Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase

The Hedgehog Pathway Effector Smoothened Exhibits Signaling Competency in the Absence of Ciliary Accumulation

(2014) Chih-Wei Fan et al.   CHEMISTRY & BIOLOGY

Roles for Hedgehog signaling in adult organ homeostasis and repair

(2014) R. Petrova et al.   DEVELOPMENT

Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation

(2014) S. Li et al.   Science Signaling

A Broadly Conserved G-Protein-Coupled Receptor Kinase Phosphorylation Mechanism Controls Drosophila Smoothened Activity

(2014) Dominic Maier et al.   PLoS Genetics

Decoding the phosphorylation code in Hedgehog signal transduction

(2013) Yongbin Chen et al.   CELL RESEARCH

Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling

(2013) X. Yang et al.   JOURNAL OF CELL SCIENCE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner

(2012) Junkai Fan et al.   DEVELOPMENTAL BIOLOGY

DrosophilaCK1-γ,gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking

(2012) William J. Gault et al.   JOURNAL OF CELL BIOLOGY

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

(2011) Q. Shi et al.   DEVELOPMENT

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

(2011) Yongbin Chen et al.   PLOS BIOLOGY

Mechanism and evolution of cytosolic Hedgehog signal transduction

(2010) C. W. Wilson et al.   DEVELOPMENT

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

(2010) Y. Chen et al.   GENES & DEVELOPMENT

Casein Kinase 2 Promotes Hedgehog Signaling by Regulating both Smoothened and Cubitus Interruptus

(2010) Hongge Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gilgamesh Is Required for rutabaga-Independent Olfactory Learning in Drosophila

(2010) Ying Tan et al.   NEURON

Regulation of Smoothened by Drosophila G-protein-coupled receptor kinases

(2009) Shuofei Cheng et al.   DEVELOPMENTAL BIOLOGY

Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved

(2009) M.-H. Chen et al.   GENES & DEVELOPMENT

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL