Review
Neurosciences
Andrea Moreno
Summary: The field of learning and memory traditionally viewed forgetting as an error, but recent studies suggest it may be a purposeful mechanism. Molecular pathways like postsynaptic glutamate receptors and neuromodulators are believed to be related to forgetting, providing new directions for research.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Immunology
Ivan Ballasch, Esther Garcia-Garcia, Cristina Vila, Anna Perez-Gonzalez, Anna Sancho-Balsells, Jessica Fernandez, David Soto, Mar Puigdellivol, Xavier Gasull, Jordi Alberch, Manuel J. Rodriguez, Josep M. Canals, Albert Giralt
Summary: In the last two decades, microglia have been recognized as important contributors to neurological disorders, not only through their immunological functions, but also through their ability to modulate synaptic and neural activity. The Ikzf1 gene, which plays crucial roles in regulating the function of circulating monocytes and lymphocytes, was found to be specifically expressed in adult microglia in the brain. Studies using Ikzf1 deficient mice revealed spatial learning deficits, impaired hippocampal function, and altered microglial morphology, suggesting that Ikzf1 is involved in microglial state and function. Furthermore, altered levels of Ikzf1 were observed in neurological disorder models and Alzheimer's disease patients, indicating its potential role in disease pathology.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Cell Biology
Carlos Wert-Carvajal, Melissa Reneaux, Tatjana Tchumatchenko, Claudia Clopath
Summary: Dopamine and serotonin are important neuromodulators that affect synaptic plasticity. In the hippocampus, they play different roles in encoding uncertainty and reward. This study compares different rules to describe their action and finds that their interaction improves learning performance.
Article
Cell Biology
Junfeng Su, Fengwen Huang, Yu Tian, Ran Tian, Qianqian Gao, Stephen Temitayo Bello, Dingxaun Zeng, Peter Jendrichovsky, C. Geoffrey Lau, Wenjun Xiong, Daiguan Yu, Micky Tortorella, Xi Chen, Jufang He
Summary: This study reveals the critical role of cholecystokinin (CCK) in heterosynaptic neuromodulation from the medial entorhinal cortex (MEC) to the hippocampus, affecting CA3-CA1 LTP and space-related performance.
Article
Neurosciences
William Almaguer-Melian, Daymara Merceron-Martinez, Jorge Bergado-Rosado
Summary: Synaptic plasticity plays a crucial role in memory encoding and storage. The administration of erythropoietin (EPO) has been shown to restore synaptic function and improve learning and memory ability. In a study using the fimbria-fornix lesion model, it was found that EPO can recover the capacity of synapses to produce long-lasting increases in transmission efficiency.
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Neurosciences
Qinghu Yang, Da Song, Zhen Xie, Guiqiong He, Juan Zhao, Zhe Wang, Zhifang Dong, Heao Zhang, Liang Yang, Ming Jiang, Yili Wu, Qing Shi, Junjie Li, Jun Yang, Zhantao Bai, Zhenzhen Quan, Hong Qing
Summary: This study reveals the role of optogenetic activation of CA3 pyramidal neurons in restoring the spatial memory of APP/PS1 mice. The stimulation enhances synaptic density/strength, synaptic plasticity, and activates astrocytes. Inhibiting the activity of CA3 astrocytes disrupts this restoration effect, resulting in reduced synaptic density/strength and cognitive impairments in the mice.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Cell Biology
Rudi Tong, Thomas Edward Chater, Nigel John Emptage, Yukiko Goda
Summary: Dendrites play a crucial role in integrating incoming synaptic information, with individual dendritic branches considered as signal processing units. This study explores how neighboring synapses shape the boundaries of functional dendritic units, highlighting the involvement of multiple signaling pathways in regulating the local pattern of synaptic strengths.
Article
Biochemistry & Molecular Biology
Grzegorz Wiera, Katarzyna Lebida, Anna Maria Lech, Patrycja Brzdak, Inge Van Hove, Lies De Groef, Lieve Moons, Enrica Maria Petrini, Andrea Barberis, Jerzy W. Mozrzymas
Summary: This study demonstrates that MMP3 plays a key role in iLTP mechanisms, affecting behaviors that in part depend on GABAergic plasticity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Yuki Aoki, Taiki Yokoi, Shota Morikawa, Nahoko Kuga, Yuji Ikegaya, Takuya Sasaki
Summary: As animals explore environments, hippocampal place cells fire at progressively earlier phases of theta oscillations. This study used optogenetic stimulation to replicate theta phase precession and evaluated its significance on place cell spike patterns. The results showed that place cells activated during phase precession stimulation displayed stronger reactivation and more stable place fields.
