Autophagy in Traumatic Brain Injury: A New Target for Therapeutic Intervention

Long noncoding RNAs in the mTOR signaling network: biomarkers and therapeutic targets

(2018) Tinglei Huang et al.   APOPTOSIS

Suppression of FoxO3a attenuates neurobehavioral deficits after traumatic brain injury through inhibiting neuronal autophagy

(2018) Liqian Sun et al.   BEHAVIOURAL BRAIN RESEARCH

LncRNA NEAT1 promotes autophagy in MPTP-induced Parkinson's disease through stabilizing PINK1 protein

(2018) Wang Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptome analysis reveals mechanisms of geroprotective effects of fucoxanthin in Drosophila

(2018) Alexey Moskalev et al.   BMC GENOMICS

Mdivi-1 alleviates blood-brain barrier disruption and cell death in experimental traumatic brain injury by mitigating autophagy dysfunction and mitophagy activation

(2018) Qiong Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Melatonin Balance the Autophagy and Apoptosis by Regulating UCP2 in the LPS-Induced Cardiomyopathy

(2018) Pan Pan et al.   MOLECULES

Simultaneous induction and blockade of autophagy by a single agent

(2018) Karolina Kucharewicz et al.   Cell Death & Disease

Neuroprotective effects of pifithrin-α against traumatic brain injury in the striatum through suppression of neuroinflammation, oxidative stress, autophagy, and apoptosis

(2018) Ya-Ni Huang et al.   Scientific Reports

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

Association of Respiratory Syncytial Virus Toll-Like Receptor 3-Mediated Immune Response with COPD Exacerbation Frequency

(2017) Daishun Liu et al.   INFLAMMATION

Therapeutic Implications of Autophagy Inducers in Immunological Disorders, Infection, and Cancer

(2017) Sanguine Byun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation

(2017) Lifa Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Extracellular Signal-Regulated Kinase/Nuclear Factor-Erythroid2-like2/Heme Oxygenase-1 Pathway-Mediated Mitophagy Alleviates Traumatic Brain Injury-Induced Intestinal Mucosa Damage and Epithelial Barrier Dysfunction

(2017) Yinlong Liu et al.   JOURNAL OF NEUROTRAUMA

Alteration in Long Non-Coding RNA Expression after Traumatic Brain Injury in Rats

(2017) Chuan-fang Wang et al.   JOURNAL OF NEUROTRAUMA

Effects of DHA on Hippocampal Autophagy and Lysosome Function After Traumatic Brain Injury

(2017) Yan Yin et al.   MOLECULAR NEUROBIOLOGY

Targeting the NF-E2-Related Factor 2 Pathway: a Novel Strategy for Traumatic Brain Injury

(2017) Li Zhang et al.   MOLECULAR NEUROBIOLOGY

Protective Role of Apocynin via Suppression of Neuronal Autophagy and TLR4/NF-κB Signaling Pathway in a Rat Model of Traumatic Brain Injury

(2017) Yan Feng et al.   NEUROCHEMICAL RESEARCH

Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression

(2017) Zhijun Li et al.   NEUROSCIENCE

Posttraumatic administration of a sub-anesthetic dose of ketamine exerts neuroprotection via attenuating inflammation and autophagy

(2017) C.-Q. Wang et al.   NEUROSCIENCE

FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury

(2017) Chonghui Tang et al.   Stem Cells International

Trehalose improves traumatic brain injury-induced cognitive impairment

(2017) Stuart D. Portbury et al.   PLoS One

Fucoxanthin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE and Nrf2-autophagy pathways

(2017) Li Zhang et al.   Scientific Reports

FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

(2016) Antoine H. Chaanine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

(2016) Marta Pajares et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Knockout of programmed cell death 5 (PDCD5) gene attenuates neuron injury after middle cerebral artery occlusion in mice

(2016) Jianfei Lu et al.   BRAIN RESEARCH

Altered expression of long non-coding RNA and mRNA in mouse cortex after traumatic brain injury

(2016) Jianjun Zhong et al.   BRAIN RESEARCH

Mitochondrial division inhibitor 1 (Mdivi-1) offers neuroprotection through diminishing cell death and improving functional outcome in a mouse model of traumatic brain injury

(2016) Qiong Wu et al.   BRAIN RESEARCH

Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway

(2016) Yan Feng et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Luteolin Attenuates Foam Cell Formation and Apoptosis in Ox-LDL-Stimulated Macrophages by Enhancing Autophagy

(2016) Bu-Chun Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Resveratrol attenuates neuronal autophagy and inflammatory injury by inhibiting the TLR4/NF-κB signaling pathway in experimental traumatic brain injury

(2016) YAN FENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Poststroke Induction of  -Synuclein Mediates Ischemic Brain Damage

(2016) T. Kim et al.   JOURNAL OF NEUROSCIENCE

Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy

(2016) Chao Lin et al.   JOURNAL OF PINEAL RESEARCH

Quercetin attenuates neuronal autophagy and apoptosis in rat traumatic brain injury model via activation of PI3K/Akt signaling pathway

