Parallel lives of symbionts and hosts: chemical mutualism in marine animals

Mechanistic Investigations of PoyD, a Radical S-Adenosyl-l-methionine Enzyme Catalyzing Iterative and Directional Epimerizations in Polytheonamide A Biosynthesis

(2018) Aubérie Parent et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In situ metabolomic- and transcriptomic-profiling of the host-associated cyanobacteria Prochloron and Acaryochloris marina

(2017) Lars Behrendt et al.   ISME Journal

Enzymatic N- and C-Protection in Cyanobactin RiPP Natural Products

(2017) Debosmita Sardar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges

(2017) Vinayak Agarwal et al.   Nature Chemical Biology

De novo design and engineering of non-ribosomal peptide synthetases

(2017) Kenan A. J. Bozhüyük et al.   Nature Chemistry

Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges

(2017) Gerald Lackner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of chemoautotrophic symbiosis in the giant shipwormKuphus polythalamia(Bivalvia: Teredinidae) extends wooden-steps theory

(2017) Daniel L. Distel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary administration of tetrodotoxin and its putative biosynthetic intermediates to the captive-reared non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster

(2017) Yuta Kudo et al.   TOXICON

Sponge-associated bacteria mineralize arsenic and barium on intracellular vesicles

(2017) Ray Keren et al.   Nature Communications

An amphibian chemical defense phenotype is inducible across life history stages

(2017) Gary M. Bucciarelli et al.   Scientific Reports

Tetrodotoxin-Producing Bacteria: Detection, Distribution and Migration of the Toxin in Aquatic Systems

(2017) Timur Magarlamov et al.   Toxins

Increased Biosynthetic Gene Dosage in a Genome-Reduced Defensive Bacterial Symbiont

(2017) Juan Lopera et al.   mSystems

Cyclic Guanidine Compounds from Toxic Newts Support the Hypothesis that Tetrodotoxin is Derived from a Monoterpene

(2016) Yuta Kudo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Unique Tryptophan C-Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway

(2016) Anirudra Parajuli et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Lanthipeptide-like N-Terminal Leader Region Guides Peptide Epimerization by Radical SAM Epimerases: Implications for RiPP Evolution

(2016) Sebastian W. Fuchs et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lack of Overt Genome Reduction in the Bryostatin-Producing Bryozoan Symbiont “Candidatus Endobugula sertula”

(2016) Ian J. Miller et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Catalytic Mechanism of the Marine-Derived Macrocyclase PatGmac

(2016) Natércia F. Brás et al.   CHEMISTRY-A EUROPEAN JOURNAL

Tetrodotoxin

(2016) Max N. Lorentz et al.   CURRENT BIOLOGY

Polytheonamide biosynthesis showcasing the metabolic potential of sponge-associated uncultivated ‘Entotheonella’ bacteria

(2016) Michael F Freeman et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Combinatorial biosynthesis of RiPPs: docking with marine life

(2016) Debosmita Sardar et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Mechanisms of cyanobactin biosynthesis

(2016) Clarissa Melo Czekster et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The B12-Radical SAM Enzyme PoyC Catalyzes Valine Cβ-Methylation during Polytheonamide Biosynthesis

(2016) Aubérie Parent et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Calyculin: Nature's way of making the sponge-derived cytotoxin

(2016) Toshiyuki Wakimoto et al.   NATURAL PRODUCT REPORTS

Biosynthesis of polyketides by trans-AT polyketide synthases

(2016) Eric J. N. Helfrich et al.   NATURAL PRODUCT REPORTS

Seven enzymes create extraordinary molecular complexity in an uncultivated bacterium

(2016) Michael F. Freeman et al.   Nature Chemistry

Zachsia zenkewitschi (Teredinidae), a Rare and Unusual Seagrass Boring Bivalve Revisited and Redescribed

(2016) J. R. Shipway et al.   PLoS One

Metagenomic Analysis of the Sponge Discodermia Reveals the Production of the Cyanobacterial Natural Product Kasumigamide by ‘Entotheonella’

(2016) Yu Nakashima et al.   PLoS One

Metabolic model for diversity-generating biosynthesis

(2016) Ma. Diarey Tianero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for the broad substrate selectivity of a peptide prenyltransferase

(2016) Yue Hao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization

(2016) Emilia Oueis et al.   ChemistryOpen

Structure of the cyanobactin oxidase ThcOx fromCyanothecesp. PCC 7425, the first structure to be solved at Diamond Light Source beamline I23 by means of S-SAD