Article
Biology
Tanja Fuchsberger, Claudia Clopath, Przemyslaw Jarzebowski, Zuzanna Brzosko, Hongbing Wang, Ole Paulsen
Summary: The study suggests that dopamine can induce input-specific long-term potentiation in hippocampal synapses, affecting memory connections between neurons. This mechanism can control memory allocation and enable different types of reinforcement learning, while also enhancing the activation strength and spatial information carrying capacity of reactivated neurons.
Article
Pharmacology & Pharmacy
Wonseok Chang, Jihua An, Geun Hee Seol, Seung Ho Han, Jaeyong Yee, Sun Seek Min
Summary: Trans-anethole has neuroprotective effects and can positively influence synaptic plasticity, which suggests its potential for improving cognitive impairment caused by neurodegenerative diseases.
Article
Neurosciences
Price Obot, Galadu Subah, Antonia Schonwald, Jian Pan, Libor Velisek, Jana Veliskova, Patric K. Stanton, Eliana Scemes
Summary: Pannexin 1 (Panx1) is a widely expressed protein that forms plasma membrane channels allowing the passage of anions and moderate-sized signaling molecules. Previous studies have shown that activation of Panx1 channels contributes to various neurological disorders, and limited research suggests their involvement in hippocampus dependent learning. In this study, Panx1-null mice were used to investigate their role in working and reference memory and it was found that Panx1 channels in both astrocytes and neurons are critical for long-term spatial reference memory formation and consolidation. Recordings in hippocampal slices of Panx1-null mice showed a decrease in long-term potentiation and long-term depression, without affecting basal synaptic transmission or pre-synaptic paired-pulse facilitation.
Article
Multidisciplinary Sciences
Jae Hoon Jung, Lyndsey M. Kirk, Jennifer N. Bourne, Kristen M. Harris
Summary: Long-term potentiation is a cellular mechanism of learning and memory characterized by changes in vesicle density and structure of vesicle tethering filaments, resulting in an increase in release probability following LTP.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Marie Oule, Erika Atucha, Tenyse M. Wells, Tamar Macharadze, Magdalena M. Sauvage, Michael R. Kreutz, Jeffrey Lopez-Rojas
Summary: The Kv4.2 channels selectively modulate the excitability of medial dendrites of dentate GCs, impacting the spatial pattern separation capability of animals.
Article
Biochemistry & Molecular Biology
Zhaowei Liu, Zhanqiang Du, Kai Li, Yangguang Han, Guogang Ren, Zhuo Yang
NEUROCHEMICAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
Rupy Kaur Matharu, Lena Ciric, Guogang Ren, Mohan Edirisinghe
Article
Chemistry, Multidisciplinary
Yuen-Ki Cheong, Mariana P. Arce, Alejandro Benito, Daijie Chen, Noemi Luengo Crisostomo, Laxmi Kerai, Guillermo Rodriguez, Jose L. Valverde, Mansukhlal Vadalia, Arisbel Cerpa-Naranjo, Guogang Ren
Review
Chemistry, Multidisciplinary
Xiuyi Yang, Etelka Chung, Ian Johnston, Guogang Ren, Yuen-Ki Cheong
Summary: Antibiotic resistance poses a significant threat to public health, and nanoparticles with antimicrobial efficacy have the potential to combat this issue. More research is needed to fully understand the mechanisms of action and advance biomedical applications further.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Simon P. Graham, Yuen-Ki Cheong, Summer Furniss, Emma Nixon, Joseph A. Smith, Xiuyi Yang, Rieke Fruengel, Sabha Hussain, Monika A. Tchorzewska, Roberto M. La Ragione, Guogang Ren
Summary: The study evaluated five AVNPs for their viricidal activity against PRRSV, with CuNP showing the most effective reduction in virus titers at lower concentrations and achieving significant reduction in just 1.5 minutes. Direct contact between viruses and AVNP was necessary for optimal virus reduction, which was attributed to the inert nature of the AVNPs.
Review
Physics, Applied
Esra Altun, Mehmet Onur Aydogdu, Etelka Chung, Guogang Ren, Shervanthi Homer-Vanniasinkam, Mohan Edirisinghe
Summary: The synergy of metal-based nanoparticles (MBNPs) and antibiotics plays a crucial role in overcoming bacterial resistance, enhancing antibacterial effect, and reducing the dosage of active pharmaceutical ingredients.
APPLIED PHYSICS REVIEWS
(2021)
Article
Materials Science, Multidisciplinary
Rupy Kaur Matharu, Yuen-Ki Cheong, Guogang Ren, Mohan Edirisinghe, Lena Ciric
Summary: This study demonstrates the strong antiviral properties of novel copper-silver and copper-zinc intermetallic nanoparticles against RNA and DNA viruses, making them significant alternatives to conventional antiviral therapies and decontamination agents.