(2016) Guoliang Du et al.   NEUROLOGICAL RESEARCH

Interference with Protease-activated Receptor 1 Alleviates Neuronal Cell Death Induced by Lipopolysaccharide-Stimulated Microglial Cells through the PI3K/Akt Pathway

(2016) Yuxin Li et al.   Scientific Reports

Role of the AMPK signaling pathway in early brain injury after subarachnoid hemorrhage in rats

(2015) Ji-Yang An et al.   ACTA NEUROCHIRURGICA

Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma

(2015) Marta M. Lipinski et al.   ANTIOXIDANTS & REDOX SIGNALING

Traumatic Brain Injury-Induced Neuronal Apoptosis is Reduced Through Modulation of PI3K and Autophagy Pathways in Mouse by FTY720

(2015) Li Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms

(2015) Lulu Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cellular Mechanisms of Toll-Like Receptor-3 Activation in the Thalamus Are Associated With White Matter Injury in the Developing Brain

(2015) Regina Vontell et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Protective Effects of Taurine against Closed Head Injury in Rats

(2015) Ming Sun et al.   JOURNAL OF NEUROTRAUMA

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

(2015) Peidu Jiang et al.   METHODS

Rosiglitazone exerts neuroprotective effects via the suppression of neuronal autophagy and apoptosis in the cortex following traumatic brain injury

(2015) JUNCHAO YAO et al.   Molecular Medicine Reports

Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic death

(2015) CHANG-MENG CUI et al.   Molecular Medicine Reports

Methylene blue exerts a neuroprotective effect against traumatic brain injury by promoting autophagy and inhibiting microglial activation

(2015) MINGFEI ZHAO et al.   Molecular Medicine Reports

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Melatonin protects the brain from apoptosis by enhancement of autophagy after traumatic brain injury in mice

(2015) Ke Ding et al.   NEUROCHEMISTRY INTERNATIONAL

17AAG improves histological and functional outcomes in a rat CCI model through autophagy activation and apoptosis attenuation

(2015) Lixin Ma et al.   NEUROSCIENCE LETTERS

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

Attenuation of Cell Death in Injured Cortex After Post-Traumatic Brain Injury Moderate Hypothermia: Possible Involvement of Autophagy Pathway

(2015) Yichao Jin et al.   World Neurosurgery

Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic–Ischemic Brain Damage in Neonatal Rats

(2015) Deyuan Li et al.   PLoS One

Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness

(2014) Robert S.B. Clark et al.   Autophagy

Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury

(2014) Chinmoy Sarkar et al.   Autophagy

Posttraumatic administration of luteolin protects mice from traumatic brain injury: Implication of autophagy and inflammation

(2014) Jianguo Xu et al.   BRAIN RESEARCH

2-Methoxyestradiol Attenuates Autophagy Activation After Global Ischemia

(2014) Xiao-Yu Xin et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

Crosstalk between autophagy and proteasome protein degradation systems: possible implications for cancer therapy

(2014) Slawomir Wojcik   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

Imidazole inhibits autophagy flux by blocking autophagic degradation and triggers apoptosis via increasing FoxO3a-Bim expression

(2014) ZHENXING LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

2-Methoxyestradiol confers neuroprotection and inhibits a maladaptive HIF-1α response after traumatic brain injury in mice

(2014) Eva-Verena Schaible et al.   JOURNAL OF NEUROCHEMISTRY

Apelin-13 Attenuates Traumatic Brain Injury-Induced Damage by Suppressing Autophagy

(2014) Hai-Jun Bao et al.   NEUROCHEMICAL RESEARCH

Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: The role of inhibition of Drp1 in ischemic brain damage

(2014) Wei Zuo et al.   NEUROPHARMACOLOGY

Hydrogen Sulfide Offers Neuroprotection on Traumatic Brain Injury in Parallel with Reduced Apoptosis and Autophagy in Mice

(2014) Mingyang Zhang et al.   PLoS One

Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death

(2014) C-J Lin et al.   Cell Death & Disease

FOXO Transcription Factors: Their Clinical Significance and Regulation

(2014) Yu Wang et al.   Biomed Research International

Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells

(2013) Li-li Hou et al.   ACTA PHARMACOLOGICA SINICA

Long-Term Disability and Survival in Traumatic Brain Injury: Results From the National Institute on Disability and Rehabilitation Research Model Systems

(2013) Jordan C. Brooks et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Tools and techniques to measure mitophagy using fluorescence microscopy

(2013) Nick J Dolman et al.   Autophagy

The interplay between epigenetic silencing, oncogenic KRas and HIF-1 regulatory pathways in control of BNIP3 expression in human colorectal cancer cells

(2013) Ewelina Swiderek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

(2013) Pedro J. Batista et al.   CELL

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Autophagy in inflammation, infection, neurodegeneration and cancer

(2013) Daniela S. Arroyo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury

(2013) Huang Fang et al.   Journal of Neuroinflammation

Melatonin-enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage

(2013) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Neuroprotective effect of ceftriaxone in a rat model of traumatic brain injury

