The successes and failures of physiologically based pharmacokinetic modeling: there is room for improvement

ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport-Mediated PK and DDIs in Humans

(2013) M J Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The Utility of Modeling and Simulation in Drug Development and Regulatory Review

(2013) Shiew-Mei Huang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Physiologically based pharmacokinetic (PBPK) modeling: It is here to stay!

(2012) Amin Rostami-Hodjegan et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer

(2012) Sravanthi Cheeti et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Lead PK Commentary: Predicting Human Pharmacokinetics

(2011) Malcolm Rowland et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmacokinetic modeling approach

(2011) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Semi-Mechanistic Model to Predict the Effects of Liver Cirrhosis on Drug Clearance

(2010) Trevor N. Johnson et al.   CLINICAL PHARMACOKINETICS

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

(2010) P Zhao et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lumping of physiologically-based pharmacokinetic models and a mechanistic derivation of classical compartmental models

(2010) Sabine Pilari et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice

(2010) Trevor N. Johnson et al.   PEDIATRIC ANESTHESIA