EMERGENT MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Adil Loya, Antash Najib, Fahad Aziz, Asif Khan, Guogang Ren, Kun Luo, Adil Loya
Summary: Adding metal oxide nanoparticles to fluids can enhance their thermal conductive properties, which is useful for high-end fluid heat-transfer applications. These nanoparticles can improve the properties of both polar and nonpolar fluids. Molecular dynamic simulations were used to disperse nanoparticles in hydrocarbon and aqueous-based fluids, and the results were validated using autocorrelation function and experimental data.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Maarij Khan, Zia-ur-Rehman Mashwani, Muhammad Ikram, Naveed Raja, Azza H. Mohamed, Guogang Ren, Ahmad A. Omar
Summary: This review article provides a detailed overview of the therapeutic actions and mechanisms of green synthesized cerium oxide nanoparticles in the medical field, which can contribute to the advancement and precision of medicine and provide important information for disease diagnosis and treatment strategies.
Article
Multidisciplinary Sciences
Adil Loya, Jacqueline L. Stair, Farid Uddin, Guogang Ren
Summary: This research focuses on investigating the interactions between surface-treated nanoparticles and liquid media through lab-based experimentation and simulation. The study explores the compatibility and diffusivity of modified CuO nanoparticles with short-chain carboxylate-terminated molecules in biofluids. Additionally, the efficacy of Cu/CuONPs in killing SARS-CoV1/2 and other airborne viruses is highlighted.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Environmental
Hailiang Mu, Xiangqun Zhuge, Guogang Ren, Kun Luo, Zhengping Ding, Yurong Ren, Zhihong Luo, Maryam Bayati, Ben Bin Xu, Xiaoteng Liu
Summary: A significantly extended battery life, improved rate performance and full-discharge capacity were achieved by using dual functional mesoporous silica (mSiO2) colloidal electrolytes for lithium-oxygen batteries. The mSiO2 with a high specific surface area exhibited a stable colloid after mixing with 1.0 M LiClO4/DMSO, suppressing side reactions and accelerating the decomposition of the discharge product. This study provides new insights into the design and development of novel lithium metal batteries using non-aqueous electrolytes.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Infectious Diseases
Amalia Miranda, Tamara Akpobolokemi, Etelka Chung, Guogang Ren, Bahijja Tolulope Raimi-Abraham
Summary: Plant-mediated green synthesis is a cost-effective and eco-friendly method to synthesize metallic nanoparticles. This study investigated the influence of experimental pH on the antimicrobial properties of silver nanoparticles synthesized using Spinacia oleracea leaf extract. The results showed that experimental pH played a significant role in determining the antimicrobial activity of the synthesized silver nanoparticles.
Article
Oncology
Zohreh Salari, Ahmad Khosravi, Elham Pourkhandani, Elaheh Molaakbari, Ehsan Salarkia, Alireza Keyhani, Iraj Sharifi, Hadi Tavakkoli, Samira Sohbati, Shahriar Dabiri, Guogang Ren, Mohammad Shafie'ei
Summary: This study compared the effects of 6-gingerol, cisplatin, and their combination on apoptotic and angiogenetic activities in ovarian cancer cells. The results showed that the combination therapy of 6-gingerol and cisplatin had a significant promotion on cell apoptosis and suppression on angiogenesis.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Kun Luo, Ya Li, Tong Liu, Xiangqun Zhuge, Etelka Chung, Andrew R. Timms, Simon P. Graham, Guogang Ren
Summary: Copper nanoparticles and gold nanoclusters have high catalytic performance in generating hydrogen peroxide, which can be used to kill disease-causing microbes and carry carbon-free energy. By decorating the surface of copper nanoparticles with gold nanoclusters using galvanic displacement, a novel method was demonstrated to selectively produce hydrogen peroxide. The optimized copper-gold bimetallic nanoparticles exhibited excellent catalytic activity and durability.
Article
Multidisciplinary Sciences
Ehsan Salarkia, Mahdis Mehdipoor, Elahe Molaakbari, Ahmad Khosravi, Mohammad Reza Sazegar, Zohreh Salari, Iman Rad, Shahriar Dabiri, Siyavash Joukar, Iraj Sharifi, Guogang Ren
Summary: The study investigates the effectiveness of synthesized polymeric mesoporous silica nanoparticles (MSN) as carriers for oral insulin and their interactions with insulin and IR through in-silico docking. The MSN family demonstrated a significant reduction in blood glucose levels and exhibited safety, non-toxicity, fast operation, self-repairing pancreas, cost-effectiveness, and high efficiency in the oral insulin delivery system. Docking results revealed strong interactions between MSN compounds and insulin and IR, offering promising prospects for diabetes treatment.