(2016) Andrew F. Bent et al.   Acta Crystallographica Section D-Structural Biology

Modularity of RiPP Enzymes Enables Designed Synthesis of Decorated Peptides

(2015) Debosmita Sardar et al.   CHEMISTRY & BIOLOGY

Identification and analysis of the bacterial endosymbiont specialized for production of the chemotherapeutic natural product ET-743

(2015) Michael M. Schofield et al.   ENVIRONMENTAL MICROBIOLOGY

Complexity of Naturally Produced Polybrominated Diphenyl Ethers Revealed via Mass Spectrometry

(2015) Vinayak Agarwal et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

An overview on the origin and production of tetrodotoxin, a potent neurotoxin

(2015) S. Jal et al.   JOURNAL OF APPLIED MICROBIOLOGY

Defensive symbioses of animals with prokaryotic and eukaryotic microorganisms

(2015) Laura V. Flórez et al.   NATURAL PRODUCT REPORTS

Structural analysis of leader peptide binding enables leader-free cyanobactin processing

(2015) Jesko Koehnke et al.   Nature Chemical Biology

Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms

(2015) Reiko Ueoka et al.   Nature Chemical Biology

Is phototridachiahydropyrone a true natural product?

(2015) Margherita Gavagnin et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

De novo synthesis of a sunscreen compound in vertebrates

(2015) Andrew R Osborn et al.   eLife

Is phototridachiahydropyrone a true natural product?

(2015) Margherita Gavagnin et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

RadicalS-Adenosyl Methionine Epimerases: Regioselective Introduction of DiverseD-Amino Acid Patterns into Peptide Natural Products

(2014) Brandon I. Morinaka et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides

(2014) Wael E. Houssen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phosphocalyculin C as a pyrophosphate protoxin of calyculin C in the marine sponge Discodermia calyx

(2014) Yoko Egami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ascidian photosymbiosis: Diversity of cyanobacterial transmission during embryogenesis

(2014) Euichi Hirose   GENESIS

Genetic differentiation among isolates ofTeredinibacter turnerae,a widely occurring intracellular endosymbiont of shipworms

(2014) Marvin A. Altamia et al.   MOLECULAR ECOLOGY

An environmental bacterial taxon with a large and distinct metabolic repertoire

(2014) Micheal C. Wilson et al.   NATURE

Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont

(2014) Toshiyuki Wakimoto et al.   Nature Chemical Biology

Latitudinal Variation of a Defensive Symbiosis in the Bugula neritina (Bryozoa) Sibling Species Complex

(2014) Jonathan Linneman et al.   PLoS One

Gill bacteria enable a novel digestive strategy in a wood-feeding mollusk

(2014) Roberta M. O’Connor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assessing the Combinatorial Potential of the RiPP Cyanobactin tru Pathway

(2014) Duane E. Ruffner et al.   ACS Synthetic Biology

Recognition Sequences and Substrate Evolution in Cyanobactin Biosynthesis

(2014) Debosmita Sardar et al.   ACS Synthetic Biology

Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection

(2014) Vaishali Bane et al.   Toxins

The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster

(2014) Greg Mann et al.   Acta Crystallographica Section F-Structural Biology Communications

Aestuaramides, a Natural Library of Cyanobactin Cyclic Peptides Resulting from Isoprene-Derived Claisen Rearrangements

(2013) John A. McIntosh et al.   ACS Chemical Biology

Structure of PatF fromProchloron didemni

(2013) Andrew F. Bent et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The Cyanobactin Heterocyclase Enzyme: A Processive Adenylase That Operates with a Defined Order of Reaction

(2013) Jesko Koehnke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Enzymatic Route to Selenazolines

(2013) Jesko Koehnke et al.   CHEMBIOCHEM

A Bacterial Source for Mollusk Pyrone Polyketides

(2013) Zhenjian Lin et al.   CHEMISTRY & BIOLOGY

Genome Mining Expands the Chemical Diversity of the Cyanobactin Family to Include Highly Modified Linear Peptides

(2013) Niina Leikoski et al.   CHEMISTRY & BIOLOGY

Defensive Bacteriome Symbiont with a Drastically Reduced Genome

(2013) Atsushi Nakabachi et al.   CURRENT BIOLOGY

Diversity and Biosynthetic Potential of Culturable Microbes Associated with Toxic Marine Animals

