Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction

Development of a physiologically based pharmacokinetic (PBPK) model for methyl iodide in rats, rabbits, and humans

(2016) Lisa M. Sweeney et al.   INHALATION TOXICOLOGY

Predicting Passive and Active Tissue:Plasma Partition Coefficients: Interindividual and Interspecies Variability

(2014) Christopher D. Ruark et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing

(2014) Barbara A. Wetmore et al.   TOXICOLOGICAL SCIENCES

Cytochrome P450 site of metabolism prediction from 2D topological fingerprints using GPU accelerated probabilistic classifiers

(2014) Jonathan D Tyzack et al.   Journal of Cheminformatics

Quantitative structure-pharmacokinetic relationship (QSPkP) analysis of the volume of distribution values of anti-infective agents from j group of the ATC classification in humans

(2013) Bruno Louis et al.   ACTA PHARMACEUTICA

Understanding the in vivo performance of enteric coated tablets using an in vitro-in silico-in vivo approach: Case example diclofenac

(2013) Atsushi Kambayashi et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Quantitative Structure–Activity Relationship Models of Clinical Pharmacokinetics: Clearance and Volume of Distribution

(2013) Vijay K. Gombar et al.   Journal of Chemical Information and Modeling

An Algorithm for Evaluating Potential Tissue Drug Distribution in Toxicology Studies from Readily Available Pharmacokinetic Parameters

(2013) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Quantitative Structure – Clearance Relationships of Acidic Drugs

(2013) Zvetanka Zhivkova et al.   MOLECULAR PHARMACEUTICS

Prediction and evaluation of route dependent dosimetry of BPA in rats at different life stages using a physiologically based pharmacokinetic model

(2013) Xiaoxia Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example

(2012) Vikash Kumar Sinha et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer

(2012) Sravanthi Cheeti et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms

(2012) Johannes Kirchmair et al.   Journal of Chemical Information and Modeling

Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 2: Clearance

(2012) Franco Lombardo et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Comprehensive Assessment of Human Pharmacokinetic Prediction Based on In Vivo Animal Pharmacokinetic Data, Part 1: Volume of Distribution at Steady State

(2012) Franco Lombardo et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Quantitative structure—plasma protein binding relationships of acidic drugs

(2012) Zvetanka Zhivkova et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Pharmacokinetic Model of cis- and trans-Permethrin Disposition in Rats and Humans With Aggregate Exposure Application

(2012) Rogelio Tornero-Velez et al.   TOXICOLOGICAL SCIENCES

Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science

(2011) Malcolm Rowland et al.   Annual Review of Pharmacology and Toxicology

Exposure-based prioritization of chemicals for risk assessment

(2011) Peter P. Egeghy et al.   ENVIRONMENTAL SCIENCE & POLICY

Application of a source-to-outcome model for the assessment of health impacts from dietary exposures to insecticide residues

(2011) Paul S. Price et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: Chlorpyrifos and parathion

(2011) Robert J. Foxenberg et al.   TOXICOLOGY

Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans

(2011) Jeffrey W. Fisher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Assessment ofin silicomodels for fraction of unbound drug in human liver microsomes

(2010) Hua Gao et al.   Expert Opinion on Drug Metabolism & Toxicology

Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model

(2010) Rogelio Tornero-Velez et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A unified algorithm for predicting partition coefficients for PBPK modeling of drugs and environmental chemicals

(2010) Thomas Peyret et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

QSAR application for the prediction of compound permeability with in silico descriptors in practical use

(2009) Kazuya Nakao et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Demonstration of the equivalent pharmacokinetic/pharmacodynamic dosing strategy in a multiple-dose study of gefitinib

(2009) S. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

(2008) R. S. Obach et al.   DRUG METABOLISM AND DISPOSITION

Quantifying the Relationships among Drug Classes

(2008) Jérôme Hert et al.   Journal of Chemical Information and Modeling

Network-based prediction of human tissue-specific metabolism

(2008) Tomer Shlomi et al.   NATURE BIOTECHNOLOGY

Prodrugs: design and clinical applications

(2008) Jarkko Rautio et al.   NATURE REVIEWS DRUG DISCOVERY

Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model

(2008) Jennifer L. Buur et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

General approach for the calculation of tissue to plasma partition coefficients

(2007) Walter Schmitt   TOXICOLOGY IN VITRO