Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making
出版年份 2018 全文链接
标题
Challenges Associated With Applying Physiologically Based Pharmacokinetic Modeling for Public Health Decision-Making
作者
关键词
-
出版物
TOXICOLOGICAL SCIENCES
Volume 162, Issue 2, Pages 341-348
出版商
Oxford University Press (OUP)
发表日期
2018-01-27
DOI
10.1093/toxsci/kfy010
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications
- (2017) Alicia Paini et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Development of a Combined In Vitro Physiologically Based Kinetic (PBK) and Monte Carlo Modelling Approach to Predict Interindividual Human Variation in Phenol-Induced Developmental Toxicity
- (2017) Marije Strikwold et al. TOXICOLOGICAL SCIENCES
- Multiscale modelling approaches for assessing cosmetic ingredients safety
- (2017) Frédéric Y. Bois et al. TOXICOLOGY
- Combining transcriptomics and PBPK modeling indicates a primary role of hypoxia and altered circadian signaling in dichloromethane carcinogenicity in mouse lung and liver
- (2017) Melvin E. Andersen et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Physiologically based pharmacokinetic modeling of human exposure to perfluorooctanoic acid suggests historical non drinking-water exposures are important for predicting current serum concentrations
- (2017) Rachel Rogers Worley et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- A tissue dose-based comparative exposure assessment of manganese using physiologically based pharmacokinetic modeling—The importance of homeostatic control for an essential metal
- (2017) P. Robinan Gentry et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- A global human health risk assessment for octamethylcyclotetrasiloxane (D 4 )
- (2017) Robinan Gentry et al. TOXICOLOGY LETTERS
- Using physiologically based pharmacokinetic modeling and benchmark dose methods to derive an occupational exposure limit for N-methylpyrrolidone
- (2016) T.S. Poet et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Multimedia & PBPK modelling with MERLIN-Expo versus biomonitoring for assessing Pb exposure of pre-school children in a residential setting
- (2016) Tine Fierens et al. SCIENCE OF THE TOTAL ENVIRONMENT
- Estimating Margin of Exposure to Thyroid Peroxidase Inhibitors Using High-Throughputin vitroData, High-Throughput Exposure Modeling, and Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling
- (2016) Jeremy A. Leonard et al. TOXICOLOGICAL SCIENCES
- Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards
- (2016) Hisham El-Masri et al. TOXICOLOGICAL SCIENCES
- Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction
- (2016) Jingtao Lu et al. PLoS Computational Biology
- Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective
- (2015) HM Jones et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data
- (2015) Karina Claassen et al. CURRENT PHARMACEUTICAL DESIGN
- Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK)
- (2015) Marc-André Verner et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
- (2015) Hasan Erbil Abaci et al. Integrative Biology
- Development and application of a human PBPK model for bromodichloromethane to investigate the impacts of multi-route exposure
- (2015) Elaina M. Kenyon et al. JOURNAL OF APPLIED TOXICOLOGY
- Reconstructing exposures from biomarkers using exposure-pharmacokinetic modeling – A case study with carbaryl
- (2015) Kathleen Brown et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Development of a physiologically based pharmacokinetic model for assessment of human exposure to bisphenol A
- (2015) Xiaoxia Yang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Unraveling bisphenol A pharmacokinetics using physiologically based pharmacokinetic modeling
- (2015) Xiaoxia Yang et al. Frontiers in Pharmacology
- Systems biology modeling of omics data: effect of cyclosporine a on the Nrf2 pathway in human renal cells
- (2014) Jérémy Hamon et al. BMC Systems Biology
- The successes and failures of physiologically based pharmacokinetic modeling: there is room for improvement
- (2014) Italo Poggesi et al. Expert Opinion on Drug Metabolism & Toxicology
- A physiologically based pharmacokinetic model for the oxime TMB-4: simulation of rodent and human data
- (2013) Teresa R. Sterner et al. ARCHIVES OF TOXICOLOGY
- Dispelling urban myths about default uncertainty factors in chemical risk assessment – sufficient protection against mixture effects?
