Integration of Life-Stage Physiologically Based Pharmacokinetic Models with Adverse Outcome Pathways and Environmental Exposure Models to Screen for Environmental Hazards

SHEDS-HT: An Integrated Probabilistic Exposure Model for Prioritizing Exposures to Chemicals with Near-Field and Dietary Sources

(2014) Kristin K. Isaacs et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Development of a consumer product ingredient database for chemical exposure screening and prioritization

(2014) M.-R. Goldsmith et al.   FOOD AND CHEMICAL TOXICOLOGY

Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms

(2014) Nicole C Kleinstreuer et al.   NATURE BIOTECHNOLOGY

Immediate and long-term consequences of vascular toxicity during zebrafish development

(2014) T.L. Tal et al.   REPRODUCTIVE TOXICOLOGY

Species Extrapolation of Life-Stage Physiologically-Based Pharmacokinetic (PBPK) Models to Investigate the Developmental Toxicology of Ethanol Using In vitro to In vivo (IVIVE) Methods

(2014) Sheppard A. Martin et al.   TOXICOLOGICAL SCIENCES

Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

(2014) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human

(2013) Marije Strikwold et al.   ARCHIVES OF TOXICOLOGY

A Computational Model Predicting Disruption of Blood Vessel Development

(2013) Nicole Kleinstreuer et al.   PLoS Computational Biology

Disruption of embryonic vascular development in predictive toxicology

(2012) Thomas B. Knudsen et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Developmental expression of drug metabolizing enzymes: Impact on disposition in neonates and young children

(2012) R.N. Hines   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of Pbpk Models for Pfoa and Pfos for Human Pregnancy and Lactation Life Stages

(2012) Anne E. Loccisano et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses

(2011) Jörg Kessler et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment

(2011) Richard S. Judson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

(2011) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

(2010) Daniel M. Rotroff et al.   TOXICOLOGICAL SCIENCES

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

(2009) Agnès Poirier et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

(2009) Agnès Poirier et al.   MOLECULAR PHARMACEUTICS

The ontogeny of drug metabolism enzymes and implications for adverse drug events

(2008) Ronald N. Hines   PHARMACOLOGY & THERAPEUTICS

Estimating Consumer Exposure to PFOS and PFOA

(2008) David Trudel et al.   RISK ANALYSIS