Long non-coding RNAs and cancer: a new frontier of translational research?

Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation

(2011) Zhe Yang et al.   ANNALS OF SURGICAL ONCOLOGY

A critical role for non-coding RNAGAS5in growth arrest and rapamycin inhibition in human T-lymphocytes

(2011) Gwyn T. Williams et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome

(2011) M. S. Kumar et al.   BLOOD

Genetic variants in ultraconserved elements and risk of breast cancer in Chinese population

(2011) Hao Shen et al.   BREAST CANCER RESEARCH AND TREATMENT

Long Intergenic Noncoding RNAs: New Links in Cancer Progression

(2011) M.-C. Tsai et al.   CANCER RESEARCH

Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers

(2011) R. Kogo et al.   CANCER RESEARCH

YY1 Tethers Xist RNA to the Inactive X Nucleation Center

(2011) Yesu Jeon et al.   CELL

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

MEG3 imprinted gene contribution in tumorigenesis

(2011) Leonidas Benetatos et al.   INTERNATIONAL JOURNAL OF CANCER

lincRNAs act in the circuitry controlling pluripotency and differentiation

(2011) Mitchell Guttman et al.   NATURE

MicroRNAs in body fluids—the mix of hormones and biomarkers

(2011) Maria Angelica Cortez et al.   Nature Reviews Clinical Oncology

Diagnostic performance of the PCA3 urine test

(2011) George Leighton Lee et al.   Nature Reviews Urology

MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region

(2011) A.-r. Yoon et al.   NUCLEIC ACIDS RESEARCH

Expression profiling reveals MSX1 and EphB2 expression correlates with the invasion capacity of Wilms tumors

(2011) Albert Chetcuti et al.   PEDIATRIC BLOOD & CANCER

LINE-1 Hypomethylation During Primary Colon Cancer Progression

(2011) Eiji Sunami et al.   PLoS One

RNAcode: Robust discrimination of coding and noncoding regions in comparative sequence data

(2011) S. Washietl et al.   RNA

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

(2011) M. E. Askarian-Amiri et al.   RNA

Kcnq1ot1: A chromatin regulatory RNA

(2011) Chandrasekhar Kanduri   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Expression and Function of a Large Non-coding RNA Gene XIST in Human Cancer

(2011) Sarah M. Weakley et al.   WORLD JOURNAL OF SURGERY

Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity

(2011) Nicolas Léveillé et al.   Nature Communications

Response to “The Reality of Pervasive Transcription”

(2011) Harm van Bakel et al.   PLOS BIOLOGY

The Reality of Pervasive Transcription

(2011) Michael B. Clark et al.   PLOS BIOLOGY

Identification of differentially expressed genes using an annealing control primer system in stage III serous ovarian carcinoma

(2010) Yun-Sook Kim et al.   BMC CANCER

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

The c.469+46_56del mutation in the homeobox MSX1 gene—A novel risk factor in breast cancer?

(2010) Tomasz Sliwinski et al.   Cancer Epidemiology

PCA3: From basic molecular science to the clinical lab

(2010) John R. Day et al.   CANCER LETTERS

Recurrent Focal Copy-Number Changes and Loss of Heterozygosity Implicate Two Noncoding RNAs and One Tumor Suppressor Gene at Chromosome 3q13.31 in Osteosarcoma

(2010) I. Pasic et al.   CANCER RESEARCH

Natural Mutagenesis of Human Genomes by Endogenous Retrotransposons

(2010) Rebecca C. Iskow et al.   CELL

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

Long antisense non-coding RNAs and their role in transcription and oncogenesis

(2010) Kevin V. Morris et al.   CELL CYCLE

The ZEB/miR-200 feedback loop—a motor of cellular plasticity in development and cancer?

(2010) Simone Brabletz et al.   EMBO REPORTS

The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS

(2010) Krisztina Szegedi et al.   EXPERIMENTAL DERMATOLOGY

An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells

(2010) Manuele Castelnuovo et al.   FASEB JOURNAL

Characterization of the RNA content of chromatin

(2010) T. Mondal et al.   GENOME RESEARCH

Identification of Long stress-induced non-coding transcripts that have altered expression in cancer

(2010) Jessica M. Silva et al.   GENOMICS

Large non-coding RNAs: missing links in cancer?