(2013) Changmeng Cui et al.   NEUROLOGICAL SCIENCES

Role of mitochondrial fission in neuronal injury in pilocarpine-induced epileptic rats

(2013) X. Qiu et al.   NEUROSCIENCE

Mechanism underlying the inhibitory effect of Apelin-13 on glucose deprivation-induced autophagy in rat cardiomyocytes

(2013) HUI JIAO et al.   Experimental and Therapeutic Medicine

Chemopreventative effects of tetrahydrocurcumin on human diseases

(2013) Jia-Ching Wu et al.   Food & Function

FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway

(2012) Jingyi Zhou et al.   Autophagy

Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction

(2012) Shihui Xing et al.   Autophagy

Curcumin inhibits HMGB1 releasing and attenuates concanavalin A-induced hepatitis in mice

(2012) Chao Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apelin-13 Protects the Brain Against Ischemic Reperfusion Injury and Cerebral Edema in a Transient Model of Focal Cerebral Ischemia

(2012) Mehdi Khaksari et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Tetrahydrocurcumin Ameliorates Homocysteinylated Cytochrome-c Mediated Autophagy in Hyperhomocysteinemia Mice after Cerebral Ischemia

(2012) Neetu Tyagi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

(2012) Sen Lin et al.   Journal of Neuroinflammation

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Necrostatin-1 Suppresses Autophagy and Apoptosis in Mice Traumatic Brain Injury Model

(2012) Yao-Qi Wang et al.   NEUROCHEMICAL RESEARCH

[Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice

(2012) T. Wang et al.   NEUROSCIENCE

Long non-coding RNAs and cancer: a new frontier of translational research?

(2012) R Spizzo et al.   ONCOGENE

Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes

(2011) Youngil Lee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Clinical Practice Guideline for Emergency Department Ketamine Dissociative Sedation: 2011 Update

(2011) Steven M. Green et al.   ANNALS OF EMERGENCY MEDICINE

Microautophagy in mammalian cells: Revisiting a 40-year-old conundrum

(2011) Dalibor Mijaljica et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1

(2011) Anthony MJ Sanchez et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage

(2011) Gang Chen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

FoxO3a Changes in Pyramidal Neurons and Expresses in Non-Pyramidal Neurons and Astrocytes in the Gerbil Hippocampal CA1 Region After Transient Cerebral Ischemia

(2011) Ki-Yeon Yoo et al.   NEUROCHEMICAL RESEARCH

Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice

(2011) C.-L. Luo et al.   NEUROSCIENCE

Ketamine as a neuroprotective and anti-inflammatory agent in children undergoing surgery on cardiopulmonary bypass

(2011) Adnan T. Bhutta et al.   Pediatric Critical Care Medicine

Impairing the Mitochondrial Fission and Fusion Balance: A New Mechanism of Neurodegeneration

(2010) Andrew B. Knott et al.   Annals of the New York Academy of Sciences

Regulation of the Nrf2–Keap1 Antioxidant Response by the Ubiquitin Proteasome System: An Insight into Cullin-Ring Ubiquitin Ligases

(2010) Nicole F. Villeneuve et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms and Biology of B-Cell Leukemia/Lymphoma 2/Adenovirus E1B Interacting Protein 3 and Nip-Like Protein X

(2010) Ji Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

(2010) Weiliang Fan et al.   Autophagy

Docosahexaenoic acid (DHA) and the developing central nervous system (CNS) – Implications for dietary recommendations

(2010) Philippe Guesnet et al.   BIOCHIMIE

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia

(2010) Korapat Mayurasakorn et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes

(2010) Mitsunori Miyazaki et al.   FEBS Journal

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Toll-like receptor 4 in CNS pathologies

(2010) Madison M. Buchanan et al.   JOURNAL OF NEUROCHEMISTRY

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Tetrahydrocurcumin confers protection against amyloid β-induced toxicity

(2010) Shilpa Mishra et al.   NEUROREPORT

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

(2009) Daniel M. Rosenbaum et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibitory Effects of Ketamine on Lipopolysaccharide-Induced Microglial Activation

(2009) Yi Chang et al.   MEDIATORS OF INFLAMMATION

p65/RelA Modulates BECN1 Transcription and Autophagy

(2009) T. Copetti et al.   MOLECULAR AND CELLULAR BIOLOGY

Robust Docosahexaenoic Acid–Mediated Neuroprotection in a Rat Model of Transient, Focal Cerebral Ischemia

(2009) Ludmila Belayev et al.   STROKE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural basis of target recognition by Atg8/LC3 during selective autophagy

(2008) Nobuo N. Noda et al.   GENES TO CELLS

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology

Activation of Nrf2–ARE pathway in brain after traumatic brain injury

(2008) Wei Yan et al.   NEUROSCIENCE LETTERS

Autophagy is activated and might protect neurons from degeneration after traumatic brain injury

(2008) Yan-Bo Zhang et al.   Neuroscience Bulletin