(2013) Rocky Chau et al.   Marine Drugs

Turnerbactin, a Novel Triscatecholate Siderophore from the Shipworm Endosymbiont Teredinibacter turnerae T7901

(2013) Andrew W. Han et al.   PLoS One

Bacterial Endosymbiosis in a Chordate Host: Long-Term Co-Evolution and Conservation of Secondary Metabolism

(2013) Jason C. Kwan et al.   PLoS One

Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills

(2013) Sherif I. Elshahawi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Relative configuration of luminaolide

(2013) Norihito Maru et al.   TETRAHEDRON LETTERS

Larval pufferfish protected by maternal tetrodotoxin

(2013) Shiro Itoi et al.   TOXICON

Decoding and Recoding the Ribosomal Peptide Universe

(2012) Eric W. Schmidt   CHEMISTRY & BIOLOGY

Structures of Cyanobactin Maturation Enzymes Define a Family of Transamidating Proteases

(2012) Vinayak Agarwal et al.   CHEMISTRY & BIOLOGY

Calyxamides A and B, Cytotoxic Cyclic Peptides from the Marine Sponge Discodermia calyx

(2012) Miki Kimura et al.   JOURNAL OF NATURAL PRODUCTS

Evolutionary Divergence of Sedoheptulose 7-Phosphate Cyclases Leads to Several Distinct Cyclic Products

(2012) Shumpei Asamizu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

(2012) Jesko Koehnke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Microbial Distribution and Abundance in the Digestive System of Five Shipworm Species (Bivalvia: Teredinidae)

(2012) Meghan A. Betcher et al.   PLoS One

Genome streamlining and chemical defense in a coral reef symbiosis

(2012) J. C. Kwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metagenome Mining Reveals Polytheonamides as Posttranslationally Modified Ribosomal Peptides

(2012) M. F. Freeman et al.   SCIENCE

Meta-omic Characterization of the Marine Invertebrate Microbial Consortium That Produces the Chemotherapeutic Natural Product ET-743

(2011) Christopher M. Rath et al.   ACS Chemical Biology

On the origins and biosynthesis of tetrodotoxin

(2011) Rocky Chau et al.   AQUATIC TOXICOLOGY

Accessing the Hidden Majority of Marine Natural Products through Metagenomics

(2011) Mohamed S. Donia et al.   CHEMBIOCHEM

Linking Chemistry and Genetics in the Growing Cyanobactin Natural Products Family

(2011) Mohamed S. Donia et al.   CHEMISTRY & BIOLOGY

Ribosomal Route to Small-Molecule Diversity

(2011) Ma. Diarey B. Tianero et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic Basis of Ribosomal Peptide Prenylation in Cyanobacteria

(2011) John A. McIntosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using the Acropora digitifera genome to understand coral responses to environmental change

(2011) Chuya Shinzato et al.   NATURE

Extreme genome reduction in symbiotic bacteria

(2011) John P. McCutcheon et al.   NATURE REVIEWS MICROBIOLOGY

Variation in Tropical Reef Symbiont Metagenomes Defined by Secondary Metabolism

(2011) Mohamed S. Donia et al.   PLoS One

Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron symbiosis

(2011) M. S. Donia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria

(2010) Kaarina Sivonen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The hidden diversity of ribosomal peptide natural products

(2010) Eric W Schmidt   BMC BIOLOGY

Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE1-34

(2010) Wael E. Houssen  et al.   CHEMBIOCHEM

Marine Molecular Machines: Heterocyclization in Cyanobactin Biosynthesis

(2010) John A. McIntosh et al.   CHEMBIOCHEM

Polyketide β-Branching in Bryostatin Biosynthesis: Identification of Surrogate Acetyl-ACP Donors for BryR, an HMG-ACP Synthase

(2010) Tonia J. Buchholz et al.   CHEMISTRY & BIOLOGY

Bryostatins: biological context and biotechnological prospects

(2010) Amaro E Trindade-Silva et al.   CURRENT OPINION IN BIOTECHNOLOGY

Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads

(2010) Eric W Schmidt et al.   CURRENT OPINION IN BIOTECHNOLOGY

Trabectedin therapy for sarcomas

(2010) Paolo G Casali et al.   CURRENT OPINION IN ONCOLOGY

A cytotoxic peptide from a marine sponge exhibits ion channel activity through vectorial-insertion into the membrane

