Article
Plant Sciences
Ji-Ye Lim, Ji-Hyun Lee, Dae-Ho Yun, Young-Mi Lee, Dae-Ki Kim
Summary: Nodakenin exhibits anti-inflammatory, antioxidant, and anti-apoptotic activities by regulating oxidative stress, inflammatory response, and apoptosis-related proteins, suggesting it may be an adjunctive preventive agent for liver injury.
Article
Plant Sciences
In-Chul Lee, Jong-Sup Bae
Summary: Aloin, the main component of Aloe, exhibits anti-inflammatory effects by inhibiting LPS-induced vascular inflammatory responses.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Genki Hiramatsu, Daisuke Uta, Kenichi Mihara, Tsugunobu Andoh, Toshiaki Kume
Summary: Panaxytriol inhibits the activation of microglia in LPS-induced BV-2 cells by suppressing the NF-kappa B signaling pathway.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yosuke Yamawaki, Hiroki So, Kana Oue, Satoshi Asano, Hisako Furusho, Mutsumi Miyauchi, Kotaro Tanimoto, Takashi Kanematsu
Summary: Periodontal disease is associated with neural diseases, and Porphyromonas gingivalis induces brain inflammation and neural damage through inflammatory responses. The antidepressant imipramine inhibits inflammatory responses and ameliorates neural damage related to periodontal disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Chamera, Katarzyna Curzytek, Kinga Kaminska, Ewa Trojan, Monika Leskiewicz, Kinga Tylek, Magdalena Regulska, Agnieszka Basta-Kaim
Summary: This study found that quetiapine can reduce inflammation and microglial activation, and alter the expression of cell markers. Additionally, CD200Fc also has a significant effect on the inflammation levels in MIA OCCs. Therefore, quetiapine and CD200Fc have a positive impact on neuroimmunological changes.
Article
Pharmacology & Pharmacy
Yang Fu, Hong-jin Zhang, Wei Zhou, Ze-qun Lai, Yi-Fei Dong
Summary: This investigation reveals that sophocarpine treatment can alleviate lipopolysaccharide (LPS) stimulated sepsis-induced cardiomyopathy (SIC) by repressing oxidative stress, autophagy, inflammation, and apoptosis via inhibition of the TLR-4/NF-kappa B pathway and activation of the Nrf2/HO-1 pathway. These findings suggest that sophocarpine could be a potential therapeutic approach for treating SIC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bingjin Li, Wei Yang, Tongtong Ge, Yao Wang, Ranji Cui
Summary: This article discusses the candidate mechanisms by which stress can lead to dysregulated microglia, which in turn contribute to the pathogenesis of depressive disorders. It suggests that changes in microglial function can strongly influence neuronal network activity through dysregulated cytokine secretion and increased release of neurotoxic metabolites, thereby contributing to pathological outcomes in response to stress.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Food Science & Technology
Atita Panyathep, Khanittha Punturee, Teera Chewonarin
Summary: Inflammatory response caused by bacterial infection after colorectal cancer surgery is a major concern. Green coffee bean extract, particularly the ethyl acetate insoluble fraction (EIF) containing chlorogenic acid (CGA), was found to inhibit TLR4 expression and NF-κB activation, resulting in the suppression of inflammatory response and CRC metastasis in colon cancer cells. Therefore, CGA-rich fraction from green coffee bean extract can be developed as an adjunctive treatment for colorectal cancer surgery to enhance therapeutic efficacy and survival rate.
Article
Immunology
He-Tao Bian, Ling Xiao, Liang Liang, Yin-Ping Xie, Hui-Ling Wang, Gao-Hua Wang
Summary: Depression is a common mental disorder with limited effective treatments available. Studies have shown that inhibition of HDAC3, such as with RGFP966, can improve depressive-like behaviors by inhibiting neuroinflammation and microglial activation. This suggests that targeting the HDAC3 pathway could be a potential treatment strategy for depression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Neurosciences
Erika Vazquez-Juarez, Ipsit Srivastava, Maria Lindskog
Summary: Misregulation of synaptic transmission, particularly decreased glutamate reuptake, may contribute to psychiatric disorders. Inhibition of glutamate transporters results in retuning of synaptic transmission, lowering the threshold for long-term synaptic potentiation (LTP). Similar LTP threshold reduction is observed in a depression rat model with low levels of glutamate transporters. Ketamine, an antidepressant, reverses the effects of increased glutamate on synaptic retuning, suggesting its mechanism of action in restoring synaptic tuning.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Joon Park, Eun Yeong Lim, Yun Tai Kim
Summary: This study found that AYE inhibits microglial activation-mediated inflammatory pain by suppressing the NF-kappa B and MAPK signaling pathways. Oral administration of AYE alleviated pain hypersensitivity and microglial activation in the spinal cord. The major active components in AYE, chlorogenic acid and t-Ferulic acid, showed inhibitory effects on LPS-induced microglial activation.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Shou-Lun Lee, Ssu-Chieh Tu, Ming-Yen Hsu, Ting-Yu Chin
Summary: The study demonstrated the neuroprotective effect of diosgenin on LPS-induced neural damage in both in vitro and in vivo experiments. Diosgenin effectively prevented neurite shortening and reduced proinflammatory cytokine expression in neurons, as well as improved motor dysfunction and dopaminergic neuron damage in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sopana Jamornwan, Tanida Chokpanuwat, Kwanchanok Uppakara, Sunhapas Soodvilai, Witchuda Saengsawang
Summary: Panduratin A possesses anti-inflammatory properties by suppressing microglial activation through the NF-kappa B signaling pathway and enhancing the production of anti-inflammatory cytokines.
Article
Immunology
Lourdes Fernandez de Cossio, Chloe Lacabanne, Maude Bordeleau, Garance Castino, Phillip Kyriakakis, Marie-Eve Tremblay
Summary: Inflammation during pregnancy can impact brain development and result in disorders in offspring. Microglia play a critical role in this process, and alterations in their function may affect cognition and neurodevelopment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Lei Liu, Kathryn N. Kearns, Ilyas Eli, Khadijeh A. Sharifi, Sauson Soldozy, Elizabeth W. Carlson, Kyle W. Scott, M. Filip Sluzewski, Scott T. Acton, Kenneth A. Stauderman, M. Yashar S. Kalani, Min Park, Petr Tvrdik
Summary: The study revealed that microglia participate in ischemic brain injury through previously undetected mechanisms, which may provide new avenues for therapeutic interventions.