(2010) M. Huarte et al.   HUMAN MOLECULAR GENETICS

Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a

(2010) Kyoko L. Yap et al.   MOLECULAR CELL

Research Resource: Expression Profiling Reveals Unexpected Targets and Functions of the Human Steroid Receptor RNA Activator (SRA) Gene

(2010) Charles E. Foulds et al.   MOLECULAR ENDOCRINOLOGY

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Highly parallel SNP genotyping reveals high-resolution landscape of mono-allelic Ube3a expression associated with locus-wide antisense transcription

(2010) Koji Numata et al.   NUCLEIC ACIDS RESEARCH

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

(2010) Yongjun Chu et al.   NUCLEIC ACIDS RESEARCH

lncRNAdb: a reference database for long noncoding RNAs

(2010) Paulo P. Amaral et al.   NUCLEIC ACIDS RESEARCH

CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

(2010) Jiayi Wang et al.   NUCLEIC ACIDS RESEARCH

EMX2 is epigenetically silenced and suppresses growth in human lung cancer

(2010) J Okamoto et al.   ONCOGENE

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

(2010) P Mestdagh et al.   ONCOGENE

CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer

(2010) A Lujambio et al.   ONCOGENE

Regulation of Emx2 Expression by Antisense Transcripts in Murine Cortico-Cerebral Precursors

(2010) Giulia Spigoni et al.   PLoS One

Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma

(2010) C. Braconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-transcriptional regulation of miR-27 in murine cytomegalovirus infection

(2010) A. H. Buck et al.   RNA

ncRNAimprint: A comprehensive database of mammalian imprinted noncoding RNAs

(2010) Y. Zhang et al.   RNA

Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNA

(2010) D. Cazalla et al.   SCIENCE

Noncoding RNA Gas5 Is a Growth Arrest- and Starvation-Associated Repressor of the Glucocorticoid Receptor

(2010) T. Kino et al.   Science Signaling

Most “Dark Matter” Transcripts Are Associated With Known Genes

(2010) Harm van Bakel et al.   PLOS BIOLOGY

A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivo

(2009) K. Li et al.   BLOOD

A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster

(2009) X. Zhang et al.   BLOOD

Transcribed-ultra conserved region expression is associated with outcome in high-risk neuroblastoma

(2009) Paola Scaruffi et al.   BMC CANCER

A Susceptibility Locus for Papillary Thyroid Carcinoma on Chromosome 8q24

(2009) H. He et al.   CANCER RESEARCH

Non-codingRNA sequence variations in human chronic lymphocytic leukemia and colorectal cancer

(2009) Sylwia E. Wojcik et al.   CARCINOGENESIS

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer

(2009) Wing Pui Tsang et al.   CARCINOGENESIS

SRA and its binding partners: an expanding role for RNA-binding coregulators in nuclear receptor-mediated gene regulation

(2009) Shane M. Colley et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

TGF-β3 and cancer: A review

(2009) H.G. Laverty et al.   CYTOKINE & GROWTH FACTOR REVIEWS

ConteXt of change-X inactivation and disease

(2009) Ruben Agrelo et al.   EMBO Molecular Medicine

Maternally Expressed Gene 3 (MEG3) Noncoding Ribonucleic Acid: Isoform Structure, Expression, and Functions

(2009) Xun Zhang et al.   ENDOCRINOLOGY

Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis

(2009) Imad J. Matouk et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

The regulation of non-coding RNA expression in the liver of mice fed DDC

(2009) Joan Oliva et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Identification and characterisation of a novel antisense non-coding RNA from the RBM5 gene locus

(2009) Nina D. Rintala-Maki et al.   GENE

Rational Design of Ligands Targeting Triplet Repeating Transcripts That Cause RNA Dominant Disease: Application to Myotonic Muscular Dystrophy Type 1 and Spinocerebellar Ataxia Type 3

(2009) Alexei Pushechnikov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Altered Nuclear Retention of mRNAs Containing Inverted Repeats in Human Embryonic Stem Cells: Functional Role of a Nuclear Noncoding RNA