(2010) Masayuki Iwamoto et al.   FEBS LETTERS

Insights into Heterocyclization from Two Highly Similar Enzymes

(2010) John A. McIntosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Circular Logic: Nonribosomal Peptide-like Macrocyclization with a Ribosomal Peptide Catalyst

(2010) John A. McIntosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Behavioral and Chemical Ecology of Marine Organisms with Respect to Tetrodotoxin

(2010) Becky L. Williams   Marine Drugs

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms

(2010) Kento Koketsu et al.   Nature Chemical Biology

The Genetic and Molecular Basis for Sunscreen Biosynthesis in Cyanobacteria

(2010) E. P. Balskus et al.   SCIENCE

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Highly Diverse Cyanobactins in Strains of the Genus Anabaena

(2009) N. Leikoski et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Tartrolon D, a Cytotoxic Macrodiolide from the Marine-Derived ActinomyceteStreptomycessp. MDG-04-17-069

(2009) Marta Pérez et al.   JOURNAL OF NATURAL PRODUCTS

Pederin-Type Pathways of Uncultivated Bacterial Symbionts: Analysis ofO-Methyltransferases and Generation of a Biosynthetic Hybrid

(2009) Katrin Zimmermann et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Using Marine Natural Products to Discover a Protease that Catalyzes Peptide Macrocyclization of Diverse Substrates

(2009) Jaeheon Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomal peptide natural products: bridging the ribosomal and nonribosomal worlds

(2009) John A. McIntosh et al.   NATURAL PRODUCT REPORTS

The Complete Genome of Teredinibacter turnerae T7901: An Intracellular Endosymbiont of Marine Wood-Boring Bivalves (Shipworms)

(2009) Joyce C. Yang et al.   PLoS One

Luminaolide, a novel metamorphosis-enhancing macrodiolide for scleractinian coral larvae from crustose coralline algae

(2009) Makoto Kitamura et al.   TETRAHEDRON LETTERS

Biosynthesis of toxic naturally-occurring seafood contaminants

(2009) John A. Kalaitzis et al.   TOXICON

Genomics and Evolution of Heritable Bacterial Symbionts

(2008) Nancy A. Moran et al.   Annual Review of Genetics

Microcyclamide Biosynthesis in Two Strains of Microcystis aeruginosa: from Structure to Genes and Vice Versa

(2008) N. Ziemert et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Widespread Occurrence and Lateral Transfer of the Cyanobactin Biosynthesis Gene Cluster in Cyanobacteria

(2008) N. Leikoski et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Evolutionary Relationships of "Candidatus Endobugula" Bacterial Symbionts and Their Bugula Bryozoan Hosts

(2008) G. E. Lim-Fong et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cellular Origin of Dysiherbaine, an Excitatory Amino Acid Derived from a Marine Sponge

(2008) Ryuichi Sakai et al.   CHEMBIOCHEM

In Vivo and In Vitro Trans-Acylation by BryP, the Putative Bryostatin Pathway Acyltransferase Derived from an Uncultured Marine Symbiont

(2008) Nicole B. Lopanik et al.   CHEMISTRY & BIOLOGY

Identification of the bacterial symbiont Entotheonella sp. in the mesohyl of the marine sponge Discodermia sp.

(2008) Wolfram M Brück et al.   ISME Journal

The ecology and phylogeny of cyanobacterial symbionts in sponges

(2008) Kayley M. Usher   Marine Ecology-An Evolutionary Perspective

Metabolites from symbiotic bacteria

(2008) Jörn Piel   NATURAL PRODUCT REPORTS

A global assembly line for cyanobactins

(2008) Mohamed S Donia et al.   Nature Chemical Biology

Trading molecules and tracking targets in symbiotic interactions

(2008) Eric W Schmidt   Nature Chemical Biology

Metabolic interactions between algal symbionts and invertebrate hosts

(2008) DAVID YELLOWLEES et al.   PLANT CELL AND ENVIRONMENT

Enzymes of the shikimic acid pathway encoded in the genome of a basal metazoan, Nematostella vectensis, have microbial origins

(2008) A. Starcevic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages

(2008) T. L. Simmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of tetrodotoxin and 4,9-anhydrotetrodotoxin in cultured juvenile kusafugu Fugu niphobles by dietary administration of natural toxic komonfugu Fugu poecilonotus liver

(2008) Michiko Kono et al.   TOXICON