Yu, Hai -Lei Ding, Jun -Li Cao
Summary: PVNCRF neurons in the paraventricular nucleus of the hypothalamus play a role in isoflurane anesthesia and its modulation by acute stress. Inhibition of PVNCRF neurons can facilitate emergence from anesthesia, while activation of these neurons delays emergence.
BRITISH JOURNAL OF ANAESTHESIA
(2023)