(2009) Ling-Ling Chen et al.   MOLECULAR CELL

Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals

(2009) Mitchell Guttman et al.   NATURE

An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

(2009) Yoshiko Maida et al.   NATURE

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

(2009) Mark M Pomerantz et al.   NATURE GENETICS

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling

(2009) Sari Tuupanen et al.   NATURE GENETICS

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

The impact of retrotransposons on human genome evolution

(2009) Richard Cordaux et al.   NATURE REVIEWS GENETICS

UBE3A/E6-AP regulates cell proliferation by promoting proteasomal degradation of p27

(2009) Amit Mishra et al.   NEUROBIOLOGY OF DISEASE

Telomerase activity is associated with an increase in DNA methylation at the proximal subtelomere and a reduction in telomeric transcription

(2009) Laura J. Ng et al.   NUCLEIC ACIDS RESEARCH

GNAS1 T393C polymorphism is associated with histopathological response to neoadjuvant radiochemotherapy in esophageal cancer

(2009) H Alakus et al.   PHARMACOGENOMICS JOURNAL

The tumor suppressor WTX shuttles to the nucleus and modulates WT1 activity

(2009) M. N. Rivera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

(2009) Ahmad M. Khalil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of human noncoding RNAs in the control of tumorigenesis

(2009) L. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genetic Signatures of Noncoding RNAs

(2009) John S. Mattick   PLoS Genetics

Extended follow-up of the Finnish cartilage-hair hypoplasia cohort confirms high incidence of non-Hodgkin lymphoma and basal cell carcinoma

(2008) Mervi Taskinen et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation

(2008) Shiro Tochitani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased copy number of the TERT and TERC telomerase subunit genes in cancer cells

(2008) Ying Cao et al.   CANCER SCIENCE

SNPs in ultraconserved elements and familial breast cancer risk

(2008) Rongxi Yang et al.   CARCINOGENESIS

3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA

(2008) Jeremy E. Wilusz et al.   CELL

UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion

(2008) Fan Wang et al.   FEBS LETTERS

Identification of the human homolog of the imprinted mouse Air non-coding RNA

(2008) Iveta Y. Yotova et al.   GENOMICS

HOXA11 DNA methylation-A novel prognostic biomarker in ovarian cancer

(2008) Heidi Fiegl et al.   INTERNATIONAL JOURNAL OF CANCER

A Novel H19 Antisense RNA Overexpressed in Breast Cancer Contributes to Paternal IGF2 Expression

(2008) N. Berteaux et al.   MOLECULAR AND CELLULAR BIOLOGY

A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

(2008) Monika Martick et al.   NATURE

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE

Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA

(2008) Wenqiang Yu et al.   NATURE

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription

(2008) Xiangting Wang et al.   NATURE

p53 mRNA controls p53 activity by managing Mdm2 functions

(2008) Marco M. Candeias et al.   NATURE CELL BIOLOGY

Antisense transcripts are targets for activating small RNAs

(2008) Jacob C Schwartz et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NRED: a database of long noncoding RNA expression

(2008) Marcel E. Dinger et al.   NUCLEIC ACIDS RESEARCH

Rfam: updates to the RNA families database

(2008) P. P. Gardner et al.   NUCLEIC ACIDS RESEARCH

GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer

(2008) M Mourtada-Maarabouni et al.   ONCOGENE

The H19 locus acts in vivo as a tumor suppressor

(2008) T. Yoshimizu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells

(2008) S. A. Korneev et al.   RNA

RNA Exosome Depletion Reveals Transcription Upstream of Active Human Promoters

(2008) Pascal Preker et al.   SCIENCE

Differentiating Protein-Coding and Noncoding RNA: Challenges and Ambiguities

(2008) Marcel E. Dinger et al.   PLoS Computational Biology

Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells

(2008) Kevin V. Morris et al.   PLoS Genetics

Non-coding transcript in T cells (NTT): Antisense transcript activates PKR and NF-κB in human lymphocytes

(2007) Nayara Delgado André et al.   BLOOD CELLS MOLECULES AND DISEASES

The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta–Notch pathway in neuroblastoma

(2007) Ingrid Revet et al.   EXPERIMENTAL CELL RESEARCH