Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation

Endoplasmic Reticulum Stress Induces Tau Pathology and Forms a Vicious Cycle: Implication in Alzheimer's Disease Pathogenesis

(2018) Yuen-Shan Ho et al.   JOURNAL OF ALZHEIMERS DISEASE

The extracellular signal-regulated kinase 1/2 pathway in neurological diseases: A potential therapeutic target (Review)

(2017) Jing Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cox-2 Plays a Vital Role in the Impaired Anxiety Like Behavior in Colchicine Induced Rat Model of Alzheimer Disease

(2016) Susmita Sil et al.   BEHAVIOURAL NEUROLOGY

Role of cox-2 mediated neuroinflammation on the neurodegeneration and cognitive impairments in colchicine induced rat model of Alzheimer's Disease

(2016) Susmita Sil et al.   JOURNAL OF NEUROIMMUNOLOGY

Neurodegenerative and neurological disorders by small inhaled particles

(2016) Harm J. Heusinkveld et al.   NEUROTOXICOLOGY

Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

(2016) L. Calderón-Garcidueñas et al.   REVUE NEUROLOGIQUE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

U0126 Protects Cells against Oxidative Stress Independent of Its Function as a MEK Inhibitor

(2015) Qunxiang Ong et al.   ACS Chemical Neuroscience

Effects of prenatal exposure to silver nanoparticles on spatial cognition and hippocampal neurodevelopment in rats

(2015) Jinjin Wu et al.   ENVIRONMENTAL RESEARCH

Silica nanoparticles increase human adipose tissue-derived stem cell proliferation through ERK1/2 activation

(2015) Ki Joo Kim et al.   International Journal of Nanomedicine

PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load

(2015) David Chun-Hei Poon et al.   Journal of Neuroinflammation

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

(2015) Mikael Marttinen et al.   Molecular Neurodegeneration

Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration

(2015) Linda Gibbons et al.   NEUROBIOLOGY OF AGING

Synaptic degeneration in rat brain after prolonged oral exposure to silver nanoparticles

(2015) Joanna Skalska et al.   NEUROTOXICOLOGY

Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia

(2015) Mathilde Delaval et al.   Particle and Fibre Toxicology

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

(2015) Marina E Vance et al.   Beilstein Journal of Nanotechnology

Hippocampal-Prefrontal Circuit and Disrupted Functional Connectivity in Psychiatric and Neurodegenerative Disorders

(2015) Ming Li et al.   Biomed Research International

Brain Localization and Neurotoxicity Evaluation of Polysorbate 80-Modified Chitosan Nanoparticles in Rats

(2015) Zhong-Yue Yuan et al.   PLoS One

Fine Particulate Matter Air Pollution and Cognitive Function Among Older US Adults

(2014) J. A. Ailshire et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Functional roles of CREB as a positive regulator in the formation and enhancement of memory

(2014) Satoshi Kida et al.   BRAIN RESEARCH BULLETIN

Surface modifications of silica nanoparticles are crucial for their inert versus proinflammatory and immunomodulatory properties

(2014) Alessandrini et al.   International Journal of Nanomedicine

Different susceptibility of prefrontal cortex and hippocampus to oxidative stress following chronic social isolation stress

(2014) Jelena Zlatković et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53

(2014) Silvia Rossi et al.   Molecular Neurodegeneration

Differential Sensitivity of Prefrontal Cortex and Hippocampus to Alcohol-Induced Toxicity

(2014) Anna-Kate Fowler et al.   PLoS One

Uptake of silica nanoparticles: Neurotoxicity and Alzheimer-like pathology in human SK-N-SH and mouse neuro2a neuroblastoma cells

(2014) Xifei Yang et al.   TOXICOLOGY LETTERS

JNK inhibitor SP600125 protects against lipopolysaccharide-induced acute lung injury via upregulation of claudin-4

(2014) YUELIANG ZHENG et al.   Experimental and Therapeutic Medicine

SiO2 nanoparticles change colour preference and cause Parkinson's-like behaviour in zebrafish

(2014) Xiang Li et al.   Scientific Reports

Local and regional heterogeneity underlying hippocampal modulation of cognition and mood

