Article
Endocrinology & Metabolism
Leah T. Braun, Frederick Vogel, Stephanie Zopp, German Rubinstein, Katharina Schilbach, Heike Kunzel, Felix Beuschlein, Martin Reincke
Summary: This study aimed to analyze the diurnal salivary cortisol profiles in patients with different types of Cushing's syndrome (CS). The results showed significant differences between Cushing subtypes, but diurnal cortisol profiles were not useful for subtyping CS in everyday clinical practice.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2022)
Article
Endocrinology & Metabolism
Hanna Franziska Nowotny, Matthias K. Auer, Christian Lottspeich, Heinrich Schmidt, Ilja Dubinski, Martin Bidlingmaier, Jo Adaway, James Hawley, Brian Keevil, Nicole Reisch
Summary: The study found that adrenal 11oxC19 androgens exhibit a diurnal pattern in both patients and controls, with distinct peaks and declines throughout the day, being more pronounced in 21OHD patients. Compared to controls, the correlations between the corresponding steroids were weaker in patients, indicating that 11oxC19 steroids may be suitable for treatment monitoring in 21OHD patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Ursula G. Saelzler, Paul Verhaeghen, Matthew S. Panizzon, Scott D. Moffat
Summary: This investigation reviewed decades of research on the hypersecretion of the glucocorticoid cortisol in individuals with Alzheimer's disease (AD), finding that AD is associated with basal cortisol elevations. However, there was no evidence of circadian dysrhythmia among individuals with AD, suggesting that basal hypersecretion of cortisol is a characteristic of AD while circadian dysrhythmia is not. Further research is needed to understand the role and timing of cortisol elevations in the progression of AD.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Haimei Xie, Xiaomei Zheng, Ye Huang, Weihao Li, Wenkai Wang, Qiao Li, Jiangtao Hou, Lulu Luo, Xiuying Kuang, Chuan-Quan Lin
Summary: Saliva composition has diurnal variations, which are not affected by citric acid stimulation. The variation characteristics of male and female under resting state and acid stimulation are basically the same, with the trend of salivary alpha-amylase activity being opposite to that of cortisol.
Review
Endocrinology & Metabolism
Michelle Henry, Kevin Garth Flusk Thomas, Ian Louis Ross
Summary: Sleep is critical for cognitive well-being and disruptions can lead to memory deficits, with cortisol levels potentially playing a role in this relationship. Patients with AD experience disrupted sleep and impaired memory due to consistent cortisol imbalances from glucocorticoid therapy, highlighting the importance of restoring a normal circadian rhythm. Future initiatives should focus on improving cognitive performance and quality of life for AD patients through prioritizing and optimizing sleep.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Zebin Wang, Shan Zeng, Yan Jing, Wenjuan Mao, Hongyan Li
Summary: Sarm1 plays a role in regulating circadian rhythm disturbances and AD progression. Sarm1 deficiency improves cognitive disorders, reduces Aβ plaque deposition, inhibits astrocyte activation, improves circadian rhythm, and alters clock molecule expression. These findings suggest that Sarm1 could be a therapeutic target to improve circadian rhythm and impede AD progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Daniel J. van Wamelen, Daniele Urso, K. Ray Chaudhuri
Summary: This study evaluated the impact of clock time on motor performance in de novo drug-naive patients with PD, showing diurnal variations in motor function and bradykinesia scores throughout the day.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Endocrinology & Metabolism
Cathy Degroote, Roland von Kanel, Livia Thomas, Claudia Zuccarella-Hackl, Nadine Messerli-Burgy, Hugo Saner, Roland Wiest, Petra H. Wirtz
Summary: Research shows that patients with coronary heart disease (CHD) and hypertension have decreased activity in the hypothalamus-pituitary-adrenal (HPA) axis, which may contribute to an increased risk of cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Md Farhad Hossain, Ni Wang, Ruijun Chen, Siwen Li, Jaydeep Roy, Md Giash Uddin, Zhong Li, Lee Wei Lim, You-Qiang Song
Summary: Melatonin plays crucial roles in Alzheimer's disease by promoting autophagy, improving sleep quality, and counteracting oxidative stress. The therapeutic potential of melatonin in AD may involve its multifunctional properties.
AGEING RESEARCH REVIEWS
(2021)
Review
Medicine, General & Internal
Maria G. Filippa, Maria G. Tektonidou, Aimilia Mantzou, Gregory A. Kaltsas, George P. Chrousos, Petros P. Sfikakis, Maria P. Yavropoulou
Summary: Iatrogenic adrenal insufficiency due to long-term use of exogenous glucocorticoids is common in rheumatoid arthritis patients, with a proportion needing small doses of glucocorticoids for clinical remission. Inadequate production of endogenous cortisol relative to enhanced clinical needs associated with the systemic inflammatory response may operate in RA, with the underlying mechanisms still unknown. Further research is needed on the pathogenetic role of compromised adrenal reserve in RA.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Environmental Sciences
Irene Sanchez, Jose Enrique de la Rubia Orti, Jose Luis Platero, Gonzalo Mariscal, Carlos Barrios
Summary: Elite basketball training results in increased physiological stress and higher salivary cortisol secretion in female basketball players. The secretion rhythm of cortisol may change over the course of the week and in response to competitive demands.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Biochemistry & Molecular Biology
Susanne Klaus, Carla Igual Gil, Mario Ost
Summary: The mammalian system of energy balance regulation is intrinsically rhythmic, driven by cellular circadian clocks and synchronized by external or internal cues. Mitochondria play a crucial role in energy generation and may influence the circadian system through endocrine-acting molecules. FGF21 and GDF15 are endocrine-acting metabolic mediators that show diurnal oscillations and impact brain master clock and systemic metabolism. More research is needed to understand the molecular mechanisms underlying energy balance regulation by mitokines and their role in health and disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Chris Ho Ching Yeung, C. Mary Schooling
Summary: This study found that systemic inflammatory regulators were not associated with the risk of Alzheimer's disease, but Alzheimer's disease was suggestively associated with certain specific inflammatory regulators.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Microbiology
Celeste Allaband, Amulya Lingaraju, Cameron Martino, Baylee Russell, Anupriya Tripathi, Orit Poulsen, Ana Carolina Dantas Machado, Dan Zhou, Jin Xue, Emmanuel Elijah, Atul Malhotra, Pieter C. Dorrestein, Rob Knight, Gabriel G. Haddad, Amir Zarrinpar
Summary: The study demonstrates that obstructive sleep apnea induces global changes in the cyclical dynamics of the gut microbiome and metabolome, increasing proinflammatory and proatherogenic substances while decreasing protective ones.
Article
Oncology
Ganesh R. Pawar, Yogeeta O. Agrawal, Kartik T. Nakhate, Chandragouda R. Patil, Charu Sharma, Shreesh Ojha, Umesh B. Mahajan, Sameer N. Goyal
Summary: This study confirmed the ameliorative effect of ghrelin on depression-like behavior induced by a high-fat diet and disturbed diurnal rhythm. The study also found that ghrelin has antioxidant and anti-inflammatory effects.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)