- (2013) Olwenn V Martin et al. Environmental Health
- Comparison of PBTK model and biomarker based estimates of the internal dosimetry of acrylamide
- (2013) R.S. DeWoskin et al. FOOD AND CHEMICAL TOXICOLOGY
- Characterization of the human kinetic adjustment factor for the health risk assessment of environmental contaminants
- (2013) Mathieu Valcke et al. JOURNAL OF APPLIED TOXICOLOGY
- The Utility of Modeling and Simulation in Drug Development and Regulatory Review
- (2013) Shiew-Mei Huang et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Physiologically based pharmacokinetic model of lapatinib developed in mice and scaled to humans
- (2013) Susan F. Hudachek et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Physiologically-based pharmacokinetic model for Fentanyl in support of the development of Provisional Advisory Levels
- (2013) Harish Shankaran et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model
- (2013) Xiaoxia Yang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Novel physiologically based pharmacokinetic modeling of patupilone for human pharmacokinetic predictions
- (2012) Binfeng Xia et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials
- (2012) R Leong et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Computational toxicology: Physiologically based pharmacokinetic models (PBPK) for lifetime exposure and bioaccumulation of polybrominated diphenyl ethers (PBDEs) in marine mammals
- (2012) Liesbeth Weijs et al. ENVIRONMENTAL POLLUTION
- Development of a Human Physiologically Based Pharmacokinetic (PBPK) Toolkit for Environmental Pollutants
- (2011) Patricia Ruiz et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Reproducible Research in Computational Science
- (2011) R. D. Peng SCIENCE
- Physiologically Based Pharmacokinetic Model Use in Risk Assessment—Why Being Published Is Not Enough
- (2011) Eva D. McLanahan et al. TOXICOLOGICAL SCIENCES
- Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans
- (2011) Jeffrey W. Fisher et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans
- (2011) Weihsueh A. Chiu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Development and application of a physiologically based pharmacokinetic model for triadimefon and its metabolite triadimenol in rats and humans
- (2011) Susan Ritger Crowell et al. TOXICOLOGY LETTERS
- Prediction of human pharmacokinetics and tissue distribution of apicidin, a potent histone deacetylase inhibitor, by physiologically based pharmacokinetic modeling
- (2010) Beom Soo Shin et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review
- (2010) P Zhao et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Toxicity Testing in the 21st Century: A Vision and a Strategy
- (2010) Daniel Krewski et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
- A stochastic whole-body physiologically based pharmacokinetic model to assess the impact of inter-individual variability on tissue dosimetry over the human lifespan
- (2010) Rémy Beaudouin et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Evaluation and prediction of pharmacokinetics of PFOA and PFOS in the monkey and human using a PBPK model
- (2010) Anne E. Loccisano et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- PBPK modelling of inter-individual variability in the pharmacokinetics of environmental chemicals
- (2010) Frédéric Y. Bois et al. TOXICOLOGY
- Reproducible research and Biostatistics
- (2009) Roger D. Peng BIOSTATISTICS
- Physiological modeling and derivation of the rat to human toxicokinetic uncertainty factor for the carbamate pesticide aldicarb
- (2009) M. Pelekis et al. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
- Characterizing uncertainty and population variability in the toxicokinetics of trichloroethylene and metabolites in mice, rats, and humans using an updated database, physiologically based pharmacokinetic (PBPK) model, and Bayesian approach
- (2009) Weihsueh A. Chiu et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Bisphenol A levels in blood depend on age and exposure
- (2009) Hans Mielke et al. TOXICOLOGY LETTERS
- Predicting Plasma Concentrations of Bisphenol A in Children Younger Than 2 Years of Age after Typical Feeding Schedules, using a Physiologically Based Toxicokinetic Model
- (2008) Andrea N. Edginton et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- A PBPK Model for Evaluating the Impact of Aldehyde Dehydrogenase Polymorphisms on Comparative Rat and Human Nasal Tissue Acetaldehyde Dosimetry
- (2008) Justin G. Teeguarden et al. INHALATION TOXICOLOGY
- Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans
- (2008) T. Watanabe et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Approaches for Applications of Physiologically Based Pharmacokinetic Models in Risk Assessment
- (2008) Chad M. Thompson et al. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
- Development of good modelling practice for physiologically based pharmacokinetic models for use in risk assessment: The first steps
- (2008) George Loizou et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Development and specification of physiologically based pharmacokinetic models for use in risk assessment
- (2007) Rebecca A. Clewell et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More