(2014) Lindsay Tannenholz et al.   Frontiers in Behavioral Neuroscience

Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease

(2013) Suthicha Wuwongse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Discovery of a Potential Anti-Inflammatory Agent: 3-Oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile

(2013) Ran You et al.   JOURNAL OF MEDICINAL CHEMISTRY

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus

(2013) Mazen A. Kheirbek et al.   NEURON

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Epidemiology of Alzheimer Disease

(2013) R. Mayeux et al.   Cold Spring Harbor Perspectives in Medicine

Exposure to Particulate Air Pollution and Cognitive Decline in Older Women

(2012) Jennifer Weuve   ARCHIVES OF INTERNAL MEDICINE

Mesoporous silica nanoparticles in nanotechnology

(2012) Dennis Douroumis et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Exposure to silver nanoparticles does not affect cognitive outcome or hippocampal neurogenesis in adult mice

(2012) Peidang Liu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

The ageing cortical synapse: hallmarks and implications for cognitive decline

(2012) John H. Morrison et al.   NATURE REVIEWS NEUROSCIENCE

Review: Activation patterns of microglia and their identification in the human brain

(2012) D. Boche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neurotoxicity of Silica Nanoparticles: Brain Localization and Dopaminergic Neurons Damage Pathways

(2011) Jie Wu et al.   ACS Nano

The carcinogenic action of crystalline silica: A review of the evidence supporting secondary inflammation-driven genotoxicity as a principal mechanism

(2011) Paul J. A. Borm et al.   CRITICAL REVIEWS IN TOXICOLOGY

Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocamus of Wistar rats

(2011) Yang et al.   International Journal of Nanomedicine

Increased serum levels of dehydroepiandrosterone (DHEA) and interleukin-6 (IL-6) in women with mild to moderate Alzheimer's disease

(2011) Sigbritt Rasmuson et al.   INTERNATIONAL PSYCHOGERIATRICS

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Erk1/2 Inhibit Synaptic Vesicle Exocytosis through L-Type Calcium Channels

(2011) J. Subramanian et al.   JOURNAL OF NEUROSCIENCE

Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology

(2011) L K Fonken et al.   MOLECULAR PSYCHIATRY

Current status and future prospects of nanotechnology in cosmetics

(2011) Albert Mihranyan et al.   PROGRESS IN MATERIALS SCIENCE

The Role of Environmental Exposures in Neurodegeneration and Neurodegenerative Diseases

(2011) Jason R. Cannon et al.   TOXICOLOGICAL SCIENCES

The Tail Suspension Test

(2011) Adem Can et al.   Jove-Journal of Visualized Experiments

The Mouse Forced Swim Test

(2011) Adem Can et al.   Jove-Journal of Visualized Experiments

Are synapses targets of nanoparticles?

(2010) Sergei V. Fedorovich et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

(2010) Robert Field et al.   BRAIN BEHAVIOR AND IMMUNITY

Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice

(2010) Yuta Takahashi et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Size-dependent impairment of cognition in mice caused by the injection of gold nanoparticles

(2010) Yu-Shiun Chen et al.   NANOTECHNOLOGY

Degeneration and repair in central nervous system disease

(2010) Eng H Lo   NATURE MEDICINE

Silica-Based Nanoparticle Uptake and Cellular Response by Primary Microglia

(2009) Judy Choi et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Exposure to manufactured nanoparticles in different workplaces

(2009) Derk Brouwer   TOXICOLOGY

Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B

(2009) Hyun-Jeong Eom et al.   TOXICOLOGY IN VITRO

Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles☆

(2009) M.F. Rahman et al.   TOXICOLOGY LETTERS

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

(2008) M. C. Pott Godoy et al.   BRAIN

Applications and implications of nanotechnologies for the food sector

(2008) Qasim Chaudhry et al.   Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment

Neurobehavioral effects of ambient air pollution on cognitive performance in US adults

(2008) Jiu-Chiuan Chen et al.   NEUROTOXICOLOGY

Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro

(2008) Eun-Jung Park et al.   TOXICOLOGY LETTERS